Researching to enhance competitive advantages for small and medium enterprises by collecting primary data of 315 small and medium enterprises in Tra Vinh, using multivariate regression, the research has showed 6 factors that affect to the competitive advantages for small and medium enterprises in Tra Vinh: principles changing, different costs, time controls, input activities controls, capacity controls, macro policies controls. Since then, the research implied the policies for future integration such as: improving management capacity, qualifications and awareness of small and medium enterprises' owners in Tra Vinh province on competitive advantages; Supporting businesses to develop marketing and sales activities; to support activities to provide information about markets, partners, customers for small and medium enterprises; Promote training of human resources and technology development of enterprises; Building a channel to receive feedback on institutional and business environment factors according to the provincial competitiveness index; There are preferential credit policies for small and medium enterprises.