ABSTRACT Rapid determination of the dissolution behavior of a compound fertilizer is difficult in agricultural industry. In this work, we describe a simple and rapid method for quantifying the disintegration properties of compound fertilizer for the indirect evaluation of their dissolution. The effects of screen mesh, disintegration time, temperature, fertilizer-water ratio, stacking mode and particle size on fertilizer disintegration test were studied. Under standardized conditions, the maximum and minimum relative standard deviation (RSD) were 12.7% and 0.9%, respectively. The mean deviations of the measured data were > 4%, standard deviations > 4.6%, and interquartile ranges > 6.7%. The feasibility, accuracy, error tolerance, and consistency of this lift disintegration method meet industrial requirements and can be utilized for the rapid determination of the solubility of compound fertilizers.