Maximum Principal Strain Research Articles

Abstract 1007: A Novel Heterogeneous Murine Aortic Model Derived From Micro-computed Tomography

Introduction: Strength and structural stability of the aorta primarily comes from collagen that is mostly found in the media layer of the aorta along with elastin. The risk of life-threatening aortic rupture increases in cases of aortic aneurysm diseases due to local deformation and weakening of the aortic wall. How does local structure affect how the aorta responds to stress? We hypothesize that material and geometric heterogeneity affect the local biomechanics of the aortic wall and that the local responses to stress are not necessarily the same as the global response. Our goal is to develop a novel finite element model (FEM) of collagen and elastin behavior in murine aorta derived from high-resolution micro-computed tomography (microCT). This model will allow us to study how the aorta deforms to blood pressure at the local level. Approach: The collagen and elastin from 100 vertical slices of microCT scans of a murine aorta were segmented, smoothed and meshed to create 3D models for FEM and the aortic ring was divided into 8 sections of varying geometry and composition. Local stress-strain relationships were extracted from uniaxial loading conditions. Simulations were conducted where the stiffness of collagen was set equal to (1X) or made stiffer than elastin by a factor of 10 (10X) or 100 (100X). The average Young’s modulus, E, for each section was calculated and used as parameters for FEM of the aortic ring to investigate the global mechanical behavior of the aortic wall. Results/Conclusions: The strains generated in the radial direction are greater than the strains in the hoop direction in each of the 8 heterogeneous sections of the aortic ring. There was significant variability in the E values in the 10X and 100X systems. FEM of a materially uniform aortic ring yielded smaller maximum principal logarithmic strains compared to a ring that was materially heterogeneous. This study provides evidence that local structure and material distribution are important in aortic biomechanics. Pathogenesis of aneurysmal disease is dependent on collagen and elastin turnover. Aneurysm rupture results from mechanical failure: peak wall stress exceeds local tissue strength. This novel method will allow for development of a complex aortic fracture model to study aortic pathologies.

Experimental study on the deterioration of mechanical properties of sandy mudstone under different water-gas interactions

Based on the water-rock-gas coupling test system, the work combined the scanning electron microscope and XTDIC 3D full-field strain measurement system. The Brazilian splitting test was performed on four groups of sandy mudstone specimens under contrast (CO), mash-gas soaking (MS), water-mash gas soaking (WM), and water-soaking (WS) conditions. The tensile strength, deformation failure, and microscopic characteristics of fractures were studied to reveal the deterioration mechanism of the tensile properties of sandy mudstone under water-gas coupling. The results showed that the uniaxial tensile strength of sandy mudstone specimens under the three soaking conditions was less than that of the contrast conditions. Compared with specimens in the CO group, the tensile strength of specimens in MS-WS groups was reduced; the WS group decreased the most. Specimens changed from brittle failure to plastic failure after soaking. The decrease rate in strength after the peak was consistent with the change trend in tensile strength. It led to a larger localized deformation zone of specimens and more obvious displacement. The deformation localization zone of the WS group was the broadest, with the most intense displacement. Besides, stress concentration first occurred in the submerged part of the WM group. Fractures expanded in the direction of maximum principal strain. The internal pore structure of sandy mudstone specimens in each group changed after soaking. The average porosity, maximum pore area, and probability entropy of specimens in WS-MS groups increased compared to the CO group. The WS group had the largest reduction and the MS group had the smallest. The pre-peak energy storage capacity of sandy mudstone specimens was gradually weakened. Compared with the CO group, that in the WS-MS groups was reduced. The WS group had the greatest reduction, and the MS group had the smallest. The deterioration effect of water on the interior of sandy mudstone was stronger than that of gas. The work is of great significance for understanding the stability of coal and rocks in closed-pit high-gas mines.

Biomechanical behavior of three‐dimensional bioactive composite constructs on extraction socket remodeling

AbstractObjectivesLoss of mechanostimulation leads to dimensional alterations in the extraction socket. The study aims to use three‐dimensional spatial stimulation of the socket wall to assess if bioactive composite constructs could generate mechanostimulative activity.MethodsAnalysis of the biomechanical behavior of the three‐dimensional bioactive composite constructs was done in a model created using ANSYS, and mechanical properties were assessed using finite element analysis.ResultsTotal deformation on the mandible was higher in alginate bioglass and chitosan alginate bioglass than gelatin. Bioglass composites were capable of generating a higher strain on the surrounding alveolar bone than gelatin. The maximum principal elastic strain and equivalent (von Mises) stress of chitosan and bioglass were higher than those of gelatin.SignificanceDifferential stress/strain generated on the alveolar bone with a three‐dimensional approach from early stages of remodeling will have a profound effect on the reduction of alveolar bone loss.

Head Impact Kinematics and Brain Tissue Strains in High School Lacrosse.

Male lacrosse and female lacrosse have differences in history, rules, and equipment. There is current debate regarding the need for enhanced protective headwear in female lacrosse like that worn by male lacrosse players. To inform this discussion, 17 high school lacrosse players (6 female and 11 male) wore the Stanford Instrumented Mouthguard during 26 competitive games over the 2021 season. Time-windowing and video review were used to remove false-positive recordings and verify head acceleration events (HAEs). The HAE rate in high school female lacrosse (0.21 per athlete exposure and 0.24 per player hour) was approximately 35% lower than the HAE rate in high school male lacrosse (0.33 per athlete exposure and 0.36 per player hour). Previously collected kinematics data from the 2019 high school male and female lacrosse season were combined with the newly collected 2021 kinematics data, which were used to drive a finite element head model and simulate 42 HAEs. Peak linear acceleration (PLA), peak angular velocity (PAV), and 95th percentile maximum principal strain (MPS95) of brain tissue were compared between HAEs in high school female and male lacrosse. Median values for peak kinematics and MPS95 of HAEs in high school female lacrosse (PLA, 22.3g; PAV, 10.4rad/s; MPS95, 0.05) were lower than for high school male lacrosse (PLA, 24.2g; PAV, 15.4rad/s; MPS95, 0.07), but the differences were not statistically significant. Quantifying a lower HAE rate in high school female lacrosse compared to high school male lacrosse, but similar HAE magnitudes, provides insight into the debate regarding helmets in female lacrosse. However, due to the small sample size, additional video-verified data from instrumented mouthguards are required.

Approach for contact medical device development via integrated testing, skeletal muscle modeling, and finite element analysis

Development of novel medical devices for the treatment of musculoskeletal pain associated with neuro-muscular trigger points requires a model for relating the mechanical responses of in vivo biological tissues to applied palliative physical pressures and a method to design treatments for optimal effects. It is reasonable to hypothesize that the efficacy of therapeutic treatment is proportional to the maximum tensile strain at trigger point locations. This work presents modeling of the mechanical behavior of biological tissue structures and treatment simulations, supported by indentation experiments and finite element (FE) modeling. The steady-state indentation responses of the tissue structure of the posterior neck were measured with a testing device, and an FE model was constructed using a first-order Ogden hyperelastic material model and calibrated with the experimental data. The error between experimental and FE-generated displacement-load curves was minimized via a two-stage optimization process comprised of an Optimal Latin Hypercube design-of-experiments analysis and a Bayesian optimization loop. The optimized Ogden model had an initial shear modulus (μ) of 5.16 kPa and a deviatoric exponent (α) of 11.90. Another FE model was developed to simulate the deformation of the tissue structures in the posterior neck adjacent to the C3 vertebrae in response to indentation loading, in order to determine the optimal location and angle to apply an indentation force for maximum therapeutic benefit. The optimal location of indentation was determined to be 28° lateral from the sagittal plane along the surface of the skin, measured from the centerline of the spine, at an angle of 8° counterclockwise from the surface normal vector. The optimized spatial orientation of the indentation corresponded to the average of the maximum principal strain across the deep muscle region of the model.

Simplifying finite elements analysis of four-point bending tests for flip chip microcomponents

PurposeThe purpose of this study is to propose a simplifying approach for modelling a reliability test. Modelling the reliability tests of printed circuit board (PCB)/microelectronic component assemblies requires the adoption of several simplifying assumptions. This study introduces and validates simplified assumptions for modeling a four-point bend test on a PCB/wafer-level chip scale packaging assembly.Design/methodology/approachIn this study, simplifying assumptions were used. These involved substituting dynamic imposed displacement loading with an equivalent static loading, replacing the spherical shape of the interconnections with simplified shapes (cylindrical and cubic) and transitioning from a three-dimensional modelling approach to an equivalent two-dimensional model. The validity of these simplifications was confirmed through both quantitative and qualitative comparisons of the numerical results obtained. The maximum principal plastic strain in the solder balls and copper pads served as the criteria for comparison.FindingsThe simplified hypotheses were validated through quantitative and qualitative comparisons of the results from various models. Consequently, it was determined that the replacement of dynamic loading with equivalent static loading had no significant impact on the results. Similarly, substituting the spherical shape of interconnections with an equivalent shape and transitioning from a three-dimensional approach to a two-dimensional one did not substantially affect the precision of the obtained results.Originality/valueThis study serves as a valuable resource for researchers seeking to model accelerated reliability tests, particularly in the context of four-point bending tests. The results obtained in this study will assist other researchers in streamlining their numerical models, thereby reducing calculation costs through the utilization of the simplified hypotheses introduced and validated herein.

Setting hinge position distal to the proximal margin of the distal lateral femur reduces the maximum principal strains of the hinge area and risk of hinge fractures.

The optimal hinge position to prevent hinge fractures in medial closing wedge distal femoral osteotomy (MCWDFO) based on the biomechanical background has not yet been well examined. This study aimed to examine the appropriate hinge position in MCWDFO using finite element (FE) analysis to prevent hinge fractures. Computer-aided design (CAD) models were created using composite replicate femurs. FE models of the MCWDFO with a 5° wedge were created with three different hinge positions: (A) 5 mm proximal to the proximal margin of the lateral epicondylar region, (B) proximal margin level and (C) 5 mm distal to the proximal margin level. The maximum and minimum principal strains in the cortical bone were calculated for each model. To validate the FE analysis, biomechanical tests were performed using composite replicate femurs with the same hinge position models as those in the FE analysis. In the FE analysis, the maximum principal strains were in the order of Models A > B > C. The highest value of maximum principal strain was observed in the area proximal to the hinge. In the biomechanical test, hinge fractures occurred in the area proximal to the hinge in Models A and B, whereas the gap closed completely without hinge fractures in Model C. Fractures occurred in an area similar to where the highest maximal principal strain was observed in the FE analysis. Distal to the proximal margin of the lateral epicondylar region is an appropriate hinge position in MCWDFO to prevent hinge fractures. Level V.

Parametric analysis of craniocerebral injury mechanism in pedestrian traffic accidents based on finite element methods

PurposeThe toughest challenge in pedestrian traffic accident identification lies in ascertaining injury manners. This study aimed to systematically simulate and parameterize 3 types of craniocerebral injury including impact injury, fall injury, and run-over injury, to compare the injury response outcomes of different injury manners. MethodsBased on the total human model for safety (THUMS) and its enhanced human model THUMS-hollow structures, a total of 84 simulations with 3 injury manners, different loading directions, and loading velocities were conducted. Von Mises stress, intracranial pressure, maximum principal strain, cumulative strain damage measure, shear stress, and cranial strain were employed to analyze the injury response of all areas of the brain. To examine the association between injury conditions and injury consequences, correlation analysis, principal component analysis, linear regression, and stepwise linear regression were utilized. ResultsThere is a significant correlation observed between each criterion of skull and brain injury (p < 0.01 in all Pearson correlation analysis results). A 2-phase increase of cranio-cerebral stress and strain as impact speed increases. In high-speed impact (> 40 km/h), the Von Mises stress on the skull was with a high possibility exceed the threshold for skull fracture (100 MPa). When falling and making temporal and occipital contact with the ground, the opposite side of the impacted area experiences higher frequency stress concentration than contact at other conditions. Run-over injuries tend to have a more comprehensive craniocerebral injury, with greater overall deformation due to more adequate kinetic energy conduction. The mean value of maximum principal strain of brain and Von Mises stress of cranium at run-over condition are 1.39 and 403.8 MPa, while they were 1.31, 94.11 MPa and 0.64, 120.5 MPa for the impact and fall conditions, respectively. The impact velocity also plays a significant role in craniocerebral injury in impact and fall loading conditions (the p of all F-test < 0.05). A regression equation of the craniocerebral injury manners in pedestrian accidents was established. ConclusionThe study distinguished the craniocerebral injuries caused in different manners, elucidated the biomechanical mechanisms of craniocerebral injury, and provided a biomechanical foundation for the identification of craniocerebral injury in legal contexts.

Numerical simulation of the distal stent graft-induced new entry after TEVAR.

The study aimed to investigate the mechanical factors for distal stent graft-induced new entry (dSINE) in aortic dissection patients and discussed these factors in conjunction with aortic morphology. Two patients (one dSINE and one non-dSINE), with the same age, gender, and type of implanted stent, were selected, then aortic morphological parameters were calculated. In addition, the stent material parameters used by the patients were also fitted. Simulations were performed based on the patient's aortic model and the stent graft used. The true lumen segment at the distal stent graft was designated as the "dSINE risk zone," and mechanical parameters (maximum principal strain, maximum principal stress) were computed. When approaching the area with higher mechanical parameters in the dSINE risk zone, dSINE patient exhibited higher values and growth rates in mechanical parameters compared to non-dSINE patient. Furthermore, dSINE patient also presented larger aortic taper ratio, stent oversizing ratio, and expansion mismatch ratio of the distal true lumen (EMRDTR). The larger mechanical parameters and growth rates in dSINE patient corresponded to a greater aortic taper ratio, stent oversizing ratio, and EMRDTR. The failure of dSINE prediction by the stent tortuosity index indicated that mechanical parameters were the fundamental reasons for dSINE development.

Post-Buckling Analysis of Arch and Serpentine Structures Under End-to-End Compression

Abstract Arch and serpentine structures are two fundamental structural forms with significant applications in various fields. When subjected to compressive loading at both ends, these structures undergo flexural-torsional post-buckling, resulting in complex deformation modes that are challenging to describe using basic functions (e.g., trigonometric functions and polynomial functions), posing significant challenges in finding analytical solutions. In this study, we propose a novel approach to address this issue. By representing the lateral displacement with a trigonometric series expansion and utilizing the equilibrium equation, the angular displacement is expressed in terms of special functions known as Mathieu functions. Furthermore, the energy method is employed to obtain analytical solutions for the flexural-torsional post-buckling deformation components. The theoretical findings are validated through experiments and finite element analysis. Based on the theoretical results, explicit analytical expressions for the maximum principal strain and the bending-torsion ratio of the structures are derived, offering valuable insights for the design of arch and serpentine structures in practical applications.

Stress reduction through cortical bone thickening improves bone mechanical behavior in adult female Beclin-1+/- mice.

Fragility fractures, which are more prevalent in women, may be significantly influenced by autophagy due to altered bone turnover. As an essential mediator of autophagy, Beclin-1 modulates bone homeostasis by regulating osteoclast and chondrocyte differentiation, however, the alteration in the local bone mechanical environment in female Beclin-1+/- mice remains unclear. In this study, our aim is to investigate the biomechanical behavior of femurs from seven-month-old female wild-type (WT) and Beclin-1+/- mice under peak physiological load, using finite element analysis on micro-CT images. Micro-CT imaging analyses revealed femoral cortical thickening in Beclin-1+/- female mice compared to WT. Three-point bending test demonstrated a 63.94% increase in whole-bone strength and a 61.18% increase in stiffness for female Beclin-1+/- murine femurs, indicating improved biomechanical integrity. After conducting finite element analysis, Beclin-1+/- mice exhibited a 26.99% reduction in von Mises stress and a 31.62% reduction in maximum principal strain in the femoral midshaft, as well as a 36.64% decrease of von Mises stress in the distal femurs, compared to WT mice. Subsequently, the strength-safety factor was determined using an empirical formula, revealing that Beclin-1+/- mice exhibited significantly higher minimum safety factors in both the midshaft and distal regions compared to WT mice. In summary, considering the increased response of bone adaptation to mechanical loading in female Beclin-1+/- mice, our findings indicate that increasing cortical bone thickness significantly improves bone biomechanical behavior by effectively reducing stress and strain within the femoral shaft.

Comprehensive integrity assessment of spent nuclear fuel cladding during normal and postulated conditions of transportation

As a part of Spent Nuclear Fuel (SNF) management, it is important to maintain the cladding integrity to prevent the potential release of hazardous radioactive materials. Accordingly, assessing the integrity of SNF under the generated shock and vibration loads during normal conditions is essential for safe transportation. In this study, failure criteria for two zirconium alloys were derived by utilizing data from tensile property tests, mechanical model calculations, and machine learning estimations. Integrity assessment under normal and postulated transportation conditions was also performed via finite element analyses. Loading conditions were generated by real time-acceleration data collected during transportation tests in the Republic of Korea. Shock and vibration loads were applied to a simplified light-water reactor assembly. Furthermore, postulated transportation conditions and pre-cracked cladding were assumed for more challenging conditions. Consequently, a comprehensive integrity assessment of SNF cladding under shock and vibration loads for both free-defect and defective (pre-cracked) cladding was conducted. In each case, the resultant maximum principal strains, stress intensity amplitudes, and stress intensity factors were significantly smaller than the strain-based failure criteria, S-N curve, and fracture toughness, respectively. Therefore, the integrity of SNF cladding under transportation conditions remained intact even when assuming further challenging postulated transportation load conditions.

Biomechanical evaluation of four different framework designs of cantilever zirconia resin bonded fixed dental prosthesis: A three-dimensional finite element analysis study

: To measure stress and strain concentrations on four different RBFDP designs and its effect on cement layer and the Periodontal tissues using FEA.: Using CBCT data, two 3D models of a maxilla with missing lateral Incisor were printed. Tooth preparation for RBFDP was done. One model had proximal-groove of 4mm and other had 3mm proximal-groove. Four designs of cantilever RBFDPs were designed. Model-1: #21 abutment/ 3x3mm connector; Model-2: #21 abutment/ 3x4mm connector; Model-3: #23 abutment/ 3x3mm connector and; Model-4: #23 abutment/ 3x4mm connector. All Models were converted into FEA models, occlusal force of 200N was loaded at 450 to long axis of pontic and FEA was carried out. Maximum Principal Strain(MPS) in the RBFDP framework, periodontal tissues and Maximum Shear Stress(MSS) in cement layer were measured to evaluate the impact on periodontal tissues and the risk for framework-debonding respectively.: The MPS of framework in decreasing order was: Model-1&amp;#62;Model-2&amp;#62;Model-3&amp;#62;Model-4. The MPS of PDL: Model-1 and Model-2 &amp;#62; Model-3 and Model-4. MSS in cement layer: Model-1 and Model-2 &amp;#62; Model-3 and Model-4. Adhesion area with shear stress &amp;#62;11MPa: Model-1 and Model-2 &amp;#62; Model-3 and Model-4. MPS and MMS values were lower in models with 3×4mm connector than models with 3x3mm connector.: Adequate Connector dimension and adhesion-area are critical for success of RBFDP. Within the limitations of this study, RBFDP design with 3x4mm connector and Maxillary Canine as abutment for replacing Maxillary Lateral Incisor is better option in terms of framework-debonding risk and preservation of periodontal tissues.

Stress redistribution and stress triaxiality effect on the fatigue life of notched Ni-based single crystal superalloy at 760℃

The multiaxial stress state caused by geometric discontinuities will result in significant differences in the fatigue performance compared to the uniaxial stress state. It is crucial importance to research the notch fatigue behaviors of nickel-based single crystal (Ni-SX) superalloys at high temperature. This study investigated the impact of stress redistribution and stress triaxiality on the fatigue life of notched Ni-based single crystal superalloy at 760℃. The high temperature fatigue tests were carried out on the specimens under different stress ratios and the stress amplitudes under the same life conditions were obtained. A novel anisotropic damage model, incorporating the influence of stress triaxiality is proposed coupled with crystal plasticity theory. Based on experimental findings, an evaluation of the test parameters was conducted.The results showed that Mises stress, maximum principal stress, normal stress of principal stress along the loading direction, maximum principal strain, and strain along the loading direction were inadequate in reflecting the significant variations of samples observed among different stress ratios. However, the stress triaxiality at the unloading valley exhibited a high sensitivity to changes in fatigue life. To evaluate the fatigue life of notched specimens under different stress ratios, an improved Basquin’s type life prediction model was proposed, utilizing the stress triaxiality at the unloading valley. The proposed model demonstrates a favorable normalization trend for the fatigue life of notched specimens subjected to various stress concentration factor (SCF) conditions.

Progression of partial to complete ruptures of the Achilles tendon during rehabilitation: Astudy using a finite element model.

Substantial research on complete Achilles tendon ruptures is available, but guidance on partial ruptures is comparatively sparse. Conservative management is considered acceptable in partial tendon ruptures affecting less than 50% of the tendon's width, but supporting experimental evidence is currently lacking. Using a previously validated finite element model of the Achilles tendon, this study aimed to assess whether loading conditions simulating an early functional rehabilitation protocol could elicit progression to a complete rupture in partial ruptures of varying severity. In silico tendon rupture simulations were performed to locate the most likely rupture site for least, moderate, and extreme subtendon twist configurations. These three models were split at the corresponding rupture site and two sets of partial ruptures were created for each, starting from the medial and lateral sides, and ranging from 10% to 50% loss of continuity. Simulations were conducted with material parameters from healthy and tendinopathic tendons. Partial ruptures were considered to progress if the volume of elements showing a maximum principal strain above 10% exceeded 3 mm3. To assess whether the tendinopathic tendons typical geometric characteristics could compensate for the inferior material properties found in tendinopathy, an additional model with increased cross-sectional area in the free tendon region was developed. Progression to complete ruptures occurred even with less than a 50% loss of continuity, regardless of subtendon twisting, and material parameters. The tendinopathic tendon model with increased cross-sectional area showed similar results. These findings suggest the current criteria for surgical treatment of partial ruptures should be reconsidered. Statement of clinical significance: The clinical significance and most appropriate treatment of partial ruptures of the Achilles tendon is unclear. Despite the widespread use of the "50% rule" in treatment decisions of partial tendon ruptures, experimental evidence supporting it is missing. The present study provides new data, from a validated aponeurotic and free Achilles tendon finite element model, showing that partial ruptures may progress to complete ruptures under loading conditions elicited from functional rehabilitation protocols, even for partial ruptures affecting less than 50% of the tendon's width. Under these novel findings, the current criteria for surgical treatment of partial ruptures should be reconsidered.

Prediction of fractures by using the stress field in medium to deep shale gas reservoirs: A case study of Late Ordovician–early Silurian shale gas reservoirs in the Nanchuan region, South China

Containing representative shale gas reservoirs, the Wufeng–Longmaxi Formations in the Nanchuan region in South China have been modified by three compressional tectonic movements (in the Late Jurassic to Early Cretaceous, Late Cretaceous, and Cenozoic to present). These movements formed deeply buried reservoirs with complex in situ stresses and rapid directional changes, influencing the state of shale gas reservoirs fractures. Numerical modeling applied to model the stress field in the three periods showed that the maximum compressive horizontal principal stress (σHmax), strain rate, and fault slip rate regimes transformed from a thrust and strike-slip regime to a thrust and strike-slip regime to a thrust regime. The σHmax direction changed from NW–SE and WNW–ESE to WNW–ESE and nearly E–W and then to multiple directions. The magnitude of strain rate changed from -16 ∼ -15 to -17.7 ∼ -15.6 to -18.8 ∼ -15.8. The fault slip rate changed from 0 to 0.029 mm/a to 0–0.0026 mm/a to 0–0.0012 mm/a. These data strongly agree with data from drilled wells and outcrops and show that the present-day stress field is the superposed effect of multistage movements. Semiquantitative research was conducted on shale gas fracture openness and fracture development. Fracture openness is favorable when the angle between the σHmax direction and nearby faults is ≤45° and the distance from the fault is >2 km, and fracture development is favorable when the magnitude of the strain rate is <-17.6 and the fault slip rate is <0.00036 mm/a. Accordingly, we predicted fractured shale gas reservoirs.

Biomechanical analysis of alveolar bones with compromised quality supporting a 4-unit implant bridge; a possible association with implant-related sequestration (IRS).

This study aimed to investigate the strain in the bone surrounding dental implants supporting a 4-unit bridge and assess the role of excessive strain as a possible risk factor for implant related sequestration (IRS)or peri-implant medication-related osteonecrosis of the jaw (PI-MRONJ). A 3D-mandibular model was constructed using computed tomography and segmented it into cortical and cancellous bones. The 4-unit implant-supported bridges replacing the mandibular posteriors were constructed, and each featuring two, three, and four implants, respectively. The Young's modulus was assigned based on the quality of the bone. A maximum occlusal force of 200N was applied to each implant in the axial and in a 30-degree oblique direction. The maximum principal strain of the fatigue failure range (> 3000 µε) in the bone was analyzed. The volume fraction of fatigue failure was higher in poor-quality bone compared to normal bone and oblique load than in axial load. An increasing number of implants may dissipate excessive strain in poor-quality bones. Occlusal force applied to poor-quality bone can result in microdamage. Given that unrepaired microdamage may initiate medication-related osteonecrosis of the jaw, long-term occlusal force on fragile bones might be a risk factor. When planning implant treatment for patients with compromised bone status, clinical modifications such as strategic placement of implants and optimization of restoration morphology should be considered to reduce excessive strain which might be associated with IRS or PI-MRONJ.

Stress Changes in the Canine Radius after Locking Plate Fixation Using Finite Element Analysis.

The aim of this study was to evaluate the stress changes in the radii beneath the locking plates (LP) of dogs implanted with LP using finite element analysis (FEA). The study included radii harvested from eight dogs. After computed tomography (CT) scans of the forelimb, the articular surface of the radius was fixed using resin. Material tests were conducted to identify the yield and fracture points and for verification with FEA. The CT data of the radius were imported into FEA software. The radii were classified into three groups based on the placement of the LP (nonplate placement, intact group; 1 mm above the radial surface, LP + 1 mm group; 3 mm above the radial surface, LP + 3 mm group). Equivalent, maximum, and minimum principal stresses and minimum principal strain were measured after FEA at the radial diaphysis beneath the plate. In shell elements, the LP + 1 mm and LP + 3 mm groups showed a significantly lower maximum principal stress compared with the intact group. In solid elements, the LP + 1 mm and LP + 3 mm groups showed a significantly higher equivalent stress and a significantly lower maximum principal stress compared with the intact group. When an axial load is applied to the radius, LP placement reduces the tension stress on the cortical bone of the radius beneath the plate, possibly related to implant-induced osteoporosis and bone formation in the cortical bone beneath the plate.

Finite element model of ocular adduction with unconstrained globe translation

Details of the anatomy and behavior of the structures responsible for human eye movements have been extensively elaborated since the first modern biomechanical models were introduced. Based on these findings, a finite element model of human ocular adduction is developed based on connective anatomy and measured optic nerve (ON) properties, as well as active contractility of bilaminar extraocular muscles (EOMs), but incorporating the novel feature that globe translation is not otherwise constrained so that realistic kinematics can be simulated. Anatomy of the hemisymmetric model is defined by magnetic resonance imaging. The globe is modeled as suspended by anatomically realistic connective tissues, orbital fat, and contiguous ON. The model incorporates a material subroutine that implements active EOM contraction based on fiber twitch characteristics. Starting from the initial condition of 26° adduction, the medial rectus (MR) muscle was commanded to contract as the lateral rectus (LR) relaxed. We alternatively modeled absence or presence of orbital fat. During pursuit-like adduction from 26 to 32°, the globe translated 0.52 mm posteriorly and 0.1 mm medially with orbital fat present, but 1.2 mm posteriorly and 0.1 mm medially without fat. Maximum principal strains in the optic disk and peripapillary reached 0.05–0.06, and von-Mises stress 96 kPa. Tension in the MR orbital layer was ~ 24 g-force after 6° adduction, but only ~ 3 gm-f in the whole LR. This physiologically plausible simulation of EOM activation in an anatomically realistic globe suspensory system demonstrates that orbital connective tissues and fat are integral to the biomechanics of adduction, including loading by the ON.

Development of a head-weighted injury criterion for evaluation of multiple types of AIS 4+ injuries for vulnerable road users

Vulnerable Road users (VRUs) often suffer multiple fatal head injury types simultaneously in road accidents. In this study, a head-weighted injury criterion (HWIC4) was proposed for assessing the risk of head AIS 4+ injuries considering multiple injury types. Firstly, the kinematic characteristics of VRUs in the 50 in-depth accidents were reconstructed by using multi-body system models, and head injuries were reconstructed using eight head kinematic-based injury criteria and eight brain tissue injury criteria via the THUMS (Ver. 4.0.2) head finite element model. The predictive capability of each injury criterion to predict head AIS 4+ injuries was assessed and four better predictors (HIC15, angular acceleration, coup pressure, and maximum principal strain) were selected. The different head injury types and the weighting parameters for each injury type were taken into account in the development of HWIC4. Finally, the effectiveness and evaluation of HWIC4 for head AIS 4+ injury was validated based on the area under of receiver operating characteristic (AUROC) curve and reconstruction results from 10 additional selected accident cases. The results showed that HWIC4 has a good predictive capability for head AIS 4+ injuries with an AUROC of 0.983, which means that HWIC4 is superior and more reliable than a single head injury criterion. This knowledge further improves the capability of head injury criteria to predict head AIS 4+ injuries.