The object of this research is to examine the combined effects of mass and thermal Biot numbers on the properties of a Powell-Erying fluid flow that is two-dimensional, constant, viscous, incompressible, and non-Newtonian. In the direction of the flow is an extending sheet encircled by a porous medium. Further consideration is given to the existence of a chemical reaction, thermophoresis, Brownian motion, and velocity lapse, among other factors. Utilizing the Powell-Erying Cauchy non-Newtonian model, the viscoelastic effect is accounted for. When establishing concentration and temperature boundary conditions, thermal and mass Biot numbers are incorporated. By utilizing graphs, one can examine the impacts of a variety of engineering parameters on concentration profiles, velocity, and temperature. This is accomplished through the implementation of numerical solutions derived via the Runge–Kutta method. By utilizing graphs, one can examine the impacts of a variety of engineering parameters on concentration profiles, velocity, and temperature. This is accomplished through the implementation of numerical solutions derived via the Runge–Kutta method. Furthermore, the Nusselt number, Skin-friction, and Sherwood number coefficients are evaluated and shown in a tabular format utilizing the same parameters. In the end, the numerical outcomes obtained from this investigation are substantiated and considered to be highly consistent with the findings that were previously documented.