Electronic cigarettes entered the market in 2007 as an alternative to conventional tobacco products, and their use has increased significantly worldwide. Due to the emergence of various harmful effects and attracting attention, their sale was banned in our country and many other countries. However, according to the research, the use of e-cigarettes is increasing rapidly in the world and in Türkiye, and the rate of use at young ages is quite high especially. Its supply can be easily made through online sales on many websites. Despite this growing popularity, little is known about the potential effects of e-cigarettes on human health. This is particularly important in the presence of flavoring compounds, solvents, additives, and other ingredients that are added intentionally or unintentionally and whose long-term effects are uncertain. This is because every day a new product with new ingredients, flavors, and properties is introduced to the market. Previous studies have focused on measuring known toxicants, particularly those found in traditional cigarettes, while fewer have investigated unknown compounds and transformation products formed during the e-cigarette process in these diverse and ever-evolving products. It seems that the e-cigarette market is growing and developing rapidly in our country, as in the whole world, and product sales continue to increase despite all kinds of bans. However, when we look at the literature, the research conducted is insufficient, as mentioned above, and there are points that need to be further emphasized.