Studies on the efficacy of indigenous plant products and cow dung powder on the lesser grain borer, Rhyzopertha dominica (Fabricius) in wheat (Triticum aestivum), were conducted to determine the effects of the aforementioned plant products and cow dung powder on Percent Mortality, Adult Emergence, and Percent Weight loss. This experiment was carried out using a Completely Randomized Design (CRD). Rhyzopertha dominica orientation was found to be maximum in control and minimum in Mustard oil treatments. Mustard oil treated wheat grains showed the minimum amount of Adult Emergence and Weight loss when compared to control. The wheat treated with Mustard oil (100.00%) had the maximum percentage mortality rate. As a result, the current laboratory investigations amply demonstrated the practically complete efficacy of native plant products and cow dung powder on wheat. Accordingly, it can be said that these products were affordable, convenient, and eco-friendly. It's indeed simple to implement for controlling the stored pest in wheat.