Major Transport Research Articles

MARITIME MUSEUMS VS SEAPORT MUSEUMS NAVIGATING THE EVOLUTION FROM MARITIME PORT BUSINESS TO THE MARITIME TOURISM INDUSTRY

Ocean-based countries has more advantages compare to a landlock regions where there face challenges on the access to the oceanography activities. Beyond major maritime trading and transportation business, maritime tourism business is one of the economically contributing sectors for coastal region nations. The main aim of this paper is to (a) identify the role of seaport museum and maritime museum, (b) to explore the benefits of seaport museum and maritime museum towards seaport industry, (c) proposing a framework for the future research direction on seaport tourism as a complementary business opportunity for seaport industry. Bibliometric analysis technique was adopted with VoS viewer, and a content analysis on 30 research articles were performed to derive the results and then coded with NVivo 12 software. The result shows that, there are nine key measurement factors needed to be considered to archive the objectives. Seaport museum and maritime museum are not the same, whereas maritime museum only focuses on all the sea-based artifacts while seaport museum focuses on the specific sea-based artifacts which are in the port limits. Moreover, both the museums encourage the port city development and have a high impact to the seaport revenue generation.

Imaging the impact of blood-brain barrier disruption induced by focused ultrasound on P-glycoprotein function

The P-glycoprotein (P-gp/ABCB1) is a major efflux transporter which impedes the brain delivery of many drugs across the blood-brain barrier (BBB). Focused ultrasound with microbubbles (FUS) enables BBB disruption, which immediate and delayed impact on P-gp function remains unclear. Positron emission tomography (PET) imaging using the radiolabeled substrate [11C]metoclopramide provides a sensitive and translational method to study P-gp function at the living BBB.A FUS protocol was devised in rats to induce a substantial and targeted disruption of the BBB in the left hemisphere. BBB disruption was confirmed by the Evan's Blue extravasation test or the minimally-invasive contrast-enhanced MRI. The expression of P-gp was measured 24 h or 48 h after FUS using immunostaining and fluorescence microscopy. The brain kinetics of [11C]metoclopramide was studied by PET at baseline, and both immediately or 24 h after FUS, with or without half-maximum P-gp inhibition (tariquidar 1 mg/kg). In each condition (n = 4–5 rats per group), brain exposure of [11C]metoclopramide was estimated as the area-under-the-curve (AUC) in regions corresponding to the sonicated volume in the left hemisphere, and the contralateral volume. Kinetic modeling was performed to estimate the uptake clearance ratio (R1) of [11C]metoclopramide in the sonicated volume relative to the contralateral volume.In the absence of FUS, half-maximum P-gp inhibition increased brain exposure (+135.0 ± 12.9%, p < 0.05) but did not impact R1 (p > 0.05). Immediately after FUS, BBB integrity was selectively disrupted in the left hemisphere without any detectable impact on the brain kinetics of [11C]metoclopramide compared with the baseline group (p > 0.05) or the contralateral volume (p > 0.05). 24 h after FUS, BBB integrity was fully restored while P-gp expression was maximally down-regulated (−45.0 ± 4.5%, p < 0.001) in the sonicated volume. This neither impacted AUC nor R1 in the FUS + 24 h group (p > 0.05). Only when P-gp was inhibited with tariquidar were the brain exposure (+130 ± 70%) and R1(+29.1 ± 15.4%) significantly increased in the FUS + 24 h/tariquidar group, relative to the baseline group (p < 0.001).We conclude that the brain kinetics of [11C]metoclopramide specifically depends on P-gp function rather than BBB integrity. Delayed FUS-induced down-regulation of P-gp function can be detected. Our results suggest that almost complete down-regulation is required to substantially enhance the brain delivery of P-gp substrates.

Prehospital times and outcomes of patients transported using an ambulance trauma transport protocol: A data linkage analysis from New South Wales Australia

IntroductionPrehospital trauma systems are designed to ensure optimal survival from critical injuries by triaging and transporting such patients to the most appropriate hospital in a timely manner. ObjectivesWe sought to evaluate whether prehospital time and location (metropolitan versus non-metropolitan) were associated with 30-day mortality in a cohort of patients transported by road ambulance using a trauma transport protocol. MethodsData linkage analysis of routinely collected ambulance and hospital data across all public hospitals in New South Wales (NSW). The data linkage cohort included adult patients (age ≥ 16years) transported by NSW Ambulance, where a T1 Major Trauma Transport Protocol was documented by paramedic crews and transported by road to a public hospital emergency department in NSW for two years between January 2019 and December 2020. The outcomes of interest were prehospital times (response time, scene time and transport time) and 30-day mortality due to injury. Results9012 cases were identified who were transported to an emergency department with T1 protocol indication. Median prehospital transport times were longer in non-metropolitan road transports [n = 3,071, 98 min (71–126)] compared to metropolitan transports [n = 5,941, 65 min (53–80), p < 0.001]. There was no significant difference in 30-day mortality between the two groups (1.24% vs 1.65%, p = 0.13). In the subgroup of patients with abnormal vital signs, the only predictors of mortality were increasing age, presence of severe injury (OR 24.87, 95%CI 11.02, 56.15, p < 0.001), and arrival at a non-trauma facility (OR 3.01, 95%CI 1.26, 7.20, p < 0.05). Increasing transport times were not found to increase the odds of 30-day mortality. DiscussionIn the context of an inclusive trauma system and an established prehospital major trauma protocol, increasing prehospital transport times and scene location were not associated with increased mortality.

Geospatial Analysis of Informal Settlement Development in Cape Town

Informal settlements are a major influence in the urban growth of developing countries such as South Africa. There are also associated with negative socio-economic factors such as unemployment and are lacking in terms of secure land tenure arrangements. This research focuses on developing a geospatial understanding of the internal dynamics of informal settlement development within the City of Cape Town. To investigate how informal settlements are established and developed in a local context, the informal settlements of Imizamo Yethu, Langa, and Siqalo were monitored for the period 2011-2019 using image classification to determine the development, complexity, and compactness of the dwellings. The overall accuracy of the classified maps thus developed ranged between 88 and 96%. Change detection analysis was subsequently used to identify the geospatial trends for each informal settlement across all three. The combination of linear regression and ordinary least squares analysis determined that the major spatial trend driving growth was densification, which was correlated with the availability of open space, unemployment, poverty, and GDP. Furthermore, densification was identified along the major formal external transport routes and informal internal transport networks. It was found that individual settlements present unique internal geospatial development dynamics in the macroeconomic context of Cape Town, but that these tend to differ in the microeconomic context of the city. Among the explanatory variables for this situation were sloped lands, employment opportunities, and neighbouring areas where the incomes of the residents were higher. Across all the informal settlements, open space proved to be the most significant factor, while GDP played the most influential role in explaining shack compactness over time. This study could be used to contribute to policy and decision-making in the formalisation process in these informal settlements.

Major Facilitator Superfamily Transporter Participates in the Formation of Dimeric Sorbicillinoids Pigments.

Understanding the biosynthetic pathways of fungal pigments can help elucidate their roles in fungal growth processes. Trichodimerol is a unique cage-like dimeric sorbicillinoids pigment that is commonly isolated from many fungi, however, its biosynthesis is just partially clarified. In this study, we report that a biosynthetic gene cluster encoded major facilitator superfamily transporter (StaE) from the fungus Stagonospora sp. SYSU-MS7888 is involved in the formation of trichodimerol, together with several other dimeric sorbicillinoids. Using Aspergillus oryzae NSARI as a heterologous host, we demonstrated that the formation of dimeric sorbicillinoids required co-expression of the transporter StaE with biosynthetic genes (two PKSs and one monooxygenase) that are responsible for constructing the monomer precursor sorbicillinol. Fluorescence microscopy results showed that eGFP-tagged StaE is localized on the endoplasmic reticulum, suggesting that sorbicillinoid dimerizations might be compartmentalized in this organelle.

Evaluating the impacts of major transportation disruptions – San Francisco Bay Area case study

The constraints of transportation networks are fundamental to disaster planning. Having the capability of evaluating the emergent dynamics of such networks in the context of large traffic incidents can inform the design of traffic management strategies. On February 7, 2019, the Richmond-San Rafael Bridge in the San Francisco Bay Area, connecting multiple cities and carrying over 100 000 vehicles daily, had to be suddenly closed for over 9 hours due to a structural failure of its upper deck. This incident caused major disruptions in the region as the typical traffic was interrupted and detoured as travelers found alternate routes. In this study, we demonstrate the capability of large-scale traffic impact assessments of major network disruptions using the Richmond-San Rafael Bridge closure as a case study. Using a high-performance, parallel-discrete event traffic simulation, we assess the traffic impacts resulting from the bridge closure at both the regional system and city levels. Our model estimates that the region incurred an additional 14 000 vehicle hours of delay and 600 000 vehicle miles in distance due to the bridge closure. The incident affected over 55 000 trips; certain trips experienced an increase of 46 min in delay and 26 miles in travel distance. The median traffic volume on neighborhood streets in San Francisco, Vallejo, and San Rafael increased by 30%, 22%, and 13%, respectively. The results suggest that the cities’ local roads provided the additional adaptive capacity to disperse the traffic. With large-scale modeling of a critical network disruption using dynamic rerouting capability, complete road network, and full demand, we provide valuable insights into the response dynamics of this specific event. In doing so, the value of such regional analyses to incident and disaster planning is demonstrated.

Project Chief Engineer: An Industry Review of a New Position on Design–Build Teams for Major Transportation Projects

Project Chief Engineer: An Industry Review of a New Position on Design–Build Teams for Major Transportation Projects

Computational Modeling of Substrate-Dependent Mitochondrial Respiration and Bioenergetics in the Heart and Kidney Cortex and Outer Medulla.

Integrated computational modeling provides a mechanistic and quantitative framework to characterize alterations in mitochondrial respiration and bioenergetics in response to different metabolic substrates in-silico. These alterations play critical roles in the pathogenesis of diseases affecting metabolically active organs such as heart and kidney. Therefore, the present study aimed to develop and validate thermodynamically constrained integrated computational models of mitochondrial respiration and bioenergetics in the heart and kidney cortex and outer medulla (OM). The models incorporated the kinetics of major biochemical reactions and transport processes as well as regulatory mechanisms in the mitochondria of these tissues. Intrinsic model parameters such as Michaelis-Menten constants were fixed at previously estimated values, while extrinsic model parameters such as maximal reaction and transport velocities were estimated separately for each tissue. This was achieved by fitting the model solutions to our recently published respirometry data measured in isolated rat heart and kidney cortex and OM mitochondria utilizing various NADH- and FADH2-linked metabolic substrates. The models were validated by predicting additional respirometry and bioenergetics data, which were not used for estimating the extrinsic model parameters. The models were able to predict tissue-specific and substrate-dependent mitochondrial emergent metabolic system properties such as redox states, enzyme and transporter fluxes, metabolite concentrations, membrane potential, and respiratory control index under diverse physiological and pathological conditions. The models were also able to quantitatively characterize differential regulations of NADH- and FADH2-linked metabolic pathways, which contribute differently toward regulations of oxidative phosphorylation and ATP synthesis in the heart and kidney cortex and OM mitochondria.

Glutamate-aspartate transporter dysfunction enhances aminoglycoside-induced cochlear hair cell death via NMDA receptor activation

Glutamate is a crucial neurotransmitter for hearing transduction in the cochlea, but excess glutamate is detrimental to the survival of cochlear sensory cells. Glutamate-aspartate transporter (GLAST) is the major transporter for glutamate removal; however, its role in aminoglycoside-induced hair cell loss is not well studied. In the present study, we first investigated the localization and expression of GLAST over the course of development of the mouse cochlea, and we found that inhibition of GLAST increased hair cell death. However, when the glutamate receptor NMDAR was inhibited by D-AP5, hair cell death was no longer increased by the GLAST inhibitor. Our results indicate that GLAST inhibition aggravates damage to cochlear hair cells, which may occur via NMDAR, and this suggests new clinical strategies for ameliorating the ototoxicity associated with the dysfunction of glutamate metabolism.

Bioactive copper(II) agents and their potential involvement in the treatment of copper deficiency-related orphan diseases

The deregulation of copper homoeostasis can promote various diseases such as Menkes disease or hypertrophic cardioencephalomyopathy. We have recently synthesized solid copper(II) complexes ([Cu(His)2Cl2] and [Cu(Ser)2]), stable in physiological media and with potential as therapeutic agents. This report describes: i) the biocompatibility of these complexes at concentrations up to 100 μM using a differentiated Caco-2 cells model; ii) their transport across the intestinal epithelium using a transepithelial resistance assay and monitoring the amount of copper complexes at the apical and basolateral sides of the cells. The results suggest that the flow occurs through paracellular routes. The intracellular copper retention was <2.7% with no significant differences in intracellular copper content between 6 h and 48 h, suggesting an early copper retention process. Furthermore, this is the first evidence that demonstrates [Cu(His)2Cl2] and [Cu(Ser)2] induce transcriptional downregulation of the four major copper transporters (CTR1, DMT1, ATP7A, ATP7B), and the upregulation of the metallothionein gene expression. A remarkable finding was the increase in cytochrome c oxidase activity observed after the treatment of differentiated Caco-2 cells with copper(II) complexes at concentrations of 50–100 μM. The understanding of the transport mechanisms of these copper(II) complexes across the intestinal epithelium and of their subsequent biological activities could contribute to the development of optimal pharmaceutical formulations for the therapy of copper deficiency-related diseases.

Hypertension depresses but exercise training restores both Mfsd2a expression and blood-brain barrier function within PVN capillaries.

Hypertension augments while exercise training corrects the increased vesicle trafficking (transcytosis) across the blood-brain barrier (BBB) within preautonomic areas and the autonomic imbalance. There is no information on a possible mechanism(s) conditioning these effects. Knowing that Mfsd2a is the major transporter of docosahexaenoic acid (DHA) and that Mfsd2a knockout mice exhibited leaky BBB, we sought to identify its possible involvement in hypertension- and exercise-induced transcytosis across the BBB. Spontaneously hypertensive rats (SHR) and Wistar rats were submitted to treadmill training (T) or kept sedentary (S) for 4 wk. Resting hemodynamic/autonomic parameters were recorded in conscious chronically cannulated rats. BBB permeability within the hypothalamic paraventricular nucleus (PVN) was evaluated in anesthetized rats. Brains were harvested for Mfsd2a and caveolin-1 (an essential protein for vesicle formation) expression. SHR-S versus Wistar-S exhibited elevated arterial pressure (AP) and heart rate (HR), increased vasomotor sympathetic activity, reduced cardiac parasympathetic activity, greater pressure variability, reduced HR variability, and depressed baroreflex control. SHR-S also showed increased BBB permeability, reduced Mfsd2a, and increased caveolin-1 expression. SHR-T versus SHR-S exhibited increased Mfsd2a density, reduced caveolin-1 protein expression, and normalized PVN BBB permeability, which were accompanied by resting bradycardia, partial AP drop, reduced sympathetic and normalized cardiac parasympathetic activity, increased HR variability, and reduced pressure variability. No changes were observed in Wistar-T versus Wistar-S. Training is an efficient tool to rescue Mfsd2a expression, which by transporting DHA into the endothelial cell reduces caveolin-1 availability and vesicles' formation. Exercise-induced Mfsd2a normalization is an important mechanism to correct both BBB function and autonomic control in hypertensive subjects.

Interaction of Human OATP1B1 with PDZK1 Is Required for Its Trafficking to the Hepatocyte Plasma Membrane.

Uptake of xenobiotics by hepatocytes is mediated by specific proteins, including organic anion transporting polypeptides (OATPs), residing on the basolateral (sinusoidal) plasma membrane. Many of the OATPs have PDZ consensus binding sites, determined by their C-terminal 4 amino acids, while others do not. Mouse and rat OATP1A1 are associated with PDZK1, which is necessary for their trafficking to the plasma membrane. humanOATP1B1 (hOATP1B1) is a major drug transporter in human liver. Although localized to the plasma membrane, it was thought to lack a PDZ consensus motif, suggesting that the trafficking paradigm for murine OATPs is not applicable to human liver. The aim of the present study was to determine whether hOATP1B1 is a ligand for hPDZK1. hOATP1B1 immunoprecipitates with hPDZK1 following co-expression in 293T cells as well as in normal human liver. Co-expression with each of the 4 PDZ domains revealed interaction with domain 1 only. A truncated version of hOATP1B1 that lacks its terminal 4 amino acid PDZ binding motif as well as hOATP1B3, which does not contain a PDZ binding consensus motif, failed to interact with hPDZK1. Immunofluorescence microscopy of hOATP1B1 in stably transfected HeLa cells that endogenously express hPDZK1 showed that it distributes predominantly along the plasma membrane whereas hOATP1B1 lacking its terminal 4 amino acids distributes primarily intracellularly with little plasma membrane localization. Similar to findings in rats and mice, human OATP1B1 is a ligand for PDZK1 and requires interaction with PDZK1 for optimal trafficking to the hepatocyte plasma membrane. SIGNIFICANCE: Previous studies suggested that OATP1B1, a major xenobiotic transporter in human liver, does not have a PDZ binding consensus motif and does not follow the paradigm for subcellular trafficking and function that was established for OATP1A1 in murine liver. We now demonstrated that OATP1B1 but not OATP1B3 has a PDZ binding consensus motif that mediates binding to PDZK1 and is required for its trafficking to the plasma membrane. Such interaction could be an important previously unrecognized modulator of transport function.

Analyzing the impact of Russia-Ukraine crisis on the Indian economy using input-output modeling

PurposeThe conflict in Russian Ukraine is a problem for the world economy because it hinders growth and drives up inflation when it is already high. The trade route between India and Russia is also impacted by the Russia-Ukraine crisis. This study aims to compile the most recent data on how the present global economic crisis is affecting it, with particular emphasis on the Indian economy.Design/methodology/approachThis research develops a mathematical forecasting model to evaluate how the Russia-Ukraine crisis would affect the Indian economy when perturbations are applied to the major transport sectors. Input-output modeling (I-O model) and interval programing (IP) are the two precise methods used in the model. The inoperability I-O model developed by Wassily Leontief examines how disruption in one sector of the economy spreads to the other. To capture data uncertainties, IP has been added to IIM.FindingsThis study uses the forecasted inoperability value to analyze how the sectors are interconnected. Economic loss is used to determine the lowest and highest priority sectors due to the Russia-Ukraine crisis on the Indian economy. Furthermore, this study provides a decision-support conclusion for studying the sectors under various scenarios.Research limitations/implicationsIn future studies, other sectors could be added to study the Russian-Ukrainian crises’ effects on the Indian economy. Perturbation is only applied to transport sectors and could be applied to other sectors for studying the effects of the crisis. The availability of incomplete data is a significant concern in this study.Originality/valueRussia-Ukraine conflict is a significant blow to the global economy and affects the global transportation network. This study discusses the application of the IIM-IP model to the Russia-Ukraine conflict. It also forecasts the values to examine how the crisis affected the Indian economy. This study uses a variety of scenarios to create a decision-support conclusion table that aids decision-makers in analyzing the Indian economy’s lowest and most affected sectors as a result of the crisis.

Strategic Position of Riau Islands Province: A Study of Modus Operandi of Drugs Smuggling in Indonesia

The rampant case of drug smuggling in Riau Islands Province and the lack of study on its modus operandi created a gap in the current research on the topic. The objective of this study is to discover the modus operandi used, the kinds of drugs being smuggled, and the reason Riau Islands was chosen as a strategic location for the smuggling route. The data was gathered through a structured interview with the local agencies directly involved in the supervision and security against drug smuggling in Riau Islands Province. The research methodology uses interactive analysis and thematic analysis methods. The results show that the modus operandi used can be categorized as the usage of camouflage techniques such as deceptive packaging and hidden compartment; Smuggling on a person using body packing and body strapping; and conducting transactions on the high seas using large ship, speed boat, and luxury yacht while employing a ship-to-ship system, and a fishing boat. The three main drugs smuggled is Methamphetamine, Ecstasy, and Marijuana with several other in a smaller quantity. Lastly, Riau Islands Province is bordered by several countries, a major transportation route such as the Malacca Strait and the island of Sumatera. Due to the plethora of drugs smuggled and the modus operandi displayed, it is necessary for law enforcement to increase the supervision and ways to identify and counter the smuggler’s action and to secure the territory.

Refinement of safety and efficacy of anti-cancer chemotherapeutics by tailoring their site-specific intracellular bioavailability through transporter modulation.

Low intracellular bioavailability, off-site toxicities, and multi drug resistance (MDR) are the major constraints involved in cancer chemotherapy. Many anticancer molecules fail to become a good lead in drug discovery because of their poor site-specific bioavailability. Concentration of a molecule at target sites is largely varied because of the wavering expression of transporters. Recent anticancer drug discovery strategies are paying high attention to enhance target site bioavailability by modulating drug transporters. The level of genetic expression of transporters is an important determinant to understand their ability to facilitate drug transport across the cellular membrane. Solid carrier (SLC) transporters are the major influx transporters involved in the transportation of most anti-cancer drugs. In contrast, ATP-binding cassette (ABC) superfamily is the most studied class of efflux transporters concerning cancer and is significantly involved in efflux of chemotherapeutics resulting in MDR. Balancing SLC and ABC transporters is essential to avoid therapeutic failure and minimize MDR in chemotherapy. Unfortunately, comprehensive literature on the possible approaches of tailoring site-specific bioavailability of anticancer drugs through transporter modulation is not available till date. This review critically discussed the role of different specific transporter proteins in deciding the intracellular bioavailability of anticancer molecules. Different strategies for reversal of MDR in chemotherapy by incorporation of chemosensitizers have been proposed in this review. Targeted strategies for administration of the chemotherapeutics to the intracellular site of action through clinically relevant transporters employing newer nanotechnology-based formulation platforms have been explained. The discussion embedded in this review is timely considering the current need of addressing the ambiguity observed in pharmacokinetic and clinical outcomes of the chemotherapeutics in anti-cancer treatment regimens.

Adaptive Dynamic Additional Margin With N-Level Hierarchy Optimization for Inner Detector Speed Control

Pipeline transportation, as one of the five major transportation methods, has its unique advantages, and its safety guarantee is particularly important. The inner detector is an important tool for pipeline inspection, and its stable real-time speed is an important guarantee to ensure the accuracy of the inspection results for pipeline safety. We proposed an interval dynamic matrix control with additional margin (AM-IDMC), which achieves remarkable results for the speed control of the inner detector. Firstly, we improved AM-IDMC and designed a new penalty factor with adaptive dynamic trigger conditions. Secondly, we design a heuristic evolutionary algorithm N-Level Hierarchy Optimization (NLHO), and give a complete algorithm flow. Then, for the real-time speed control problem of the inner detector, we propose three evaluation index functions, which can be adaptively combined into a comprehensive objective function according to the motion state of the inner detector. Finally, the experimental verification proves the effectiveness and feasibility of the NLHO algorithm on the real-time speed control problem of the inner detector by adaptive dynamic additional margin (ADAM).

Transport Policy as a Way to Strengthen Geostrategic Position – A Review of Vienna as a Centre of Air and High-Speed Rail Transport in Central Europe

Vienna’s geostrategic importance fluctuated through the ages because of the power clashes and subsequent political and socio-economic impacts on the population. This paper assesses its current position in a historical context and then focuses more on the socio-economic dimensions such as interconnectedness and other transport aspects of the geostrategic position. Air and environmentally friendlier modes of passenger transport like high-speed rail are considered and analysed in the European context. This paper also reviews the results and issues dealing with the development of the Vienna Airport and the progress of high-speed railway projects in the Central European Economies (CEEs) after the European Union’s enlargement in 2004. The results suggest that after a restoration period of Vienna’s geostrategic position between 1995–2005, there is currently only a moderate and slowly growing exercise of power, control or influence over the CEEs. The results suggest that there is competition from busier German hub airports as well as the growing importance of CEE airports in transit and growing passenger transport performance figures. The lack of environmentally friendly high-speed infrastructure as a viable option instead of the fastest air travel is preventing Vienna to strengthen its strategic position. Its strategic importance is highly affected by the underdeveloped transport networks in CEEs and the future development of the Vienna Airport as a major transport hub.

Landscape changes in the Tombstone Territorial Park region (central Yukon, Canada) from multilevel remote sensing analysis

Northern ecosystems are vulnerable to surface disturbances caused by warming climate and human activities. The Ogilvie Mountains in central Yukon are an important region that should be monitored, as it is a major transportation corridor connecting northern communities. This study aims to characterize 35 years of landscape changes in the Tombstone Territorial Park and the surrounding region of the Ogilvie Mountains by detecting and interpreting landscape changes using a Landsat-derived trend analysis and multilevel image interpretation. Statistically significant spectral changes occurred in 24% of the study area between 1986 and 2021, and most of these changes are gradual and associated with vegetation succession and hydrological processes (i.e., erosion and deposition). Other landscape changes included wildfires, slumps, changes to riverbanks and lake shores, earlier melting of icings in the summer, degradation on the peripheries of some ice-wedge polygonal terrain, and potential insect damage to forests. Our investigation reveals that the extent and magnitude of landscape changes in the study area are influenced by climate, geomorphic setting, ecological succession, and glacial history of the region. Given a varied combination of ecotypes, spatial and temporal variations are to be expected in terms of the response of the landscape to climate and anthropogenic disturbances.

The role of GLUT2 in glucose metabolism in multiple organs and tissues.

The glucose transporter family has an important role in the initial stage of glucose metabolism; Glucose transporters 2 (GLUTs, encoded by the solute carrier family 2, SLC2A genes) is the major glucose transporter in β-cells of pancreatic islets and hepatocytes but is also expressed in the small intestine, kidneys, and central nervous system; GLUT2 has a relatively low affinity to glucose. Under physiological conditions, GLUT2 transports glucose into cells and allows the glucose concentration to reach balance on the bilateral sides of the cellular membrane; Variation of GLUT2 is associated with various endocrine and metabolic disorders; In this study, we discussed the role of GLUT2 in participating in glucose metabolism and regulation in multiple organs and tissues and its effects on maintaining glucose homeostasis.

Spns2/S1P: it takes two to tango with inflammation and metabolic rewiring during sepsis.

Sepsis is the result of a dysregulated host response to an infection and causes high morbidity and mortality at the intensive care units worldwide. Despite intensive research, the current management of sepsis is supportive rather than curative. Therefore, new therapeutic interventions for sepsis and septic shock patients are urgently needed. In this issue of EMBO Reports, Fang etal have used rat sepsis models to show that macrophage-expressed SPNS2, a major transporter of S1P, is a crucial mediator of metabolic reprogramming of macrophages during sepsis which regulates inflammation via the lactate-ROS axis.