Mean Vertical Diameter Research Articles

Morphological Characteristics of Normal Foveal Avascular Zone by Optical Coherence Tomography Angiography.

Purpose To provide quantitative measurements for the foveal avascular zone (FAZ) and to describe its morphological characteristics by optical coherence tomography angiography (OCT-A). Design Cross-sectional observational case series. Methods Healthy volunteers were recruited and evaluated using Triton-DRI SS-OCT Angiography. A 4.5 × 4.5 mm square was evaluated by OCT-A center around the fovea. Superficial and deep capillary plexus were identified, and different quantitative measurements were conducted along with categorization of the FAZ pattern. Results Eighty-two eyes (41 volunteers) were evaluated. Mean age was 30.59 ± 7.6 years (23–42 years). Mean subcentral retinal thickness was 200.1 ± 5.66 um (192–210 um). The number of terminal vessels was variable (range, 8–11). Mean maximum terminal vessel-to-vessel intervening distance was 527.8 ± 60.3 um (471–674 um). Mean minimum terminal vessel-to-vessel intervening distance was 296.7 ± 45.8 um (233–373 um). Mean maximum horizontal diameter of FAZ (superficial) was 716.17 ± 124.09 um, while mean maximum vertical diameter of FAZ (superficial) was 667.76 ± 131.28 um. Mean maximum horizontal diameter of FAZ (deep) was 823.19 ± 144.92 um, while mean maximum vertical diameter of FAZ (deep) was 794.03 ± 150.28 um. OCT-A detected different FAZ patterns; horizontally oval configuration in 32 eyes (39%), rounded configuration in 24 eyes (29.3%), pentagon configuration in 14 eyes (17.1%), and vertically oval and nonspecific configuration in 6 eyes each (7.3%). Conclusion OCT-A could efficiently provide both quantitative and qualitative assessment of normal FAZ; such characterizations were difficult by standard FAZ assessment procedures like FFA.

Detection and characterization of anterior loop, accessory mental foramen, and lateral lingual foramen by using cone beam computed tomography

Statement of problemThe presence of an anterior loop (AL), accessory mental foramen (AMF), or lateral lingual foramen (LLF) adds complexity to the mental foraminal region, and consequently, implant placement in this region can damage the nerves and blood vessels if the structures are not carefully identified. PurposeThe purpose of this retrospective study was to evaluate the characteristics of the AL, AMF, and LLF to provide recommendations for surgeons operating in the mandibular mental foraminal region. Material and methodsReconstructed cone beam computed tomography (CBCT) images in 306 Southern Chinese patients were retrospectively analyzed. The prevalence of the anterior loop was assessed, and the anterior loop length (ALL) was measured from the most anterior point of the mental foramen to the most mesial part of the anterior loop. The prevalence, location of the AMF as related to the mental foramen, and adjacent teeth were analyzed. Additionally, the distance from the mental foramen to AMF centers were measured. The prevalence, diameter, and location of the LLF were evaluated. The chi-square test was used for prevalence analysis (α=.05). ResultsAnterior loops were identified in 67.8% of the 612 hemimandibles, with a mean length of 3.3 ±1.2 mm, ranging from 1.2 to 7.3 mm. A total of 5.56% of the hemimandibles had an ALL ≥5 mm, and male patients had a statistically longer loop length (P=.006). The ALL on the right side was found to be statistically longer than that on the left side (P=.002). No statistically significant differences in the ALL were found among different age groups (P=.124). AMFs were observed in 10.5% of the patients, with most located in the posterosuperior position of the mental foramen. The mean distance between the center of the AMF and the mental foramen was 5.1 ±1.4 mm. LLFs presented in 69.9% of patients, with 74.0% located in the premolar region. The mean vertical diameter of the LLF was 0.9 ±0.3 mm, and the mean distance from LLF to the mandibular inferior border was 7.1 ±1.9 mm. ConclusionsThis study revealed that ALs, AMFs, and LLFs occurred often in the Southern Chinese population. Identifying the presence of the AL, AMF, and LLF is important before surgery in the mental foraminal region.

A Cohesin Subunit Variant Identified from a Peripheral Sclerocornea Pedigree.

Background Sclerocornea is a rare congenital disorder characterized with the opacification of the cornea. Here, we report a nonconsanguineous Chinese family with multiple peripheral sclerocornea patients spanning across three generations inherited in an autosomal dominant manner. Methods This is a retrospective case series of a peripheral sclerocornea pedigree. Comprehensive ophthalmic examinations were conducted and assessed on 14 pedigree members. Whole-exome sequencing was used to identify the genetic alterations in the affected pedigree members. Lymphoblastoid cell lines (LCLs) were established using blood samples from the family members. Functional tests were performed with these cell lines. Results Six affected and eight unaffected members of a family with peripheral sclerocornea were examined. All affected individuals showed features of scleralization over the peripheral cornea of both eyes. Mean horizontal and vertical corneal diameter were found significantly decreased in the affected members. Significant differences were also observed on the mean apex pachymetry between affected and unaffected subjects. These ophthalmic parameters did not resemble that of cornea plana. A RAD21C1348T variant was identified by whole-exome sequencing. Although this variant causes RAD21 R450C substitution at the separase cleavage site, cells from peripheral sclerocornea family members had no mitosis and ploidy defects. Conclusion We report a family of peripheral sclerocornea with no association with cornea plana. A RAD21 variant was found cosegregating with peripheral sclerocornea. Our results suggest that RAD21 functions, other than its cell cycle and chromosome segregation regulations, could underline the pathogenesis of peripheral sclerocornea.

Division of Sacrospinous and Sacrotuberous Ligaments Expands Access Through Greater Sciatic Foramen: Anatomic Study with Application to Resection of Greater Sciatic Foramen Tumors

Tumors of the greater sciatic foramen remain difficult to treat. They often have both intrapelvic and extrapelvic components that may limit visualization and make safe resection of the tumor difficult. Therefore the goal of the present anatomic study was to quantitate how much additional surgical working space could be gained by transection of the sacrospinous and sacrotuberous ligaments. Sixteen sides from 9 fresh-frozen Caucasian cadaveric torsos underwent transgluteal dissection and exposure of the greater sciatic foramen and associated liagments. With the piriformis in place, the vertical and horizontal diameters of the greater sciatic foramen were measured. Next, the sacrotuberous and sacrospinous ligaments were cut at their ischial attachments. The vertical diameter of the now confluent greater and lesser sciatic foramina (V2) was measured. The mean vertical diameter of the greater sciatic foramen (V1) was 54.8 ± 9.7 mm. The horizontal diameter of the greater sciatic foramen had a mean of 44.3 ± 6.1 mm with a range of 30-52 mm. After transection of the sacrotuberous and sacrospinous ligaments, the vertical distance of the greater and lesser sciatic foramina (V2) had a mean of 74.8 ± 6.8 mm with a range of 60.1-90 mm. The mean ratio of V2 to V1 was 1.40. The vertical length of the greater sciatic foramen increased, on average, 40% after resection of the sacrotuberous and sacrospinous ligaments. The results of this study support an alternative technique for resecting large intrapelvic tumors via a transgluteal approach.

Morphometric analysis of infraorbital foramen in South Indian dry skulls

Objective- The infraorbital foramen is located on the maxillary bone 1 cm under the infraorbital margin. Infra orbital nerve blocks are done in children for managing the postoperative pain which can occur after cleft lip operation and endoscopic sinus operation. Infraorbital nerve can also be damaged in cases of zygomatic complex fractures which are one of the most common facial injuries. So, this study was undertaken to analyze the anatomical variations by comparing various morphometric measurements of infraorbital foramen in dry skulls of adult South Indian population.Materials and methods- 60 dry skulls of unknown sex were used for the study. Various measurements and distance from various surgical landmarks were measured to evaluate the location of infraorbital foramen on both sides. Statistical Analysis was done for the above measurements mean and standard deviation, median, range, and mode were calculated.Results: The mean distance of infraorbital foramen from piriform aperture, lower end of alveolus of maxilla and infraorbital margin was 18.39, 27.88 and 7.09mm on the right and 17.89, 27.31 and 6.95mm on the left side. The mean vertical and horizontal diameter was 3.78 and 3.50mm on the right side and 3.48 and 3.35mm on the left side. In our study, the most common site of IOF in Indian skulls was found to be in line with the second premolar tooth (59.01%), followed by its position between the first and second premolar tooth (27.87%).Conclusion- These results will be helpful for surgeons while doing maxillofacial surgery and regional block anesthesia.Bangladesh Journal of Medical Science Vol.17(4) 2018 p.562-566

Zygomaticofacial, Zygomaticoorbital, and Zygomaticotemporal Foramina.

This study aimed to assess the anatomical and morphometric characteristics of the main zygomaticofacial (ZFF), zygomaticoorbital (ZOF), and zygomaticotemporal (ZTF) foramina in Brazilian dry skulls. 61, 69, and 42 skulls for ZFF, ZOF, and ZTF were evaluated by a single calibrated examiner for format, transverse and vertical diameters, and distances from the foramina to anatomical landmarks. Paired t test, Wilcoxon test, Pearson and Spearman correlations were used. Circular outline was the predominant format for ZFF and ZTF, while oval format was the most frequent for ZOF. Median distances from ZFF to frontozygomatic and zygomaticomaxillary sutures were higher on right and left sides of the skulls, respectively (P < 0.005). Mean ZOF transverse diameter was significantly higher on the right sides of the skulls and presented positive correlation between sides (P < 0.05). No differences were observed for mean vertical diameter and distance from the ZOF to the inferolateral angle of the orbit (P > 0.05). No significant difference was found for distance from the ZTF to zygomatic arch between sides (P > 0.05), although there was a positive correlation (P < 0.05). Significant differences were found when analyzing the anatomical and morphometric aspects of ZFF, ZOF, and ZTF.

Preliminary Study of the Differences in Optic Nerve Head Hemoglobin Measures Between Patients With and Without Childhood Glaucoma.

To evaluate the effectiveness of quantifying color changes in the optic nerve head in retinal photographs of patients with childhood glaucoma. In this observational study, three photographs of the optic nerve head were obtained in 28 patients with childhood glaucoma and 28 age- and sex-matched healthy participants (the childhood glaucoma and control groups, respectively). The Laguna Optic Nerve Head Hemoglobin (ONhE) software (Insoft SL, Tenerife, Spain) was used to determine hemoglobin levels in the optic nerve head. The following parameters were quantified: the hemoglobin levels in the optic nerve head across the whole disc, in 24 sectors (the optic nerve head divided by two concentric rings and eight 45-degree radial sectors), and in the vertical disc diameter (sectors 8 and 20), and the estimated cup-disc ratio and Glaucoma Discriminant Function, which combines the slope of the hemoglobin amount with the mean vertical disc diameter. Patient ages ranged from 9 to 14 years (median: 11 years) in the childhood glaucoma group, and 7 to 13 years (median: 9 years) in the control group (P < .061). Eyes in the childhood glaucoma group showed a significantly higher cup-disc ratio compared to eyes in the control group (0.6 ± 0.2 vs 0.5 ± 0.1, respectively; P < .0001). In the childhood glaucoma group, the Glaucoma Discriminant Function was found to be significantly lower than in the control group (-6.5 ± 31.1 vs 9.4 ± 17.1, respectively; P < .0001). There were no significant differences in the hemoglobin levels in the optic nerve head across the whole disc between eyes in the childhood glaucoma and control groups (58.2% ± 10.9% vs 58.5% ± 6.7%, respectively; P = .847). The Laguna ONhE software showed good reproducibility in measuring percentages of hemoglobin levels in both groups. The Laguna ONhE software is useful for patients with childhood glaucoma. However, hemoglobin levels in the optic nerve head across the whole disc may have normal values. This method had good reliability and is easy to implement in routine clinical practice. [J Pediatr Ophthalmol Strabismus. 2017;54(6):387-394.].

Computed Tomographic Assessment of Optic Foramen

A detailed morphometric study of optic foramen was conducted in the CT scans of 30 adult patients. The quantitative and qualitative parameters were observed. The transverse diameter (TD), the vertical diameter (VD) and the distance of optic foramen to apex of petrous temporal bone were measured as quantitative parameters. The qualitative parameters measured were shape, margin and confluence. The frequency of range of transverse and vertical diameters was also observed. A comparison was made between right and left sided morphometric values. The mean transverse diameter of optic foramen was found to be greater on right side, whereas mean vertical diameter was observed to be greater in left sided optic foramen.

Foveal Avascular Zone in Normal Tension Glaucoma Measured by Optical Coherence Tomography Angiography.

Aim To measure diameter of foveal avascular zone (FAZ), FAZ area, and vessel density using Optical Coherence Tomography Angiography (OCT-A) in patients with normal tension glaucoma (NTG) and to establish the possible role of OCT-A in diagnosis and follow-up of patients with NTG. Methods Twenty-one eyes of 21 patients with NTG and 30 eyes of 30 healthy subjects underwent complete ophthalmic examination as well as OCT-A on ZEISS AngioPlex. 3 × 3 macula scans were used to measure vertical, horizontal, and maximum diameter of FAZ by two graders. Mean values and interobserver variability were analyzed. Image J was used for analysis of FAZ area and vessel density. Results Mean vertical diameter (t = 5.58, p < 0.001), horizontal diameter (t = 3.59, p < 0.001), maximum diameter (t = 5.94, p < 0.001), and FAZ area (t = 5.76, p < 0.001) were statistically significantly enlarged in the NTG group compared to those in the control group. Vessel density (t = −5.80, p < 0.001) was statistically significantly decreased in the NTG group compared to that in the control group. Conclusion OCT-A could have an important role in the future in diagnosis of patients with NTG. In patients with NTG, there is larger FAZ area, while the vessel density is reduced in comparison to the control group.

Retrospective morphometric analysis of the infraorbital foramen with cone beam computed tomography.

The aim of our study is to examine the morphometric characteristics of the infraorbital foramen (IOF) and its anatomic localization by using cone-beam computerized tomography (CBCT). In our study, the anatomic characteristics of the IOF were identified by studying retrospectively the CBCT images of one hundred twenty-five (125) patients. These characteristics were assessed statistically in terms of age, gender, and right-left side. In our study, 42% of them had IOF in circular form and 58% in oval form. Of them 66.90% of those in oval form were in oblique direction, 28.30% of them were in vertical direction, and 4.80% of them were in horizontal direction. The mean vertical diameter of the IOF was found as 3.71 ± 0.61 mm and its mean horizontal diameter was found as 3.17 ± 0.56 mm. The mean distance of IOF to midline were measured as 25.10 ± 2.17 mm, distance to upper edge of the orbita was measured as 41.91 ± 2.77 mm, distance to infraorbital edge was measured as 5.63 ± 1.77 mm, distance to the lateral nasal wall was measured as 9.32 ± 2.68 mm, distance to spina nasalis anterior was measured as 17.97 ± 3.99 mm, thickness of the soft tissue on the foramen was measured as 11.52 ± 2.40 mm, and distance between the right and the left IOF was measured as 50.20 ± 3.90 mm. Accessory foramen was found in 56.60% ratio. This study reveals that CBCT may guide for local anesthesia applications and for other invasive procedures in order to prevent the damage of the neurovascular structures during maxillofacial surgery by identifying the distances of anatomic points such as IOF having surgically importance.

Diametric measurement of foveal avascular zone in healthy young adults using optical coherence tomography angiography.

BackgroundThe objective of this study is to measure the diameter size of foveal avascular zone (FAZ) in both eyes of healthy young adults using optical coherence tomography (OCT) angiography.MethodsA cross sectional study to measure the foveal avascular zone in healthy young adults. Subjects underwent OCT angiography using Zeiss AngioPlex OCT angiography in both eyes.Results30 eyes of 15 healthy young adults were evaluated. The mean horizontal FAZ diameter of superficial vascular plexus was 661.166 ± 119.99 microns and mean vertical FAZ diameter was 660.033 ± 96.169 microns (P = 0.9442). The mean horizontal FAZ diameter of deep vascular plexus was 1011.2 ± 154.526 microns and the mean vertical FAZ diameter of deep vascular plexus was 818.033 ± 102.108 microns. There was no difference between the contralateral eyes of subjects in FAZ diameter of both superficial and deep capillary plexuses.ConclusionThe mean diametric size of FAZ in superficial capillary plexus is 660.599 ± 0.801 microns and deep capillary plexus is 914.616 ± 136.589 microns. There was no significant difference with the contralateral eyes.

Características clínicas de la cabeza del nervio óptico en recién nacidos sanos

ObjectiveTo determine the size and clinical features of the optical disc in healthy term infants. MethodologyDescriptive, observational, cross-sectional, and retrospective study based on complete medical records of newborns at the Angeles Pedregal Hospital, Mexico DF, from May to August 2015. The measurements of the optical disc and clinical features were obtained from digital photographs and evaluated by 2experts. Frequencies, means and standard deviation were calculated using the SPSS version 17.0 for Windows. ResultsThe study included a total of 121 patients and 121 eyes. There were 65 males. The mean vertical diameter was 1.60±0.17mm, horizontal diameter 1.31±0.13mm, optical disc area 1.43±0.26mm2, and cup to disc ratio 0.25±0.11. The neuroretinal ring colour was orange in 116 (95.9%) eyes. The cribriform plate was not visible in any patient, and in 90 (74.4%) eyes the appearance of the vessels in the papilla was central, and nasal in the rest. The cilioretinal artery was present in 38 (31.4%) eyes. A hyper- and hypo-pigmented peripapillary ring was observed in 114 eyes (94.2%). ConclusionThe mean area of the optic nerve is 1.43±0.26mm2, slightly higher than previously reported. The mean cup to disc ratio is less than 0.3, as reported in the literature, and it is noteworthy that all eyes have a hyper-pigmented and hypo-pigmented peripapillary ring.

A new technique for in-situ measurements of bubble characteristics in bubble columns operated in the heterogeneous regime

In order to characterize bubbles in dense, heterogeneous bubbly flows such as those encountered in industrial bubble columns, a new measuring technique based on the spatial correlation of phase indicator functions is proposed. By analyzing its principle of operation, it is shown that the correlation coefficient decreases with the ratio of the distance between two optical probes to the bubble size. Hence for a known distance, the bubble size, and more precisely the Sauter mean horizontal diameter of bubbles is accessible. A dedicated sensor has been designed using conical mono-fiber optical probes. It has been compared to alternate measuring techniques in the complex bubbly flows produced in an I.D. 400mm bubble column with gas superficial velocities from 3 to 35cm/s. The performances of the correlation sensor happen to be quite satisfactory, with typical uncertainties about 15–20%, and even less (<10%) in absence of flow reversal. Similar performances are also obtained for conical mono-fiber optical probes when measuring the Sauter mean vertical diameter of bubbles.

Anatomical and Radiological Aspects of the Supratrochlear Foramen in Brazilians.

The supratrochlear foramen is an anatomic variation of great clinical and anthropologic interest. Although many studies addressed this subject in different ethnic groups, there are no studies regarding Brazilians. To verify the incidence and morphometric measures of the supratrochlear foramen in Brazilian humeri. A total of 330 dry humeri were analysed and divided in three groups: bones presenting the supratrochlear foramen (Group 1), bones displaying a translucent foramen (Group 2) and humeri without the foramen (Group 3). The aperture was measured with a digital vernier caliper. Radiographic pictures with different incidences were taken. Our analysis showed that 22.5% of humeri belonged in Group 1, 41.2% in Group 2, and 36.3% in Group 3. The mean vertical diameter and the mean horizontal diameter of the supratrochlear foramen on the left side were 2.779±2.050 mm and 2.332±1.23 mm, respectively. The mean vertical diameter and the mean horizontal diameter of the foramen on the right side were 2.778±2.197 mm, and 2.365±1.396 mm, respectively. The student's t-test showed that there was no significant difference regarding the size of the foramen between both sides. The best X-ray machine setup was 50 kilo voltage and 0.08 milliamperage per second, associated with a slight increase in the distance of the x-ray tube. The aperture seems to be the key point during the pre-operative planning of intramedullary fixation, since it has direct relation to the size of the intramedullary canal, thus, being an entity of clinical, anatomical, anthropological, radiological, and surgical interest.

An osteological study of supratrochlear foramen of humerus of south Indian population with reference to anatomical and clinical implications.

The supratrochlear foramen (STF) is an important and relatively common anatomic variation in the lower end of the humerus in humans. The present study on south Indian population is an attempt to highlight the incidence, morphological features and clinical importance of STF. The study was conducted on dried human humeri of unknown sex and free of pathological changes. The presence of a STF was noted for its shape and divided into three types (oval, round, and irregular). In bones where the foramen was absent the translucency of the septum between the coronoid and the radial fossa was noted by placing the lower end of the humerus against the X-ray view box. Out of the 142 humeri studied, 72 humeri (50.7%) were right sided and 70 humeri (49.2%) were left sided. In these 142 humeri, 38 humeri (26.7%) showed the presence of STF. The majority of STF were round shaped in 47.37%, followed by oval shaped in 42.11% and 10.53% were irregular in shape. The STF was absent in 36 humeri (25.35%) and 68 humeri (47.89%) showed the translucency of septum. The mean transverse diameter on right side was 4.50±3.183 mm and 3.32±3.222 mm on left side. The mean vertical diameter was 3.88±2.391 on right side and 3.68±3.532 mm on left side. Its existence is important to the orthopaedician in the preoperative planning of nailing fractures of the distal humerus and to the radiologist for differentiating it from an osteolytic or cystic lesion.

An anatomical study of the supratrochlear foramen of the Jining population.

The supratrochlear foramen (STF) is an important variation in the lower end of the humerus where the septum separating the coronoid and olecranon fossa is perforated. There are no studies in the literature on the STF of the Jining population. This study will make a contribution to anatomy and anthropology by adding new data. STF was studied in detail in 262 adult dried humeri of unknown sex and age. The topographical anatomy of the STF was studied, morphometric measurements were taken, and the specimens were photographed with a digital camera. The prevalence of the STF was 10.3%, with 18 cases on the left side and 9 cases on the right side. The STF occurred in 4 shapes: oval, 19 cases; round, 4 cases; triangular, 2 cases; and rectangular, 2 cases. The mean transverse diameter of STF was 4.47 mm and 3.26 mm on the left and right sides, respectively; the mean vertical diameter of STF was 5.07 mm and 3.56 mm on the left and right sides, respectively; and the average surface area of STF was 13.1 mm2 and 18.43 mm2 on the left and right sides, respectively. The STF of the Jining population was more common on the left side, with oval being the most common shape. The two sides did not show any statistically significant differences. The findings of this study may be of clinical significance to surgeons and osteologists and may have anthropological or forensic importance.

Senile scleral plaques imaged with enhanced depth optical coherence tomography.

Senile scleral plaques (SSP) are sharply demarcated greyish areas located just anterior to the insertions of the horizontal rectus muscles and thus are frequently encountered during transscleral intravitreal injections. The aim of this study was to characterize SSP using enhanced depth imaging spectral domain anterior segment optical coherence tomography (OCT) in a cohort of patients attending intravitreal injection clinics. Prospective cross-sectional study of 380 patients attending the clinic for intravitreal injections at the Department of Ophthalmology at the Bern University Hospital. Thirty-two patients with SSP were identified and the anatomical features were assessed using anterior segment OCT. In our patient cohort, we found a SSP prevalence of 8.2%. Senile scleral plaques were easily identifiable using anterior segment OCT and were found at the insertion sites of the horizontal recti muscles. The mean horizontal diameter was 2.2 mm (±760 μm SD), the mean vertical diameter was 3.3 mm (±144 μm SD), and the average surface area was 5.3 mm(2) (±0.4 mm(2) SD). The mean senile scleral plaque thickness was 0.6 mm (±149 μm SD). The mean distance from the limbus was 2.24 mm for nasally located SSP and 3.22 mm for temporally located SSP. SSP are frequently encountered during intravitreal injections as they are located just anterior to the insertion sites of the horizontal recti muscles. Because the scleral stroma is rarefied and due to calcifications within SSP, these areas should be avoided when performing multiple intravitreal injections as this may result in rupture of the sclera.

Morphology and morphometry of infra orbital foramen in South Indian adult dry skulls

Abstract Background: The infra orbital foramen (IOF) situated below infra-orbital margin (IOM) transmits infra­orbital nerve and infra- orbital vessels. The knowledge of the dimension, shape and direction of the IOF has important implications in various surgical and anaesthetic procedures. This will avoid iatrogenic injury to neurovascular bundle emerging from the IOF. Material and methods: Sixty adult dry skulls of unknown sex from the Department of Anatomy and Department of Forensic Medicine were used. IOF on both sides of skulls were assessed for the shape and direction by inspection. The vertical and horizontal diameter of the IOF was measured using a digital Vernier caliper to the nearest millimeters and the results were statistically analyzed. Results: The shape of the IOF was vertically oval in majority of the skulls (37.5%) and was semi lunar shaped in 10.83% of the skull. The IOF was directed infero­medially in about 52.5% of the cases and was directed medially in 6.67% of the cases. The mean transverse diameter was 2.96mm and the mean vertical diameter was 3.7mm. All the above results were compared with studies of previous workers. Conclusion: The present study confirms that there is racial as well as regional variation in the shape and dimensions of IOF, thus emphasizing the need to have morphometric data for South Indian population.

Histomorphometric study of testis in deltamethrin treated albino rats

Deltamethrin, a type II synthetic pyrethroid, has lead to a widespread concern over the potential adverse effects on human health. Adult Wistar albino rats, weighing 150–200 g, were divided into two groups of ten animals each. The group II rats were injected with deltamethrin (1 mg/kg body weight) intraperitoneally, for five days/week for a month. The group I were controls. Animals were sacrificed within 24 h of the last injection by perfusion under anesthesia. Paraffin sections (8 μm) were cut, and stained with hematoxylin and eosin. Histomorphometry was done. There was a decrease in the body weight but increase in the weight of the testis of rat. The mean vertical, antero-posterior and transverse diameter of the testis is reduced. The basement membrane enclosing the seminiferous tubules appeared thickened at sites. The number of seminiferous tubules per unit area is statistically significantly reduced. There was a generalized significant decrease in the diameter and the epithelium thickness (height) of the seminiferous tubules, associated collapse and distortion at sites of the tubules predominantly in the central region. The data obtained in the present work suggest that gonadal (testis) changes could seriously affect the reproductive potential of the rat.

Racial variation in optic nerve head parameters quantified in healthy newborns by handheld spectral domain optical coherence tomography

To characterize optic nerve head (ONH) morphology and parameters, including vertical disk diameter, vertical cup diameter, and vertical cup/disk ratio in healthy, full-term newborns using a handheld spectral domain optical coherence tomography (SD-OCT) device. In this prospective observational case series, healthy white, black, and Hispanic full-term newborns delivered at the Duke Birthing Center between August 2010 and May 2011 underwent dilated fundus examination and SD-OCT imaging of the optic nerve in each eye. OCT parameters were calculated and compared for each group of infants. A total of 58 consecutive newborns of white (n = 22), black (n = 15) and Hispanic (n = 21) ethnicity were included. Mean vertical disk diameter in white, black, and Hispanic newborns was 1.29 ± 0.15 mm (standard deviation), 1.38 ± 0.14 mm, and 1.38 ± 0.14 mm, respectively (white versus Hispanic, P = 0.02; white versus black, P = 0.07). Mean vertical cup diameter in white, black, and Hispanic newborns was 0.44 ± 0.15 mm, 0.56 ± 0.23 mm, and 0.46 ± 0.30 mm, respectively (white versus black, P = 0.03). Mean vertical cup/disk ratio was 0.34 ± 0.10 for white, 0.40 ± 0.17 for black, and 0.33 ± 0.20 for Hispanic newborns (P = 0.07 for white versus black). Handheld SD-OCT is an effective means of imaging the ONH in newborns. Racial differences in cup/disk ratio are present at birth. These data may serve as the beginning of a normative dataset for characterizing development of the ONH as well as for comparison to the neonatal ONH in disease states.