Maximum Bending Stress Research Articles

High-precision Roundness Measuring System for Tungsten Ball Tips with the Diameter of Less than 100 µm

Abstract Tungsten balls with a diameter of less 100 μm can function as probe tips for micro-coordinate measuring machines (CMMs) to measure ultraprecise workpieces with complex features. A high-precision measuring system was developed to evaluate the roundness of self-made tungsten ball tips. The system based on two-point method was composed of two oppositely placed interferometers and a turntable. The turntable rotated the tested ball, and the interferometers measured the variation in radius. A new model based on minimum zone method was proposed to evaluate roundness. The fabrication principle of tungsten balls was introduced and the analysis was conducted on the maximum permissible contact force and bending stress of tungsten ball tips. The elastic mechanism was designed based on the analysis. A ruby sphere with a sphericity of 130 nm was measured to verify the system's effectiveness. Repeated experiments were performed for two tungsten ball tips. Results show the roundness error of tungsten ball-A is between 550.9 and 586.2 nm with a standard deviation of 11.0 nm while tungsten ball-B’s roundness error is between 898.5 and 959.9 nm with a standard deviation of 21.7 nm. The uncertainty is calculated as 144.6 nm. The developed system can stably measure the roundness of tungsten ball tips.

Multi-objective optimization of helical gear transmission geometric parameters using MOPSO

Abstract Helical gears are widely used in mechanical devices, but insufficient tooth strength can easily lead to premature failure, which is an urgent problem to be solved. To overcome this challenge, this paper introduces a multi-objective particle swarm optimization algorithm, which comprehensively considers the comprehensive effects of modification coefficient, number of teeth, and modulus on the performance of helical gears. By constructing a mathematical model with the geometric parameters of helical gears as the core design variables, aiming to minimize the difference between the maximum bending stress of helical gear roots and the contact stress on the tooth surface, we have achieved optimization of gear performance. Using MATLAB for algorithm programming, the established model was efficiently optimized and solved. After optimization, the bending strength difference and tooth surface bearing capacity of the gear pair have been significantly improved, ensuring the stability and reliability of the operation of the high-pressure sleeve disassembly transmission device.

Composites with Synergistically Enhanced Thermodynamic and Mechanical Properties for Geothermal Heat Exchangers

Geothermal energy, derived from the radioactive decay of elements within the Earth's core, is a renewable and clean energy source. The extraction of geothermal energy primarily depends on ground heat exchangers. To address the issue of incompatibility between corrosion resistance, high thermal conductivity, and mechanical performance in current ground heat exchangers, this study develops composites (PEPOE/SCA@SiC) composed of high‐density polyethylene (HDPE) modified with toughener polyethylene‐octene copolymer elastomer (POE) and silicon carbide (SiC) crystals modified with γ‐aminopropyltriethoxysilane (SCA). HDPE offers excellent corrosion resistance, SiC crystals provide efficient phonon transport, and SCA improves the interface compatibility of the composite. The thermal conductivity of PEPOE/SCA@SiC reaches 3.83 W m−1K−1, with a maximum tensile strength of 20.3 MPa, a tensile elastic modulus of up to 498 MPa, and a maximum bending stress of 22.2 MPa with a bending elastic modulus of 561 MPa. Corrosion resistance tests indicate no signs of corrosion in PEPOE/SCA@SiC when exposed to geothermal simulation fluids at 90 °C for 30 days. This study demonstrates that PEPOE/SCA@SiC composites have substantial potential for application in ground heat exchangers, offering promising prospects for advancing sustainable use of geothermal energy and environmental protection.

Design and Finite Element Analysis of a Thresher for Palm Oil (Elaies guineensis) Extraction Plant

This study presents the design and Finite Element Analysis (FEA) of a thresher used in palm oil (Elaeis guineensis) extraction plants. The FEA was performed to ensure safe and cost effective of the thresher before fabrication. The analytical design of the threshing shaft and drum of the thresher was validated using SolidWorks (2021) CAD software for static simulation, employing plain carbon steel as the material. For the threshing shaft, forces of and were applied at strategic points, resulting in a maximum bending stress of , significantly below the yield strength of . The shaft's diameter of 50 mm was confirmed as adequate with a factor of safety (FOS) ranging from 3.17 to 142.42, validating the shaft design's safety for fabrication. Similarly, the drum unit, supported by a spider arm and cylindrical bars, was subjected to an equivalent twisting moment of 861.25 Nm and a batch weight of 1226.25 N. The maximum von Mises stress of was well within safe limits, indicating robustness under operational loads. The maximum resultant displacement and equivalent strain were respectively which can be said to be minimal, reinforcing the drum's structural integrity. A minimum FOS of 20.45 further highlighted the drum's durability and resistance to fatigue. These results confirm the reliability and safety of the designed thresher components, ensuring efficient and sustainable palm oil extraction.

Composition design and mechanical properties of B4C/Al-Zn-Mg-Cu functionally graded materials prepared by laser additive manufacturing

In this study, three types of three-layer functionally graded materials (FGMs) were designed by mainting the average content of the reinforcement constant and changing the span of the composition. The B4C particle-reinforced Al-matrix FGMs and a homogeneous composite (HC) with the same average composition were prepared using the laser additive manufacturing technique. The FGMs had a higher average secondary-phase content and grain size than the HC. Large (black) and reticulated (white) secondary phases corresponding to B4C phase, T phase, and MgZn2 were observed in the as-deposited FGM samples. The content of the secondary phase in the middle layer was generally low. The bottom layer, which was in direct contact with the substrate, exhibited the smallest grain size. The hardness and wear resistance significantly improved owing to the high B4C content in the top layer. The flexural behaviors of each layer of the FGM in different directions were systematically studied. The plasticity of the single-layer material decreased with increase in the B4C content. When the bottom layer had a high B4C content, the flexural ability significantly reduced. Among all the samples, G2 with 8% B4C particle content in the top layer exhibited the best comprehensive mechanical properties. The hardness value, wear rate of the top layer, maximum bending stress, and maximum bending strain of the FGM were 177.5 HV, 0.367 × 10−3mm3/(N·m), 585.6 MPa, and 7.36%, respectively. This study can provide a reference value for the future design and development of wear-resistant gradient materials for aerospace applications.

Optimization of Flywheel Design for the Engine CT-195 to Reduce Weight & Minimized Cost

Abstract: A flywheel stores energy in the form of kinetic (rotational) energy. Whereas each energy storage system has its inherent advantages and disadvantages compared to the others, it is the overall system performance and simplicity of flywheels that make them especially attractive for a variety of applications. Flywheel is mechanical device which is used to store the kinetic energy. There are many causes of flywheel failure. But maximum tensile and bending stresses induced in the web and rim under the action of centrifugal forces are the main causes of flywheel Failure. By changing the dimensions and shape and the materials and use such materials which increases stored energy and maintain minimum stresses with reduce mass of flywheel. It shows that smart design of flywheel geometry could both have a significant effect on the Specific Energy performance and reduce the operational loads exerted on the shaft/bearings due to reduced mass at high rotational speeds. we will compare the theoretical values of moment of Inertia with the Creo-Mechanic values so that the clear objective of the project can be seen. Our Main object is to optimise the flywheel weight without changing other important parameter like moment of inertia and its kinetic energy storage capacity.

Structural Design Analysis Torque Links of Nose Landing Gear on Light Aircraft

Torque links are components of Nose Landing Gear on the designed lightweight aircraft, that connect between the inner and outer cylinders of an oleo-pneumatic shock strut. They prevent torsion or twisting between those components and vibrations at retractable nose landing gear, the safety of these components is very important, especially when landing aircraft. This paper studies the stress and deformation contours of the torque link design with variations of hole geometry to get the optimal design, with the lightest possible weight but still reliable and safe. The upper torque link is modeled as a simply supported beam with a moment on one end derived from impact force when landing. Maximum bending stresses occur in areas near holes and the connection part of the torque link. This analysis with a tetra mesh by changing the hole position and geometry. The final torque link design results in a weight reduction of up to 23.75% with a maximum stress is 157.4 MPa and displacement is 0.0166 mm. Torque link design optimization results are then modally analyzed, and four natural frequencies and the mode shape are done. The natural frequency of vibration of different mode shapes obtained ranges from 4.2259 kHz to 6.1319 kHz, and this is still below the limit of 0.1 kHz (around 6,000 rpm engine). Finally, the optimal design torque links were obtained, safe from static and dynamic loads with a Factor of Safety 1.78 (>1.5) according to the FAR-23 standard.

Stochastic Optimization-Based Comparative Study of New Energy Vehicles’ Noise Characteristics

The gearbox gearbox transmission system, which is the foundation of a new energy vehicle, is responsible for the crucial duty of power transmission. In reality, the reducer gearbox system is the primary source of noise inside cars because of the design of the system, mistakes made during manufacturing and assembly, and gear engagement impulses. The research target is the second-stage retarder gearbox system of a new energy vehicle. A three-dimensional model of the retarder gearbox system is created using the Romax software.Static and dynamic analyses were carried out in Romax software based on the five typical conditions of start, acceleration, equal speed, deceleration, and stop in order to derive performance data such as maximum contact and bending stresses of the gears, single-position length load distribution, gearbox error, etc. In the NVH analysis, the system’s vibration acceleration was ascertained using the findings of the gearbox error analysis. In order to provide comparative data for vibration and noise reduction of gear modification, the comparative study analyses the data output results under various working conditions and analyses the relationship between gear engagement force and gear vibration.

An approach for analysis of a single energy pile subjected to a horizontal load in sand

Many studies on horizontally loaded energy piles have tended to ignore the impact of axial frictional resistance in the analysis processes or lacked experimental validation. The effect of axial frictional resistance may be considered by conveniently calculating the frictional resistance and revealing the mechanism of axial frictional resistance. Our proposed displacement analysis approach takes into account pile-sand axial friction during heating. Validation was carried out through a centrifuge test case. Subsequent parametric analyses explored the influence of pile diameter and Young's modulus on the lateral response of the pile. Comparative results between the centrifuge test and proposed approach underscored its effectiveness in capturing the impact of friction resistance on energy piles during heating. The parametric analyses show that the increase in pile diameter from 0.5 m to 0.7 m and Young's modulus from 10 GPa to 20 GPa led to a decrease in normalized pile top displacement by 50.68% and 28.33%, a decrease in maximum soil pressure in front of the pile by 16.18% and 11.59%, and a decrease in maximum bending stress of the pile by 3.27% and an increase by 14.48%, respectively.

Epoxy-Printed Circuit Board Interfacial Fracture Reliability Under Three-Point and Four-Point Bend Loading After Sustained Elevated Temperature Exposure

Abstract The survivability and reliability of commercial electronic components under very high thermo-mechanical loads are improved using underfilling and potting methods. Potting protects from operating conditions such as moisture, water, or corrosive agents. Furthermore, potting offers damping against shock and vibrations, heat dissipation, and structural support. Being one of the most cost-efficient methods, potting greatly increases reliability and therefore reduces costs for replacements and repairs. It also addresses trapped hot air issues better than other restraint technologies. In potted electronic assemblies, interfacial delamination at the epoxy and printed circuit board (PCB) interface has been one of the major failure modes. Interfacial delamination happens at the epoxy/PCB interface under dynamic shock loads, which leads to failures at the solder interconnects of the electronic components. Sustained operation and storage at elevated temperatures change the interfacial characteristics at the epoxy/PCB interface. This research is focused on interfacial failure mechanics at epoxy/PCB interfaces with high-temperature isothermal aging. In the selection of the epoxy potting material and the reliability assessments of the supplemental restraint systems, fracture parameters such as steady-state strain energy release rate stress and fracture toughness are critical. Rectangular beam specimens of the epoxy/PCB interface are fabricated for different potting compounds, and the fracture behavior is studied under quasi-static monotonic three-point and four-point bend loads. One of the main differences between three-point and four-point bend loading is that the maximum bending stress occurs at the midpoint under the point of loading of the specimen in three-point bending, whereas the peak stress is distributed over the section of the specimen between the loading points in four-point bending. Four different potting compounds with diverse properties have been studied. The recommended curing schedule from the manufacturer has been chosen and followed for all the potting compounds. The epoxy/PCB interfacial samples are aged at a high temperature of 100 °C for 30–180 days. Damage has been assumed to happen at the epoxy/PCB interface under dynamic loads. The critical load of crack initiation for the epoxy/PCB interface has been determined from the experimental findings, and it is used in the computation of fracture toughness values. The fracture toughness values are compared for the various epoxy/PCB systems based on the number of days of thermal aging and the method of flexure testing. A cohesive zone model has been constructed for predominantly mode-I delamination with four-point bend stress to predict the interfacial delamination behavior at the epoxy/PCB interfaces. It has been assumed that the bulk material is linear elastic during the bending load. The cohesive zone has been modeled at the interface, where the interfacial fracture has been assumed to occur. The fracture behavior in the simulation is predicted based on the fracture parameters determined through the experiment. The computed cohesive zone parameters are unique to the interfaces, and they can be used across various applications with the same epoxy/PCB interface to predict interfacial delamination and to select a more suitable potting material.

Effect of the Number of Shells on Selected Mechanical Properties of Parts Manufactured by FDM/FFF Technology

Abstract The technological parameters of 3D printing have an influence on the mechanical properties of the manufactured components. The purpose of the article was to study the comparative influence of the technological parameter of the number of shells variable in two stages (2 and 10) on selected mechanical properties. The maximum tensile stress for the number of shells 10 was 39.80 MPa, which is higher compared to the number of shells 2: 30.98 MPa. In the case of the maximum bending stress for the number of shells 10, an average value of 61.02 MPa was obtained, which is higher compared to the number of shells of 2: 37.46 MPa. Furthermore strong fit of the Kelvin-Voight model was obtained, as confirmed by the values of the Cℎi 2: 0.0001 and R 2: 0.997 coefficients.

Analysis of Tensile and Bending Strength of Coconut Fiber Reinforcement Composite on Quasi Isotropic Laminates Stacking Sequence

A composite is a material structure composed of two or more combinations of constituents combined macroscopically, where the two combinations do not dissolve each other. The first phase is called reinforcement, while the second phase is called matrix. This study aims to analysis the tensile and bending strength values of coconut fiber reinforced composites with a sequence of layers of quasi-isotropic fiber laminates. Experimental studies were carried out on polyester resin composites reinforced with coconut fiber in the fiber layer sequences of [0°/0°/0°], [+45°/0°/-45°] and [+60°/0°/-60°]. Tensile test specimen standards refer to ASTM D-3039 and bending test standards refer to ASTM D-7264. The results of the blistering test obtained a maximum stress of 18.3298 N/mm2 in the fiber layer sequence [0°/0°/0°] and a minimum stress of 10.8966 N/mm2 in the fiber layer sequence [+60°/0°/ -60°]. Meanwhile, the bending test results showed that the maximum bending stress was 76.065 N/mm2 in the fiber layer sequence [0°/0°/0°] and the minimum stress was 30.256 N/mm2 in the fiber layer sequence [+45°/0°/-45 °].

Design and analysis of serviceable cantilever fit snap in automotive plastic parts

Purpose Snap fits are crucial in automotive applications for rapid assembly and disassembly of mating components, eliminating the need for fasteners. This study aims to focus on designing and analyzing serviceable cantilever fit snap connections used in automobile plastic components. Snap fits are classified into permanent and semi-permanent fittings, with permanent fittings having a snap clipping angle between 0° and 5° and semi-permanent fittings having a clipping angle between 15° and 45°. Polypropylene random copolymer is chosen for its exceptional fatigue resistance and elasticity. Design/methodology/approach The design process includes determining dimensions, computing assembly, disassembly pressures and creating three-dimensional computer-aided design models. Finite element analysis (FEA) is used to evaluate the snap-fit mechanism’s stress, deformation and general functionality in operational scenarios. Findings The study develops a modified snap-fit mechanism with decreased bending stress and enhanced mating force optimization. The maximum bending stress during assembly is 16.80 MPa, requiring a mating force of 7.58 N, while during disassembly, it is 37.3 MPa, requiring a mating force of 16.85 N. The optimized parameters significantly improve the performance and dependability of the snap-fit mechanism. The results emphasize the need of taking into account both the assembly and disassembly processes in snap-fit design, because the research demonstrates greater forces during disassembly. The approach developed integrates FEA and design for assembly (DFA) concepts to provide a solution for improving the efficiency and reliability of snap-fit connectors in automotive applications. Originality/value The research paper’s distinctiveness comes from the fact that it presents a thorough and realistic viewpoint on snap-fit design, emphasizes material selection, incorporates DFA principles and emphasizes the specific requirements of both assembly and disassembly operations. These discoveries may enhance the efficiency, reliability and sustainability of snap-fit connections in plastic automobile parts and beyond. In conclusion, the idea that disassembly needs to be done with a lot more force than installation in a snap-fit design can have a good effect on buzz, squeak and rattle and noise, vibration and harshness characteristics in automobiles.

Effect of partial sand replacement with PVC and glass mix on flexural behavior of concrete

Waste in millions of tons is produced in the world each year and most of it is not recyclable. Furthermore, recycling waste consumes energy and produces pollution. In addition, the accumulation of waste in suburbs and disposal of waste is dangerous for the environment. Using waste material in concrete production is an appropriate method for achieving two goals i.e. eliminating waste and adding positive properties in concrete. Since the green concrete industry is expanding, it is necessary to evaluate concrete that contains waste from all aspects to determine its capability. This research consists of analyzing the use of waste as a partial substitute for sand. Leading waste material that has been used as substitutes is highlighted and the characteristic of the resulting concrete is evaluated in this research. Among other findings, rubber was found to have improved fire resistance and ductility in concrete, and agricultural and Polyethylene terephthalate (PET) wastes were successfully used in non-structural concrete, while glass helped to improve thermal stability. In this research aggregate and sand is replaced by waste materials of Polyvinyl Chloride (PVC) and Glass to check their effect on the mechanical properties. Lab tests were performed to analyze the flexural behavior of concrete samples having waste material. The results show how partial replacement of sand affects the behavior of concrete and based on that specify the conditions where it can be used. The results show that Young’s modulus, maximum bending stress, and bending deflection varies with the percentage composition of PVC and glass. Bedding stress and bending deflection decrease with PVC and glass composition up to 35%. Although Young’s modulus is fluctuating bending deflection will decrease.

Roof movement and instability fracture characteristics in shallow-buried thin coal seam conventional mining faces

The variation in the width of the mining face significantly affects the stability of the face, leading to potential roof fracturing and collapse. Additionally, strong mining pressure can manifest, severely impeding the safe production of coal mines. This study uses the No. 16705 conventional working face of Jinda Coal Mine as its engineering background to investigate the characteristics of roof strata movement and instability under conditions of variable-width mining in shallow-buried thin coal seams. First, the dynamic load of the roof strata is estimated based on the key strata theory. Next, a mechanical model of the immediate roof strata movement in the working face is established based on the theory of elastic thin plates, which has been used to reveal the impact of different dimensions of the overhanging plate structure and residual overhanging structures in the corner on roof movement and its associated fracture mechanics. The findings indicated that the maximum bending deformation, deformation moment, and bending stress all have an exponential function relationship with the roof width. Similarly, these metrics have an exponential function relationship with the overhanging span of the roof. In addition, these parameters all have a linear functional relationship with the size of the residual overhanging structures in the corner. Finally, the effect of roof instability on overlying pressure is analyzed, and both the initial fracture step length and cyclic movement fracture step length of the roof are estimated. These insights offer valuable scientific guidance and a theoretical foundation for analyzing the adaptability of load-bearing pillars pressure in thin coal seam mining faces, bearing significant relevance to safety production.

Research on the Influence of Compression and Offset of Cushion Blocks on the Axial Strength of Transformers

The instability of the winding-cushion structure is one of the primary causes of transformer failures. Insulation cushion compression and offset are the predominant forms leading to structural instability. Therefore, this paper, using the SFSZ7-31500/110 transformer as an example, first derives the theoretical formula for mechanical stress calculation. It clarifies the key influencing parameters of the winding-cushion block structure on the axial bending stress of the winding. Subsequently, an electromagnetic force finite element calculation model is established to obtain the axial force distribution in the winding and the distribution of unbalanced displacement during short-circuit processes. Based on the force and offset distribution, a specific cushion block compression and offset test platform is constructed. By setting different cushion block variables, the effects of cushion block unbalanced height and cushion block offset on the winding’s bending elastic modulus are determined. Finally, a simulation model for stress calculation of the winding-cushion block structure is established, revealing the influence pattern of cushion block compression and offset instability on the axial strength of the winding. The results of this study indicate that the greater the uneven cushion block height, the lower the axial strength of the winding. Under the same cushion block offset angle, winding structures with non-uniform cushion block offsets exhibit the worst axial stability. When the offset angles are 30°, 45°, and 60°, the maximum axial bending stress of the winding increases by 1.73%, 3.46%, and 7.82%, respectively. Increasing the offset angle exacerbates the decrease in the axial strength of the winding up to a certain extent. The findings in this study have significant implications for enhancing a transformer’s short-circuit resistance.

Early-stage modeling and analysis of continuum compliant structure for multi-DOF endoluminal forceps using pseudo-rigid-body model

Early detection and treatment of intraluminal diseases enable minimally invasive surgery and can lead to a high cure rate. Advanced devices with multiple degrees of freedom (DOFs) make narrow intraluminal procedures easier and safer. In a previous study, we developed a multi-DOF compliant endoluminal forceps with a tendon-sheath mechanism. The maximum bending stress of this design was reduced by changing the thickness of a compliant hinge in each segment, and the forceps achieved a wide range of motion. However, its deformed shapes with a non-constant curvature, due to a compliant inhomogeneous-thickness hinge structure, hinder fine manipulation in a narrow lumen. Here, we construct an accurate model of this compliant inhomogeneous-thickness hinge structure using pseudo-rigid-body model. In the proposed method, each compliant hinge is represented by a torsion spring and rotational joint, and the deformed shape is estimated from the bending angle caused by the tensile force. We derive the coefficient of dynamic friction by considering the friction between the wire and compliant joint based on a belt friction model. These novel calculations allow to consider individual differences in material properties and surface roughness. We experimentally confirm the feasibility of constructing a highly accurate model with a lower calculation cost than the finite element method. Our proposal seems suitable for developing dexterous forceps and other endoluminal devices, such as catheters, which mitigate operation errors and help approach lesions in narrow lumens.

Numerical analysis of wood beam bending with verification of breaking force

The work represents the continuation of the research of the maximum bending stress force of a wooden beam up to the moment of failure, which is defined experimentally and with a corresponding mathematical model. The goal was to confirm the accuracy of the mathematical model of the breaking force using numerical simulation and the Solid Works software. Five different types of wood and five different beam thicknesses were used as input parameters whose influence was monitored trough the simulation. The stress deformation state and deflection for the calculated fracture forces were analysed separately for each variant. The breaking force model, which is defined depending on the density of the wood and the thickness of the board, proved to be adequate for defining the maximum stresses and deflections when bending beams.

Structural Response Analysis for Multi-Linked Floating Offshore Structure Based on Fluid–Structure Coupled Analysis

Recently, offshore structures for eco-friendly energy, such as wind and solar power, have been developed to address the problem of insufficient land space; in the case of energy generation, they are designed on a considerable scale. Therefore, the scalability of offshore structures is crucial. The Korea Research Institute of Ships & Ocean Engineering (KRISO) developed multi-linked floating offshore structures composed of floating bodies and connection beams for floating photovoltaic systems. Large-scale floating photovoltaic systems are mainly designed in a manner that expands through the connection between modules and demonstrates a difference in structural response with connection conditions. A fluid–structure coupled analysis was performed for the multi-linked floating offshore structures. First, the wave load acting on the multi-linked offshore floating structures was calculated through wave load analysis for various wave load conditions. The response amplitude operators (RAOs) for the motions and structural response of the unit structure were calculated by performing finite element analysis. The effects of connection conditions were analyzed through comparative studies of RAOs and the response’s maximum magnitude and occurrence location. Hence, comparing the cases of a hinge connection affecting heave and pitch motions and a fixed connection, the maximum bending stress of the structure decreased by approximately 2.5 times, while the mooring tension increased by approximately 20%, confirmed to be the largest change in bending stress and mooring tension compared to fixed connection. Therefore, the change in structural response according to connection condition makes it possible to design a higher structural safety of the structural member through the hinge connection in the construction of a large-scale multi-linked floating offshore structure for large-scale photovoltaic systems in which some unit structures are connected. However, considering the tension of the mooring line increases, a safety evaluation of the mooring line must be performed.

Long non-coding RNA Homeobox D gene cluster antisense growth-associated long noncoding RNA/microRNA-182-5p/Homeobox protein A10 alleviates postmenopausal osteoporosis via accelerating osteoblast differentiation of bone marrow mesenchymal stem cells

BackgroundStudies have illuminated that long non-coding RNA (lncRNA) influences bone cell differentiation and formation. Nevertheless, whether lncRNA Homeobox D gene cluster antisense growth-associated long noncoding RNA (HAGLR) was implicated in postmenopausal osteoporosis (PMOP) was yet uncertain.PurposeThe research was to explore HAGLR’s role in the osteogenic differentiation (OD) process of bone marrow mesenchymal stem cells (BMSCs).MethodsBMSCs were isolated from mouse bone marrow tissues and identified by electron microscope and flow cytometry. HAGLR, microRNA (miR)-182-5p, and homeobox protein A10 (Hoxa10) levels in BMSCs were detected. Mouse BMSC OD process was induced, and calcium deposition and alkaline phosphatase content were analyzed, as well as expressions of runt-related transcription factor 2, osteopontin, and osteocalcin, and cell apoptosis. Bilateral ovaries were resected from mice to construct the ovariectomized model and bone mineral density, maximum bending stress, maximum load, and elastic modulus of the femur were tested, and the femur was histopathologically evaluated. Chondrocyte apoptosis in the articular cartilage of mice was analyzed. Analysis of the interaction of HAGLR, miR-182-5p with Hoxa10 was conducted.ResultsHAGLR and Hoxa10 were down-regulated and miR-182-5p was elevated in PMOP patients. During the BMSC OD process, HAGLR and Hoxa10 levels were suppressed, while miR-182-5p was elevated. Promotion of HAGLR or suppression of miR-182-5p accelerated OD of BMSCs. Inhibition of miR-182-5p reversed the inhibitory effect of HAGLR on BMSC OD. In in vivo experiments, up-regulating HAGLR alleviated PMOP, while silencing Hoxa10 reversed the effects of upregulating HAGLR. HAGLR performed as a sponge for miR-182-5p, while miR-182-5p targeted Hoxa10.ConclusionIn general, HAGLR boosted the OD process of BMSCs and relieved PMOP via the miR-182-5p/Hoxa10 axis. These data preliminarily reveal the key role of HAGLR in PMOP, and the research results have a certain reference for the treatment of PMOP.