The article reveals the directions to solve the problem of modernisation of agricultural production management, the use of digital technologies, and automated agrotechnical solutions to ensure food security in the country and individual regions. The object of the study is the regional agro-industrial complex, functioning and developing under the conditions of new economic and technological challenges. The purpose of the study is to form conceptual ideas about approaches to the management of agricultural production at the regional level to ensure a new quality of development of the agro-industrial sector in the conditions of global technological changes and increasing environmental uncertainty. It is concluded that the management of the agroindustrial complex of the Russian regions based on the application of digital technologies determines the nature of the functioning and development of the Russian agroindustrial complex in accordance with modern trends and challenges from the external environment.