Aim: Kinesiotaping (KT) is a non-invasive method used for the treatment of pain and muscle dysfunction. In this study we assess the effect of KT on carpal tunnel syndrome (CTS). Material and Method: A total of 56 patients diagnosed with CTS were randomly selected and KT applicated two times for a period of three days. Results were evaluated before and after the application using the Boston carpal tunnel questionnaire, the visual analog scale (VAS) and the Duruoz hand index. Results: The mean age of the patients included in the study was 42.9±11.7 years, with 41 being female (73.2%) and 15 male (26.8%). A majority of the KT applications (83.2%) were done on the right hand of the patients, 8.9% were on the left hand, and 1.8% were bilateral. There was a statistical difference, according to Paired-samples t test of VAS, Boston carpal tunnel questionnaire and Duruoz hand index. (p = 0.00/p=0.000/p= 0.011). Moreover, in terms of gender, the Boston function severity score (FSS) after application was statistically higher in the female participants compared to the male participants ( p = 0.047). Conclusion: Following the application of KT, pain intensity was reduced, hand function and daily activities were improved for the patients with CTS. Greater improvement was observed after the application with KT in the male patients compared to the female patients.