The islands of Bermuda preserve carbonates from several glacial and interglacial intervals with demonstrated potential for reconstructing past North Atlantic climate. Here, we describe new clumped and conventional stable isotope data from Dendostrea (oyster) shells collected from a Last Interglacial / Marine Isotope Stage 5e (MIS 5e) deposit. Interpretation of these and past data is supported by new amino acid racemization age dating results from nine localities around Bermuda.We find that the fossil oyster population on Verrill Island (within the present Great Sound of Bermuda) records MIS 5e temperatures and water δ18O values that are similar to modern. These data contrast with the much cooler temperatures and lighter reconstructed water δ18O values reconstructed for sites on the southern shore. This contrast may in part be due to timing, with the Verrill Island deposit plausibly representing an earlier and warmer portion of MIS 5e. The data also reflect meaningful, highly local differences in environment, with modern Great Sound shells perhaps living in partially restricted waters buffered from cooler and groundwater-influenced conditions along the South Shore. The mobility of Cittarium pica marine snails used in previous work likely also introduces exaggerated variability in those cases. Critically, incorporation of clumped isotope data across multiple sites and genera enables an understanding of Bermudian MIS 5e climate that would be meaningfully different if given data from only one site. We seek to illustrate both the complexities and potential of working with clumped isotope paleoclimate data from coastal deposits.