Control Malfunction Research Articles

Transcriptomic Evidence Reveals the Dysfunctional Mechanism of Synaptic Plasticity Control in ASD

Background/Objectives: A prominent endophenotype in Autism Spectrum Disorder (ASD) is the synaptic plasticity dysfunction, yet the molecular mechanism remains elusive. As a prototype, we investigate the postsynaptic signal transduction network in glutamatergic neurons and integrate single-cell nucleus transcriptomics data from the Prefrontal Cortex (PFC) to unveil the malfunction of translation control. Methods: We devise an innovative and highly dependable pipeline to transform our acquired signal transduction network into an mRNA Signaling-Regulatory Network (mSiReN) and analyze it at the RNA level. We employ Cell-Specific Network Inference via Integer Value Programming and Causal Reasoning (CS-NIVaCaR) to identify core modules and Cell-Specific Probabilistic Contextualization for mRNA Regulatory Networks (CS-ProComReN) to quantitatively reveal activated sub-pathways involving MAPK1, MKNK1, RPS6KA5, and MTOR across different cell types in ASD. Results: The results indicate that specific pivotal molecules, such as EIF4EBP1 and EIF4E, lacking Differential Expression (DE) characteristics and responsible for protein translation with long-term potentiation (LTP) or long-term depression (LTD), are dysregulated. We further uncover distinct activation patterns causally linked to the EIF4EBP1-EIF4E module in excitatory and inhibitory neurons. Conclusions: Importantly, our work introduces a methodology for leveraging extensive transcriptomics data to parse the signal transduction network, transforming it into mSiReN, and mapping it back to the protein level. These algorithms can serve as potent tools in systems biology to analyze other omics and regulatory networks. Furthermore, the biomarkers within the activated sub-pathways, revealed by identifying convergent dysregulation, illuminate potential diagnostic and prognostic factors in ASD.

Integration of in-wheel motor sensorless systems and hierarchical direct yaw moment control for distributed drive electric vehicles

Ensuring robust and reliable control of distributed vehicles powered by in-wheel motor systems poses a significant challenge due to the harsh operating environments and high costs of such motor systems. Poor motor control, parameter variations, and sensor malfunction under these conditions can compromise the vehicle yaw stability. Integrating permanent magnet synchronous motor (PMSM) sensorless systems with vehicle yaw moment control offers a cost-effective solution for this issue without wheel angular speed sensors while enhancing yaw stability. In this paper, a composite nonlinear feedback sliding mode controller that can enhance the PMSM speed response is proposed. The proposed scheme exhibits a rotor speed overshoot and transient time of only 0.64% and 0.07s, respectively, which are smaller and shorter compared with other methods under motor parameter changes. Subsequently, the key states and tire-road friction coefficients required for vehicle control were estimated using sensorless rotor speeds and unscented Kalman filters, enabling the integration of the PMSM sensorless system with the vehicle yaw moment control. Additionally, a fuzzy adaptive hybrid sliding mode method is presented for yaw moment control enhancement. This method maintained the smallest sideslip angle root mean square error during double lane changes (0.4192 deg) compared with other methods. Analysis results show that different motor controllers and parameter changes significantly affect the vehicle dynamics performance. The proposed integrated scheme is feasible and effectively enhances the yaw moment control via high-performance sensorless PMSM systems.

Adaptation of Motor Control Through Transferring Mirror-Image Kinematics Between Dual Arms

Developing a learning model that adapts to changes in the body is critical for improving the flexibility of machine intelligence. During recovery from a controller malfunction, humans use the information obtained from previous experiences. One possible explanation for the recovery process is that information from the remaining controller was transformed and used. Modeling this mechanism will aid in the development of an adaptive motor-learning model capable of quickly recovering from controller malfunctions. We proposed a learning model for explaining the reused information of the remaining controllers in a pair of controllers. Simulations of a pair of upper limbs validated that the learning model could find a simple transformation, such as a reflection between the left and right arms, using optimization.

Limb Loss and Specialized Leg Dynamics in Tiny Water-Walking Insects.

The air-water interface of the planet's water bodies, such as ponds, lakes, and streams, presents an uncertain ecological niche with predatory threats from above and below. As Microvelia americana move across the water surface in small ponds, they face potential injury from attacks by birds, fish, and underwater invertebrates. Thus, our study investigates the effects of losing individual or pairs of tarsi on M. americana's ability to walk on water. Removal of both hind tarsi causes M. americana to rock their bodies (yaw) while running across the water surface at $\pm 19^{\circ }$, compared to $\pm 7^{\circ }$ in nonablated specimens. This increase in yaw, resulting from the removal of hind tarsi, indicates that M. americana use their hind legs as "rudders" to regulate yaw, originating from the contralateral middle legs' strokes on the water's surface through an alternating tripod gait. Ablation of the ipsilateral middle and hind tarsi disrupts directionality, making M. americana turn in the direction of their intact limbs. This loss of directionality does not occur with the removal of contralateral middle and hind tarsi. However, M. americana lose their ability to use the alternating tripod gait to walk on water on the day of contralateral ablation. Remarkably, by the next day, M. americana adapt and regain the ability to walk on water using the alternating tripod gait. Our findings elucidate the specialized leg dynamics within the alternating tripod gait of M. americana, and their adaptability to tarsal loss. This research could guide the development and design strategies of small, adaptive, and resilient micro-robots that can adapt to controller malfunction or actuator damage for walking on water and terrestrial surfaces.

Navigating Quality Assessment Hurdles in Clinical Laboratory Services: A Comprehensive Review in Resource-Limited Settings.

External quality assessment is the process of evaluating the performance of a laboratory and the competence of professionals. Participation in EQA and standardizing the quality of laboratory services are a mandatory requirements for accreditation. This review is aimed at identifying and discussing challenges that hinder the effective implementation of an EQA program in countries with resource limited setting. To obtain abundant information, articles were identified by searching the literature publishedin English using the National Library of Medicine, PubMed, Science Direct and AMC digital library databases. The articles identified in the references were manually searched and included. After the article was identified, it was imported to Endnote version 8.1 and exported to Microsoft Word for citation. Based on this review, the major identified challenges that hinder the implementation of an EQA program include the high cost of control materials, malfunction and lack of maintenance for equipment failure and breakdown, a knowledge gap among laboratory professionals, noncommutability of control samples, and difficulty in assigning target values. In addition, failing to participate in EQA and failing to take corrective action are the major challenges identified. As a result, applying to an EQA program in resource-limited counties was highly challenging. To attain high performance in the laboratory and to provide quality laboratory service for patient care, the EQA supplier and the user laboratory must pay attention to these issues and take appropriate corrective actions for ongoing quality improvement and accreditation.

Fault detection and state estimation in robotic automatic control using machine learning

In the commercial and industrial sectors, automatic robotic control mechanisms, which include robots, end effectors, and anchors containing components, are often utilized to enhance service quality. Robotic systems must be installed in manufacturing lines for a variety of industrial purposes, which also increases the risk of a robot, end controller, and/or device malfunction. According to its automated regulation, this may hurt people and other items in the workplace in addition to resulting in a reduction in quality operation. With today's advanced systems and technology, security and stability are crucial. Hence, the system is equipped with fault management abilities for the identification of developing defects and assessment of their influence on the system's activity in the upcoming utilizing fault diagnostic methodologies. To provide adaptive control, fault detection, and state estimation for robotic automated systems intended to function dependably in complicated contexts, efficient techniques are described in this study. This paper proposed a fault detection and state estimation using Accelerated Gradient Descent based support vector machine (AGDSVM) and gaussian filter (GF) in automatic control systems. The Proposed system is called (AGDSVM + GF). The proposed system is evaluated with the following metrics accuracy, fault detection rate, state estimation rate, computation time, error rate, and energy consumption. The result shows that the proposed system is effective in fault detection and state estimation and provides intelligent control automatic control.

Hyperfocus symptom and internet addiction in individuals with attention-deficit/hyperactivity disorder trait.

Hyperfocus symptom is the intense concentration on a certain object. It is a common but often overlooked symptom in those with attention-deficit/hyperactivity disorder (ADHD). Hyperfocus disrupts attention control and results in a focus on inappropriate behaviors. It allows individuals to focus on internet use and make them use internet excessively. This excessive internet use can lead to an addiction. This study investigated the status of IA and hyperfocus, the mediation effect of hyperfocus in relation to IA, and the relationship between ADHD subtypes and hyperfocus in those with ADHD symptoms. This web-based cross-sectional study included 3,500 Japanese adults who completed internet-based questionnaires, which included the Adult ADHD Self-Report Scale (ASRS), Internet Addiction Test (IAT), and Hyperfocus Scale (HFS) to assess ADHD symptoms, internet dependence, and hyperfocus symptoms, respectively. The mediating role of HFS in the relationship between ASRS and IAT was assessed by mediation analysis. To analyze the relationship between hyperfocus symptoms and ADHD subtypes, we compared the correlation of HFS with the Inattention and Hyperactive Scores of ASRS. ADHD traits were associated with higher IAT scores (p < 0.001) and higher HFS scores (p < 0.001). Mediation analysis and bootstrap testing showed that HFS significantly mediated the association between ASRS and IAT. Analyses of ADHD subtypes demonstrated that HFS was significantly correlated with the Inattention (R = 0.597, p < 0.001) and Hyperactive (R = 0.523, p < 0.001) Scores. The correlation between HFS and the Inattention Score was significantly higher than that between HFS and the Hyperactive Score (p < 0.001). Our findings suggest that hyperfocus may play an important role in addictive behavior in ADHD as a manifestation of attentional control malfunction.

Performance improvement of shunt active power filter based on indirect control with a new robust phase-locked loop

Introduction. Since the development of the first active power filter (APF) in 1976, many efforts have been focused on improving the performances of the APF control as the number of different nonlinear loads has continued to increase. These nonlinear loads have led to the generation of different types of current harmonics, which requires more advanced controls, including robustness, to get an admissible total harmonic distortion (THD) in the power system. Purpose. The purpose of this paper is to develop a robust phase-locked loop (PLL) based on particle swarm optimization-reference signal tracking (PSO-RST) controller for a three phase three wires shunt active power filter control. Methodology. A robust PLL based on PSO-RST controller insert into the indirect d-q control of a shunt active power filter was developed. Results. Simulation results performed under the MATLAB/SimPowerSystem environment show a higher filtering quality and a better robustness compared to the classical d-q controls. Originality. Conventional PLLs have difficulty determining the phase angle of the utility voltage sources when grid voltage is distorted. If this phase angle is incorrectly determined, this leads to a malfunction of the complete control of the active power filters. This implies a bad compensation of the current harmonics generated by the nonlinear loads. To solve this problem we propose a robust and simple PLL based on PSO-RST controller to eliminate the influence of the voltage harmonics. Practical value. The proposed solution can be used to improve the functioning of the shunt active power filter and to reduce the amount of memory implementation.

Heat generation and thermal runaway mechanisms induced by overcharging of aged lithium-ion battery

Overcharging occurs owing to the malfunction of charge control and inappropriate battery management system. Overcharging mechanisms, aging mechanisms, and the influence of aging on overcharging are studied in this work. The results indicate that normal charging, lithium plating, electrolyte oxidation and decomposition, excessive electrolyte decomposition, and solid electrolyte interface decomposition and regeneration occur with charging. Much heat is produced in the reactions between lithium plating and the electrolyte, which is the main reason for thermal runaway during overcharging. The primary aging mechanisms of a battery cycled at 40 ℃ and 10 ℃ are solid electrolyte interface growth and lithium plating, respectively, where the former increases and the latter decreases the safety of the lithium-ion battery during overcharging. The trigger for thermal runaway during overcharging changes from a local, micro-level internal short circuit to solid electrolyte interface decomposition and regeneration when the state of health is less than 70 % cycled at 40 ℃. If the electrolyte is depleted and the temperature is less than that promoting cathode decomposition, thermal runaway does not occur during overcharging.

Control of arm movements in Friedreich\u2019s ataxia patients: role of sensory feedback

Friedreich’s ataxia (FA) is a hereditary system degeneration, which progressively affects sensory functions such as proprioceptive feedback, which causes progressive ataxia in FA patients. While major clinical features of movement disorders in FA patients have been identified, the underlying impaired neural control is not sufficiently understood. To elucidate the underlying control mechanism, we investigated single-joint movements of the upper limb in FA patients. Small, tolerable force perturbations were induced during voluntary single-joint arm movements to examine the compensatory reaction of the FA patient’s motor system. Movement kinematics were measured, and muscle torques were quantified. We first found that as in healthy subjects, unperturbed single-joint movements in FA patients preserved similar temporal profiles of hand velocity and muscle torques, however, scaled in duration and amplitude. In addition, the small perturbations were compensated for efficiently in both groups, with the endpoint error < 0.5° (maximum displacement of 5–15°). We further quantified the differences in movement time, torque response, and displacement between patients and controls. To distinguish whether these differences were caused by a malfunction of top-down control or a malfunction of feedback control, the responses were fitted with a detailed model of the stretch reflex. The model simulations revealed that the feedback delay, but not the feedback gain was affected in FA patients. They also showed that the descending control signal was scaled in time and amplitude and co-contraction was smaller in FA patients. Thus, our study explains how the motor deficits of FA patients result from pathological alterations of both top-down and feedback control.

Slight overcharging cycling failure of commercial lithium-ion battery induced by the jelly roll destruction

Lithium-ion battery is the main power source of electric vehicles and hybrid electric vehicles due to its excellent properties. However, battery suffers overcharging during its use because of inconsistency among batteries, malfunction of charge control and inappropriate battery management. The failure behaviour, mechanism and diagnosis of battery under slight overcharging cycling are studied in this work. The experimental results indicate that battery capacity is approximately zero after failure. The industrial computed tomography images indicate that the jelly roll is destroyed by internal short circuit. This is the reason of battery failure. Impedances of battery increase much. The results of energy dispersive spectrometer indicate the occurrence of Al3+ ions. It means that the aluminium current collector is corroded. Finally, incremental capacity analysis and resistance estimation can be used to diagnose jelly roll destruction and detect failure battery respectively.

Heat generation and thermal runaway of lithium-ion battery induced by slight overcharging cycling

Slight overcharging cycling occurs due to the malfunction of charge control, inconsistency of lithium-ion batteries and inappropriate battery management. It is important to find whether it causes heat accumulate, increases the temperature of battery and triggers thermal runaway. The results of thermal stability test of slightly overcharged batteries indicate that the thermal stability of slightly overcharged battery decreases due to the cathode structure change when the voltage is less than 4.6 V. When it is greater than 4.6 V, lithium plating also makes battery thermal stability decrease. The results of heat generation and thermal runaway tests of batteries with and without current interruption device indicate that the internal resistance increase after slight overcharging is why the heat generation of battery increases. The heat generation induced by side reaction increases when the temperature reaches the threshold. The temperature threshold of exothermic reactions decreases during charging compared to that during rest with the same state of charge (SOC). Although the cycling is interrupted, thermal runaway still occurs. The battery with lower temperature and higher SOC is more dangerous than that with higher temperature and lower SOC in some cases. It is important to control SOC and temperature during charging.

Quantitative analysis of aging and detection of commercial 18650 lithium-ion battery under slight overcharging cycling

Lithium-ion batteries are widely used in electric vehicles to solve the problems of greenhouse gas emission. However, overcharging occurs due to the inconsistency of lithium-ion batteries, malfunction of charge control and inappropriate battery management. In order to solve the safety and cycle life problems of batteries suffering slight overcharging, quantitative analysis of the aging behavior, aging mechanisms and detection of slight overcharging cycling are studied in this manuscript. The results indicate that the cycle life of battery decreases linearly and exponentially with the upper cut-off voltage increasing when capacity and resistance are used as the threshold of the end of life respectively. The batteries have tolerance to slight overcharging with voltage lower than 4.6 V. The generated gas is not the main aging mechanism. Loss of active material is the main aging mechanism when the batteries are cycled at 4.4 V. Charging stress is the key factor triggering the loss of active material. The main aging mechanism becomes to be loss of lithium with the increase of voltage and cycle number due to the electrolyte oxidation, reduction and lithium plating. The differential voltage, coulombic efficiency and fast resistance increase are used as warming parameters of slight overcharging cycling.

On the need of addressing voltage sag and short interruption concerns in power supply system design and operation

Voltage sags and interruptions are generally caused by faults on power supply systems. Voltage sags and interruptions significantly reduce electric power quality and can result to equipment failures, control malfunctions, and other technical and financial losses. In our research, we proof the need of addressing voltage sag and short interruption concerns in power supply systems to make them safer and more cost-effective. We describe certain characteristics of voltage sags and short interruptions, determine what causes them, how they affect various types of equipment, and how to improve design and operation of power supply systems taking into account protection from voltage sags and short interruptions.

EVALUATION OF RELIABILITY INDICATORS OF MOBILE COMMUNICATION SYSTEM BASES

In this study, the reliability of mobile system base stations (BTS) is assessed by analyzing data obtained on faults in about 200 BTS over a six-month period. Five BTSs with the highest number of failures and duration of failure were selected in these BTSs. Based on the data obtained, reliability parameters were calculated and compared. The study used Weibull’s dismissal process distribution method. The breakdown times of each BTS were sorted. In all five BTS, it was found that β(where the value of β is the approximate value obtained from the values of the smallest squares of the Weibull graph), thus reducing the failure rate. Defects can be caused by poor quality control, manufacturing defects, poor handling and various malfunctions. Detailed information on the problem was provided and described.

PLC Tabanlı Uygulamalar: Mill Makinelerinde Oluşacak İş Kazalarının PLC Kullanılarak Önlenmesi

In recent years, the use of automation systems has been increasing, and the basis of these automation systems is generally Programmable Logic Controller (PLC) based application. PLC is used for automation in the industry where there are many advanced machines and devices. In industrial automation systems, it is also used Supervisory Control and Data Acquisition (SCADA), Human - Machine Interface (HMI) systems to ensure safe, quality, and fast production by minimizing human errors and intervention. Because of these systems used in the industries, the automation software developed enables 24/7 production with high quality and low cost. Large-scale companies prefer to use automation systems in order to minimize worker labor and error, prevent work accidents, reduce costs, and make high quality and fast production. PLCs are widely used in packaging systems, especially in the food, chemical, tire, automotive industries, as well as in cement plants, ventilation and cooling facilities, and textile factories. These systems, which are widely used in industries, are preferred due to simple programming structure, ease of setup, use and assembly, durable operation in difficult working environments, low failure, low maintenance cost, and low energy consumption. This article presents the usage and application areas of PLC based automation systems. In addition, a case study is presented that Mill machines, commonly found in truck tire manufacturing factories, are secured using PLC and HMI. Input and output cards have been added to these machines to provide security automatically. As a result of the case study, the production is made faster and with higher quality, and employees are provided with a safer environment. In addition, thanks to the developed HMI interface, Mill machines are able to control and monitor malfunctions and safety situations without the need for additional maintenance personnel.

High-Temperature Operating Characteristics of Inverter Using SBD-Integrated MOSFET

In the conventional SiC-MOSFET, a PN junction diode is included between the source and drain. This P-N junction diode not only causes device degradation, but also generates a large reverse recovery surge voltage during high temperature operation. This surge voltage increases the electrical stress of the power converter, causing dielectric breakdown and control malfunction. We have developed a SBD integrated SiC-MOSFET. This MOSFET reduces the occurrence of reverse recovery surge voltage during high-temperature operation caused by inactivating the included PN junction diode. In this paper, we discuss the characteristics of the inverter composed of the developed SiC-MOSFET in high-temperature operation. As a result, the inverter using a SBD integrated SiC-MOSFET with the PN junction diode deactivated was able to reduce surge voltage at high temperature operation.

Capacity fading and thermal stability of LiNi Co Mn O2/graphite battery after overcharging

• Quantitative analysis of battery aging mechanisms after one cycle overcharging. • Thermal stability of battery after one cycle overcharging is studied. • Thermal stability of overcharged battery is explained by aging mechanisms. • Suggestion to the following use of battery after overcharging is provided. Lithium ion batteries are widely used in many fields due to their excellent properties. Overcharging occurs during their usage because of malfunction of charge control, inappropriate battery management system and inconsistency among batteries. This work studies whether the battery is suitable for use after overcharging or not based on aging and thermal stability analysis. The results indicate that overcharging (Voltage < 5 V) has a small influence on capacity fading of battery. Onset temperature of exothermic reactions, thermal runaway and maximum thermal runaway temperatures decrease and thermal stability of battery becomes worse. This is mainly caused by SEI growth and structure damage of cathode. And the thermal stability of battery decreases with the increase of overcharging voltage. Considering that slight overcharging influences capacity fading less, the battery with LiNi x Co y Mn z O 2 and graphite as cathode and anode respectively can be used after slight overcharging. Considering the influences of slight overcharging on thermal stability, some measures should be employed to maintain the operation temperature range of battery under the self-exothermic temperature indicated in this research.

Modelling of air handling unit subsystem in a commercial building

A real-time energy management system was developed to improve the energy efficiency of an Air Handling Unit (AHU). The system consists of models to analyse the performance of subsystems in an AHU, which was tested using actual data collected from AHU operation via wireless monitoring. The system detects control-related malfunctions such as simultaneously turning on the cooling coil and the pre-heating coil. The system estimated that this type of control malfunction wastes 63,455 kWh within the cooling coil and the pre-heating coil. Furthermore, the system helped identify other energy saving opportunities through set point changes. For the tested case, the opportunities identified had the potential of 77,141 kWh of energy saving during the same study period.

Mechanical design optimization of a series elastic actuator considering the control performance

Purpose Actuators for human-interactive robot systems require transparency and guaranteed safety. An actuation system is called transparent when it is able to generate an actuation force as desired without any actuator dynamics. The requirements for the transparent actuation include high precision and large frequency bandwidth in actuation force generation, zero mechanical impedance and so on. In this paper, a compact rotary series elastic actuator (cRSEA) is designed considering the actuation transparency and the mechanical safety. Design/methodology/approach The mechanical parameters of a cRSEA are optimally selected for the controllability, the input and output torque transmissibility and the mechanical impedance by simulation study. A mechanical clutch that automatically disengages the transmission is devised such that the human is mechanically protected from an excessive actuation torque due to any possible controller malfunction or any external impact from a collision. The proposed cRSEA with a mechanical clutch is applied to develop a wearable robot for incomplete paraplegic patients. To verify torque tracking performance and disengagement of the mechanical clutch, experiments were conducted. Findings As the effects of the gear ratio, N1, on the four control performance indexes are conflicting, it should be carefully selected such that the controllability and the output torque transmissibility are maximized, while the disturbance torque transmissibility and the mechanical impedance are minimized. When the four control performance indexes were equally weighted, N1 was selected as 30. Experimental results showed that the designed cRSEA provided good control performances and the mechanical clutch worked properly. Originality/value It is important to design the actuator so as to maximize the control performance in accordance with its purpose. This paper presents the design guidelines for the SEA by introducing four control performance indexes and analyzing how the performance indexes vary according to the change of design parameter. From the viewpoint of practicality, a mechanical clutch design method that prevents excessive torque from being transmitted to the wearer and an analysis to solve the locking phenomenon when using a worm gear are presented, and a design method of SEA satisfying both control performance and practicality is presented.