Maintaining Skin Health Research Articles

27510 Dysbiotic skin microbiome network of individual mediated host response to pollution stress

Urban living has been reported to cause various skin disorders. Air pollutants and skin microbiome are among the key factors associated with urbanization-related skin alterations. However, the causal role of the skin microbiome in mediating skin physiological responses to pollution stressors remains to be elucidated. The objectives of this research were to study the effect of pollution stressors on skin microbiome and the causal effect on skin physiological responses. 16s sequencing technology was used to profile skin microbiome of subjects living in Shanghai and Chongming (a rural area of the Shanghai municipal) with subgroups of smokers and non-smokers in both locations. Microbiome networks of individuals (MNIs) were then constructed to analyze the effect of pollution stressors on microbiome network and the downstream mediation effect on skin physiology. Urban living–related pollution stressors affected skin microbiome causing dysbiotic MNIs. MNI dysbiosis mediated the adverse effects of air pollution on skin physiology. A smoking lifestyle deepened the negative effects of pollution stress on skin microbiota. This is the first study that characterizes network signature of the skin microbiome at individual level and reveals the role of skin microbiome in mediating skin’s responses towards environmental stressors. These findings further strengthened the importance of microbiome function in maintaining skin health. Interventions that protect and enhance the microbiome may be an effective strategy for protecting against skin damage caused by pollution.

PENGARUH MINYAK ZAITUN (OLIVE OIL) TERHADAP KERUSAKAN INTEGRITAS KULIT PADA PASIEN DM TIPE II DI KECAMATAN PAGAR MERBAU

The success of changing the damage to the integrity of the skin in patients with Diabetes Mellitus Type II depends not only on early detection, but also on understanding the causative mechanism. One condition that can cause damage to the integrity of the skin was the xerosis and pruritus on skin . The purpose of this study to determine the effect of Oil Olive to damage the integrity of the skin in patients with DM type II in the District of Pagar Merbau. This type of research uses the Quasy Experiment Method using the One-Group Pretest-Posttest Design research design. Determination of the sample was done by purposive sampling, with a total sample of 22 people. Data analysis was performed using Paired Sample T Test with 95% confidence interval and α= 0.05. The results of this study indicate the change in damage to the integrity of the skin before and after given a basting oil olives with a p-value = 0.000 (α> 0.05). Conclusion, there was an influence of olive oil on damage to skin integrity in patients with type II DM in Pagar Merbau District which was carried out in accordance with standards. For Health Institutions the need for supervision and counseling to the community that the importance of maintaining skin health especially in patients with diabetes mellitus in Pagar Merbau District
 
 
 

Effects of Eggshell Membrane on Keratinocyte Differentiation and Skin Aging In Vitro and In Vivo.

Skin aging is one of the hallmarks of the aging process that causes physiological and morphological changes. Recently, several nutritional studies were conducted to delay or suppress the aging process. This study investigated whether nutritional supplementation of the eggshell membrane (ESM) has a beneficial effect on maintaining skin health and improving the skin aging process in vitro using neonatal normal human epidermal keratinocytes (NHEK-Neo) and in vivo using interleukin-10 knockout (IL-10 KO) mice. In NHEK-Neo cells, 1 mg/mL of enzymatically hydrolyzed ESM (eESM) upregulated the expression of keratinocyte differentiation markers, including keratin 1, filaggrin and involucrin, and changed the keratinocyte morphology. In IL-10 KO mice, oral supplementation of 8% powdered-ESM (pESM) upregulated the expression of growth factors, including transforming growth factor β1, platelet-derived growth factor-β and connective tissue growth factor, and suppressed skin thinning. Furthermore, voltage-gated calcium channel, transient receptor potential cation channel subfamily V members were upregulated by eESM treatment in NHEK-Neo cells and pESM supplementation in IL-10 KO mice. Collectively, these data suggest that ESM has an important role in improving skin health and aging, possibly via upregulating calcium signaling.

Understanding the effects of Moringa oleifera in chronic unpredictable stressed zebrafish using metabolomics analysis

Ethnopharmacological relevanceMoringa leaves have been used for thousands of years to maintain skin health and mental fitness. People also use it to relieves pain and stress. Aim of the studyTo determine the effects of Moringa oleifera leaves ethanol-aqueous (ratio 7:3) extract (MOLE) on the chronically stressed zebrafish. MethodThe changes in the stress-related behaviour and the metabolic pathways in response to MOLE treatment in zebrafish were studied. A chronic unpredictable stress model was adopted in which zebrafish were induced with different stressors for 14 days. Stress-related behaviour was assessed using a depth-preference test and a light and dark test. Three doses of MOLE (500, 1000, and 2000 mg/L) were administered to the zebrafish. Upon sacrifice, the brains were harvested and processed for LC-MS QTOF based, global metabolomics analysis. ResultsWe observed significant changes in the behavioural parameters, where the swimming time at the light phase and upper phase of the tank were increased in the chronically stressed zebrafish treated with MOLE compared to those zebrafish which were not treated. Further, distinctive metabolite profiles were observed in zebrafish with different treatments. Several pathways that shed light on effects of MOLE were identified. MOLE is believed to relieve stress by regulating pathways that are involved in the metabolism of purine, glutathione, arginine and proline, D-glutamine, and D-glutamate. ConclusionMOLE is potentially an effective stress reliever. However, its effects in human needs to be confirmed with a systematic randomised control trial.

Effect of virgin coconut oil (VCO) on the physical stability of sweet potato leaf extract (Ipomoea batatas (L.) Lam) creams and antibacterial activity test against Staphylococcus aureus ATCC 25923

VCO (virgin coconut oil) has benefits for skin health such as softening the skin, maintaining skin health, and protecting the skin from radiation and free radicals. VCO as one of the raw materials for making cream preparations can affect its physical stability. This study aimed to analyze the effect of VCO on the physical stability of sweet potato leaf extract creams and antibacterial activity test against Staphylococcus aureus ATCC 25923. The creams were made with five formulas namely base, extract cream 2%, and VCO 1%, 3%, 5% added to the extract cream 2% respectively. Physical stability test included storage for six weeks at room temperature. Stability parameters were organoleptic observation, homogeneity, pH, spreadability, adhesivity, and cream type. Statistical analysis was carried out with the Anova and Kruskal Wallis tests. The organoleptic test results of the cream extract showed a distinctive odor, green color, with semisolid and homogeneous texture. Increasing the concentration of VCO will increase the spreadability of extract cream but did not affect pH and adhesion. The conclusion of this study was that extract cream 2% without the addition of VCO was the most stable cream formulation. Besides that, all the cream formulas did not show antibacterial activity against Staphylococcus aureus ATCC 25923.

16045 Efficacy of SPF70 sunscreen to protect skin against visible light and air pollution

Background: Sunscreens are known to protect from sun damage mainly caused by UVA/UVB lights, however the effects of visible light (VL) have been extensively investigated and correlated with skin pigmentation. Also, chronical exposition to pollution, mainly particulate matter (PM), contribute to the photoaging and skin pigmentation being a possible emerging etiologic agent for the development of melasma. Considering that, the development of dermo-cosmetic able to protect skin form VL and PM are essential to maintaining skin health.

PENGARUH MINYAK ZAITUN (OLIVE OIL) TERHADAP KERUSAKAN INTEGRITAS KULIT PADA PASIEN DM TIPE II DI KECAMATAN PAGAR MERBAU

ABSTRACT
 The success of changing the damage to the integrity of the skin in patients with Diabetes Mellitus Type II depends not only on early detection, but also on understanding the causative mechanism. One condition that can cause damage to the integrity of the skin is the xerosis and pruritus on skin . The purpose of this study to determine the effect of Oil Olive to damage the integrity of the skin in patients with DM type II in the District of Pagar Merbau . This type of research uses the Quasy Experiment Method using the One-Group Pretest-Posttest Design research design. Determination of the sample is done by purposive sampling, with a total sample of 22 people. Data analysis was performed using Paired Sample T Test with 95% confidence interval and α = 0.05. The results of this study indicate the change in damage to the integrity of the skin before and after given a basting oil olives with a p-value = 0.000 (α> 0.05). Conclusion, there is an influence of olive oil on damage to skin integrity in patients with type II DM in Pagar Merbau District which is carried out in accordance with standards. For Health Institutions the need for supervision and counseling to the community that the importance of maintaining skin health especially in patients with diabetes mellitus in Pagar Merbau District 
 Keywords : Olive Oil , Skin Integrity Damage , Type II DM patients 

Investigation of Age-Related Changes in the Skin Microbiota of Korean Women.

The microbiota of human skin is influenced by host and environmental factors. To determine if chronological age influences the composition of the skin microbiota on the forehead and hands, 73 Korean women were sorted into one of three age groups: (1) 10–29 years (n = 24), (2) 30–49 years (n = 21), and (3) 50–79 years (n = 28). From the 73 women, 146 skin samples (two skin sites per person) were collected. 16S rRNA gene amplicon sequencing was then conducted to analyze the skin microbiota. The overall microbial distribution varied on the forehead but was similar on the hands across the three age groups. In addition, the composition of the skin microbiota differed between the forehead and hands. Commensal microbiota, such as Streptococcus, Staphylococcus, Cutibacterium, and Corynebacterium, which contribute to maintaining skin health via dominant occupation, were affected by increasing age on forehead and hand skin. Alpha diversity indices increased significantly with age on forehead skin. This study indicates that older people may be more susceptible to pathogenic invasions due to an imbalanced skin microbiota resulting from age-related changes. The results of our study may help develop new strategies to rebalance skin microbiota shifted during aging.

Uji Aktivitas Antibakteri Sediaan Sabun Cair Ekstrak Daun Mengkudu (Morinda citrifolia L.) Terhadap Staphylococcus aureus

The bacteria Staphylococcus aureus are round bacteria that are shaped like a cocci, and are Gram-positive. These bacteria can be found on the skin, genitals, nasal cavity, mouth and around the anus. One of the pharmaceutical products that can maintain skin health and protect the skin is soap. The leaves of noni (M. citrifolia L.) contain various compounds such as flavonoids, tannins, saponins, alkaloids, and triterpenoids which are capable of being antibacterial. This study aims to make a liquid soap formulation from M. citrifolia L. leaf extract and its activity as an antibacterial to S aureus. The leaves of M. citrifolia L. were extracted using 96% ethanol solvent by maceration method until a thick extract was obtained. Soap formulations are made with a concentration of 20% 40% and 60%. Evaluation of soap quality includes organoleptic test, high foam test and pH test. The method of antibacterial testing is carried out in vitro by means of well diffusion. The results on the quality test of the liquid soap formulation showed that the pH and height of the foam had good results and had met the SNI 1996 Standards. From the results showed that formulation III with an extract content of 60% had a large antimicrobial activity with a value of 16.83 mm which was categorized as strong. In positive control (Dettol) 60% antimicrobial activity showed a value of 14.83 mm. The results of statistical tests were carried out by One-Way ANOVA analysis followed by LSD analysis Post hoc, liquid soap extract of M. citrifolia L. had greater antimicrobial potential than the positive control (Dettol).

Warp Speed Ahead! Technology-Driven Breakthroughs in Skin Immunity and Inflammatory Disease

The skin's physical barrier is reinforced by an arsenal of immune cells that actively patrol the tissue and respond swiftly to penetrating microbes, noxious agents, and injurious stimuli. When unchecked, these same immune cells drive diseases such as psoriasis, atopic dermatitis, and alopecia. Rapidly advancing microscopy, animal modeling, and genomic and computational technologies have illuminated the complexity of the cutaneous immune cells and their functions in maintaining skin health and driving diseases. Here, we discuss the recent technology-driven breakthroughs that have transformed our understanding of skin immunity and highlight burgeoning areas that hold great promise for future discoveries.

Maintaining skin health and integrity for staff wearing personal protective equipment for prolonged periods: a practical tip sheet

Patient skin injuries associated with medical or therapeutic devices are increasingly reported in the literature. With the coronavirus (COVID-19) pandemic, healthcare staff are wearing personal protective equipment (PPE) for prolonged periods. Anecdotally, cases of healthcare workers' self report of injuries to their face, particularly the bridge of the nose, upper cheek, forehead and above the ears, as a result of extended use of eye protection and masks is increasing. Protecting the skin of frontline healthcare staff is as important as protecting patients' skin. The tip sheet presented in this paper provides staff with a guide in the form of written and visual assistance in order to reduce the risk of device-related pressure injuries (DRPIs) in healthcare staff caused by PPE.

Guidance for Maintaining Skin Health When Utilizing Protective Masks for Prolonged Time Intervals.

Guidance for Maintaining Skin Health When Utilizing Protective Masks for Prolonged Time Intervals.

Mitochondrial Sirtuins in Skin and Skin Cancers.

Mammalian sirtuins (SIRTs 1-7) are a family of NAD+-dependent deacetylases with distinct subcellular localization and biological functions that regulate various important cellular processes. Among these, SIRTs -3, -4 and -5 are located in the mitochondria and have been implicated in caloric restriction, oxidative stress, aging and various human diseases. Emerging evidence has found dysregulation of mitochondrial sirtuins in multiple dermatological conditions, including responses to ultraviolet radiation (UVR), suggesting their importance in maintaining skin health. In this review, we discuss the roles and implications of mitochondrial sirtuins in cutaneous cellular processes, and their emerging potential as a target for the management of skin diseases, including skin cancer. Among mitochondrial sirtuins, SIRT3 is the most studied and linked to multiple skin conditions and diseases (keratinocyte differentiation, wound healing, chronological aging, UVR and ozone response, systemic sclerosis, melanoma, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)). SIRT4 has been connected to keratinocyte differentiation, chronological aging, UVR response, alopecia, BCC and SCC. Further, SIRT5 has been associated with keratinocyte differentiation, melanoma, BCC and SCC. Overall, while there is compelling evidence for the involvement of mitochondrial sirtuins in skin, additional detailed studies are needed to understand their exact roles in skin and skin cancers.

Analysing Opportunity for New Established Acne Focused Skincare Brand in Indonesian Beauty Industry

The skin is of utmost importance when people judge someone as beautiful. Maintaining skin health and people awareness toward their skin appearance is important. This beauty and health culture is validated in the presence of the growth of global skincare market from 2012 to 2025. More than 90 percent of world population is affected by acne at some point in their life. In 2010, acne ranked 8th in the list of most prevalent diseases in the world. Study from Indonesian Society of Dermatology and Venereology (INSDV) state that 60% Indonesian people are experiencing acne in 2006 and by 2008 the number reach 80% with sufferers ranging from 12-40 years old.
 The idea of this research is to help business people find the business strategy as new entrant in the beauty industry. Research is intended to analyze the environment for new established acne focused skincare brand. This paper presents external analysis consist of Porter’s Five Forces and Customer Analysis that will be concluded with Porter’s Generic Competitive Strategy

Photoprotective Activity of Topsentin, A Bis(Indole) Alkaloid from the Marine Sponge Spongosorites genitrix, by Regulation of COX-2 and Mir-4485 Expression in UVB-Irradiated Human Keratinocyte Cells.

Skin is an important barrier to protect the body from environmental stress. However, exposure to ultraviolet radiation (UV) and various environmental oxidative stresses can cause skin inflammation. Cyclooxygenase-2 (COX-2) is an inducible enzyme that mediates the formation of prostaglandin E2 (PGE2) against internal and external inflammatory stimulations. Therefore, the inhibition of COX-2 is an important approach to maintain skin health and prevent skin inflammation and carcinogenesis. Topsentin, a bis(indolyl)imidazole alkaloid isolated from the marine sponge Spongosorites genitrix, has been reported to exhibit anti-tumor and anti-microbial activities. However, the effect of topsentin on skin inflammation and its underlying molecular mechanism has not been elucidated. In the present study, we identified the photoprotective effects of topsentin on UVB irradiated human epidermal keratinocyte HaCaT cells. Topsentin suppresses COX-2 expression and its upstream signaling pathways, AP-1 and MAPK. Furthermore, topsentin inhibits miR-4485, a new biomarker selected from a microarray, and its target gene tumor necrosis factor alpha induced protein 2 (TNF-α IP2). The photoprotective effect of topsentin was also confirmed in a reconstructed human skin model. These findings suggest that topsentin may serve as a potential candidate for cosmetic formulations with skin inflammatory-mediated disorder.

Analisis Algoritma Klasifikasi C 4.5 Untuk Memprediksi Keberhasilan Immunotherapy Pada Penyakit Kutil

Maintaining skin health is one thing that is also needed. Not only health from inside, health from the outside must also be considered. There are so many skin problems that arise in the human body. Wart disease is characterized by small bumps on the surface of the skin which are generally caused by the Human Papiloma Virus (HPV) virus. One technique for treating wart disease is immunotherapy, this method is a treatment by increasing the immune system to deal with wart disease. Clinical predictions are growing very rapidly by adopting computer science and information technology in managing health and drug data, this clinical prediction can be produced from processing using data mining methods. Data mining is a popular method used to explore patterns or knowledge from large data stacks. C 4.5 algorithm which is one of the decision tree induction algorithms is also a method of data mining algorithms used to classify. This study aims to predict the success rate of immunotherapy treatment methods on wart disease with algorithm C 4.5 using RapidMiner. From the study it was known that the accuracy rate for processing immunotherapy data on wart disease to predict its success using the C 4.5 algorithm of 74.07%.

PENGGUNAAN TABIR SURYA BAGI KESEHATAN KULIT

Most activities are done outside the home often make the skin exposed to UV light. Exposure UV light excessively or in a long time can cause the occurrence of skin disorders such as Sunburn, premature aging, lowering skin immunity to skin cancer. In preventing the negative effects of UV light on the skin, various ways can be done such as by using a protector such as clothes, hats, glasses or umbrellas. But this physical protection is not sufficient because of the UV light penetrating power. Sunscreen is a skin care cosmetic that provides physical protection against UV light. Proper use of sunscreen and routine can protect the skin from the negative effects of UV light. This paper describes the effects of UV light on the skin, the function of sunscreen and the right use and compatible types sunscreen in maintaining skin health from the adverse effects of UV light.

The influence of incontinence pads moisture at the loaded skin interface

AimProlonged mechanical loading on soft tissues adjacent to bony prominences can lead to pressure ulcers. The presence of moisture at the skin interface will lower the tolerance to load. Absorbent pads manage moisture in individuals with incontinence, although their role in maintaining skin health is unknown. The present study investigated the effects of moist incontinence pads on skin physiology after periods of mechanical loading. Material and methodsTwelve healthy participants were recruited to evaluate a single incontinence pad design under three moisture conditions: 0% (dry), 50% and 100% fluid capacity. For each pad condition, pressure (9 kPa) or pressure in combination with shear (3 N) was applied to the sacrum, followed by a period of off-loading. Measures included trans-epidermal water loss (TEWL) and inflammatory biomarkers sampled at the skin interface. ResultsResults revealed no change in TEWL in the loaded dry pad condition. By contrast, when the pads contained moisture, significant increases in TEWL were observed. These increases were reversed during off-loading. Inflammatory biomarkers, specifically IL-1α/total protein ratio, were up-regulated during dry pad loading, which recovered during off-loading. Loaded moist pads caused a significant increase in biomarkers, which remained elevated throughout the test period. ConclusionThe study revealed a marked compromise to stratum corneum integrity when the skin was exposed to moist incontinence pads in combination with mechanical loads. These physiological changes were largely reversed during off-loading. Incontinence pads provided some protection in the dry state, although more research is required to determine optimal clinical guidance for their use.

Protective effects of astaxanthin on skin: Recent scientific evidence, possible mechanisms, and potential indications.

Astaxanthin is a naturally occurring ketocarotenoid which has been found to have numerous biological functions, with its strong antioxidant property being the prominent feature. The compound has attracted a great amount of interest with respect to its potential utilization in the betterment of human health. In the recent past, astaxanthin has been extensively studied with respect to its possible effect on skin health, with positive results. Astaxanthin has also shown to have anti-inflammatory, immune-modulating, and DNA repair properties, which have further encouraged its usage to maintain skin health and tackle skin damage. In this review article, we highlight the pharmacokinetic profile of the antioxidant in brief and describe the findings of various recent published research articles which studied the effect of astaxanthin in improvement of skin health. We also mention the possible mechanisms which form the basis of the positive dermatological effects of astaxanthin and the potential indications of the antioxidant molecule in cosmetology and dermatology.

Improved Skin Health in a One-Year Prospective Bioengineering Analysis of Healthcare Workers’ Hands in Long Term?Care

BACKGROUND Compromised skin integrity is a known barrier to optimal hand hygiene (HH) practice and a contributing factor to decreased HH events amongst healthcare workers (HCWs). Because traditional sensorial assessments of skin health are subjective, skin evaluation an be difficult. Adding to the complexity, HCWs daily routines such as use of personal hygiene products, impacts in-use studies of skin responses that are typically conduced over short periods of time, days or weeks. Furthermore, while these results may conclude statistically, other variables such as seasonal changes, temperature and humidity variations, episodes of increased HH due to outbreaks during the year (i.e. norovirus), limits accuracy of the skin health evaluation and true skin status of HCWs hands. METHODS A prospective one-year tracking test protocol was designed to assess skin physiologic properties of thirty-six HCW's in a?skilled nursing facility every six to eight weeks between February of?2016 to January of 2017 in response to two test products: antimicrobial soap formulated with milder surfactants, conditioners and moisturizers and alcohol sanitizer that contained emollients and moisturizers. Due to work shift, turn-over, and medical absenteeism, 12 of the 36 HCW's participated in every skin bioengineering mea?surement. RESULTS Results indicated that skin barrier function by transepidermal water loss (TEWL) showed significant improvement compared to baseline and directional improvement for hydration. Data further revealed that seasonal changes reflect on skin hydration changes, warmer weather induced higher skin hydration levels than colder weather. Skin redness showed no sign of change both instrumentally and visually, while skin pH was directionally decreased and aligned with the TEWL trend, demonstrating improvement in skin health. CONCLUSIONS Soap and sanitizer formulation with moisturizers have accumulative benefits in maintaining skin health and should be considered when choosing products for HCW's to promote optimal HH practice. Compromised skin integrity is a known barrier to optimal hand hygiene (HH) practice and a contributing factor to decreased HH events amongst healthcare workers (HCWs). Because traditional sensorial assessments of skin health are subjective, skin evaluation an be difficult. Adding to the complexity, HCWs daily routines such as use of personal hygiene products, impacts in-use studies of skin responses that are typically conduced over short periods of time, days or weeks. Furthermore, while these results may conclude statistically, other variables such as seasonal changes, temperature and humidity variations, episodes of increased HH due to outbreaks during the year (i.e. norovirus), limits accuracy of the skin health evaluation and true skin status of HCWs hands. A prospective one-year tracking test protocol was designed to assess skin physiologic properties of thirty-six HCW's in a?skilled nursing facility every six to eight weeks between February of?2016 to January of 2017 in response to two test products: antimicrobial soap formulated with milder surfactants, conditioners and moisturizers and alcohol sanitizer that contained emollients and moisturizers. Due to work shift, turn-over, and medical absenteeism, 12 of the 36 HCW's participated in every skin bioengineering mea?surement. Results indicated that skin barrier function by transepidermal water loss (TEWL) showed significant improvement compared to baseline and directional improvement for hydration. Data further revealed that seasonal changes reflect on skin hydration changes, warmer weather induced higher skin hydration levels than colder weather. Skin redness showed no sign of change both instrumentally and visually, while skin pH was directionally decreased and aligned with the TEWL trend, demonstrating improvement in skin health. Soap and sanitizer formulation with moisturizers have accumulative benefits in maintaining skin health and should be considered when choosing products for HCW's to promote optimal HH practice.