Measures Of Control Research Articles

Effect of Timing of Insulin Degludec in Relation to Age in Type One Diabetic children and Adolescents (Single Center Study)

Abstract Background Glycemic control needs optimal adjustment of basal insulin timing for better health in children with diabetes, optimal adjustment of basal insulin to overcome hypoglycemia and glycemic variability (GV) depend on its duration of action and peakless profile. Aim of the Work This study aims to identify the best timing of long-acting basal insulin (degludec) in children with type 1 diabetes mellitus. Patients and Methods The current study is an observational study studying glycemic control as evidenced by HbA1c % in relation to the time of long-acting insulin (degludec) The study included 20 patients (age between 4:18 years), with type 1 diabetes received morning dose of insulin degludec then same dose but at night. participants are regularly following up at the Pediatrics and Adolescents Diabetes Unit (PADU), children’s Hospital, Ain Shams University in the period between October 2022 and April 2023, detailed history from participants was taken including: age, history of onset and duration of DM, associated co- morbidities, family history, Insulin regimen including mode of insulin delivery, total daily insulin dose (unit per Kg per day), type of insulin, frequency of injection and current injection timing, Thorough clinical examination: anthropometric parameters were assessed on WHO Z score and clinical evaluation of injection sites for apparent lipodystrophy. Investigations included the annual follow up investigations of the patient (CBC, lipid profile, thyroid profile, liver function tests, urinary albumin creatinine ratio, celiac screening, last hemoglobin A1c) and fundus examination. Glycemic control was assessed by pre-prandial and post-prandial readings and Hb A1c. Results The current study compares participants on morning regimen degludec followed by same dose at night regarding the impact on glycemic control, showed that Hb A1c % was better in children and adolescents using insulin degludec in the morning (mean of Hb A1c (8.23 ± 0.45%) compared to when using insulin degludec at night (mean of Hb A1c 9.16 ± 2.50%), irrespective of age. Conclusion Hb A1c as a measure of glycemic control was better when insulin Degludec was used in a morning regimen than when insulin degludec was given at night. Larger studies are needed to support this and recommend the best timing for insulin degludec in Pediatric age group.

Using continuous glucose monitoring to measure and improve quality metrics: Updates on the Healthcare Effectiveness Data and Information Set 2024 Glucose Management Indicator measure.

Value-based diabetes care is a proactive approach to providing quality care to individuals with diabetes. This approach focuses on improving clinical outcomes rather than the volume of services provided. Implementation of value-based diabetes care requires an established set of standardized quality measures against which all stakeholders can assess and benchmark their performance. The National Committee for Quality Assurance recently added the Glucose Management Indicator to its Healthcare Effectiveness Data and Information Set. The Glucose Management Indicator can be used as a measure of glucose control. This article discusses the benefits of value-based care, the importance of diabetes quality measures, and how the rapidly increasing adoption of continuous glucose monitoring is impacting these measures while improving the lives of individuals with diabetes.

Wearable technology mediated biofeedback to modulate spine motor control: a scoping review

BackgroundLower back pain (LBP) is a disability that affects a large proportion of the population and treatment for this condition has been shifting towards a more individualized, patient-centered approach. There has been a recent uptake in the utilization and implementation of wearable sensors that can administer biofeedback in various industrial, clinical, and performance-based settings. Despite this, there is a strong need to investigate how wearable sensors can be used in a sensorimotor (re)training approach, including how sensory biofeedback from wearable sensors can be used to improve measures of spinal motor control and proprioception.Research questionThe purpose of this scoping review was to examine the wide range of wearable sensor-mediated biofeedback frameworks currently being utilized to enhance spine posture and motor function.MethodsA comprehensive scoping review was conducted in adherence with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Guidelines extension for Scoping Reviews (PRISMA-ScR) across the following databases: Embase, PubMed, Scopus, Cochrane, and IEEEXplore. Articles related to wearable biofeedback and spine movement were reviewed dated from 1980 - 2020. Extracted data was collected as per a predetermined checklist including the type, timing, trigger, location, and magnitude of sensory feedback being applied to the body.ResultsA total of 23 articles were reviewed and analysed. The most used wearable sensor to inform biofeedback were inertial measurement units (IMUs). Haptic (vibrotactile) feedback was the most common sensory stimulus. Most studies used an instantaneous online trigger to initiate sensory feedback derived from information pertaining to gross lumbar angles or the absolute orientations of the thorax or pelvis.ConclusionsThis is the first study to review wearable sensor-derived sensory biofeedback to modulate spine motor control. Although the type of wearable sensor and feedback were common, this study highlights the lack of consensus regarding the timing and structure of sensory feedback, suggesting the need to optimize any sensory feedback to a specific use case. The findings from this study help to improve the understanding surrounding the ecological utility of wearable sensor-mediated biofeedback in industrial, clinical, and performance settings to enhance the sensorimotor control of the lumbar spine.

Longitudinal associations between parental psychological control and adolescents' intergroup attitudes to prosocial behaviors towards ethnic outgroups.

While a substantial body of existing literature has examined the negative effects of parental psychological control on adolescents' prosocial behaviors, there is a noticeable gap in whether parental psychological control affects prosocial behaviors towards ethnic outgroup members. This three-wave longitudinal study investigated whether similar relations can be observed between parental psychological control and prosocial behaviors targeted at ethnic outgroup persons, and whether these relations are mediated by adolescents' intergroup attitudes. Participants were 412 European American adolescents (42% girls; Mage = 15.63 years at Time 1) and their primary caregivers (52% mothers) residing in the United States. They completed online questionnaires. Parents completed a measure of parental psychological control at Time 1. Adolescents completed measures of intergroup attitudes, public, and altruistic outgroup prosocial behavior at all three time points (T1, T2, T3), each approximately 8 months apart. The retention rate was 38.1% (N = 157; 44% girls) at Time 3. Path analyses revealed a direct negative link between parental psychological control and altruistic prosocial behavior towards ethnic outgroup persons but a direct positive association to public prosocial behavior towards outgroup persons. Importantly, parental psychological control was indirectly related to adolescents' prosocial behavior towards ethnic outgroup persons, via its effect on their intergroup attitudes. The findings underscore how parental psychological control and adolescents' intergroup attitudes contribute to shaping prosocial behaviors towards ethnic outgroups.

A new neuropsychological tool for simultaneous reading and executive functions assessment: initial psychometric properties.

The development of reading and complex executive functions is fundamental for achieving social, academic, and professional success. So far, there is no single neuropsychological instrument that comprehensively assesses the domains of inhibitory control, cognitive flexibility, working memory, and reading comprehension. To assess executive functions related to reading, the "Assessment of Reading and Executive Functions" (AREF) was developed. In this study, we show initial evidence of validity and reliability for four subtests - Graphophonological-Semantic Flexibility, Inhibitory Control, Flexibility, and Working Memory. A total of 93 students from 4th to 9th grade, aged 8-14, in public (n = 61) and private (n = 32) schools were evaluated. Tasks from the AREF instrument, as well as measures of reading comprehension, inhibitory control, cognitive flexibility, working memory, and intelligence, were administered. Correlations between AREF scores and the other measures were performed to assess external construct validity. Performance differences between school groups on AREF subtests were analyzed using ANOVA, t-test, and Mann-Whitney tests, and the internal consistency of the instrument's tasks was evaluated using Cronbach's alpha coefficient. The scores of the AREF subtests demonstrated significant positive correlations with reading measures (ranging from 0.339 to 0.367) and executive functions (ranging from 0.209 to 0.396). Significant differences were found in the performance of some AREF tasks when comparing individuals from public and private schools, as well as between 4th and 5th graders compared to students in higher grades. The internal consistency of the tasks was low for Graphophonological-Semantic Flexibility (Cronbach's α = 0.566), moderate for Inhibitory Control and Flexibility (Cronbach's α = 0.768), and high for Working Memory (Cronbach's α = 0.881). The results provide initial evidence of construct validity and reliability for the AREF subtests. It is expected that this new neuropsychological test will contribute to the assessment of reading skills and executive functions, assisting in guiding clinical and educational interventions for individuals with and without neurodevelopmental disorders.

The Interplay of Structuring and Controlling Teaching Styles in Physical Education and Its Impact on Students' Motivation and Engagement.

Teaching style has a significant influence on students' learning outcomes. This study focused on identifying teaching profiles in Physical Education characterized by high directiveness, using structure and control behaviors that impact students' outcomes, basic psychological needs (BPN), and engagement. It was based on the circumplex model and self-determination theory (SDT) and intended to explore how these styles affect students' motivation and engagement. A cluster-based methodological design was applied, evaluating teachers through self-reports. Adapted measures of structure and control were used to classify teachers into four distinct profiles within the educational context of Physical Education. The study identified three teaching profiles: 'high structure-low control', 'high structure-high control', 'low structure-low control', and 'low structure-high control'. The 'high structure-low control' profile showed the best results in autonomous and controlled motivation, with greater behavioral engagement among students. In contrast, the 'high structure-high control' profile was associated with higher levels of demotivation. Teaching styles of structure and control can combine in various ways among Physical Education teachers, significantly influencing student motivation, satisfaction of basic psychological needs, and engagement. It is recommended that teachers adopt behaviors that support structure without becoming controlling to enhance student learning and participation in classes.

Clinical recognition of the role of the cervical spine in signs and symptoms of altered sensorimotor control

Together with visual and vestibular input the cervical spine is vital for sensorimotor control of head and eye movement control, general body postural stability adjustments and co-ordination.Altered cervical input in persons with neck disorders can lead to signs and symptoms of impaired sensorimotor control across and within several domains. Clinical assessment for differential diagnosis and to direct management of cervical related altered sensorimotor control is clearly required in many patients. This applies not only to patients with neck disorders but also in patients with, for example vestibular disorders or concussion, presenting with signs and symptoms of altered sensorimotor control where the cervical spine may have a role to play.This paper explores the research and current knowledge in relation to clinical measures of cervical related sensorimotor control. The feasibility, responsiveness, comparison to gold standards and potential of clinical measures of cervical related sensorimotor control to assist in differential diagnosis are considered where relevant. Future research directions should examine the full complement of psychometric properties of tests and consideration of any relationships of these measures to pain, dizziness, trauma and functional implications. Development of other measures as well as use in assessing response post management are also important directions.These clinical measures, along with a skilled interview and cervical musculoskeletal examination will enable clinicians to recognise and manage impaired cervical sensorimotor control in patients with neck disorders as well as determine the role of the cervical spine in many patients presenting with signs and symptoms of altered sensorimotor control.

B - 93 The Role of ex-Gaussian Parameters and Apathy in Reward Sensitivity Using a Modified Probabilistic Learning Task

Abstract Objective The current study examined the associations of apathy with attentional processes, indicated by ex-Gaussian (Ex-G) parameters of sensorimotor response speed and reward learning. Methods One hundred college-aged participants (M age = 20.32; SD = 3.69; 69 female) completed self-report measures of depression, apathy, and attentional control. Laboratory tasks included a choice reaction time (RT) task and a modified probabilistic learning task to assess sensorimotor processing and reward sensitivity. In the probabilistic learning task, participants selected the symbol associated with a high probability of gaining a monetary reward. Choice RT data were fit with Ex-G models, from which the parameter τ (bootstrapped sampling, 1000 iterations) was derived and used as the index of attentional lapses. Results A non-linear relationship was found between apathy and reward learning. Hierarchical regression was used to examine linear and higher-order relationships between apathy and behavioral indices (Ex-G τ and reward sensitivity). Results show that apathy explained none of the variance in reward learning (β = −0.005, p = 0.792, [bootstrapCI = −0.037, 0.026]). Incorporating apathy2 into the model led to significant R2 change (0.086), F(2, 89) = 0.4.142, p = 0.019, suggesting that as apathy increases, reward learning increases (β =0.006, p = 0.002, bootstrapCI = 0.002, 0.010]). Moreover, when controlling for depression, τ significantly contributes to the model, F(3, 89) = 4.142, p = 0.019, R2 = 0.17. Interactive effects revealed that at higher levels of apathy, higher Ex-G τ significantly decreases reward sensitivity (β = −0.003, p = 0.037, 95% bootstrapCI = [−0.006, −002]). Conclusions Higher levels of apathy and attentional lapses jointly reduced reward sensitivity, highlighting the role of task disengagement in apathy.

Characterizing Mechanical Changes in the Biceps Brachii Muscle in Mild Facioscapulohumeral Muscular Dystrophy Using Shear Wave Elastography.

There is no general consensus on evaluating disease progression in facioscapulohumeral muscular dystrophy (FSHD). Recently, shear wave elastography (SWE) has been proposed as a noninvasive diagnostic tool to assess muscle stiffness in vivo. Therefore, this study aimed to characterize biceps brachii (BB) muscle mechanics in mild-FSHD patients using SWE. Eight patients with mild FSHD, the BB were assessed using SWE, surface electromyography (sEMG), elbow moment measurements during rest, maximum voluntary contraction (MVC), and isometric ramp contractions at 25%, 50%, and 75% MVC across five elbow positions (60°, 90°, 120°, 150°, and 180° flexion). The mean absolute percentage deviation (MAPD) was analyzed as a measure of force control during ramp contractions. The shear elastic modulus of the BB in FSHD patients increased from flexed to extended elbow positions (e.g., p < 0.001 at 25% MVC) and with increasing contraction intensity (e.g., p < 0.001 at 60°). MAPD was highly variable, indicating significant deviation from target values during ramp contractions. SWE in mild FSHD is influenced by contraction level and joint angle, similar to findings of previous studies in healthy subjects. Moreover, altered force control could relate to the subjective muscle weakness reported by patients with dystrophies.

Pre-natal and early life lead exposure and childhood inhibitory control: an item response theory approach to improve measurement precision of inhibitory control

BackgroundNeurodevelopmental performance tasks are often separately analyzed, even when they tap into a similar construct. This may yield mixed findings for associations of an exposure-neurobehavioral outcome. We develop an item response theory (IRT) approach to integrate multiple task variables together to improve measurement precision of the underlying construct. We apply this approach to create an integrative measure of childhood inhibitory control, and study impacts of pre/post-natal lead exposure.MethodsUsing data from a prospective cohort based in Mexico (N = 533), we created an inhibitory control scale that integrates accuracy and reaction time information from four inhibitory control tasks (Go/NoGo Letter, Go/NoGo Neutral, Go/NoGo Happy, Delis-Kaplan Executive Function System (D-KEFS) Color-Word Interference Test, Condition 3). Using a generalized partial credit item response theory model, we estimated an inhibitory control index for each participant. We then assessed adjusted associations between umbilical cord blood and 4-year lead and childhood inhibitory control. We developed a resampling approach to incorporate error estimates from the inhibitory control variable to confirm the consistency of the lead-inhibitory control associations. We modeled time-varying associations of lead with each inhibitory control measure separately.ResultsParticipants had a median age of 9 years; 51.4% were males. Umbilical cord blood [-0.06 (95% CI: -0.11, -0.01)] and 4-year lead [-0.07 (95% CI: -0.12, -0.02)] were associated with inhibitory control index at 8–10 years. A resampling approach confirmed that 4-year lead was consistently associated with childhood inhibitory control index. Umbilical cord blood and 4-year lead were each associated with 3 out of 8 measures in separate models.ConclusionThis is the first application of IRT in environmental epidemiology to create a latent variable for inhibitory control that integrates accuracy and reaction time information from multiple, related tasks. This framework can be applied to other correlated neurobehavioral assessments or other phenotype data.

Considerations for identifying subtypes of speech sound disorder.

Speech sound disorders (SSDs) in children are heterogeneous. Differentiating children with SSDs into distinct subtypes is important so that each child receives a treatment approach well suited to the particular difficulties they are experiencing. To study the distinct underlying processes that differentiate phonological processing, phonological planning or motor planning deficits. The literature on the nature of SSDs is reviewed to reveal diagnostic signs at the level of distal causes, proximal factors and surface characteristics. Subtypes of SSDs may be identified by linking the surface characteristics of the children's speech to underlying explanatory proximal factors. The proximal factors may be revealed by measures of speech perception skills, phonological memory and speech-motor control. The evidence suggests that consistent phonological disorder (CPD) can be identified by predictable patterns of speech error associated with speech perception errors. Inconsistent phonological disorder (IPD) is associated with a deficit in the selection and sequencing of phonemes, that is, revealed as within-word inconsistency and poor phonological memory. The motor planning deficit that is specific to childhood apraxia of speech (CAS) is revealed by transcoding errors on the syllable repetition task and an inability to produce [pətəkə] accurately and rapidly. Children with SSDs form a heterogeneous population. Surface characteristics overlap considerably among those with severe disorders, but certain signs are unique to particular subtypes. Careful attention to underlying causal factors will support the accurate diagnosis and selection of personalized treatment options. What is already known on the subject SSD in children are heterogenous, with numerous subtypes of primary SSD proposed. Diagnosing the specific subtype of SSD is important in order to assign the most efficacious treatment approach for each child. Identifying the distinct subtype for each child is difficult because the surface characteristics of certain subtypes overlap among categories (e.g., CPD or IPD; CAS). What this paper adds to the existing knowledge The diagnostic challenge might be eased by systematic attention to explanatory factors in relation to the surface characteristics, using specific tests for this purpose. Word identification tasks tap speech perception skills; repetition of short versus long strings of nonsense syllables permits observation of phonological memory and phonological planning skills; and standard maximum performance tests provide considerable information about speech motor control. What are the potential or actual clinical implications of this work? Children with SSDs should receive comprehensive assessments of their phonological processing, phonological planning and motor planning skills frequently, alongside examinations of their error patterns in connected speech. Such assessments will serve to identify the child's primary challenges currently and as they change over developmental time.

SO2 removal performance and breakthrough prediction of activated carbon-based chemical filters for electronics cleanroom air purification

Electronic cleanrooms have strict control requirements for SO2 concentration due its significant influence on product yield, and application of chemical filters is the main measure of SO2 control. In this study, 8 activated carbon (AC)-based chemical filters were collected and tested for their SO2 purification performance and resistance. These filters had very similar initial efficiencies (all >95 %) but large differences in 20 % breakthrough adsorption capacity (49–294 g at 9 ppm and 0.35 m/s). The adsorption capacity is found to be positively correlated with pleat density, which is a main structural parameter of pleated chemical filter. Meanwhile, the filter resistance (9.3–34 Pa at 0.35 m/s) demonstrates a decreasing and then increasing trend with increasing pleat density. This indicated the existence of an optimal range of pleat numbers that can be used to achieve a balance between resistance and adsorption capacity. A comprehensive performance evaluation index (Z′-index) is proposed for assessing the integrated resistant and adsorption capacity performance of chemical filters (19–210 g/W for 8 samples). A lumped parameter model was proposed for predicting the breakthrough curves at low concentration based on the traditional semi-empirical breakthrough models. The prediction deviation of the breakthrough curve at real cleanroom scenario (2 ppb) is less than 15 %. In addition, a rapid filter life prediction method based on filter design parameters is developed from the lumped parameter model. This work helps the understanding of the impact of filter structure parameters on performance and facilitate the development of high-performance chemical filters for SO2 contaminant control in electronic cleanrooms.

Identifying the Problem Side with Single-Leg Squat and Hamstrings Flexibility for Non-Specific Chronic Low Back Pain.

Background and Objectives: In patients with non-specific chronic low back pain (LBP), their pain and problem sides can differ. Clinical Pilates assessment provides an approach to identify the problem side, but this approach requires experience and can be subjective. This study aimed to investigate if objective measures of single-leg squat postural control and hamstrings flexibility could identify the problem side in adults with non-specific chronic LBP. Materials and Methods: Forty adults with non-specific chronic LBP were tested on single-leg squat postural control and hamstrings flexibility. The problem side of participants was assessed with the Clinical Pilates method. Paired t-tests were used to compare the postural sway parameters of the single-leg squat and hamstrings flexibility between the problem and non-problem sides. Cohen's kappa was then used to assess the agreement of postural sway and flexibility measures with the Clinical Pilates method. Results: The problem side showed smaller vertical force variance, larger sway path distances, lower peak vertical force, smaller terminal knee flexion angle, longer time to complete the five single-leg squats, and tighter hamstrings as compared to the non-problem side. However, only the overall and anteroposterior sway path distances, terminal knee flexion angle, total squat duration, and hamstrings flexibility yielded moderate to strong agreement with the Clinical Pilates method. Conclusions: Single-leg squat postural sway parameters and hamstrings flexibility can objectively identify the problem side in adults with non-specific chronic LBP.

Multicentre investigation on the effect of decompressive surgery on Balance and physical ActiviTy Levels amongst patients with lumbar Spinal stenosis (B-ATLAS): protocol for a prospective cohort study

IntroductionPatients with lumbar spinal stenosis may have poor balance, decreased physical function and problems maintaining physical activity levels due to radiculopathy. Decompressive surgery is often indicated if conservative management fails...

Neural and Behavioral Correlates of Binge Eating in 9- to 10-Year-Old Children

This observational study compared children with and without binge eating (BE) on biobehavioral measures of reward responsiveness, inhibitory control, and emotion processes, while accounting for the impact of weight. Children aged 9 to 10 years completed the baseline wave of the Adolescent Brain Cognitive Development Study (316 with BE; 7,681 without BE [no-BE]). The prevalence of binge-eating disorder in the BE group was 17.0%; clinically significant internalizing and externalizing symptoms were endorsed by 8.5% and 4.5% of the sample, respectively. The monetary incentive delay (MID) task, stop signal task (SST), and emotional N-Back (EN-Back) task were administered during neuroimaging. Analyses assessed effects of group (BE vs no-BE) on task performance and corresponding neural signal in regions of interest (ROIs). Weight status was evaluated as a covariate and as a moderator of effects. Adjusting for weight status, the BE group (vs no-BE) group showed lower activation during anticipation of reward, specifically large reward (vs no reward), in the composite ROI consisting of the dorsal striatum, nucleus accumbens, orbital frontal gyrus, amygdala, and insula. Groups did not differ significantly in other behavioral or neural outcomes. No interactions between group and weight status were observed. Blunted anticipatory responses to monetary reward were associated with binge eating during peri-adolescence and may play a role in binge eating pathophysiology. Results challenge prior findings in BE that may be confounded by weight, and highlight the importance of future prospective research across binge-eating disorder stage of illness.

Fiscal rules, capital controls, and cross-border financial integration

This paper shows that adopting fiscal rules (FRs) decreases the use of capital controls and increases cross-border financial integration. This result is robust to alternative measures of fiscal rules, capital controls, and international financial integration — it is also robust to alternative econometric approaches. It also shows that the adoption of fiscal rules increases financial integration. This paper innovatively employs a formal instrumental variables (IV) approach to tackle the endogeneity of the decision to adopt fiscal rules. The adoption of FRs is instrumented using the age dependency ratio (ADR). This strategy is particularly effective because adopting FRs is more likely when the ADR is relatively low, a finding well established in the empirical literature. Governments impose capital controls to channel domestic savings into the public sector, finance their excessive fiscal deficits, and reduce their borrowing costs. However, the uncertainty over the government's future fiscal policies may lead to capital flight. FRs ‘tie the hands’ of governments and induce them to commit themselves to fiscal discipline. Moreover, FRs can also reduce the government's borrowing costs. These effects of FRs render capital controls less necessary and lead policymakers to lift capital controls, resulting in higher cross-border financial integration.

Is the development of arrhythmia predictable in rheumatoid arthritis?

This study aimed to determine whether there is a difference in the electrocardiography (ECG) measurements of healthy controls and rheumatoid arthritis (RA) patients and to predict whether they can be used to determine the risk of arrhythmia in patients. The prospective study included 50 cardiac asymptomatic RA patients (38 males, 12 females; mean age: 46.8±9.1 years; range, 18 to 60 years) who met the 2010 American College of Rheumatology/European Alliance of Associations for Rheumatology RA criteria and 50 healthy volunteers (34 males, 16 females; mean age: 43.4±10.4 years; range, 18 to 60 years) as a control group between June 1, 2022, and August 31, 2022. Disease activity of the patients was calculated with the Disase Activity Score (DAS28). Heart rate, minimum and maximum QT intervals, QT dispersion, minimum and maximum P waves, P wave dispersion (Pd), minimum and maximum Tp-e intervals, Tp-e dispersion, minimum and maximum corrected QT (QTc) intervals, QTc dispersion, and the Tp-e/QTc ratio in ECGs were calculated. The mean disease duration of the RA group was 9.09±5.74 years. The mean C-reactive protein level was 9.83±8.29, the mean erythrocyte sedimentation rate was 26.12±16.28 mm/h, and the mean DAS28 was 3.03±0.37. There was a statistically significant increase in the maximum P wave, Pd, maximum QT, QT dispersion, maximum QTc, QTc dispersion, maximum Tp-e, Tp-e dispersion, and Tp-e/QTc dispersion parameters in the RA group compared to the control group, while there was a significant decrease in the minimum P wave, minimum QT, and minimum QTc parameters. In our study, the Pd, QTc dispersion, Tp-e dispersion, and Tp-e/QTc dispersion values of our patients, which indicate the risk of atrial and ventricular arrhythmia, were found to be significantly higher. This finding suggests that our patients had an increased risk of cardiac morbidity and mortality. Arrhythmias are the likely source of the increase in sudden cardiac death in RA, and these new indicators measured on ECG can be used as standardized cardiovascular morbidity and mortality indicators in the future.

Detection of Pharmaceutical Personal Protective Equipment in Video Stream.

Pharmaceutical manufacturing is a complex process, where each stage requires a high level of safety and sterility. Personal Protective Equipment (PPE) is used for this purpose. Despite all the measures of control, human factor (improper PPE wearing) causes numerous losses for human health and material property. This research proposes solid computer vision system for ensuring safety in pharmaceutical laboratories. For this we have tested wide range of state-of-the-art object detection methods. Composing previously obtained results in this sphere with our own approach to this problem, we have reached the high accuracy (mAP@0.5) ranging from 0.77 up to 0.98 in detecting all the elements of common set of PPE used in pharmaceutical laboratories. Our system is the step towards safe medicine producing.

How is parental psychological control associated with adolescent mental health in economically disadvantaged areas? The serial mediating role of psychological reactance and problematic smartphone use.

Adolescent mental health has been an issue of global concern, and the mental health of adolescents in economically disadvantaged areas may require additional research. The research delves into factors associated with economically disadvantaged areas' adolescent mental health, employing family systems theory, self-determination theory, and psychological reactance theory. Specifically, the present study which was done in Jingzhou country, an economically disadvantaged area of Hunan Province, China, aimed to examine the link between parental psychological control and adolescent mental health, as well as the mediating roles of psychological reactance and problematic smartphone use in this relationship. A sample of 1300 Chinese middle school students (620 girls, mean age = 14.22 ± 1.29) completed self-reported measures of parental psychological control, psychological reactance, problematic smartphone use, and adolescent mental health. Results showed that parental psychological control was negatively associated with adolescent mental health. Psychological reactance and problematic smartphone use mediated the association between parental psychological control and adolescent mental health, separately and serially. The findings of the present study enrich the literature on parenting styles and adolescent mental health in economically disadvantaged areas, and this provides an intervention perspective to reduce the negative impact of poor parenting on adolescent mental health in economically disadvantaged areas.

The Influence of Instructional Constraints and Cognitive Control on the Positivity Bias and the Positivity Effect in Autobiographical Memory.

The positivity effect and the positivity bias were examined in voluntary and involuntary autobiographical memories in a sample of younger (n = 69, Mage = 23.2) and older adults (n = 57, Mage = 67.72). The positivity effect has been shown to be sensitive to instructional constraints and cognitive resources. Instructions were manipulated in the voluntary autobiographical memory condition such that participants were instructed to retrieve memories with different levels of constraints. Participants also completed two measures of cognitive control and an assessment of future time perspective. There was no evidence of the positivity effect or positivity bias once depressive symptoms were included as a covariate in the analyses, nor did cognitive control influence memory valence. Future time perspective did not mediate the relationship between age and memory valence. These results suggest that additional research should focus on potential variables that may influence the positivity effect and bias within autobiographical memories.