AbstractQ‐matrices are crucial components of cognitive diagnosis models (CDMs), which are used to provide diagnostic information and classify examinees according to their attribute profiles. The absence of an appropriate Q‐matrix that correctly reflects item‐attribute relationships often limits the widespread use of CDMs. Rather than relying on expert judgment for specification and post‐hoc methods for validation, there has been a notable shift towards Q‐matrix estimation by adopting Bayesian methods. Nevertheless, their dependency on Markov chain Monte Carlo (MCMC) estimation requires substantial computational burdens and their exploratory tendency is unscalable to large‐scale settings. As a scalable and efficient alternative, this study introduces the partially confirmatory framework within a saturated CDM, where the Q‐matrix can be partially defined by experts and partially inferred from data. To address the dual needs of accuracy and efficiency, the proposed framework accommodates two estimation algorithms—an MCMC algorithm and a Variational Bayesian Expectation Maximization (VBEM) algorithm. This dual‐channel approach extends the model's applicability across a variety of settings. Based on simulated and real data, the proposed framework demonstrated its robustness in Q‐matrix inference.