The purpose of the article is to carry out the complex analysis of efficiency of the economic mechanism of mutual relations between participants of the dairy market and indicators of functioning of the dairy processing enterprises with the substantiation of the directions of further increase. Research methods. In the process of research a number of methods were used: abstract-logical - to formulate conclusions; comparative analysis - to compare indicators of efficiency of milk processing enterprises and identify trends in their change; tabular - for a visual representation of the results of the study; coordinate matrix - in determining the total integrated indicator of the efficiency of the economic mechanism of dairy enterprises; settlement and constructive - to calculate indicators of economic efficiency, liquidity and solvency, financial stability and business activity of enterprises; monographic - when detailing current trends in the functioning of dairy enterprises; factor analysis - to determine the factors influencing the net financial result of enterprises. Research results. The modern transformation processes taking place in the market of milk and dairy products of Ukraine are studied, the scale of reduction of the general demand and supply is established. The current state of the raw material base of milk processing enterprises of Ukraine is studied (dynamics of milk purchase prices, quality monitoring, retrospective of milk purchases by dairies). The efficiency of the economic mechanism of functioning of milk processing enterprises of the group of companies "Dairy Alliance" was monitored. The elemental structuring of the analysis of efficiency of the economic mechanism of functioning of the milk processing enterprises is offered and tested. The total integrated indicator of the efficiency of the economic mechanism of milk processing enterprises is calculated on the basis of structuring the set of priority indicators of economic efficiency, liquidity and solvency, financial stability and business activity. The main directions of increasing the efficiency of milk processing enterprises are proposed. Scientific novelty. Methodological and practical aspects of a comprehensive study of the effectiveness of the economic mechanism of functioning of dairy processing enterprises of Ukraine and substantiation of directions for its improvement have been further developed. Practical significance. These approaches and the results of the study can be used by public and sectoral authorities in the organization of monitoring and development of priority measures to improve the efficiency of domestic dairy industry. Tabl.: 3. Figs.: 1. Refs.: 21.