Maximum Response Research Articles

Semaphorin Receptors Antagonize Wnt Signaling Through Beta-Catenin Degradation.

Precise control of morphogen signaling levels is essential for proper development. An outstanding question is: what mechanisms ensure proper morphogen activity and correct cellular responses? Previous work has identified Semaphorin (SEMA) receptors, Neuropilins (NRPs) and Plexins (PLXNs), as positive regulators of the Hedgehog (HH) signaling pathway. Here, we provide evidence that NRPs and PLXNs antagonize Wnt signaling in both fibroblasts and epithelial cells. Further, Nrp1/2 deletion in fibroblasts results in elevated baseline Wnt pathway activity and increased maximal responses to Wnt stimulation. Notably, and in contrast to HH signaling, SEMA receptor-mediated Wnt antagonism is independent of primary cilia. Mechanistically, PLXNs and NRPs act downstream of Dishevelled (DVL) to destabilize β-catenin (CTNNB1) in a proteosome-dependent manner. Further, NRPs, but not PLXNs, act in a GSK3b/CK1-dependent fashion to antagonize Wnt signaling, suggesting distinct repressive mechanisms for these SEMA receptors. Overall, this study identifies SEMA receptors as novel Wnt pathway antagonists that may also play larger roles integrating signals from multiple inputs.

Optimization of Antifungal Properties of Hop Cone Carbon Dioxide Extracts Based on Response Surface Methodology.

Response surface methodology (RSM) was employed to optimize the process parameters of the supercritical carbon dioxide extraction of hop cones in terms of their antifungal properties against Fusarium culmorum and Aspergillus niger. The effects of temperature (40-50 °C), pressure (200-300 bar), and CO2 consumption (25-75 kgCO2/kg) on the extraction yield, content of α- and β-acids, as well as pathogens' growth inhibition were investigated. Both pressure and CO2 consumption had a significant effect on antifungal properties. It was observed that the best results for antifungal properties were obtained when hop cones were extracted with pure carbon dioxide at the temperature of 50 °C, under the pressure of 300 bar with CO2 consumption at the level of 75 kgCO2/kg of feed for extraction. The highest antifungal properties of hop cone supercritical carbon dioxide extracts were analyzed as 100% for Fusarium culmorum and 68% for Aspergillus niger, calculated as the growth inhibition of tested pathogens. The aim of the study was to determine the optimum values of extraction parameters to achieve the maximum response and enable us to investigate the interaction of these parameters on the antifungal properties of hop cone extracts.

Theoretical insights toward a highly responsive AgInSe2 photodetector

AbstractThis treatise showcases the design as well as modeling about a photodetector (PD) based on AgInSe2 (AISe), a direct bandgap chalcopyrite with a bandgap of 1.19 eV. The PD exhibits outstanding optical and electronic characteristics, showcasing remarkable performance. The PD has been systematically investigated by varying the width, carrier density, and defect densities of specific layers, as well as the interface defect density of specific interfaces. Various layers are optimized to enhance the overall performance of the PD and the impact of different device resistances is analyzed. The photocurrent (JSC) and voltage (VOC) of the heterostructure photodetector are determined to be 38.60 mA/cm2 and 1.0 V, in turn. The maximum responsivity (R) and detectivity (D*) are identified as 0.70 A/W and 4.60 × 1016 Jones, respectively at a wavelength of 940 nm. The spectral response exhibits significantly higher values in the range of 800–1000 nm, indicating the device's capability to detect near‐infrared (NIR) light. This research provides valuable insights for the manufacturing of AISe material‐based photodetectors with enhanced performance.

Physical Therapy Intervention Effects on Alteration of Spinal Excitability in Patients With Chronic Ankle Instability: A Systematic Review and Meta-analysis.

Chronic ankle instability (CAI) is a common injury in athletes. Different forms of physical therapy have been applied to the population with CAI to assess their impact on spinal excitability. The purpose of this systematic review and meta-analysis was to investigate the effectiveness of various physical therapy interventions on the alteration of spinal excitability in patients with CAI. Four databases (EMBASE, MEDLINE, Cochrane CENTRAL, and Scopus) were searched from inception to November 2022. A total of 253 studies were obtained and screened; 11 studies on the effects of physical therapy intervention on the alteration of spinal excitability in patients with CAI were identified for meta-analysis. Systematic review and meta-analysis. Level 3a. A total of 11 studies that included the maximal Hoffmann reflex normalized by the maximal muscle response (H/M ratio) in the peroneus longus and soleus muscles were extracted and summarized. The quality of the studies was assessed using the PEDro scale. The extracted studies had an average PEDro score of 4.7 ± 1.4, indicating that most of them had fair-to-good quality. The physical therapy interventions included cryotherapy, taping, mobilization, proprioceptive training, and dry needling. The overall effects showed that the H/M ratios of the peroneus longus (P = 0.44, I2 = 0%) and soleus (P = 0.56,I2 = 22%) muscles were not changed by physical therapy in patients with CAI. The meta-analysis indicated that physical therapy interventions such as cryotherapy, taping, mobilization, proprioceptive training, and dry needling do not alter the spinal excitability in patients with CAI. Given that only 1 study reported ineffective changes in spinal excitability with dry needling, more research is essential to establish and validate its efficacy. CRD42022372998.

Overturning resistant capacities of rocking frames with supplemental vibration control devices under pulse-type excitations

Rocking structures are vulnerable to overturn under earthquake shaking. It is necessary to reduce the overturning probability of rocking structures. Recently, inerters were proposed to control the vibrations of rocking columns, and it was found that the structure equipped with inerter has reduced probability of overturning. However, inerter does not have capacity to dissipate energy, its control performance is believed able to be enhanced once being used in conjunction with dampers. Therefore, this paper approaches rocking structural vibration control from two directions: by applying supplemental inertia and applying supplemental damping to the structure. To this end, inerter, clutched-inerter and viscous damper are selected as control devices, and two combined scenarios are also considered, with configuration Ⅰ consisting of an inerter and a viscous damper in parallel and configuration Ⅱ consisting of a clutched-inerter and a viscous damper in parallel. The analytical models of a rocking frame with supplemental control devices in variable positions are presented and the equations of motion for each model are derived. In addition, the maximum coefficient of restitution of the rocking frame with supplemental control device is derived based on the angular momentum-impulse theorem. The effects and applicable conditions of the considered devices are evaluated by means of assessing the overturning resistances, maximum responses and fragility curves of rocking frames under different conditions. The results show that, with appropriate damping coefficient and apparent mass of the inerter, the combined configurations Ⅰ and Ⅱ provide better control effectiveness than the cases with inerter, clutched-inerter or viscous damper applied individually.

Effect of BvAgNP on growth, development, and glyoxalase gene expression analysis in Mammillaria bombycina and Selenicereus undatus.

Silver nanoparticles (AgNPs) have been used in plant tissue culture as growth stimulants, promoting bud initiation, germination, and rooting. In prior studies, AgNPs were synthesized and characterized by green synthesis using extracts from Beta vulgarisvar. cicla (BvAgNP), and their functionality as seed disinfectant and antimicrobial was verified. In this study, we evaluated the effect of BvAgNP on the growth and development of Mammillaria bombycina and Selenicereus undatus in vitro, as well as the expression of glyoxalase genes. Explants from M. bombycina and S. undatus in vitro were treated with 25, 50, and 100mg/L of BvAgNP. After 90 days, morphological characteristics were evaluated, and the expression of glyoxalase genes was analyzed by qPCR. All treatments inhibited rooting for M. bombycina and no bud initiation was observed. S. undatus, showed a maximum response in rooting and bud generation at 25mg/L of BvAgNP. Scanning electron microscopy (SEM) results exhibited a higher number of vacuoles in stem cells treated with BvAgNP compared to the control for both species. Expression of glyoxalase genes in M. bombycina increased in all treatments, whereas it decreased for S. undatus, however, increasing in roots. This study presents the effects of BvAgNP on the growth and development of M. bombycina and S. undatus, with the aim of proposing treatments that promote in vitro rooting and bud initiation.

Optically responsive dry cholesteric liquid crystal marbles

Dry liquid crystal marbles are structures that consist of cholesteric liquid crystal (CLC) droplets prepared by the mixture of chiral-doped thermotropic LCs encapsulated by cellulose nanocrystals (CNCs) that have been dried under ambient conditions. The characterizations revealed that CLC droplets were successfully encapsulated by self-standing CNC shells and responsive to the external gaseous stimulus. The dry LC marbles offer several advantages over previously reported LC-based gas sensors, such as fast response against minor external stimuli, and ease of handling, which make them particularly attractive for practical applications in sensing. We demonstrate the use of these marbles for detecting toluene vapor, a common industrial solvent and pollutant, which we also use to understand the response characteristics. The dry CLC marbles exhibit a significant response to toluene vapor with a detection limit below 500 ppm, attributed to the change of pitch size of the helical structure of CLC droplets induced by the toluene vapor. The CNC-capsulated CLC droplets were stable in emulsion for up to two weeks, and their dried form exhibited a sensitive response upon toluene exposure. The real-time experiments revealed that the LC marbles can be used multiple times without a significant loss of sensitivity, where 90 % of the maximum response was observed at 13.3 ± 4.7 s. These dry LC marbles can also be utilized in other areas, including drug delivery, optical devices, and biosensors.

A novel hepatocyte ketone production assay to help the selection of nutrients for the ketogenic diet treatment of epilepsy

The classic ketogenic diet is an effective treatment option for drug-resistant epilepsy, but its high fat content challenges patient compliance. Optimizing liver ketone production guided by a method comparing substrates for their ketogenic potential may help to reduce the fat content of the diet without loss in ketosis induction. Here, we present a liver cell assay measuring the β-hydroxybutyrate (βHB) yield from fatty acid substrates. Even chain albumin-conjugated fatty acids comprising between 4 and 18 carbon atoms showed a sigmoidal concentration-βHB response curve (CRC) whereas acetate and omega-3 PUFAs produced no CRC. While CRCs were not distinguished by their half-maximal effective concentration (EC50), they differed by maximum response, which related inversely to the carbon chain length and was highest for butyrate. The assay also suitably assessed the βHB yield from fatty acid blends detecting shifts in maximum response from exchanging medium chain fatty acids for long chain fatty acids. The assay further detected a dual role for butyrate and hexanoic acid as ketogenic substrate at high concentration and ketogenic enhancer at low concentration, augmenting the βHB yield from oleic acid and a fatty acid blend. The assay also found propionate to inhibit ketogenesis from oleic acid and a fatty acid blend at low physiological concentration. Although the in vitro assay shows promise as a tool to optimize the ketogenic yield of a fat blend, its predictive value requires human validation.

High performance Al/WSe2/CuO/ITO structure based broadband photodetector

This letter reports a Al/WSe2/CuO/ITO structure based broadband photodetector. The low cost spin coating technique is utilized to deposit, p-type WSe2 film and n-type CuO film. The Al contacts were deposited over WSe2 film using thermal evaporation unit. The suggested photodetector gives the broad photo response with maximum Responsivity RS (A/W) and External Quantum Efficiency (EQE) value of 3099 A/W, 3680 A/W, and 493 A/W; 1.20 × 106%, 1.52× 106% and 2.04 × 105% at 350 nm (UV), 500 nm (visible) and 950 nm (IR) under application of −2 V bias. The EQE value beyond 100% are attributed to trap assisted photomultiplication mechanism.

Design of Soft Microjoint to Improve Robotic Cell Micromanipulation Flexibility

Dexterity micromanipulation is a significant topic in the field of robotics. Herein, a novel robotic rotating microjoint controlled by an exogenous magnetic field based on magnetic programmable soft materials, which brings more dexterity to the micromanipulation task is proposed. First, the magnetic soft material is synthesized and the microjoint is manufactured. The maximum rotation angle and response time are characterized. Then the force analysis of the microjoint in a uniform magnetic field is performed and the relationship between the deformation bending angle of a microjoint and the magnetic field magnitude is first proposed. A sliding mode controller based on the deformation mechanism of microjoints and radial basis function neural network (DMRSMC) is proposed to achieve robust deformation control of the microjoint. The experiment that depicts the microjoint is able to achieve a maximum rotation angle of 22.16° and a response time of 16 ms. The DMRSMC controller performs angle control with higher accuracy than conventional SMC and PID controllers. Finally, a dexterous suction mechanism is developed by combining the microjoint with a soft micropipette needle to achieve dexterous grasping of zebrafish embryos with a 97% success rate and an orientation adjustment error is 1.36°.

Dynamic Response Study of Overhead Contact System Portal Structure Based on Vehicle–Track–Bridge Coupled Vibration

In light of the rapid development of electrified railways, the safety and stability of train operations, as well as the catenary’s interaction with current quality, have garnered widespread attention. Electrified train operation with additional track irregularities serves as a principal excitation source within the vehicle–bridge–catenary system, significantly influencing the vibration characteristics of the system. Addressing the aforementioned issues, we first established the vehicle–track dynamics model and the bridge–catenary finite element model based on the principles of coupled dynamics of the vehicle–track system. These models are interconnected using dynamic forces between the wheel and rail. Subsequently, within the vehicle–track coupled system, track random irregularities are introduced as input excitations for the coupled model, and the dynamic response of the system is simulated and solved. Then, the obtained wheel–rail forces are applied to the bridge–catenary coupled system finite element model in the form of time-varying moving load forces. Finally, the dynamic response characteristics of the catenary portal structure under different conditions are determined. Meanwhile, a study on the vibration characteristics of the truss-type pillar portal structure was conducted, and the results were compared with those of existing models. The results indicate that the vertical and lateral forces between the vehicle and track are positively correlated with the speed and irregularity amplitude. Response values such as the derailment coefficient and wheel load reduction rate are within the specified range of relevant standards. The low-order natural resonant frequency of the truss-type pillar structure has, on average, increased by 0.86 compared to the existing pillar structure, which signifies improved stability. Furthermore, under various conditions, the average reductions in maximum displacement and stress response of this pillar structure are 13.2% and 14.19%, respectively, in comparison to the existing pillar structure, rendering it more suitable for practical engineering applications.

Knowledge, attitude and practices towards COVID-19 among Indian medical undergraduates: a questionnaire-based study.

The Coronavirus disease-19 (COVID-19) infection of severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2) has emerged as a recent pandemic, increasing the need for epidemiological studies and studies on public health. Only some studies have evaluated the awareness of medical undergraduates in India and other countries, leading to a lack of literature. This study is a descriptive cross-sectional questionnaire-based study conducted in Kasturba Medical College, Mangalore, India, between June to August 2020. An online survey using Google Forms was circulated among undergraduate medical students in India by a convenient sampling method for data collection. Descriptive analysis was derived based on frequencies and percentages, and the association with age, gender, and year of undergraduate training medical course was derived using the chi-square test. Altogether, 630 students from India responded to the survey, with a maximum response from students studying in the second year (38.7%). Nearly 63.85% of responders identified themselves as females. Knowledge regarding the human-to-human transmission of the virus, symptoms, complications, definition of "close contact, quarantine, and its indications was adequate among the students, with more than 70% correct responses. However, one-fourth of the students needed to gain more knowledge about masks. Respiratory hygiene was poor among 24.8%. Nearly 40% of students were unaware of the management of patients with COVID-19. There is a need for regular quality training and institutional programs on infection control of COVID-19 and other infectious diseases across all Indian medical colleges to educate undergraduate medical students, who are future healthcare professionals, thus minimizing the risk of transmission and providing standardized care for patients.

Highly Efficient Flexible Photodetectors Based on Pb-Free CsBi3I10 Perovskites.

Perovskites have made remarkable advancements in optoelectronics owing to their high light absorption coefficient, tunable bandgap, and long charge diffusion. Nonetheless, the practical applications of Pb-based perovskites have been hindered by the instability and toxicity of Pb, especially in flexible electronics, which require high biosecurity and low toxicity. Hence, the development of stable Pb-free perovskite materials has gained increasing attention. In this study, we synthesized stable CsBi3I10 Pb-free perovskites outside the glovebox and improved the optoelectronic and mechanical performances of the CsBi3I10-based flexible devices through polyvinylcarbazole (PVK) doping. Flexible photodetectors with the device structure of PET/ITO/PEDOT:PSS/CsBi3I10:PVK/Au was fabricated. The results indicated that the introduction of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) reduced the surface roughness of the flexible PET substrate, while PVK doping further improved the surface smoothness of CsBi3I10 thin films, thereby enhancing the interfacial charge transportation. Moreover, PEDOT:PSS and PVK acted as stepwise hole transport layers in the photodetectors. The device demonstrated a maximum responsivity of 0.3 A/W, detectivity of 2.6 × 1011 Jones, and a response time of 102 μs at 650 nm. After subjecting it to 1000 bending tests, the light current retained 80% of its initial value. This study presents a universally applicable method for controlling the surface morphology of a flexible perovskite thin film.

An investigation of glass, ITO, and quartz transparent substrates on Pd/SnO2 hydrogen sensor structure and sensitivity

Hydrogen energy has great potential as a fuel for the future, but its leakage poses a major threat. Thus, our main concern is to detect it very quickly. In this work, we investigate the effect of transparent glass, ITO, and quartz substrates on hydrogen gas sensing properties of magnetron sputter- deposited Pd-capped SnO2 (Pd/SnO2) thin film sensor material. The XRD study reveals that all Pd-capped SnO2 thin films deposited on different substrates has polycrystalline tetragonal structure. Sensors fabricated on quartz substrates exhibit homogeneous grain distributions at the interface, whereas sensors deposited on ITO and glass substrates have randomly size grains distribution at the interface. Sensors deposited on glass and ITO show lower sensitivity compare to sensors fabricated on quartz substrate at a working temperature of 250°C. The Pd/SnO2 sensor @ quartz shown a maximum response of ∼ 9.3 and better stability toward 500 ppm hydrogen gas, and a fast response/recovery time of 30/26 s for 5 ppm hydrogen gas. The sensor @ quartz substrate shows a small reduction in response and baseline at 60% RH. The sensor fabricated on quartz substrate exhibits better selectivity toward hydrogen gas and significant stability for long duration of three months in high humid conditions. The performance of the Pd/SnO2 thin sensor fabricated on quartz proves that the sensor based on average grains have a wide potential for real hydrogen gas monitoring.

Synergistic tailoring of adsorption and vacancy enrichment in lamellar stacked layers of α-MoO3 nanorods by Mg2+ for NO2 gas sensor

Extremely toxic nitrogen dioxide (NO2) was detected using lamellar layered α-MoO3. The stable orthorhombic phase of MoO3 (α-MoO3) with preferential growth along (02k0) and the nano-rectangular rods (NRs) like morphology were observed. The incorporation of Mg2+ in α-MoO3 influenced the morphology and the oxygen vacancies (VO), which were analyzed through Raman, photoluminescence, and X-ray photoelectron spectroscopy. The core level spectra provided direct evidence for VO enrichment in 3 %Mg-α-MoO3 via emergence of peak at 531.02 eV with an area of 45.15 %. NO2 response was analyzed at 150–200 °C with various NO2 concentrations. 3 %Mg-α-MoO3 NRs provided maximum response of 133.9 % for 50 ppm with low limit of detection (LOD) of 250 ppb with good response (193 s) and recovery (260 s) transient behaviors. The fabricated sensor shows high selectivity to NO2 among H2S, SO2, N2O, and NH3, also good repeatability suggesting potential suitability for NO2 detection.

Orexin neurons track temporal features of blood glucose in behaving mice

Does the brain track how fast our blood glucose is changing? Knowing such a rate of change would enable the prediction of an upcoming state and a timelier response to this new state. Hypothalamic arousal-orchestrating hypocretin/orexin neurons (HONs) have been proposed to be glucose sensors, yet whether they track glucose concentration (proportional tracking) or rate of change (derivative tracking) is unknown. Using simultaneous recordings of HONs and blood glucose in behaving male mice, we found that maximal HON responses occur in considerable temporal anticipation (minutes) of glucose peaks due to derivative tracking. Analysis of >900 individual HONs revealed glucose tracking in most HONs (98%), with derivative and proportional trackers working in parallel, and many (65%) HONs multiplexed glucose and locomotion information. Finally, we found that HON activity is important for glucose-evoked locomotor suppression. These findings reveal a temporal dimension of brain glucose sensing and link neurobiological and algorithmic views of blood glucose perception in the brain’s arousal orchestrators.

Test and analysis of walnut (Juglans regia L.) tree vibration transfer based on a low-frequency shaking table

Clarifying the low-frequency vibration transfer law of fruit trees is an important prerequisite for studying the intelligent harvesting operation of a low-frequency shaker. Through a vibration transmission test involving vibration parameters, tree parameters, and proportional acceleration, this study found that vibration frequency, amplitude, pre-tension, and rope length were the most significant influencing factors of proportional acceleration. Among them, amplitude and pre-tension have positive effects on proportional acceleration, vibration frequency and rope length have negative effects on proportional acceleration, and the interaction between amplitude and vibration frequency has significant effects on proportional acceleration. The proportional acceleration has a maximum response of 8.12 m/s2 when the vibration frequency is 6.86 Hz, the amplitude is 64.92 mm, the pre-tension is 1007.02 N, and the rope length is 6 m. The results of the study can guide research on and development of a low-frequency intelligent shaking machine as well as its field operation.

Determination of dynamic collapse limit states using the energy-based method for multi-story RC frames subjected to column removal scenarios

The Alternative Load Path method is widely adopted to perform progressive collapse analyses for reinforced concrete (RC) frame structures subjected to column removal scenarios. Considering that the progressive collapses are usually dynamic phenomena, nonlinear dynamic analyses can yield the most accurate results. However, the associated computational cost is high. Alternatively, the energy-based method (EBM) can be employed to efficiently calculate the maximum dynamic responses. Unfortunately, collapse or dynamic limit states (DLS) cannot be directly determined when the EBM is adopted for the progressive collapse analyses, because it is essentially a quasi-static approach. To tackle this issue, in this paper an EBM-Intersection Point-based (EBM-IP-based) method is proposed to effectively determine the DLS. The method is considering that the dynamic instability will occur once the dynamic capacity curve exceeds the corresponding static capacity curve. Hence, it is possible to determine the DLS by making a correction on the intersection point of the aforementioned two curves without performing nonlinear dynamic time-history analyses. Compared with the other energy components, the kinetic energy at the moment of the peak displacement response is relatively small and the effectiveness of the EBM is verified. Through both static pushdown analyses and incremental dynamic analyses for 48 column removal scenarios of six different multi-story RC frames, the effectiveness of the proposed EBM-IP-based method is verified and the associated coefficients are calibrated. Statistical information and (joint) probabilistic density functions (PDF) of the coefficients are identified. Further, stochastic analyses are carried out in order to quantify the model uncertainties when adopting the EBM-IP-based method. On the basis of all the calculation results, a Gumbel distribution is adopted to capture the PDF of the model uncertainty in relation to displacements, while a lognormal distribution is adopted to fit the PDF of the model uncertainty in terms of resistances. Moreover, a multi-variate Gaussian distribution model with two components is employed to fit the joint PDF.

Effectiveness and safety of enzalutamide and apalutamide in the treatment of patients with non-metastatic castration-resistant prostate cancer (nmCRPC): a multicenter retrospective study.

Phase III clinical trials demonstrated the efficacy of enzalutamide and apalutamide in patients with non-metastatic castration-resistant prostate cancer (nmCRPC) and PSA doubling time ≤10months. Although these drugs have been shown to vary in their adverse event (AE) profiles, the differences in their efficacy profiles remain to be evaluated. Therefore, this retrospective study was conducted to evaluate the efficacy of these drugs in patients with nmCRPC. This study evaluated 191 patients with nmCRPC treated with enzalutamide (n = 137) or apalutamide (n = 54) in the first-line setting at Jikei University Hospital or its affiliated hospitals between May 2014 and November 2022. Endpoints were defined as oncological outcomes (i.e., PSA response, PFS, PSA-PFS, MFS, CSS, and OS) and AEs. No significant differences were noted in patient backgrounds between the two groups. Patients exhibiting a maximum PSA response of >50% and >90% accounted for 74.5% and 48.9% of patients in the enzalutamide group, and 75.9% and 42.6% of patients in the apalutamide group, respectively, with no significant difference between the groups. The median PSA-PFS was 10months in the enzalutamide group but not in the apalutamide group, with no significant difference between the groups (P = 0.48). No significant differences were observed in MFS, CSS, or OS between the groups. Patients reporting AEs of all grades and grade 3 or higher accounted for 56.2% and 4.3% of those in the enzalutamide group and 57.4% and 7.4% of those in the apalutamide group, respectively. The most common AE was fatigue (26.3%) in the enzalutamide group and skin rash (27.8%) in the apalutamide group. In this retrospective study of their efficacy and safety, enzalutamide and apalutamide were shown to exhibit comparable oncological outcomes but quite different AE profiles, suggesting that their differential use may be warranted based on these findings.

Seismic control of tall buildings using vertically distributed multiple tuned mass dampers

SummaryTuned mass damper (TMD) is a seismic vibration control device used to reduce wind and seismic vibrations of structures. Although TMD is attractive to many researchers due to its simplicity, optimizing its parameters and positions is very challenging. The sensitivity of TMD to structure's frequency changes is among its weaknesses and if parameters of this system are not optimally tuned, the efficiency of this system decreases. To solve this problem, multiple tuned mass dampers (MTMDs) have been proposed. In this research, in order to study and compare single tuned mass damper (STMD) with MTMDs vertically distributed according to modal analysis, a 20‐story building is used. The structure is analyzed in OpenSees under seven ground motions with a peak ground acceleration (PGA) of 1.0 g. To optimize TMD parameters, particle swarm optimization (PSO) algorithm is used and the results are compared to those obtained from Den Hartog's approach. To be able to use PSO algorithm and optimize TMD design parameters, Matlab and OpenSees are linked together. In this paper, more than one vibration mode is used to tune and distribute dampers to overcome higher mode effects in high‐rise buildings. The results showed that depending on their different layouts and different optimization methods used, MTMDs reduce the average maximum responses of the structure by up to 12.1%. This is while STMD is able to reduce maximum responses of the structure by 4.3%.