Meaningful Relationship Research Articles

The Relationship between Gratification of Internet Usage and Negative Behavior among Youth in Malaysia

Youth are significant consumers of internet technologies. Sometimes, adolescents are directly involved in problematic internet usage, such as online gambling and pornography. They are indirectly exposed to some negative behavior, such as alcohol usage, drug usage, internet addiction, and social isolation. This study aims to identify the relationship between six factors of negative behavior and gratification in using the internet among 440 Malaysian youth by collecting data via survey. The theory applied is the uses and gratification theory (U&G). The results revealed no meaningful relationship between the gratification of using the internet and pornography, online gambling, alcohol, and drug usage. However, there was a significant positive relationship between the gratification of internet use, social isolation, and internet addiction.

HUBUNGAN PENGGUNAAN ALAT KONTRASEPSI SUNTIK DENGAN SIKLUS MENSTRUASI PADA AKSEPTOR KB SUNTIK DI POLINDES BUNGBARUH KECAMATAN KADUR KABUPATEN PAMEKASAN

One of the articles of the Millennium Development Goals (MDGs) agreed upon by 189 countries including Indonesia is the improvement of maternal health and well-being throughout the mother's life cycle, including in terms of contraception and contraceptive effects including menstrual cycle disorders. Injectable contraceptives consist of injectable contraceptives of 3 months and injectable contraceptives of 1 month. Problems that often arise are caused by 3-monthly injectable contraceptives, namely: 60% amenorrhea, 20% oligomenorrhea, and 20% polymenorrhea, while 1 monthly injectable contraceptives 85% of birth control acceptors do not experience problems or menstrual cycle disorders. The purpose of the study was to find out the relationship between the use of injectable birth control contraceptives with menstrual cycle disorders Types of quantitative research with a cross sectional approach. The population was all injectable kb acceptors totaling 180 mothers with a sample of 180 people taken with total sampling techniques. Data collection using questionnaires analyzed using chi square tests. The results of the study found that there were 128 (81.7%) respondents who experienced menstrual cycle disorders and there was a total use of injectable contraceptives for 3 months, namely 156 (86.7%) respondents, while respondents with injectable contraceptives I months were 24 (13.3%) respondents. There is a meaningful relationship between the use of injectable birth control contraceptives with the menstrual cycle in Polindes Bungbaruh, Pamekasan district with p vallue: 0.05. OR value = 0.356 means that those who use 3-month injectable birth control contraceptives are 2.78 times more likely to experience menstrual cycle disorders than respondents who use 1-month injectable birth control contraceptives. Advice that can be given to injectable birth control acceptors who have impaired menstrual cycles to use non-hormonal birth control contraceptives to avoid severe side effects. 
 

Steering-by-leaning: Feasibility of Utilising Dynamic Backrests to Control Steering in Manual Wheelchairs

Steering-by-leaning is a promising innovation for manual wheelchairs. It may enable improved energy efficiency, one-handed manoeuvrability, and increased trunk activity during wheelchair use in daily life. To explore the feasibility of this concept, the lateral trunk function of active wheelchair users was assessed before comparing 3 preliminary dynamic backrest designs in a virtual steering exercise. Repeated measures, cross-over study. A convenience sample of 15 individuals who had been full-time users of manual wheelchair for at least 1 year. Active core strength and lateral leaning range of motion were captured while sitting freely. Participants subsequently tested 3 dynamic wheelchair backrest designs on an individually adjusted laboratory wheelchair prototype by performing a virtual steering exercise. Deviations from a target movement path were analysed using repeated measures analysis of variance and Pearson correlation coefficients. Functional leaning range of motion ranged from below 10° to almost 70°, but increased significantly with use of the simplest backrest design based on a 2-dimensional hinge joint. No correlation was found between functional levels and performance parameters in the virtual steering exercise. Using an individually fitted and calibrated design, upper body-actuated wheelchair steering using a laterally tilting backrest is accessible to wheelchair users across a wide spectrum of physical abilities.

Relational values of nature: Outgrowing anthropocentrism by enriching human-nature relationships?

Increasingly, science-policy-oriented publications discuss the potential of ‘relational values of nature’ to bolster future conservation related decision-making. This paper unravels two meanings of relational values and elaborates on how these may add to the toolkit of conservation. Firstly, it is explained how relational values are a third axiological category and compare to instrumental and intrinsic values assigned to nature. Secondly, it is clarified how relational values appear part of a shift that seeks to improve conservation decision-making processes by mapping and recognising the multiple ways of valuing nature people have developed over time. This would allow to more comprehensively capture the context-specific perspectives on human-nature relations. It is argued that these two meanings of relational values underscore the need not to conflate the questions of how to make valuation methods more socially inclusive with prescriptive questions of why we should protect nature. To illustrate this, this paper focuses on New Zealand conservation legislation that demonstrates how relational values, rooted in place-based indigenous knowledge and traditions, are coded into rights of nature law. Partially based on this it is argued that while social inclusiveness in conservation is important, this may still allow for anthropocentrically inspired thinking. Ultimately, it is concluded that the potential of relational values can be more fully realised by using them to offer prescriptive guidance to conservation decision-making and practice. However, to facilitate this, their embeddedness in a meaningful relationship with, and care and respect towards, nature needs to be emphasized and mainstreamed.

Housewives' Behavior Towards the Use of Plastic Bags in North Tapanuli, North Sumatra

Excessive use of plastic bags adversely affects health and the environment based on their hard-to-decompose nature. The increase in the number of plastic bag use is strongly influenced by population growth and changes in people's lifestyles, especially in shopping patterns among housewives, besides that government policies related to the Covid pandemic have triggered an increase in the use of plastic bags. This analytical observational research aims to determine the relationship between knowledge and attitudes of housewives towards the use of plastic bags in Pasar Siborongborong Village, North Tapanuli, North Sumatra, with a cross-sectional research design with an accidental sampling method. Interviews were conducted with 95 housewives. Data were analyzed using the Chi-Square test with CI:95%. The results of research on the use of plastic bags by housewives showed that 57.9% of the knowledge level of housewives in the good category, 64.2% of housewives' attitudes in the category were not good and 77.9% of the use of plastic bags in housewives was not good. The results of the Chi-Square test analysis showed that there was no meaningful relationship between the level of knowledge of housewives towards the use of plastic bags. (p.value: 0.864). On the other hand, there is a significant relationship between the attitude of housewives towards the use of plastic bags and the p.value: 0.010. Knowledge about the use and dangers caused by plastic bags can be done through socialization with the public, including through advertisements on television and social media. The implementation of restrictions on the use of plastic bags through the paid plastic bag policy at supermarkets is felt to have not been optimal in an effort to reduce the use of plastic bags.

Experimental investigation on rock microfabrical effects on dynamic hardness behaviour

Rocks' physicomechanical properties are influenced by their textural qualities. Rock mass stability is largely governed by these variables. Many geoengineering facilities depend on the capability to assess both short and long-term rock behaviors based on the interaction between different textural characteristics and physicomechanical properties. Rock hardness is frequently used in excavation engineering and is measured by several methods with different mechanisms. The Leeb dynamic hardness method has been recently applied in rock engineering applications as a new, inexpensive, non-destructive, and portable technique. This paper aims to show the interaction between the quantitative microfabrical features and the Leeb hardness of the rocks. For this purpose, 33 various rock types were chosen by considering their physicomechanical properties and microfabrical characteristics. Thin sections were prepared and their microphotographs were analyzed by ImageJ software. Four basic characteristics, including grain perimeter and area and length of minor and major axes, were measured. Then, seven textural quantities, including equivalent diameter (Dequi), shape factor (SF), aspect ratio (AR), grain compactness (C), texture coefficient (TC), interlocking index (g), and grain size homogeneity (t), were calculated based on those basic parameters and statistically analyzed. The findings indicate that the Leeb hardness increases with increasing the grain area and perimeter, equivalent diameter, grain compactness, homogeneity of grain size, grain interlocking, and TC. In contrast, Leeb's hardness decreases with increasing the AR and SF. The texture coefficient reveals the most meaningful relationship (R2 > 0.8) with the Leeb dynamic hardness test among the studied microfabrical characteristics in sedimentary and igneous rock samples.

THE RELATIONSHIP BETWEEN WORKLOAD AND STRESS ON NURSES DURING THE COVID-19 PANDEMIC IN INTENSIVE CARE UNIT (ICU) OF MERAUKE HOSPITAL

Workload becomes a source of stress if the amount is not proportional to both physical ability and expertise and the time available to nurses. In addition, nurses are faced with the covid-19 pandemic situation which requires them to work longer and more carefully due to the infectious nature of the virus, especially in intensive care rooms. Patient care in the ICU during the pandemic requires nurses to go the extra mile because they are at the forefront of their response. This study will examine the relationship between workload and stress in nurses in the ICU room of Merauke Hospital. The method used is quantitative association with Cross Sectional approach. A total of 40 nurses were designated as research samples with total sampling techniques. The research measuring instrument used questionnaires using univariate data analysis using frequency distribution and bivariate data analysis using rho spearman. The results of the analysis of the relationship between the two variables using the Spearman rho correlations statistical test with the help of the SPSS program showed significant (p) = 0.000 smaller than (α) = 0.05. This means that there is a significant relationship between workload and nurse work stress in the ICU room of Merauke Hospital. With the Spearman correlation coefficient rho (r) = 0.964. This means that it has a strong level of relationship strength and a positive correlation coefficient value so that the relationship is unidirectional. There is a meaningful relationship between workload and nurse work stress in the ICU room of Merauke Hospital. The higher the workload, the higher the nurse's work stress level
 

Determinants of Health Seeking Culture among Women of Childbearing Age

This study examines the determinants of health-seeking culture among women of reproductive age in the Calabar Metropolis, Nigeria. The determinants identified in this study were belief systems, level of education, cost of healthcare services, and Proximity. The researcher used the descriptive survey design to sample the opinion of representatives and get a detailed description of the health-seeking culture of women of childbearing age using quantitative and qualitative data. Six hundred (600) women of childbearing age were sampled from residents in the Calabar Metropolis. Both quantitative and qualitative data were retrieved using the research questionnaire and in-depth interview schedule. The retrieved quantitative data (586) were subjected to frequency and percentage counts, and simple linear regression at a significance level of 0.05. In contrast, the qualitative data were transcribed to supplement the quantitative responses. In addition, the transcribed qualitative data were analysed by the researcher into themes based on the research objectives. The findings indicate that: there is a significant relationship between belief system and health-seeking culture among women of childbearing age; there is a substantial relationship between the level of education and health-seeking culture of women of childbearing age; the cost of healthcare has a meaningful relationship with the health-seeking culture of women of childbearing age, and there is a significant relationship between Proximity to healthcare facilities and health-seeking culture of women of childbearing age. The study concludes that women's health-seeking behaviour is significantly retrained by beliefs, education levels, cost, and Proximity. Based on this finding, it is recommended that people's opinions be strongly considered and instilled in healthcare practice. Also, reproductive health awareness should be created using various social media platforms to address issues arising from self-medication

Supporting social connection for people living with dementia: lessons from the findings of the TRIO study

PurposeThe purpose of this paper is to share the learning concerning how services and the paid carers working in them can support people living with dementia (PLWD) and their unpaid carers to overcome social isolation. This learning comes from the key findings from a Social Return on Investment (SROI) evaluation of a Shared Lives (SL) Day support service, known as TRIO.Design/methodology/approachSROI is a form of cost-benefit analysis that captures and monetises stakeholder outcomes. The SROI evaluation included a rapid evidence review, an interview study and a questionnaire study. The learning shared is drawn from the interview and questionnaire data that explored the reported outcomes relating to social connection, which included data related to participating in meaningful activities, confidence and independence.FindingsPLWD who accessed the SL Day support service experienced better social connection, a sense of control over their activities (including their social activities) and community presence. A key foundation of these outcomes was the meaningful relationship that developed between the PLWD, their unpaid carer and the paid carer.Research limitations/implicationsThis evaluation was a pilot study with a small, albeit representative sample size.Practical implicationsThe learning suggests feasible and effective ways for paid carers to support the social connection of PLWD and their unpaid carers with their wider community.Originality/valueThere has been little exploration of how community-based short breaks (like SL Day support) can enhance social connection. The authors drew on a social relational model lens to illustrate how this service type had supported successful outcomes of community and social inclusion for PLWD.

The relationship between workload and nurse stress levels

Background: Hospitals are public health service providers, which have a very important position, so the services provided must be considered and taken into account. One of the professional human resources in accordance with their fields in providing services to patients is nurses.
 Aims: The purpose of this study was to determine the relationship between workload and nurse stress levels in the Cempaka room of RS X.
 Methods: This study used a study correlation design, a Cross-Sectional approach. The study population was all nurses in the Cempaka room of the hospital. X as many as 44 nurses, using the total sampling technique, The independent variable is the workload, the dependent variable is the stress level. Data retrieval using questionnaire sheets, ordinal data scales. Analysis using spearman rank corelation test with alpha 0.05.
 Results: The results of the study found that most respondents (59.1%) had a moderate workload, and most respondents (61.4%) had moderate stress levels. The Spearman rank corelation test showed there was a meaningful relationship between workload and nurse stress levels (p = 0.001 < 0.05 then H0 was rejected).
 Conclusion: The workload is so much in meeting needs, handling problems and ultimately very draining energy both physical and cognitive abilities, which has an impact on the nurse's stressor

Visual Representation of Cultural and Collegial Collaboration.

Description Our colleagues are those on whom we not only rely to help us with patient care and advocacy but also to establish a meaningful and collaborative relationship. The connection between comrades of different departments and specialties facilitates a deep understanding of the intricacies involved in treating a variety of maladies, and we quickly find ourselves ardently discussing our own life struggles, achievements, woes, and joys with those whom we once considered strangers, which only demonstrates the steadfastness of our professional and collegial relationships. However, for a holistic approach to the discipline of healing, the interconnectedness of other subdisciplines needs to be recognized. Therefore, in an attempt to bridge the perceptual disciplinary gaps, the commonalities of approach, and affinities of cultural traditions need to be integrated. In this painting, one can appreciate a central stained-glass pattern that mimics those seen in ancient Persian forts and buildings of old. The medium used is acrylic paint, embellished with glitter and sparkling rhinestones to add an element of elegance and regality. Surrounding the central pattern are intricate and brightly colored South Asian henna designs, which often decorate the palms of individuals celebrating auspicious occasions. This combination of elements reflects how different cultures and backgrounds can intermingle and enhance both the technique as well as the visual beauty of mutual interactions and the awareness of interconnectedness.

The Impact of the Consumer-Brand Interaction and Relationship on Motivation to Buy Cosmetics in Social Media -Based on Cognitive Age-

This study conducted a survey method to analyze the influence of the consumer-brand interaction and the consumer-brand relationship on the motivation to buy cosmetics based on the cognitive age of men and women in their teens and 50s with social media accounts. As a result, as a result of classifying cognitive age based on the actual age of the subjects and their perceived age, 'same cognitive group (61.2%)' > 'lower cognitive group (24.0%)' > 'higher cognitive group (14.8%)'. In the three groups, the consumer-brand interaction and the consumer-brand relationship showed a significant positive relationship, and the consumer-brand interaction and the motivation to buy cosmetics also showed a meaningful positive relationship. In addition, the consumer-brand relationship and the motivation to buy cosmetics also showed a significant positive relationship. Accordingly, the conclusion of this study was that the consumer-brand interaction and the consumer-brand relationship by subjective age group had a positive effect on the cosmetics purchase motive. As this study empirically analyzes the influence of cognitive age on cosmetics brand marketing in social media, it is considered to be a practical implication for establishing basic data and cosmetics sales strategies that can be used for marketing.

Estimation of the Urban Temperature Reduction Effect in Low-rise Residential Areas using CFD Simulation based on the Shape of the Green Space

Purpose: Rapid urbanization has exacerbated the influence of the urban heat island effect in existing cities, particularly, in low-rise and densely-populated areas. Accordingly, small urban green spaces have been employed to lower the temperatures in urban areas and improve the quality of life. However, the current research on the quantitative analysis of the size and shape of urban green spaces, which maximize the temperature-reducing effect, is insufficient. Therefore, a quantitative analysis was performed in this study to determine the impact of the shape of an urban green space on the cooling effect of vegetation and range of impacts based on three elements: the area, perimeter, and shape index of the urban green space. Method: A computational fluid dynamics (CFD) simulation was performed and used to analyze the impact of the shape of the urban green space on the temperature-reducing effect and range of impacts by examining eighteen urban green spaces in three target areas. To this end, programs such as STAR-CCM+ and GIS were employed. Results: The analysis results show a meaningful relationship between the green space area and range of the cooling effect of the vegetation, and indicate the importance of the perimeter of the vegetation in reducing the temperature of the central and surrounding areas of the urban green space. Moreover, although the shape index is not a decisive factor, slender and intricate shapes were found to have a higher cooling effect for a short distance. Therefore, this study contributes to the establishment of a guideline for the development of a pleasant environment in existing cities.

Scoping Review of Challenges and Existing Tools

In light of the COVID-19 public health restrictions, the use of telemedicine has been on the rise. This care delivery model is valued for its potential to increase care access while providing safe care. However, it changes the way patients and providers interact. Communication during video consultations requires embodied engagement to compensate for the physical distance. This study aimed to identify patient-provider communication challenges during video consultations and assess the tools developed to support patient-provider communication according to the published literature from 2019 to 2022. Searches of eight databases (Medline (Ovid), PubMed, ProQuest Nursing and Allied Health, CINAHL, Web of Science, Scopus, PsychInfo, and Social Services Abstracts), and a Google search for grey literature were conducted. Nineteen articles met inclusion criteria. Findings show that patients and providers share the same concerns, such as a lack of trust relating to physical distance, the ability to establish a meaningful relationship, and a lack of confidence in clinical assessment. The available tools, however, are based on guidelines that are difficult to adapt to the diversity of interaction contexts. There is a need for tools that consider the complexity of patient-provider communication in order to address the challenges stemming from the lack of trust in the context of video consultations. These findings can inform strategies for effective patient-provider communication during video consultations to improve the quality of care and optimize outcomes in this context.

Ethical challenges in caring for healthy older adults: Qualitative perspectives.

Healthy aging is one of the essential aspects of a health promotion program in the elderly. Exploring ethical challenges in healthy elderly care from the perspective of nurses, older adults, and families in the Iranian context. This qualitative study was conducted using a content analysis approach in 4 health centers in northeastern Iran from 2017 to 2019. Semi-structured interviews, observation, review of elderly files, and focus groups were used to collect data. The ethics committee of the university approved this study in Iran. This study adhered to the principles of the Helsinki Declaration. Ethical principles autonomy, confidentiality, and anonymity were considered for the participants. Participants were informed about the purpose of the study and submitted written informed consent regarding their participation. The central theme was: An unfair approach to caring for healthy older adults. The three categories were as follows: Forgotten human care, disrespect, and lack of a meaningful and trustworthy relationship. The 14 subcategories highlighted the ethical challenges of healthy aging care in health centers. The findings showed that due to nurses' unfamiliarity with the concept of healthy aging, older adults are discriminated against in care centers. Creating a standard care program for healthy older adults ensures that ethical principles are followed for these clients. Various individual and organizational factors lead to an unfair approach to caring for healthy elderly in health centers. The following factors can help improve the care of healthy aging and reduce ethical challenges in this area: Introducing nurses to the concept of healthy old age and its dimensions, creating a community-based approach in health centers, prioritizing health issues over health issues, Involvement of families and older adults in needs assessment-goal setting-implementation and evaluation of health services, and design of home visit programs to provide services to healthy elderly.

The Impact of Collocational Competence on Translation Quality: Literature Review

This study reviews the literature on the significance of collocational competence on the quality of translation, being a meaningful lexical relationship between words. Though the value of recognizing collocations in translation is well acknowledged, several earlier studies have underlined students’ lack of collocational competence and the difficulties they encounter when dealing with collocations in the translation process. The current study evaluates previous research in this field and examines the influence of lexical and grammatical collocation knowledge in translation from English into Arabic and vice versa. The significance of this review lies in exploring the importance of a translator’s collocational expertise in accurately translating lexical and grammatical collocations in the target language. This review aims at answering the review question: How does collocational competence affect translation quality? To answer this question, the researchers examined many studies investigating the impact of collocational competence on the quality of translation. The review further aims at increasing awareness of the significance of this aspect of translation accuracy. The review study provides an overview of pertinent terminology and classifications and a brief introduction to the subject. Then follows an overview of the significance of collocations competence for ensuring the quality of the translation. The final section includes recommendations for translation instructors as well as translators. The review’s findings showed a substantial correlation between the quality of the translation and the adequate knowledge of lexical and grammatical collocations.

Hubungan Penggunaan Kontrasepsi Oral dengan Kejadian ‎Kanker Payudara Di RSUD Arifin Achmad Provinsi Riau

In North America, every 12 minutes a woman dies because of breast cancer. Breast cancer is the second largest after cervical cancer. Until now, the main factor is not yet known what the main causes of breast cancer. This study aimed to determine the relationship of oral contraceptive use with breast cancer incidence rates in the Arifin Achmad Hospital in Riau Province This research uses quantitative research with cross sectional design. The Sample is 67 mothers with oncology cases. Based on 67 respondents mostly mothers with onkolgi cases not using oral contraceptives for > 5 years are 55 (82.09%) and respondents who experienced breast cancer as many as 37 people (55.22%). Analysis of studies that used the chi-square statistical tests with significance level α = 0.05 with 95% confidence interval. The results obtained are H0 is accepted, which is calculated x2 ≤ x2 ≤ 3.841 table is 0.16133. So there is no meaningful relationship between the use of oral contraceptives with an incidence of breast cancer in RSUD Arifin Acmad Riau Province in 2020. From these results, it is expected to the Arifin Achmad Hospital in Riau Province in order to complement the data in medical records in order to facilitate further research.

Tax Reform and Tax Revenue Collection Performance in Ethiopia (From 2005 to 2013 EFY)

The objective of this study was to evaluate the effects of tax policy reforms on revenue generation in Ethiopia, using different tax revenue sources as a proxy for the federally collected tax revenue. To carry out this exercise, quarterly time-series data for the years (2005 - 2013 EFY) was employed. Data were gathered from both primary and secondary sources. Primary data was collected through interviews with relevant Ministry officials and experts from selected departments, and secondary data was gathered from performance reports of the Ministry. The analysis showed that the reform of the tax policy since the 2009 fiscal year has not had a positive impact on tax revenue. The tax authority's eight-year tax collection efficiency was assessed by the tax buoyancy, which was 0.76 percent between 2005 and 2012, the tax buoyancy rate was 0.9 before the tax policy reform, and 0.6 after the reform. This shows that tax collection is low after the policy reform and that the tax policy reform has an impact on revenue collection. The regression result showed that reform in Value Added Tax and Excise tax has a significant positive effect on revenue collection within the period under review; while reform in non-tax recorded a negative and insignificant effect on revenue collection. The Johansen cointegration test showed that a long-run meaningful relationship exists between tax reform and revenue collection (TR) in Ethiopia. To encourage taxpayers to comply with the law, the study suggests that the tax system should be reviewed on a regular basis, and that tax policy formulation should be carried out after proper consultation with all executives and relevant stakeholders.

Uncovering the Determinants of Birth Weight: An Investigation on Pregnant Women in Makassar City

Birth weight is an essential indicator in assessing a baby's health and a factor that affects the baby's long-term health. This study aimed to determine the relationship between the Body Mass Index (BMI), Hemoglobin levels, and Blood Pressure of mothers during pregnancy and to birth weight of the baby. The study used a cross-sectional survey of a group of mothers who gave birth in Makassar. The data on mothers during pregnancy was the maternal history recorded in the mother and Child Health Book (KIA). And the data on the birth weight of the baby was also from the KIA book with the support of secondary data from the Community Health Center and Midwife. The results showed that 41.7% of the low-birth-weight babies had mothers who experienced underweight during pregnancy, 83.3% of the low-birth-weight babies had mothers who experienced Anemia during pregnancy, and 66.7% of the low-birth-weight babies had mothers who experienced hypertension during pregnancy. There was a significant and close relationship between the mother's BMI, Hemoglobin levels, and Blood Pressure to the baby's birth weight. There was a meaningful relationship between the mother's Body Mass Index, Anemia, and Hypertension during pregnancy to low birth weight. Therefore, it is important to maintain a good quality of nutrition for mothers both before and during pregnancy, following Islamic teachings that Allah SWT has decreed for every pregnant woman a thousand good deeds every day and erases a thousand misdeeds as motivation to remain strong throughout the pregnancy process.

The association study between changes in HbA1C with rs2250486 and rs67238751 genetic variants for SLC47A1 in newly diagnosed Iranian patients with type 2 diabetes mellitus: 6months follow-up study.

One of the most well-known oral medications for the treatment of T2DM is metformin. Variants have been found in studies to be useful in detecting new genes connected to T2DM aetiology and affecting metformin's mechanism of action. In this research, we aimed to study two variations of the SLC47A1 gene; rs2250486 and rs67238751, in T2DM patients who had been taking metformin for the first 6months after the diagnosis in the Iranian population for the first time. A total of 200 individuals were recruited for the study. According to their glycosylated haemoglobin (HbA1c) levels, the patients were divided into two groups: responders (HbA1c levels were reduced by at least 1% after 6months of metformin treatment.) and non-responders. DNA was extracted from whole blood and genotyped by Tetra ARMS PCR. High-performance liquid chromatography (HPLC) was used to measure HbA1c levels at the start of the treatment and again 6months later. rs2250486 variant in the dominant model reduces the HbA1C levels after 6months of metformin treatment. In fact, when compared to the T/C + C/C genotypes, the T/T genotype improves HbA1C levels (p-value=.014). Furthermore, in the allelic model, the T allele improves HbA1C levels in comparison to the C allele (p-value=.008). After 6 months of metformin treatment, serum levels of HbA1C in responders were reduced significantly in both groups (T/T and T/C + C/C), (p-value=<.0001). However, the rs67238751 variant did not reveal a meaningful relationship with lower HbA1C levels in any of the models. This study found that the rs2250486 variant could be associated with reducing HbA1C levels while the rs67238751 variant, had no relationship.