Development of the national economy is determined by the dynamics of socio-economic processes in its regions. At the same time, a high level of territorial differentiation by a significant number of parameters can lead to increased social unrest, exacerbation of contradictions between the center and regions, the city and the rural periphery, and population conurbation in large cities. One of the key factors in the country development is human capital, in particular, its territorial distribution. The current trends of population resettlement in unregulated migration conditions determine the feasibility of implementing measures to manage migration processes in the framework of migration and economic state policy. In our opinion, migration is presented not only as a social process, but also more as an economic process because of the movement of labor resources, their professional knowledge and skills, consumers, financial resources of the population and other economic components. In this context, management involves creating the conditions for attracting the population in the territory that experiences a deficit of labor and other resources. In this regard, there is a need for systematization and generalization of knowledge about the mutual influence of migration and economic development and the formulation of a generalizing concept. Within the framework of this concept, migration management will allow taking into account the interests of all the interested parties — an individual, businesses, localities, (city, village, and region), and the macro-system (country, global territory). Effective tools for managing the territorial system and, in particular, migration processes today should include modern information analysis systems and methods based on simulation modeling among others. In this aspect, the patterns of migration, their impact on the economy, as well as the population, its types and structure, demographic behavior are considered in the studies of both Russian and Western economists. In particular, the authors study it in the framework of developing an impact model of the human capital transformation on the spatial and economic development of the territorial systems, involving the creation of appropriate model tools. An important structural element of this toolkit is the control unit for migration processes because of realization of stakeholder’s interests of the territory. The proposed conceptual approach to the development of migration management information system will provide information support in the development of practical measures in the implementation of migration and demographic policy at the regional level.