Loading and unloading truss robot for computer numerical control (CNC) punch is widely used in the production of sheet metal parts, as its reliability level is directly related to the quality of sheet metal parts. Especially for the automatic sheet metal production line, it is urgent to predict the reliability of the loading and unloading truss robot for CNC punch. In this paper, a new method for the reliability prediction of the loading and unloading truss robot for CNC punch is proposed. The method uses the component counting method to predict the failure rate and mean time between failures (MTBF) of the electrical control system. Then, according to the MTBF value of the electrical control system, the MTBF value and failure rate of the mechanical system and pneumatic system are calculated by expert scoring method based on fuzzy theory. The MTBF value and failure rate of the loading and unloading truss robot for CNC punch are estimated, and the weak link of the loading and unloading truss robot for CNC punch is obtained. Finally, through the collected fault maintenance data records, the failure modes and effects analysis (FMEA) of the loading and unloading truss robot for CNC punch is carried out, and the reliability prediction method proposed in this paper is validated by the fault location analysis results.