Objective: To compare the progression of periodontal disease of sextants in individuals with cleft lip, alveolus and palate. Materials and Methods: This longitudinal, cross-section study was performed following the STROBE Statement. The sample included the study was conducted on 30 individuals, of both genders, aged 22 to 53 years, with cleft lip, alveolus and palate. The following clinical parameters were evaluated: measurement of probing depth of the sulcus or Periodontal pocket (PD), Clinical Attachment Level (CAL), Gingival Index (GI), plaque index (PI), buccal Gingival Recession (GR) in six sites of all teeth, except for the third molars. Analysis of the variation of clinical parameters of each tooth over the study period in relation to its sextant was performed by the Kruskal-Wallis and Dunn test. The variation of clinical parameters during the study period and the age of individuals were correlated using the Spearman correlation test. All tests considered a significance level of 5%. Results: The following means were found: PD 2.4 mm, CAL 2.6 mm, GI 0.9, PI 1.0 and BR 0.3 mm. There was increase in the mean PD and CAL (p<0.001) and reduction of mean PI and GI (p<0.001) over time, yet the variation between sextants was not statistically significant. Conclusion: During the study period, there was progression of periodontal disease in all sextants, without difference between the upper anterior sextant, cleft area and the others, suggesting that the cleft, per se, is not a risk factor for periodontal disease. Clinical relevance: the epidemiology and progression of periodontal disease in individuals with cleft lip and palate must be understood in order to establish effective therapeutic approaches.