You have accessJournal of UrologyCME1 Apr 2023MP65-07 IMPACT OF SURGICAL INTERVENTION ON IRRADIATED PATIENTS' QUALITY OF LIFE Elizabeth Bearrick, Mazeed Aro-Lambo, Bridget Findlay, Paige Nichols, Katherine Anderson, and Boyd Viers Elizabeth BearrickElizabeth Bearrick More articles by this author , Mazeed Aro-LamboMazeed Aro-Lambo More articles by this author , Bridget FindlayBridget Findlay More articles by this author , Paige NicholsPaige Nichols More articles by this author , Katherine AndersonKatherine Anderson More articles by this author , and Boyd ViersBoyd Viers More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003323.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The impact of surgical intervention following radiation injury on patient quality of life (QOL) is not well studied. The objective of this study was to evaluate the effect of definitive surgical intervention on health burden and QOL among patients with a history of radiation. METHODS: Patients who underwent major intra-abdominal intervention to address radiation injury were included in the study (N=24). A validated 36-item short form (SF-36) survey was used to assess QOL domains (0-100, low-high) pre- and post-operatively. The scores obtained from these surveys were used to assess the difference in QOL before and after intervention across the group and on a per-individual basis (pairwise students-t). RESULTS: Median time from radiation to surgical intervention was 7.6 years. The etiology of radiation injury was urologic in 20(83%), colorectal in 2(8%), gynecologic in 2(8%). In total, 10(42%) patients had fistula and 8(33%) had strictures. In assessment of radiation injury burden on health in the year before surgery vs the year after, there was significantly greater hospitalizations (median 1 vs 0.5), hospitalized days (3.5 vs 0.5), and ER visits (1 vs 0; all p<0.05). There was no significant difference in hospitalizations or ER visits according to injury etiology. Pre- and post SF-36 survey was conducted a median 1.6 months prior to surgery and 5.1 months after. Figure 1. outlines the differences in pre- and post-operative QOL. Mean QOL scores improved in every domain following surgery, including physical functioning (54.6 vs 76.1), role limitations due to physical health (29.8 vs 55.6), role limitations due to emotional problems (47.4 vs 75.9), energy/fatigue (34.7 vs 55.6), emotional well-being (64.2 vs 80.1), social functioning (41.4 vs 81.3), pain (48.9 vs 78.2), and general health (45.8 vs 61.7) (all p<0.05). Per-individual pairwise comparisons were clinically significant except for physical health. CONCLUSIONS: Following definitive surgical intervention for radiation induced urinary injury there is a significant reduction in health-related complications and improved QOL across all measured domains. Such information may prove useful in directing earlier intervention and appropriately counseling patients. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e893 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Elizabeth Bearrick More articles by this author Mazeed Aro-Lambo More articles by this author Bridget Findlay More articles by this author Paige Nichols More articles by this author Katherine Anderson More articles by this author Boyd Viers More articles by this author Expand All Advertisement PDF downloadLoading ...