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Abstract
Aim: The electrophysiological impact of short-term and long-term harmaline treatment on the penicillin G-induced epileptic model in rats was examined in this study. Methods: Eighty-four adult male Wistar rats were randomly assigned to two groups: one received a single dose of harmaline, and the other received repeated doses of harmaline. Each group was further divided into six subgroups based on the dose of harmaline (0, 10, 50, or 100 mg/kg) or penicillin (control or sham). The electrophysiological data were collected using electrocorticography and analyzed using PowerLab Chart v.8 software. The statistical analysis included the latency, frequency, and amplitude of the spike-wave discharges. The serum levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) were measured using the ELISA method to assess the antioxidant effects of harmaline. Results: The results showed that both acute and chronic harmaline treatment increased the seizure threshold in a dose-dependent manner (p
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