Growing municipal solid waste (MSW) generation is a source of environmental, economic, and social concerns, especially in developing world megacities where poor MSW practices prevail. Mexico City (CDMX), one of the world's largest megacities, daily produces∼13,073Mg of MSW whose management poses a tremendous challenge to local authorities and calls for additional research to conceive sound MSW strategies. This study evaluates the fossil energy use, GHG emissions, resource recovery, and economic cost dimensions of current and five alternative MSW paths in CDMX to compare their performance and identify more sustainable MSW practices for the megacity. Impacts and benefits from the MSW paths were modeled using 2018 MSW generation data, information supplied by local authorities, and literature values. Current MSW path consumes∼387 MJfossil, generates∼501kg-CO2e, and costs∼57 USD2018 per Mg of MSW managed while it only valorizes<33% of total MSW mostly via informal truck-picking. The alternative MSW paths considerably reduce GHG emissions (∼129-360kg-CO2e/Mg) and enhance MSW valorization (∼47-88%) though, they entail higher fossil energy consumption (447-582 MJfossil/Mg) and, in general, higher cost expenditures (43-208 USD2018/Mg). Heavy reliance on landfilling, large GHG emissions, and low MSW valorization make current MSW path in CDMX unsustainable. Incineration-based MSW paths perform better in most aspects evaluated but their high costs seem prohibitive. Results suggest MSW paths featuring open windrow composting, mechanical-biological pre-treatment, material recovery facilities, and refuse-derived fuel production may be more appropriate to improve the sustainability of CDMX MSW management.