Illicit drug and alcohol-related activities pose significant challenges to metropolitan centres globally, impacting public safety and socio-economic stability. This research analyzes the spatial and temporal patterns of drugs and alcohol-related illegal activities (DARIA) in Siliguri, known as the "Gateway of North-East India." The primary objectives are to explore DARIA patterns, identify clusters and concentrated areas, and investigate contributing factors. Using GIS-based spatial analysis and geographical models, we studied incidents recorded over three years from 2021 to 2023. Advanced spatial statistical approaches were applied to identify specific clusters of DARIA occurrences. The pure temporal analysis highlighted periods of increased illegal activity. Various geographical models, including ordinary least squares (OLS), geographically weighted regression (GWR), and multiscale geographically weighted regression (MGWR), were used to examine the spatial association. The MGWR model, with an explanatory power of R2 = 0.816, provided a detailed understanding of spatial relationships and variations in DARIA. Our findings indicate specific zones with frequent DARIA occurrences, mainly near major transportation hubs, commercial points, and areas with significant mobility. Key exploratory factors such as illiteracy rate, population density, proximity to playgrounds and slums were highly associated with DARIA incidents. These findings contribute to developing safer, more resilient, and more sustainable cities worldwide.