Menopozun sağlıklı ve periodontitisli kadınlarda kortizol, alfa-amilaz, dopamin ve prolaktin seviyeleri üzerine etkisi: kesitsel bir çalışma

Abstract

Aim: In this study, we aimed to investigate the effects of menopause on serum levels of cortisol, alpha-amylase, dopamine, and prolactin in women with periodontitis and healthy controls.Methods: The study included a total of 80 women. Patients were diagnosed according to the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions criteria. The clinical examination included plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment loss (AL) measurements. The systemic levels of cortisol, alpha-amylase,dopamine, and prolactin were measured biochemically. Data were analyzed statistically. Results: The mean participant age was 44.32±3.23 (range: 33–55) years. The mean PI was 0.98±0.10, GI 0.94±0.31, PD 2.59±0.23 mm, and AL 2.65±0.16 mm. While prolactin levels were statistically significantly lower in menopausal women (p<0.05), the changes in cortisol, alpha-amylase, and dopamine levels were not significant (p>0.05). Levels of cortisol, dopamine and prolactinwere found to be significantly high in women with periodontitis (p<0.05).Conclusion: It was found that menopause had no effect on the clinical periodontal parameters and levels of cortisol, alpha-amylase, and dopamine in women with periodontitis and healthy controls.However, menopause was associated with decreased prolactin levels, independent of the presence of periodontal disease.