> After the birth of printing, books became widespread…men quickly learned [about] so many topics….[E]specially since 1563, the number of [publications] in every field is greater than all those produced in the past thousand years….I really believe that at last the world is alive, indeed [intellectually] stimulating. > > —Johannes Kepler, De Stella Nova in Johannes Kepler Gesammelte Werke , vol 1. 1937, pp 330 to 332 Scientific information is of no value without dissemination. Before the advent of the printing press, new scientific knowledge was shared by word-of-mouth, by hand-written correspondence, or by the assiduous efforts of scribes who copied information on semipermanent media in libraries of papyrus scrolls. These methods of communication all suffered from limited reader access. With the invention of the printing press in the 15th century, mass production of printed materials became possible. The practical limitations of earlier methods of information sharing were immediately eliminated, with the resulting explosive growth in the publication of books of all sorts. The sciences, in particular, benefitted greatly from mechanical printing. The scientific method and the progress of science require that new observations are shared with the scientific community, both to encourage their replication and to advance the discipline. Each new scientific observation adds to the corpus of scientific knowledge, and the more rapidly the observation can be shared, the more rapidly the field progresses. To this end, the first scientific journals were established in 1665: the French Le Journal des Scavans (January 1665) and the English Philosophical Transactions of the Royal Society of London (March 1665). These journals presented reports on topics across the spectrum of science (natural philosophy), without emphasis on any particular branch of the discipline. The first biomedical journal was Acta Medica et Philosophica Hafniensia (1673). This journal was edited by Thomas Bartholin, physician and professor of anatomy …