ABSTRACT This paper examines the effects of crises of climate change and geopolitical civil conflict in Cameroon, on the development of the ecotourism sector. Additionally, the hurdles to the regeneration of the sector post- the COVID-19 pandemic are considered. A qualitative research design was used. In-depth interviews were conducted with key informants involved in the ecotourism sector, including government officials, local community representatives, conservationists, non-governmental organizations and management of national parks. The data collected were thematically analysed, with key themes pointing towards the dire impacts of COVID-19, geopolitical and climate crises on the sector, with one of the primary consequences being inhibited movement of people, extreme weather events and changes to flora and fauna, ultimately leading to shrinkage of the sector. The central nature of conservation, linked to ecotourism, was also highlighted. The importance of collaborative management, development of dedicated policy and strategic plans for the successful regeneration of ecotourism also emerged. The paper provides contemporary insights and recommendations into the sustainable regeneration of ecotourism in the face of extreme geopolitical and socio-economic crises.