To enhance the navigation capability of the microelectromechanical system (MEMS)-based inertial navigation system (INS)/global positioning system (GPS) integrated system under satellite denied, a hybrid optimization navigation method using minimal learning parameter (MLP) to improve extreme learning machine (ELM) aided adaptive factor graph (AFG) is proposed. The proposed method mainly contains two innovative optimizations: (1) Fully considering the key parameters of each sensor in the INS/GPS integrated navigation system, the factor graph technology is introduced to develop an information fusion model for the system. Based on the maximum correlation entropy criterion and adaptive technology, the existing factor graph method for information fusion is optimized to solve the problem that the abnormal output of each sensor in the INS/GPS integrated system caused by complex environments affects the accuracy of information fusion, thus enhancing the robustness and navigation performance of the INS/GPS integrated system; (2) Moreover, ELM is optimized by MLP to predict the velocity and position observation information of the INS/GPS integrated system and tackle the performance deterioration of the system during GPS outages. The structural parameters of ELM are optimized with the MLP method, aiming to abate the computational burden of the traditional neural network (NN) to avoid “dimension explosion”, as well as enhance the generalization ability and robustness of the network to make it learn from the uncertainty of the system smoothly and quickly. Relevant ground vehicle experiments are designed to evaluate the proposed method. The experimental results demonstrate that the proposed strategy has superior performance and is more feasible for real-time implementation than other comparison approaches.