AbstractThe growth and propagation of African easterly waves (AEWs) remains an active area of research, especially for those that become tropical cyclones (TCs). This is partly due to the complex role of moisture, realized through AEW‐convection interactions. The goal of this study is to understand how environmental moisture plays a role in influencing the growth and propagation of a case of an AEW‐convection system, that became a TC and how that role relates to the West African Monsoon System. Moisture sensitivity experiments were performed in a regional and convection‐permitting novel configuration. It is found that in a moister environment, diabatic heating associated with convection coupled to the wave is shallower, ultimately, weakening the wave amplitude. Energetics are reduced in a moister environment as the African easterly jet strengthens, yet narrows, and shifts northward limiting interaction with the monsoon and the wave‐convection system. The more intense monsoonal flow in a moister environment can instigate the decoupling between convection and AEW as deep convection is more likely in the ridge rather than in the trough region. Over western Africa, more continuous rainfall over the Guinea Highlands can inhibit phase locking with the AEW. In a moister environment, the mean zonal flow is weaker and as a result, the westward translation speed of the wave due to mean flow advection is slower than in the other experiments. While the mean flow advection dominates the translation, further differences in phase speed arise from differences in convection within the wave.