Major Radiation Research Articles

Radiological consequences and lessons of the Chernobyl NPP and «Fukushima-1» NPP radiation accidents

35 years have passed since the Chernobyl NPP accident, 10 years – since the «Fukushima-1» NPP accident. At the present time extensive activities on the remediation of the consequences of two major large-scale radiation disasters are performed in the Belorussia, Russian Federation, Ukraine, and Japan. Releases of radiologically significant radionuclides after the Chernobyl NPP accident correspond to 14 exaBecquerel – higher up to an order of magnitude compared to 3 emergence power units of the «Fukushima-1» NPP. The significantly lower release rate and deposition of 80% of the radionuclides released into the atmosphere on the surface of the Pacific Ocean lead to lower up to several orders of magnitude radioactive contamination of the Japanese territory compared to the territories of the former USSR and neighboring countries after the Chernobyl NPP accident. Collective dose to the public due to the Chernobyl NPP accident is higher up to several orders of magnitude compared to the dose to the Japanese population after the «Fukushima-1» accident. No statistically reliable long-term medical consequences are expected for all groups of the Japanese public, additionally exposed due to «Fukushima-1» accident. 134 emergency workers have developed acute radiation sickness due to the Chernobyl NPP accident. Emergency workers with doses higher than 150 mSv had increased radiation-induced morbidity with leukemia and solid cancers. Among the individuals, that were kids or adolescents in the exposure period after the Chernobyl NPP accident and residing on the territories of Belorussia, Ukraine and four most radioactively contaminated regions of the Russian Federation, morbidity with thyroid cancer is increase by a factor of 10 compared to the pre-accidental levels. The following lessons of the Chernobyl NPP and «Fukushima-1» NPP can be derived: faults in the NPP design and lack of response after the recognition of the faults; lack of timely full-scale prophylactic with iodine; unjustified resettlement of the residents of the radioactively contaminated territories several years after the accident.

Primate phageomes are structured by superhost phylogeny and environment

Humans harbor diverse communities of microorganisms, the majority of which are bacteria in the gastrointestinal tract. These gut bacterial communities in turn host diverse bacteriophage (hereafter phage) communities that have a major impact on their structure, function, and, ultimately, human health. However, the evolutionary and ecological origins of these human-associated phage communities are poorly understood. To address this question, we examined fecal phageomes of 23 wild nonhuman primate taxa, including multiple representatives of all the major primate radiations. We find relatives of the majority of human-associated phages in wild primates. Primate taxa have distinct phageome compositions that exhibit a clear phylosymbiotic signal, and phage-superhost codivergence is often detected for individual phages. Within species, neighboring social groups harbor compositionally and evolutionarily distinct phageomes, which are structured by superhost social behavior. Captive nonhuman primate phageome composition is intermediate between that of their wild counterparts and humans. Phage phylogenies reveal replacement of wild great ape-associated phages with human-associated ones in captivity and, surprisingly, show no signal for the persistence of wild-associated phages in captivity. Together, our results suggest that potentially labile primate-phage associations have persisted across millions of years of evolution. Across primates, these phylosymbiotic and sometimes codiverging phage communities are shaped by transmission between groupmates through grooming and are dramatically modified when primates are moved into captivity.

Feasibility of a prehabilitation programme dedicated to older patients with cancer before complex medical–surgical procedures: the PROADAPT pilot study protocol

BackgroundAgeing is associated with an increased prevalence of comorbidities and sarcopenia as well as a decline of functional reserve of multiple organ systems, which may lead, in the context of...

Decadal application of WRF/Chem over the continental U.S.: Simulation design, sensitivity simulations, and climatological model evaluation

The WRF/Chem v3.7 is applied to 2001–2010 over the continental U.S. using the National Emission Inventory (NEI). This study will provide the baseline simulation for a future work to investigate the impacts of both climate and emission changes on the future regional air quality and human health. This paper focuses on the current year simulation design, comprehensive model evaluation, and sensitivity simulations that demonstrate the impacts of different reinitialization setup, cloud physical schemes, and emission inventories on the model predictions. Nine one-month sensitivity simulations by using different reinitialization setup and cloud microphysics and cumulus parameterizations are first conducted to provide the optimal model configurations. The model performance in predicting the regional meteorology and air quality on a decadal scale is further evaluated against available surface, satellite, and reanalysis data. The decadal WRF/Chem simulation by using NEI emissions (referred to as simulation NEI) performs well for major meteorological variables such as T2, RH2, WS10, and precipitation and shows good performance for major radiation variables such as SWDOWN, OLR, and SWCF. Large model biases still exist for cloud variables due to limitations of cloud dynamics/thermodynamics treatments and uncertainties associated with satellite retrievals. The simulation NEI also predicts O3 and PM2.5 well in terms of spatiotemporal distribution. Compared to a previous study using the Representative Concentration Pathway (RCP8.5) emissions, the simulation NEI performs better for most of variables, especially for precipitation and cloud radiative forcing due to better representation of cloud processes and also for O3 and PM2.5 in terms of spatiotemporal variations due to more accurate emission inventory. The evaluation results in this work are within the range or better than other previous studies using the WRF/Chem model and lay the foundation for more realistic projection of future climate and air quality in the future work.

Comprehensive total evidence phylogeny of chinchillids (Rodentia, Caviomorpha): Cheek teeth anatomy and evolution.

Rodents are the most diverse order of extant mammals, and caviomorph rodents, or New World hystricognaths, have a remarkable morphological disparity and a long fossil record that begins in the Eocene. Chinchilloidea is a poorly understood clade within Caviomorpha, from an evolutionary and phylogenetic perspective. It includes the extant families Chinchillidae and Dinomyidae, the extinct Neoepiblemidae and Cephalomyidae, and several extinct chinchilloids without a clear phylogenetic position, like Eoincamys, Borikenomys, Chambiramys, Ucayalimys, Incamys, Saremmys, Garridomys and Scotamys. The family Chinchillidae includes the extant Chinchilla and Lagidium, grouped in Chinchillinae, and the only living Lagostominae, Lagostomus maximus. Among extinct chinchillids, Eoviscaccia (early Oligocene-early Miocene of Argentina, Bolivia and Chile), Prolagostomus (early-middle Miocene of Argentina, Bolivia and Chile) and Pliolagostomus (early-middle Miocene of Argentina) are the only genera originally described as members of the family. Based on the study of specimens with unworn or little-worn cheek teeth, belonging to extinct and extant taxa, we propose homologies of the cheek teeth structures and perform a combined molecular and morphological phylogenetic analysis including extinct and extant taxa of all families of Chinchilloidea and all genera of Chinchillidae. Our phylogenetic analysis recovered three major lineages in the evolutionary history of Chinchilloidea. The first major lineage is composed of the extant taxa Chinchilla, Lagidium and Lagostomus, and the extinct genera Eoviscaccia, Prolagostomus, Pliolagostomus, Garridomys, Incamys, Loncolicu and Saremmys. Cephalomyid (Banderomys, Cephalomys, Litodontomys, Soriamys) and neoepiblemid (Neoepiblema, Perimys, Phoberomys, Scotamys) genera are part of the second major lineage, while dinomyids such as Dinomys, Drytomomys, Scleromys, 'Scleromys' and Tetrastylus constitute the third major lineage within Chinchilloidea. The phylogenetic position of some taxa previously considered as incertae sedis chinchilloids or without a clear suprageneric group (i.e. Incamys, Saremmys, Garridomys and Loncolicu) show that they belong to pan-Chinchillidae and conform the stem Chinchillidae along with Eoviscaccia. The euhypsodont crown Chinchillidae includes the living subfamilies Chinchillinae and Lagostominae. Dinomyidae and Eoincamys pascuali are recovered as the sisters of a major clade composed by 'Cephalomyidae'+Neopiblemidae and pan-Chinchillidae, and Chambiramys sylvaticus occupies a basal position to the same clade. Four major radiation events are identified in the evolutionary history of Chinchilloidea. The analysis of new morphological characters linked with molecular evidence as well as the addition of taxa of uncertain or unstable phylogenetic position or not considered in previous studies allowed us resolve part of the relationships within Chinchilloidea, particularly that of Chinchillidae, supporting preceding morphological hypotheses.

Genome Size in South American Gentianella (Gentianaceae, Swertiinae), with a Special Emphasis on Species from the Bolivian and Ecuadorian Andes

The subcosmopolitan genus Gentianella Moench (Gentianaceae, Swertiinae), with more than 170 currently accepted species in South America alone, is one of the emblematic examples of major and rapid radiations in the Andes. However, the taxonomy of South American Gentianella is far from being resolved. Over a century has passed since the publication of the last comprehensive treatment by Ernst Gilg in 1916. Using flow cytometry, the genome size of 115 accessions of 39 species, of which 37 were from South America, was measured, with the objective to assess the taxonomic utility of that trait. Also, the relationships of genome size with environmental factors such as mean annual temperature and precipitation, as well as the life history traits, habit, reproduction, habitat, and elevational belt were examined. The genome size values of the investigated South American accessions fell into two size classes, ranging from 2C = 7.60 pg to 11.30 pg and from 2C = 16.54 pg to 18.34 pg. The latter size class contained only accessions of G. briquetiana (Gilg) T. N. Ho & S. W. Liu. These accessions, and a further one of G. limoselloides (Kunth) Fabris with an intermediate value of 2C = 14.71 pg, were inferred to be octoploid. Genome size was not correlated with temperature, precipitation, habit, or elevational belt. By contrast, significant differences in genome size between groups were found regarding habitat and reproduction. Furthermore, genome size of one of the informal taxonomic groups of Gilg (Barbatae) differed from that of the remaining groups. However, this finding is of doubtful taxonomic relevance because of inconsistencies in the application of Gilg’s defining criterion of Barbatae, i.e., the presence of trichomes inside the corolla tube. Based on the overall results, it is concluded that genome size is not a taxonomically useful trait in South American Gentianella. Still, the data offer a first view on genome size variation and evolution in this diverse but poorly studied group.

Lean Thinking to manage a national working group on physics aspects of Stereotactic Body Radiation Therapy.

To report how the adoption of a Lean Thinking mindset in the management of a national working group (WG) on the physics of stereotactic body radiation therapy (SBRT) contributed to achieve SBRT standardization objectives. Vision for the WG has been established as fragmentation reduction and process harmonization enhancement in SBRT for Italian centers. Two main research themes of the technical aspects of SBRT emerged as areas with major standardization improvement needs, small field dosimetry and SBRT planning comparisons, to be investigated through multi-institutional studies. The management of the WG leveraged on the Lean concept of fostering self-organization in a non-hierarchical environment. Four progressive involvement levels were defined for each study. No specific "scientific" pre-experience was required to propose and coordinate a project, just requiring a voluntary commitment. People engagement was measured in terms of number of published articles. The standardization goals have been conducted through a simplified "5S" (Sort, Set in Order, Shine, Standardize, and Sustain) methodology, first considering a phase of awareness (the first three "S"), then identifying and implementing standardization actions (the last two "S"). Since the beginning, 157 medical physicists joined the AIFM/SBRT-WG. Twenty-four papers/reviews/letters have been published in the period 2014-2019 on major radiation oncology journals, authored by >100 physicists (>50% working in small hospitals). Six over 12 first authors worked in peripheral/small hospitals, with no prior publication as first author. These studies contributed to the awareness and standardization phases for both small-field dosimetry and planning. In particular, errors in small-field measurements in 8% of centers were detected thanks to a generalized output factor curve in function of the effective field size created by averaging data available from different Linacs. Furthermore, planner's experience in SBRT was correlated with dosimetric parameters in the awareness phase; while sharing median dose volume histograms (DVHs) reduced variability among centers while keeping the same level of plan complexity. Finally, all the dosimetric parameters statistically significant to the planner experience during the awareness phase, were no longer significantly different in the standardization phase. The experience of our SBRT-WG has shown how a Lean Thinking mindset could foster the SBRT procedure standardization and spread the physics of SBRT knowledge, enhancing personal growth. Our expectation is to inspire other scientific societies that have to deal with fragmented contexts or pursue processes harmonization through Lean principles.

Evaluation of shortwave and longwave radiation models for mechanistic-empirical pavement analysis

ABSTRACT Pavement temperature is one of the most important factors influencing the performance of flexible pavements. The major components of the Earth's heat balance system are downwelling shortwave radiation (D-SWR) from the sun, downwelling longwave radiation (D-LWR) from the atmosphere, and upwelling longwave radiation (U-LWR) emitted by the warm pavement surface. The Pavement ME Design (PMED) software (AASHTO, 2015. Mechanistic-empirical pavement design guide–a manual of practice. Washington, DC: AASHTO) computes temperature distributions in the pavement over depth and time using algorithms originally proposed by Dempsey et al. (1985. Environmental effects on pavements: theory manual. US Department of Transportation, Federal Highway Administration). These algorithms are largely empirical, depend heavily on imprecise corrections for cloud cover, and in some parts contradict atmospheric physics. Improved models for the major radiation components proposed here include: (1) D-SWR values modelled by the MERRA-2 climate re-analysis product from NASA (Rienecker et al., 2011. MERRA: NASA’s modern-era retrospective analysis for research and applications. Journal of Climate, 24, 3624–3648); (2) D-LWR modelled using the Idso (1981. A set of equations for full spectrum and 8-to 14-μm and 10.5-to 12.5-μm thermal radiation from cloudless skies. Water Resources Research, 17, 295–304) empirical parameterisation with a physics-consistent adjustment for cloud cover; and (3) U-LWR calculations without the physics-inconsistent cloud cover adjustment embedded in PMED. The D-SWR and D-LWR radiation models were evaluated via comparisons against ground-based radiation observations at 21 locations in the Solar Infrared Radiations Stations (SIRS) database. The MERRA-2 estimates of D-SWR, although not perfect, were found to agree substantially better than the current PMED models with the ground truth SIRS. The D-LWR fluxes from the Idso (1981. A set of equations for full spectrum and 8-to 14-μm and 10.5-to 12.5-μm thermal radiation from cloudless skies. Water Resources Research, 17, 295–304) parameterisation were also found to agree substantially better than the current PMED with the ground truth SIRS, with particularly striking improvements for the all-sky (i.e. including clouds) condition. A limited series of flexible pavement performance analyses were conducted to illustrate the potential practical impact of these radiation model changes. The new radiation models produced significantly higher pavement temperatures that lead to substantially higher total rutting, asphalt rutting, and bottom up fatigue cracking. These changes in distress magnitudes must be evaluated in qualitative terms only, as all analyses used the same field calibration coefficients for the distress models. The primary conclusion from this work is that the current radiation models incorporated in PMED are inaccurate and, in some cases, inconsistent with fundamental atmospheric physics. This can have significant impacts on predicted pavement performance. It is recommended that the current PMED radiation models be replaced by the new D-SWR, D-LWR, and U-LWR. New field calibration of the empirical distress models would be required after incorporating the new radiation models.

An early‐diverging procolophonid from the lowermost Triassic of South America and the origins of herbivory in Procolophonoidea

AbstractProcolophonoidea was the only parareptile clade to survive the end‐Permian mass extinction, and they experienced a major adaptive radiation during the Triassic. The flourishing of procolophonoid lineages in highly stressful post‐extinction environments may be, at least in part, a result of their early adaptations to herbivory, which would eventually become the most common feeding strategy in later representatives of the group. Although procolophonoids are comparatively diverse in the South African Lystrosaurus declivis Assemblage Zone, only the Gondwanan widespread taxon Procolophon trigoniceps has been thus far reported in South American deposits of similar age. Here, we present a new procolophonid genus and species from the Lower Triassic Sanga do Cabral Formation of Brazil. Oryporan insolitus gen. et sp. nov. combines typical adaptations suggestive of herbivory with primitive character states that are peculiar to early procolophonoids. Accordingly, phylogenetic analysis places the new species as an early‐diverging procolophonid, thus far the phylogenetically earliest to develop apparent adaptations for herbivory. Character optimization shows that the bulbous, labiolingually expanded molariforms of most procolophonids (usually interpreted as indicative of high‐fibre herbivory) were co‐opted from an insectivorous dentition. The new taxon also highlights the diversity of feeding habits displayed by Early Triassic procolophonoids, which was probably crucial for the survival of the clade in post‐extinction disaster communities.

Evolutionary biomechanics: hard tissues and soft evidence?

Biomechanical modelling is a powerful tool for quantifying the evolution of functional performance in extinct animals to understand key anatomical innovations and selective pressures driving major evolutionary radiations. However, the fossil record is composed predominantly of hard parts, forcing palaeontologists to reconstruct soft tissue properties in such models. Rarely are these reconstruction approaches validated on extant animals, despite soft tissue properties being highly determinant of functional performance. The extent to which soft tissue reconstructions and biomechanical models accurately predict quantitative or even qualitative patterns in macroevolutionary studies is therefore unknown. Here, we modelled the masticatory system in extant rodents to objectively test the ability of current muscle reconstruction methods to correctly identify quantitative and qualitative differences between macroevolutionary morphotypes. Baseline models generated using measured soft tissue properties yielded differences in muscle proportions, bite force, and bone stress expected between extant sciuromorph, myomorph, and hystricomorph rodents. However, predictions from models generated using reconstruction methods typically used in fossil studies varied widely from high levels of quantitative accuracy to a failure to correctly capture even relative differences between macroevolutionary morphotypes. Our novel experiment emphasizes that correctly reconstructing even qualitative differences between taxa in a macroevolutionary radiation is challenging using current methods. Future studies of fossil taxa should incorporate systematic assessments of reconstruction error into their hypothesis testing and, moreover, seek to expand primary datasets on muscle properties in extant taxa to better inform soft tissue reconstructions in macroevolutionary studies.

Evaluation of Radiation Protection Methods for Assistant Staff during CT Imaging in High-energy Trauma: Lens Dosimetry with a Phantom Study.

Staff are exposed to radiation in the scanning room when assisting with CT scans of patients requiring ventilatory support during procedures. We measured lens doses using a phantom during a high-energy trauma protocol. Dosimetry showed that the unprotected lens received 2.02 mGy on the right and 1.91 mGy on the left, which are not negligible doses. Respective exposures to the right and left lens were 53.6% and 55.1% when wearing 0.07 mm Pb protective glasses with side covers; 53.7% and 64.2% when wearing 0.7 mm Pb glasses without side covers when facing away from the patient couch; and 92.1% and 91.2% using protective shielding in the gantry. Since the face direction may change during assistance with CT imaging, it is desirable that the protective glasses have a shape with a side cover. The protective shielding had a major radiation reduction effect, although it is expensive to acquire, install, and maintain.

Primary diffuse large B-cell lymphoma of the major salivary glands: Increasing incidence and survival

BackgroundDiffuse Large B-Cell Lymphoma (DLBCL) of the major salivary glands is a rare high-grade malignancy that often presents with vague symptoms. This study aimed to evaluate its incidence and prognosis on a population level. MethodsThe Surveillance, Epidemiology, and End Results database was queried for cases of major salivary gland DLBCL. Results896 patients had DLBCL affecting the parotid gland (78.3%) or submandibular gland (19.8%). The incidence was increasing at 1.5% (P = 0.005) per year from 1973 to 2016. 24.4% of patients underwent parotidectomy, 16% had biopsy, and the remaining provided no details of diagnostic method. Five-year disease-specific survival increased from 59.8% to 84.0%. Late-stage disease (HR = 1.7, P = 0.003) and female sex (HR = 2.1, P = 0.018) were associated with increased risk of mortality. ConclusionDespite the rising incidence of major salivary gland DLBCL, chemotherapy and radiation treatment has resulted in increasingly favorable survival outcomes. The otolaryngologist - head and neck surgeon continues to play a critical role in establishing the diagnosis of salivary gland DLBCL.

Phanerozoic radiation of ammonia oxidizing bacteria

The modern nitrogen cycle consists of a web of microbially mediated redox transformations. Among the most crucial reactions in this cycle is the oxidation of ammonia to nitrite, an obligately aerobic process performed by a limited number of lineages of bacteria (AOB) and archaea (AOA). As this process has an absolute requirement for O2, the timing of its evolution—especially as it relates to the Great Oxygenation Event ~ 2.3 billion years ago—remains contested and is pivotal to our understanding of nutrient cycles. To estimate the antiquity of bacterial ammonia oxidation, we performed phylogenetic and molecular clock analyses of AOB. Surprisingly, bacterial ammonia oxidation appears quite young, with crown group clades having originated during Neoproterozoic time (or later) with major radiations occurring during Paleozoic time. These results place the evolution of AOB broadly coincident with the pervasive oxygenation of the deep ocean. The late evolution AOB challenges earlier interpretations of the ancient nitrogen isotope record, predicts a more substantial role for AOA during Precambrian time, and may have implications for understanding of the size and structure of the biogeochemical nitrogen cycle through geologic time.

Integrating Academic and Community Cancer Care and Research through Multidisciplinary Oncology Pathways for Value-Based Care: A Review and the City of Hope Experience.

As the US transitions from volume- to value-based cancer care, many cancer centers and community groups have joined to share resources to deliver measurable, high-quality cancer care and clinical research with the associated high patient satisfaction, provider satisfaction, and practice health at optimal costs that are the hallmarks of value-based care. Multidisciplinary oncology care pathways are essential components of value-based care and their payment metrics. Oncology pathways are evidence-based, standardized but personalizable care plans to guide cancer care. Pathways have been developed and studied for the major medical, surgical, radiation, and supportive oncology disciplines to support decision-making, streamline care, and optimize outcomes. Implementing multidisciplinary oncology pathways can facilitate comprehensive care plans for each cancer patient throughout their cancer journey and across large multisite delivery systems. Outcomes from the delivered pathway-based care can then be evaluated against individual and population benchmarks. The complexity of adoption, implementation, and assessment of multidisciplinary oncology pathways, however, presents many challenges. We review the development and components of value-based cancer care and detail City of Hope’s (COH) academic and community-team-based approaches for implementing multidisciplinary pathways. We also describe supportive components with available results towards enterprise-wide value-based care delivery.

The Cainozoic to present-day record of Circum-Mediterranean, NE Atlantic and North Sea Cantharidinae and Trochinae (Trochoidea, Gastropoda)-a synopsis.

Evolutionary history, diversity and (paleo)geographic distribution of Cainozoic to present-day species of the Trochidae subfamilies Cantharidinae and Trochinae are discussed based on an extensive literature survey. In total, 393 species-level taxa, assigned to 24 genera and subgenera, are listed from the NE Atlantic, the E Atlantic, the North Sea, the (Proto)-Mediterranean Sea, the Central Paratethys Sea and the Eastern Paratethys Sea. Short diagnosis and subjective and objective junior synonyms for genus-level taxa are given. Stratigraphic ranges and geographic distribution are listed for species-level taxa. The European fossil record suggests a first major radiation during the middle Eocene and a second diversity pulse during the Miocene, when most extant genera were already present. At the species level, however, the present-day fauna is geologically very young, originating during the Pleistocene and Holocene. Overall, no convincing correlation of evolution and diversity of European Cantharidinae and Trochinae with major geodynamic events (e.g. Tethys Closure) can be observed. An exception is the somewhat overlooked spectacular radiation of Cantharidinae following the hydrological isolation of the Paratethys Sea during the late Miocene. The critical evaluation of the fossil record provides anchor points to test molecular phylogenies. A major discrepancy between both approaches appears only for Jujubinus, which suggests that Paleocene species have to be excluded from the genus. Gibbuliculus nov. gen. is introduced as new genus for a group of Oligocene to Pleistocene species, placed so far in "Colliculus" sensu auctores non Monterosato, 1888. Anceps siminescui nov. nom, Gibbuliculus saccoi nov. nom, Gibbula tavanii nov. nom., Gibbula s.l. lovellreevei nov. nom. and Gibbula s.l. steiningeri nov. nom. are proposed as new names for the preoccupied Trochus semistriatus Siminescu Barbu, 1940, Gibbula protumida Sacco, 1896, Gibbula minima Tavani, 1939, Trochus (Gibbula) reevei Harmer, 1923 and Trochus amedei bicincta Schaffer, 1912.

Mentorship Initiatives in Radiation Oncology: A Scoping Review of the Literature

Although mentorship is described extensively in academic medical literature, there are few descriptions of mentorship specific to radiation oncology. The goal of the current study was to investigate the state of mentorship in radiation oncology through a scoping review of the literature. A search protocol was defined according to Preferred Reporting Items for Systematic Reviews and Meta Analyses extension for scoping reviews (PRISMA-ScR) guidelines. Predefined search terms and medical subject headings were used to search PubMed for English language articles published after January 1, 1990, on mentorship in radiation oncology. Additionally, in-press articles from major radiation oncology and medical education journals were searched. Three reviewers determined article eligibility. Included articles were classified based on predefined evaluation criteria. Fourteen publications from 2008 to 2019 met inclusion criteria. The most commonly described form of mentorship was the dyad (64.3%), followed by team (14.3%) and peer (7.1%); 2 articles did not specify mentorship type (14.3%). The most commonly mentored participants were residents (35.7%), followed by medical students (35.7%) and attendings (21.4%); 1 study included participants of all levels (7.1%). Thirteen studies (92.9%) identified an experimental study design, most of which were cross-sectional (42.9%), followed by cohort studies (28.6%) and before/after (21.4%). Median sample size, reported in 12 of 13 experimental studies, was 132 (coefficient of variation, 1.06). Although outcomes varied widely, the majority described successful implementation of mentorship initiatives with high levels of participant satisfaction. Although few initiatives are currently reported, the present study suggests that these initiatives are successful in promoting career development and increasing professional satisfaction. The interventions overwhelmingly described mentorship dyads; other forms of mentorship are either less common or understudied. Limitations included interventions not being evaluated in a controlled setting, and many were assessed using surveys with low response rates. This review highlights rich opportunities for future scholarship to develop, evaluate, and disseminate radiation oncology mentorship initiatives.

A phylotranscriptomic framework for flesh fly evolution (Diptera, Calyptratae, Sarcophagidae)

AbstractThe Sarcophagidae (flesh flies) comprise a large and widely distributed radiation within the Calyptratae (Diptera). Larval feeding habits are ecologically diverse and include sarcosaprophagy, coprophagy, herbivory, invertebrate and vertebrate predation, and kleptoparasitism. To elucidate the geographic origin and evolution of flesh fly life‐history, we inferred a backbone phylogeny based on transcriptomic data from 26 sarcophagid species covering all three subfamilies plus 15 outgroups. The phylogeny was inferred using maximum parsimony and maximum likelihood methods based on a series of supermatrices, one set with overall information content improved by MARE (2290 loci), one set with 100% gene coverage for all included species (587 loci), and the last set including mitochondrial and nuclear genes (589 loci) and additional taxa. In order to obtain a more detailed hypothesis, we utilized the supertree approach to combine results from the present study with previously published hypotheses. This resulted supertree covers 84 of the one hundred currently recognized sarcophagid genera and formed the basis for the ancestral state reconstructions. The monophyletic Sarcophagidae is well‐supported as sister to {Mystacinobiidae + Oestridae}, and relationships at the subfamily level are inferred as {Sarcophaginae, (Paramacronychiinae + Miltogramminae)}. The Sarcophagidae and each subfamily originated in the Americas, with Sarcophaginae diversifying mainly in the Neotropics, whereas the major radiation of both Miltogramminae and Paramacronychiinae occurred in the Palaearctic. Sarcosaprophagy is reconstructed as the ancestral larval feeding habit of the family Sarcophagidae and each subfamily. The ancestral sarcophagid larva probably utilized dead invertebrates as food, and the food spectrum expanded together with the diversification of breeding strategies. Particularly, kleptoparasitism in Miltogramminae is derived from sarcosaprophagy and may be seen as having derived from the breeding biology of ‘lower’ miltogrammines, the larvae of which feed on buried vertebrate carrion.

Behavioural imprint of the Ordovician Radiation: Evidence from Middle–Upper Ordovician deep-sea trace fossils in western Inner Mongolia, North China

Trace fossils are unique evidence of the body plan and behavioural complexity of animals. Major radiation periods in the Phanerozoic were associated with not only changes in biodiversity, biomass, and ecosystems but also transformations in the relatively implicit, behavioural world. Here we report on a diverse ichnoassemblage from the Middle–Upper Ordovician deep-marine deposits of Inner Mongolia, North China, totalling 24 ichnogenera (including two undetermined forms). They include Alcyonidiopsis, Bifasciculus, Bifungites, Chondrites, Circulichnis, ?Cochlichnus, Dendrorhaphe, Diplocraterion, Halopoa, Gyrophyllites, Monofungites, Multina, Nereites, Paleodictyon, Phymatoderma, Ptychoplasma, Rhizocorallium, Sinusichnus, Taenidium, Thalassinoides, Trichichnus, Zoophycos, bag-like trace, and closed ring trace. Highly regular and complex burrow systems have been discovered, i.e., the branched circular pattern of Circulichnis sinensis, elaborate radial graphoglyptid tunnel system Dendrorhaphe racemosa ichnosp. nov., sinusoid mazework Sinusichnus sinuosus, and the boxwork bag-like trace consisting of highly symmetric horizontal galleries and numerous semi-equidistant vertical shafts. The occurrence of these complex trace fossils suggests distinct behavioural complication and novelty in deep-sea communities during the Middle–Late Ordovician. We speculate that along with the onshore–offshore displacement of ichnofauna and significant expansion of deposit-feeding structures possibly driven by accelerated competition in the shallow-marine niches and aided by ameliorated deep-sea benthic food level, there was underlying behavioural evolution towards more delicate, geometric, and efficient feeding patterns. The Late Ordovician may represent the early peak not only in ichnodiversity but also in ichnodisparity and behavioural complexity of deep-sea ichnofauna, which probably reflect the complex interplay of biodiversity, biomass, and ecological changes during the Ordovician Radiation.

Dual-Band Printed Monopole Antenna Design

Design procedure of a high gain dual-band printed monopole antenna, resonating at 2.4 GHz and 5.5 GHz, is presented. The proposed design meets the specifications required by WI-FI, WIMAX and radio frequency identification (RFID) reader applications. Our design utilizes Rogers RT/Duroid 5880(tm) substrate, and the major radiation element is an annular circular patch shape. The design was improved by adding a face-to-face fork shape metal inside the annular circular patch. The antenna feed consists of a microstrip line and a slotted transformer section for matching purpose. A prototype of the proposed antenna was fabricated and the measurements of the return loss and antenna radiation pattern were performed. The comparison between the results obtained from the simulation and the measurements showed an excellent agreement.

Collections‐based systematics and biogeography in the 21st century: A tribute to Dr. Vicki Funk

Collections‐based systematics and biogeography in the 21st century: A tribute to Dr. Vicki Funk