Maxillary Carcinoma Research Articles

Spontaneous Cerebrospinal Fluid Rhinorrhea as the Primary Manifestation of Maxillary Carcinoma-Case Report-

A 66-year-old man presented with a maxillary carcinoma manifesting as unrelenting spontaneous cerebrospinal fluid (CSF) rhinorrhea. Anterior craniofacial resection of the tumor was performed with multilayered repair of the dura mater. Maxillary carcinoma usually manifests as nasal blockage, epistaxis, or a mass lesion. This case highlights the necessity for a high index of suspicion for malignant tumor and the need for meticulous repair of the dura mater to seal off the CSF leakage.

Selection of the optimal radiotherapy technique for locally advanced maxillary carcinoma using a three-dimensional treatment planning system

To compare the isodose distribution of three radiotherapy techniques for locally advanced maxillary sinus carcinoma and analyze the potential of three-dimensional (3D) conformal radiotherapy planning in order to determine the optimal technique for target dose delivery, and spare uninvolved healthy tissue structures. Computed tomography (CT) scans of fourteen patients with T3-T4, N0, M0 maxillary sinus carcinoma were acquired and transferred to 3D treatment planning system (3D-TPS). The target volume and uninvolved dose limiting structures were contoured on axial CT slices throughout the volume of interest combining three variants of treatment plans (techniques) for each patient: 1. A conventional two-dimensional (2D) treatment plan with classically shaped one anterior + two lateral opposite fields and two types of 3D conformal radiotherapy plans were compared for each patient. 2. Three-dimensional standard (3D-S) plan: one anterior + two lateral opposite coplanar fields, which outlines were shaped with multileaf collimator (MLC) according to geometric information based on 3D reconstruction of target volume and organs at risk as seen in the beam eye's view (BEV) projection. 3. Three-dimensional non-standard (3D-NS) plan: one anterior + two lateral noncoplanar fields, which outlines were shaped in the same manner as in 3D-S plans. The planning parameters for target volumes and the degree of neurooptic structures and parotid glands protection were evaluated for all three techniques. Comparison of plans and treatment techniques was assessed by isodose distribution, dose statistics, and dose-volume histograms. The most enhanced conformity of the dose delivered to the target volume was achieved with 3D-NS technique, and significant differences were found comparing 3D-NS vs. 2D (Dmax: p<0.05; Daver: p<0.01; Dmin: p<0.05; V90: p<0.05, and V95: p<0.01), as well as 3D-NS vs. 3D-S technique (Dmin: p<0.05; V90: p<0.05, and V95: p<0.01), while there were no differences between 2D vs. 3D-S technique. 3D-S conformal plans were significantly superior to 2D plans regarding the protection of parotid glands, and the additional improvement of dose conformity was achieved with 3D-NS technique. 3D-NS technique resulted in the decrease of Dmax for ipsilateral retina compared with 3D-S technique, while the level of Dmax for optic nerve was increased (within an acceptable range) with 3D-NS technique. In this study, 3D planning of radiotherapy for locally advanced maxillary sinus carcinoma with noncoplanar fields, which number did not exceed the number of fields for conventional arrangement enabled conformal delivering of the adequate dose to the target volume with the improved sparing of adjacent uninvolved healthy tissue structures.

528 The choice of optimal radiotherapy technique for locally advanced maxillary carcinoma using 3D treatment planning system

In the cat we used the horseradish peroxidase (HRP) technique to investigate the location of the motor nuclei projecting through the median and the ulnar nerves. Each nucleus is described by its longitudinal extent along the rostro-caudal spinal cord axis and by its dorso-ventral and medio-lateral position within the ventral horn. The topographical relations between different nuclei are, however, only provisionally ascertained with the HRP technique, since the simultaneous use of different fluorescent tracers in the same animal is a more powerful approach to establish the spatial relations between different neuronal populations. One example with the latter technique is reported, which demonstrates the complete overlap of two different nuclei.

眼窩底浸潤をきたした上顎癌T3症例の手術と再建

眼窩底浸潤をきたした上顎癌T3症例の手術と再建

Enhancement of cell killing by induction of apoptosis after treatment with mild hyperthermia at 42 degrees C and cisplatin.

Ohtsubo, T., Igawa, H., Saito, T., Matsumoto, H., Park, H. J., Song, C. W., Kano, E. and Saito, H. Enhancement of Cell Killing by Induction of Apoptosis after Treatment with Mild Hyperthermia at 42 degrees C and Cisplatin. Radiat. Res. 156, 103-109 (2001). We examined the interactive effects of cisplatin (1.0 microg/ml) combined with hyperthermia on cell killing and on the induction of apoptosis in IMC-3 human maxillary carcinoma cells. The cytotoxic effects of hyperthermia on IMC-3 cells at 44 degrees C were greater than at 42 degrees C, as has been reported for many other cells. The induction of apoptosis, DNA fragmentation and poly(ADP-ribose) polymerase cleavage were greater after hyperthermia at 44 degrees C for 30 min compared with treatment at 42 degrees C for 105 min, even though both of these heat doses were isoeffective in reducing cell survival to 50%. Treatment with cisplatin at 37 degrees C for up to 120 min did not result in cytotoxicity or the induction of apoptosis. The enhancement ratio for treatment with cisplatin at 42 degrees C was greater than that at 44 degrees C. More apoptosis was induced after the treatment with cisplatin at 42 degrees C compared to treatment with cisplatin at 44 degrees C. Taking these findings together, the combination of cisplatin and hyperthermia at 42 degrees C appeared to be more effective than cisplatin with hyperthermia at 44 degrees C for the induction of apoptosis in IMC-3 cells.

Acidic environment modifies heat- or radiation-induced apoptosis in human maxillary cancer cells

Purpose: The effects of hyperthermia or irradiation on cell killing and induction of apoptosis were evaluated using human maxillary carcinoma IMC-3 cells and low pH (pH 6.8) adapted cells (IMC-3-pH). Methods and Materials: Cellular heat-sensitivity or radiosensitivity was determined using the clonogenic assay. Apoptosis was assessed on the basis of a flow cytometric determination of the DNA content, DNA fragmentation, and poly(ADP-ribose)polymerase cleavage. Results: When IMC-3 cells or IMC-3-pH cells were exposed to heat at 44°C in pH 6.8 medium, an increase in thermosensitivity was observed compared with when the IMC-3 cells were exposed to heat at 44°C in pH 7.4 medium. However, the selective reduction in survival was not observed after irradiation. In IMC-3 cells, apoptosis after heating at 44°C for 60 min in pH 7.4 medium occurred earlier than that after 8 Gy irradiation, although both thermal and irradiated doses decreased the cell count to 10%. The degree of apoptosis after heating at pH 6.8 in IMC-3 cells or IMC-3-pH cells was greater than that at pH 7.4 in IMC-3 cells. However, the degree of apoptosis after 8 Gy irradiation at pH 6.8 in IMC-3 cells or IMC-3-pH cells was smaller than that at pH 7.4 in IMC-3 cells. Conclusion: Hyperthermia treatment is more effective at inducing apoptosis than radiation is in tumors that contain a population of low pH adapted cells.

악성변화를 동반한 반전성 유두종의 임상적 고찰

Background and Objectives: Inverted Papilloma is a benign neoplastic lesion which shows high recurrence rate and possibility of association with malignacy. Squamous cell carcinoma arising in inverted papilloma has been reported in the literature. But most reported series have very few patients with this disease. This report was conducted to investigate clinical characteristics and treatment outcome of squamous cell carcinoma arising in inverted papilloma. Materials and Methods: We reviewed clinical data of eight patients who have been treated from January 1982 to March 1998 for squamous cell carcinoma arising in inverted papilloma. Results: Synchronus tumor was 6 cases and metachronus tumor was 2 cases. The most common presenting symptom was unilateral nasal obstruction. Others were nasal bleeding, rhinorrhea, and periorbital swelling with eyeball deviation. Stage at diagnosis was according to modified Kadish staging system, 5 cases of B stage, 1 of C stage and 2 of D stage. All patients were treated with surgical excision and postoperative radiation therapy was done in 6 cases. In 2 cases, postoperative radiation therapy was not performed because they refused radiation therapy. In case of stage B, all lived more than 3 years and prognosis was better than C stage. Conclusion: We suggest that modified Kadish staging system is more helpful than maxillary carcinoma staging system in prediction of prognosis of squamous cell carcinoma arising in inverted papilloma. We recommend wide surgical excision in squamous cell carcinoma and long term follow up period after inverted papilloma operation due to the possibility of metachronus. (J Clinical Otolaryngol 1999;10:66-70)

Correlation of Epidermal Growth Factor Receptor and Radiosensitivity in Human Maxillary Carcinoma Cell Lines

To determine the relationship between epidermal growth factor receptor (EGFR) and radiosensitivity, we immunostained cells from three maxillary carcinoma cell lines with an anti-EGFR antibody. The intensity of staining reactivity, determined by means of an image analysis system, was expressed as grey value (0-black to 255-white). The mean grey values for cell lines IMC-2, IMC-3, and IMC-4 were 181, 210, and 222, respectively, and differed significantly (p<0.001). This indicates that IMC-2 had the highest number of EGFR, followed by IMC-3 and IMC-4. The cells were then irradiated at 1, 2, 4, or 6 Gy, and cell survival was assessed by means of a standard colony-forming assay. IMC-2 had the highest survival rates at 1, 2 and 4 Gy, followed by IMC-3 and IMC-4. Therefore, the survival rates for IMC-2, IMC-3, and IMC-4 after irradiation increased in proportion to the amount of EGFR in each cell line. These results support the findings of previous clinical studies which showed that increased expression of EGFR was associated with higher recurrence rates of glottic and maxillary sinus carcinoma in patients treated with radiation therapy. The amount of EGFR in cells may therefore be associated with their radiosensitivity.

逆行性経カテーテル動脈塞栓法を併用した上顎癌の外科的療法の１例

A clear visual field and hemostasis are difficult to achieve because of considerable hemorrhage during resection of maxillary carcinomas, especially in patients undergoing posterior resection.This paper describes how hemorrhage can be controlled by retrograde transcatheter arterial embolization therapy, in which a catheter is placed in the superficial temporal artery to permit continuous intraarterial infusion of chemotherapy.

ヒドロキシアパタイト・リン酸三カルシウム複合体，チタンメッシュプレート，腹直筋皮弁により頭蓋顔面複合再建を行った１例

The present paper describes complex reconstruction of the craniofacial region after extensive resection of a maxillary carcinoma. We performed en bloc craniofacial resection in a 50-year-old man with a primary mucoepidermoid carcinoma of the maxillary sinus that involved the middle of the skull base. The dura and orbital contents were preserved because there was no intracranial or intraorbital tumor invasion. The resulting defect was reconstructed with a free flap, hydroxyapatite and tricalcium phosphate composite, and a titanium mesh plate. Satisfactory shape and function of the face were obtained. There has been no evidence of recurrence as of 24 months postoperatively.

Enhancement of cisplatin sensitivity and platinum uptake by 40 °C hyperthermia in resistant cells

We studied the cytotoxic and pharmacological properties of 40 °C hyperthermia and CDDP in CDDP-sensitive (IMC-3) and CDDP-resistant (IMC-3-DDP) human maxillary carcinoma cells. Heating at 40 °C alone caused almost no cell killing to IMC-3 and IMC-3-DDP cells. In both cell lines, the dose-dependent cytotoxicity of 2-h exposures to CDDP was increased at 40 °C in comparison to 37 °C. Heating at 40 °C also potentiated CDDP cytotoxicity in both IMC-3 and IMC-3-DDP cells with thermal chemoenhancement ratios (CER) of 1.48 and 1.94, respectively. The intracellular CDDP uptake level of IMC-3-DDP at 37 °C was significantly reduced compared with IMC-3 cells. At 40 °C, however, hyperthermia increased platinum accumulation by factors of 1.4 and 1.8 in IMC-3 and IMC-3-DDP cells, respectively. These findings indicated that CDDP sensitivity was hyperthermically chemopotentiated in CDDP-resistant variants rather than in the control clones. Thus, clinical cancer chemotherapy with CDDP may be improved by an appropriate combination with hyperthermia even at 40 °C.

Flow cytometry predicting therapeutic effectiveness of multimodality intervention in patients with maxillary carcinoma

Otolaryngology–Head and Neck SurgeryVolume 117, Issue 2 p. P133-P133 Article Flow Cytometry Predicting Therapeutic Effectiveness of Multimodality Intervention in Patients with Maxillary Carcinoma David J. Halvorson MD, David J. Halvorson MD (presenter) Birmingham, Ala.Search for more papers by this author David J. Halvorson MD, David J. Halvorson MD (presenter) Birmingham, Ala.Search for more papers by this author First published: 01 August 1997 https://doi.org/10.1016/S0194-59989780245-8Read the full textAboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume117, Issue2August 1997Pages P133-P133 RelatedInformation

Flow Cytometry Predicting Therapeutic Effectiveness of Multimodality Intervention in Patients with Maxillary Carcinoma

Otolaryngology–Head and Neck SurgeryVolume 117, Issue 2 p. P133-P133 Article Flow Cytometry Predicting Therapeutic Effectiveness of Multimodality Intervention in Patients with Maxillary Carcinoma David J. Halvorson MD, David J. Halvorson MD (presenter) Birmingham, Ala.Search for more papers by this author David J. Halvorson MD, David J. Halvorson MD (presenter) Birmingham, Ala.Search for more papers by this author First published: 01 August 1997 https://doi.org/10.1016/S0194-59989780245-8Read the full textAboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume117, Issue2August 1997Pages P133-P133 RelatedInformation

High urinary hydroxyproline excretion in patients with advanced head and neck cancer

We studied the urinary excretion of hydroxyproline, measured as the hydroxyproline-to-creatinine ratio (HOP/Cr), in sixty-six patients with head and neck disease including, 18 patients with head and neck cancer. Urinary hydroxyproline excretion was determined before treatment by the linear gradient elution method. Although the urinary excretion of hydroxyproline is considered to be useful in monitoring cancer tissue such as prostate carcinomas, no studies have been performed on the urinary excretion of hydroxyproline in patients with head and neck cancer. The HOP/Cr was significantly higher in cancer patients than in the healthy control. The ratio of patients with T3/T4 cancers was higher than in patients with benign tumors (p<0.05), chronic inflammatory diseases (p<0.01) or T1/T2 cancer (p<0.05). The high HOP/Cr with T3/T4 head and neck cancer corresponded to the extent of tumor invasion into the surrounding tissues such as muscles and bone. This suggests that HOP/Cr may be useful as a supplementary parameter for the assessment of tumor invasiveness which is masked in head and neck carcinomas such as skull base or maxillary carcinomas.

両側性上顎癌例

The case of a 67-year-old male with a bilateral maxillary carcinoma is reported. In 1976, the patient had an operation and irradiation therapy for a right maxillary carcinoma at another hospital, and was tumor-free for 19 years. In 1995, he developed a squamous cell carcinoma of the opposite side, the left maxillary sinus (T3N1M0, stage III). He received combination therapy consisted of intra-maxillary resection of the tumor, radiotherapy to the left maxillary field without the neck field, and chemotherapy with 5-fluorouracil (5-FU) administered from the left superficial temporal artery. Before the chemotherapy, a chemosensitivity test (ATP assay) was carried out. The results showed that 5-FU was the only effective drug. The left cervical metastatic lymph node has completely disappeared following therapy with 5-FU only for over one year. Therefore, this was a true-positive case. In our department, 15 patients have been treated according to the results of the ATP assay, and the clinical predictive accuracy is 87% thus far.

Intraoperative frozen section diagnosis of oral and maxillary squamous carcinoma

Intraoperative frozen section diagnosis of oral and maxillary squamous carcinoma

In vitro effects of hyperthermia combined with cisplatin or peplomycin on the human maxillary carcinoma cell line IMC-2

We examined the interactive effects of hyperthermia combined with cisplatin (CDDP) (0.5 μg/ml) or peplomycin (PEP) (1.0 μg/ml) on surviving fractions of human maxillary carcinoma IMC-2 cells. Either CDDP or PEP enhanced the 44°C thermosensitivity of thermotolerant cells after heating at 42°C for 2 hours. The development of thermo-tolerance at 42°C with either of the two drugs for 2 hours was not inhibited by CDDP, but it was partially inhibited by PEP. Moreover, for PEP throughout the entire period of 42–44°C step-up heating, the 44°C thermosensitivity of thermotolerant cells after heating at 42°C with PEP for 2 hours was enhanced similarly to that at 44°C with PEP. Heating at 42°C combined with either of the two drugs showed a marked interactive effect.

Maxillary carcinoma arising in a postoperative sinus: Koide C, Imai A, Yamamoto Y, et al. Ann Otol Rhinol Laryngol 104:493, 1995

Maxillary carcinoma arising in a postoperative sinus: Koide C, Imai A, Yamamoto Y, et al. Ann Otol Rhinol Laryngol 104:493, 1995

Maxillary Carcinoma Arising in a Postoperative Sinus

Maxillary Carcinoma Arising in a Postoperative Sinus

上顎癌の治療成績

上顎癌の治療成績