Malignant Synovioma Research Articles

Malignant synovioma of the hand

Summary 1.A case of malignant synovioma of the hand is described. 2.The typical clinical and pathological characteristics of this tumour are discussed after a brief review of 143 reported cases. 3.The necessity of sending all cystic tumours of synovial membrane for examination is emphasised. 4.An operation is described, using a bone graft to maintain the width of the palm after excision of a finger and metacarpal. 5.Treatment is reviewed. Neither local excision nor amputation is successful. Irradiation after excision has yielded better results, but the numbers are too few to be statistically significant. Only four five-year survivals are reported from 143 cases.

Giant-Cell Tumors of Soft-Tissue Origin

The benign giant-cell tumor is the most common neoplasm occurring in the periarticular tissues, ligaments, tendons, and bursae located near joints. Jaffe, Lichtenstein, and Sutro, in 1941, added 55 cases to a total of 339 previously reported in the literature. The tumor is variously known as xanthoma, myeloplaxoma, endothelioma, myeloma, and granulation-tissue tumor. The other benign tumors occurring in the same areas are chondroma, osteochondroma, ganglioma, lipoma, fibroma, and angioma. Malignant neoplasms are rare and include chondrosarcoma, fibrosarcoma, and the socalled malignant synovioma. These latter are subdivided into spindle-cell, alveolar, and anaplastic types.

Malignant synovioma of the knee joint

A brief history of synoviomas in the knee joint has been given. These tumors are rare. A case of malignant synovioma (synovial endothelial sarcoma) of the knee joint is here presented. Symptoms are chiefly pain and swelling. Trauma is said to be a causative factor in many cases. In this case “chronic synovitis might be held accountable for the neo-plastic development.” Adenopathy is rare. The tumor is radio resistant. Metastases occur late to the lymph glands, liver and lungs. In this case aspiration, palpation, and roentgenograms showing soft tissue detail, helped to establish the diagnosis of tumor within the joint. Pneumographic examination is suggested as an aid to diagnosis when bloody fluid is aspirated from a joint in which there is no history of recent trauma. Recurrence is most likely in all cases. Early diagnosis is essential. If malignant changes are found, amputation is the treatment of choice.