Main Text Research Articles

Prospects for breast cancer immunotherapy using microRNAs and transposable elements as objects.

One of the directions in treatment of chemoresistant breast cancer (BC) may include new methods of activating the immune response against tumor cells. Clinically used checkpoint inhibition using antibodies to PD-1 and PD-L1 works in some patients, but the lack of biomarkers means number of respondents is low. The possibility of combining this method with chemotherapy is limited by an increased risk of toxic liver damage, development of immune-related pneumonitis, and thyroid dysfunction. This article includes introduction into the clinic of new methods of immunotherapy for BC, among which epigenetic activation of retroelements, double-stranded transcripts of which stimulate the interferon response against the tumor, is promising. For this purpose, inhibitors of DNA methyltransferase*, histone deacetylase* and histone methyltransferase* are used (* subtitles in the main text). Their antitumor effect is also mediated by removal of repressive epigenetic marks from tumor suppressor genes. However, numerous studies have proven the role of retroelements in the carcinogenesis of various malignant neoplasms, including BC. Moreover, endogenous retroviruses HERV-K and LINE1 retrotransposons are planned to be used as diagnostic biomarkers for BC. Therefore, a rational approach to using viral mimicry in antitumor therapy of BC may be the simultaneous suppression of specific retrotransposons (drivers for carcinogenesis) using reverse transcriptase inhibitors and silencing of specific transposons involved in carcinogenesis using complementary microRNAs. To determine possible pathways of influence in this direction, 35 specific transposon-derived microRNAs* changes in BC were identified, which can become guides for targeted therapy of BC.

Gain-switched pulse generation of 5.3 ps from 30 GHz-modulation-bandwidth 1270 nm DFB laser diode: erratum.

We present an erratum to our Letter [Opt. Lett.48, 6344 (2023)10.1364/OL.510237]. This erratum corrects the error of Figs.3(b) and 4(b) made via incorrect scaling in the horizontal axes. The corrections have no influence on the main text and conclusions of the original Letter.

Reprint of: Examining U.S. disparities in smoking among rural versus urban women of reproductive age: 2002–2019

ObjectiveThis study is part of a programmatic investigation of rural disparities in cigarette smoking examining disparities in smoking prevalence and for the first-time quit ratios among adult women of reproductive age (18–44 years), a highly vulnerable population due to risk for multigenerational adverse effects. MethodsData came from 18 years (2002–2019) of the U.S. National Survey on Drug Use and Health (NSDUH) among women (n = 280,626) categorized by rural-urban residence, pregnancy status, using weighted logistic regression models testing time trends and controlling for well-established sociodemographic predictors of smoking (race/ethnicity, education, income). Concerns regarding changes in survey methods used before 2002 and after 2019 precluded inclusion of earlier and more recent survey years in the present study. ResultsOverall smoking prevalence across years was greater in rural than urban residents (adjusted odds ratio [AOR] = 1.11; 95%CI, 1.07–1.15; P < .001) including those not-pregnant (AOR = 1.10; 1.07–1.14; P < .001) and pregnant (AOR = 1.29; 1.09–1.52; P < .001). Overall quit ratios across years were lower in rural than urban residents (AOR = 0.93; 0.87–0.99; P < .001) including those not-pregnant (AOR = 0.93; 0.88–1.00, P = .035) and pregnant (AOR = 0.78; 0.62–0.99; P = .039). Interactions of rural versus urban residence with study years for prevalence and quit ratios overall and by pregnancy status are detailed in the main text. ConclusionsThese results support a longstanding and robust rural disparity in smoking prevalence among women of reproductive age including those currently pregnant and provides novel evidence that differences in smoking cessation contribute to this disparity further underscoring a need for greater access to evidence-based tobacco control and regulatory interventions in rural regions.

AFRIMETS supplementary comparison on calibration of caliper

Main textNational Metrology Institutes from 12 African countries, namely Egypt, Morocco, Ghana, Nigeria, Ethiopia, Kenya, Tanzania, Zambia, Zimbabwe, Botswana, Mauritius and South Africa have participated in an international supplementary comparison on the calibration of caliper.This comparison was a part of larger supplementary comparison between 13 African countries for the calibration of hand measuring instruments. This larger comparison which was carried out during the period between December 2019 - December 2022 has been piloted by NIS, Egypt and has been registered in BIPM-KCDB database on December 2019. The artifacts have been prepared by NIS, Egypt and measured before sent to circulate between all participant countries in round-robin scheme and returned back again for NIS, Egypt where a final measurement was made for stability check.The main purpose of these comparisons is to support submission of CMCs for calibration of hand length measuring instruments in BIPM-KCDB.To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.The final report has been peer-reviewed and approved for publication by the CCL, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

AFRIMETS supplementary comparison on calibration of feeler gauges

Main textNational Metrology Institutes from 8 African countries, namely Egypt, Morocco, Nigeria, Tanzania, Zambia, Zimbabwe, Botswana, and South Africa have participated in an international supplementary comparison on the calibration of feeler gauges.This comparison was a part of larger supplementary comparison between 13 African countries for the calibration of hand measuring instruments. This larger comparison which was carried out during the period between December 2019 - December 2022 has been piloted by NIS, Egypt and has been registered in BIPM-KCDB database on December 2019. The artifacts have been prepared by NIS, Egypt and measured before sent to circulate between all participant countries in round-robin scheme and returned back again for NIS, Egypt where a final measurement was made for stability check.The main purpose of these comparisons is to support submission of CMCs for calibration of hand length measuring instruments in BIPM-KCDB.To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.The final report has been peer-reviewed and approved for publication by the CCL, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

AFRIMETS supplementary comparison on calibration of dial gauge

Main textNational Metrology Institutes from 11 African countries, namely Egypt, Morocco, Nigeria, Ethiopia, Kenya, Tanzania, Zambia, Zimbabwe, Botswana, Mauritius and South Africa have participated in an international supplementary comparison on the calibration of Dial Indicators.This comparison was a part of larger supplementary comparison between 13 African countries for the calibration of hand measuring instruments. This larger comparison which was carried out during the period between December 2019 - December 2022 has been piloted by NIS, Egypt and has been registered in BIPM-KCDB database on December 2019. The artifacts have been prepared by NIS, Egypt and measured before sent to circulate between all participant countries in round-robin scheme and returned back again for NIS, Egypt where a final measurement was made for stability check.The main purpose of these comparisons is to support submission of CMCs for calibration of hand length measuring instruments in BIPM-KCDB.To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.The final report has been peer-reviewed and approved for publication by the CCL, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

Assessing the Transparency of Methods in Scientific Reporting

Enhancing transparency in scientific reports is crucial to foster trust, facilitate reproducibility, and ensure the integrity of research, ultimately advancing the progress of knowledge and innovation. To devise strategies for enhancing transparency in scientific reports, the initial step is to assess the current state: to objectively measure the current level of transparency, identifying its shortcomings and associated factors, and to gauge improvements, for instance, following interventions. Here we present a new tool and a proof of concept to this endeavor. Using a checklist, we evaluated the methods transparency of a corpus of 180 papers published in 2011 and 2021 in five top-tier psychology journals. We specifically focused on the materials, procedures, and characteristics of population and sample. We summarized the level of transparency in the methods of each paper with the Transparency Of Methods (TOM) score. This score consists of the proportion of relevant information regarding the method that is available to the reader of a scientific report, either in the main text of the paper, or the appendixes, supplementary materials, and online open repository. It ranges from 0 (i.e., no transparency in the relevant aspects of the methods and materials) to 1 (i.e., the scientific report is fully transparent in all the relevant materials and methods). The results affirm TOM’s potential for assessing the transparency of scientific reporting and offer two snapshots of transparency in the methods of published papers, a decade apart. While they indicate progress has been made, there remains room for further enhancements and highlight specific areas that require attention. In conclusion, this work underscores the ongoing need for improvement in methods’ transparency and introduces a valuable tool, demonstrating its applicability as a means to evaluate the transparency of scientific reports.

AFRIMETS supplementary comparison on pin gauges

Main textNational Metrology Institutes from 6 African countries, namely Egypt, Nigeria, Zambia, Zimbabwe, Botswana, and Mauritius have participated in an international supplementary comparison on the calibration of pin gauges.This comparison was a part of larger supplementary comparison between 13 African countries for the calibration of hand measuring instruments. This larger comparison which was carried out during the period between December 2019 - December 2022 has been piloted by NIS, Egypt and has been registered in BIPM-KCDB database on December 2019. The artifacts have been prepared by NIS, Egypt and measured before sent to circulate between all participant countries in round-robin scheme and returned back again for NIS, Egypt where a final measurement is made for stability check.The main purpose of these comparisons is to support submission of CMCs for calibration of hand length measuring instruments in BIPM-KCDB.To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.The final report has been peer-reviewed and approved for publication by the CCL, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

AFRIMETS supplementary comparison on calibration of setting rods

Main textNational Metrology Institutes from 8 African countries, namely Egypt, Nigeria, Kenya, Tanzania, Zambia, Zimbabwe, Botswana, and Mauritius have participated in an international supplementary comparison on the calibration of setting rods.This comparison was a part of larger supplementary comparison between 13 African countries for the calibration of hand measuring instruments. This larger comparison which was carried out during the period between December 2019 - December 2022 has been piloted by NIS, Egypt and has been registered in BIPM-KCDB database on December 2019. The artifacts have been prepared by NIS, Egypt and measured before sent to circulate between all participant countries in round-robin scheme and returned back again for NIS, Egypt where a final measurement was made for stability check.The main purpose of these comparisons is to support submission of CMCs for calibration of hand length measuring instruments in BIPM-KCDB.To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.The final report has been peer-reviewed and approved for publication by the CCL, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

Report on key comparison AFRIMETS.AUV.V-K5 and linking to CCAUV.V-K5

Main textFollowing the completion of the fifth CIPM key comparison (KC) in the area of vibration concerning sinusoidal acceleration, participating Regional Metrology Organizations (RMOs) have the responsibility to disseminate the Key Comparison Reference Values (KCRV) to non-participating National Metrology Institutes (NMIs), thereby establishing a traceable link between NMIs participating in regional comparisons and the KCRVs. The comparison results reported here have that objective. The comparison was piloted by AFRIMETS with participants from three NMIs, situated in two RMOs, namely SIM and APMP.The respective Degrees of Equivalence, linked to the KCRVs, are reported. The final report has been peer-reviewed and approved for publication by the CCAUV, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.The final report has been peer-reviewed and approved for publication by the CCAUV, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

금연공익광고 ‘노담’시리즈에 대한 텍스트 언어학적 연구 -2020년 광고를 중심으로-

This study analyzes the linguistic characteristics of the 2020 anti-smoking public service advertisement series 'Nodam'. The 2020 Nodam advertisements consist of three stories. The first story comprises three independent texts in an interview format, but they are unified into a single text through a repeated ‘question-answer' structure and recurring slogans. The second story is a single text woven from the relay-style narratives of five individuals, with independent subtexts bound together by cohesive devices. The third story has a single text structure consisting of one main text and a slogan. In terms of meaning construction, the first and second stories expand the advertisement's meaning and reinforce its purpose by linking subtexts through the same message and cohesive devices. The third story addresses e-cigarettes and smoking students, broadening the target and scope of the anti-smoking message. Additionally, as the advertisements target teenagers, they use abbreviations, neologisms, trendy expressions, and loanwords to capture teenagers' interest and elicit their empathy and participation.

Research on McLuhan's Media Theory

McLuhan is a master of media theory in the 20th century, who put forward influential media theories such as "Global Village", "The medium is the message", "The medium is an extension of the human being. He put forward influential media theories such as "Global Village", "Media is Information", "Media is an Extension of Human", and so on. McLuhan's profound insights and interdisciplinary thinking have had a profound impact on contemporary communication and art theories, and have helped to understand the interaction between the media and human beings in modern society. This paper examines McLuhan's media theory and consists of three parts: an introduction, two main chapters and a conclusion. The introduction part mainly explains the origin of the selected topic, and clarifies the innovation of this paper's research as well as the research methodology. The first chapter of the main text part discusses the relationship between media and communication, and the division of hot and cold media in turn. The second chapter discusses the dialectical relationship between media and contemporary art and technology from the perspectives of epistemology of media technology and media aesthetics, which is of great practical significance for us to correctly understand the relationship between media technology and human beings and society. The conclusion part summarizes the inevitability of McLuhan's media theory ideas, and further composes and elaborates that McLuhan's media theory is somewhat innovative.

Research on McLuhan's Media Theory

McLuhan is a master of media theory in the 20th century, who put forward influential media theories such as "Global Village", "The medium is the message", "The medium is an extension of the human being. He put forward influential media theories such as "Global Village", "Media is Information", "Media is an Extension of Human", and so on. McLuhan's profound insights and interdisciplinary thinking have had a profound impact on contemporary communication and art theories, and have helped to understand the interaction between the media and human beings in modern society. This paper examines McLuhan's media theory and consists of three parts: an introduction, two main chapters and a conclusion. The introduction part mainly explains the origin of the selected topic, and clarifies the innovation of this paper's research as well as the research methodology. The first chapter of the main text part discusses the relationship between media and communication, and the division of hot and cold media in turn. The second chapter discusses the dialectical relationship between media and contemporary art and technology from the perspectives of epistemology of media technology and media aesthetics, which is of great practical significance for us to correctly understand the relationship between media technology and human beings and society. The conclusion part summarizes the inevitability of McLuhan's media theory ideas, and further composes and elaborates that McLuhan's media theory is somewhat innovative.

SCHOOL LIFE ADVISOR’S PROFILE AND CHARACTERISTICS IN THE GREEK EDUCATION SYSTEM

The School Life Advisors (SLA) in education are primarily tasked with resolving situations and behaviors that affect students in the school environment. The purpose of this work is to present the personal characteristics that a (SLA) must possess to deal with various cases of counseling approaches in education. This paper first describes the environment that prevails in schools and the usefulness of the teacher and the (SLA), while then reference is made to systematic consultation and the interaction between (SLA) and student. Then follows the main text of the work in which the individual personal characteristics of the (SLA) are described.&lt;p&gt; &lt;/p&gt;&lt;p&gt;&lt;strong&gt; Article visualizations:&lt;/strong&gt;&lt;/p&gt;&lt;p&gt;&lt;img src="/-counters-/soc/0745/a.php" alt="Hit counter" /&gt;&lt;/p&gt;

Non-Invasive 3D Breast Tumor Localization: A Viable Alternative to Invasive Tumor Marking.

Background: We present a detailed description and the preliminary results of our original technique for non-invasive three-dimensional tumor localization in the breast, which was created as an alternative to standard invasive tumor marking before neoadjuvant systemic therapy (NAST), aiming to enable adequate surgery after complete tumor regression. Methods: A detailed description of the technique is provided in the main text. The technique's feasibility and precision were assessed in a single-arm, prospective study based on the histological parameters of the adequacy and rationality of the excision of completely regressed tumor beds. Results: Out of 94 recruited patients, 15 (16%) were deemed unsuitable, mainly due to the tumors' inadequate ultrasound visibility. Among the 79 processed patients, 31 (39%) had complete clinical regression after NAST and were operated on using our technique. The histological parameters of surgical precision (signs of tumor regression: 24/31; microscopic cancer residues: 7/31) were verified in all excised specimens (100% precision). There were no positive margins in seven cases with microscopic residues, indicating our technique's capacity to enable oncologically safe post-NAST surgery. Conclusions: The proposed technique is feasible and satisfactorily accurate in determining the location of regressed tumors, thus representing an alternative to invasive tumor marking, especially in surgical centers lacking trained staff and equipment for invasive marking. The technique's limitations are mainly related to the inadequate ultrasound visibility of the tumor.

Real-world analysis of the underdiagnosis, clinical outcomes and associated burden of hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) in the United States

BackgroundThrombotic microangiopathy (TMA) associated with hematopoietic stem cell transplantation (HSCT-TMA) is a serious post-transplant complication. Diagnosis is difficult due to overlapping symptoms with other conditions and a lack of universally adopted diagnostic criteria.MethodsThis retrospective, observational study investigated HSCT-TMA incidence between July 2009–August 2020 using the TriNetX US Electronic Medical Record database. Patients who underwent autologous or allogeneic HSCT procedures and had conditioning agents were stratified as follows: confirmed TMA (≥1 hemolytic uremic syndrome (HUS)/TMA diagnosis code), suspected TMA [no HUS/TMA code but met modified published Cho (adult) or Jodele (pediatric) diagnostic criteria (further information in main text), and non-TMA (met neither criteria). Baseline demographics, clinical characteristics and outcomes, and all-cause unadjusted healthcare resource utilization (HCRU) within 12-months of HSCT, were assessed. Statistical comparisons were against the non-TMA cohort (p&amp;lt;0.05).ResultsThe study included 16,809 adults and 901 pediatrics. Of these, 125 adults (0.7%) and 30 pediatrics (3.3%) had confirmed TMA, 3029 (18.0%) adults and 94 (10.4%) pediatrics had suspected TMA; 13,655 (81.2%) adults and 777 (86.2%) pediatrics met non-TMA criteria. Confirmed and suspected TMA incidences were higher after allogeneic HSCT in adults. In pediatrics, confirmed TMA incidence was higher following autologous transplantation, and suspected TMA higher after allogeneic transplantation. Confirmed and suspected TMA patients had significantly higher Charlson Comorbidity Indexes pre-HSCT and more post-HSCT complications. In adults with confirmed and suspected TMA, mortality estimates within 12-months of HSCT were significantly higher compared to non-TMA patients, and numerically higher in pediatrics. All confirmed and suspected TMA patients had significantly more ER visits, inpatient stays and ICU admissions. HCRU within 12-months of HSCT was higher in all confirmed TMA patients; ≤0.1% of patients with suspected TMA, and 25.6–50.0% of patients with confirmed TMA, received complement inhibitors.ConclusionsOur results demonstrate that incidence of HSCT-TMA in the real world, as per billing codes, is low compared with historical literature. However, a proportion of suspected TMA cases, based on diagnosis criteria, share similarly poor outcomes and HCRU. HSCT-TMA is likely underdiagnosed, or under-coded, in real world practice. Our study highlights the need for greater vigilance to this severe complication.

Contribution of the “Professija” Publishing House to the pool of textbooks in the bibliography science

Textbook review: Korshunov O. P. Bibliography science : Textbook / O. P. Korshunov, N. K. Lelikova, T. F. Likhovid ; under the general editorship of N. K. Lelikova. 2nd edition, revised and expanded. St. Petersburg : Profession, 2023. 334 p. (The textbook for the bachelor’s degree course).The textbook continues the tradition of “Professija” Publishing House of publishing practical guides, reference and educational literature in bibliography. All the publications are in great demand, both among practitioners, the faculty and students. For example, the “The Bibliographer's Handbook” has gone through four editions. The textbook by I. G. Morgenstern for many years has been the main source of knowledge for the students in the context of the “General Bibliography Science” course. The peer-reviewed textbook by O.P. Korshunov, N.K. Lelikova and T.F. Likhovid is published in its second edition. The authors of the textbook present the material based on the system-activity, documentary, information and communication concept of the general theory of bibliography origins as introduced by O.P. Korshunov. The textbook consists of three sections: “Fundamentals of the theory of bibliographic information”, “Bibliographic activity – the central category of the theory of bibliography”, “Bibliography science – the science of bibliography”. The lists of recommended reading are provided at the end of each section. A Dictionary of Basic Terms is a valuable addition to the main text. The textbook material is significantly amended, as many new standards on bibliography were introduced and changes were made to the terminology, with the factual material updated.

Examining U.S. disparities in smoking among rural versus urban women of reproductive age: 2002–2019

ObjectiveThis study is part of a programmatic investigation of rural disparities in cigarette smoking examining disparities in smoking prevalence and for the first-time quit ratios among adult women of reproductive age (18–44 years), a highly vulnerable population due to risk for multigenerational adverse effects. MethodsData came from 18 years (2002–2019) of the U.S. National Survey on Drug Use and Health (NSDUH) among women (n = 280,626) categorized by rural-urban residence, pregnancy status, using weighted logistic regression models testing time trends and controlling for well-established sociodemographic predictors of smoking (race/ethnicity, education, income). Concerns regarding changes in survey methods used before 2002 and after 2019 precluded inclusion of earlier and more recent survey years in the present study. ResultsOverall smoking prevalence across years was greater in rural than urban residents (adjusted odds ratio [AOR] = 1.11; 95%CI, 1.07–1.15; P < .001) including those not-pregnant (AOR = 1.10; 1.07–1.14; P < .001) and pregnant (AOR = 1.29; 1.09–1.52; P < .001). Overall quit ratios across years were lower in rural than urban residents (AOR = 0.93; 0.87–0.99; P < .001) including those not-pregnant (AOR = 0.93; 0.88–1.00, P = .035) and pregnant (AOR = 0.78; 0.62–0.99; P = .039). Interactions of rural versus urban residence with study years for prevalence and quit ratios overall and by pregnancy status are detailed in the main text. ConclusionsThese results support a longstanding and robust rural disparity in smoking prevalence among women of reproductive age including those currently pregnant and provides novel evidence that differences in smoking cessation contribute to this disparity further underscoring a need for greater access to evidence-based tobacco control and regulatory interventions in rural regions.

La polémica sobre la existencia de una poesía antillana y la presencia del tema negro en la literatura puertorriqueña (1932-1933)

The objective of this article is to study the texts on the polemic generated between 1932 and 1933 about the existence of Antillean poetry and the presence of the black theme in Puerto Rican national literature. The main texts of the controversy have been analysed from the perspective of socio-critical theory to identify the social-historical themes addressed by the writers involved. This research has made it possible to establish a relationship between the debate that arose and the conception of the Puerto Rican national imaginary defended by its main participants: Luis Palés Matos and José I. de Diego Padró.

PROTECTION OF FAMILY PROPERTY AND INTERESTS OF CREDITORS

The article examines the monograph by A. V. Kopylov “Legates, fideicommissas and donations in case of death in Roman classical law” (M., Gorodets, 2021). It is noted that a monograph on the stated topic is a natural stage of the author’s research work. The monograph rst of all determines the place of these institutions in Roman civil law. At the same time, the connection between these institutions of inheritance law and the institutions of property law and, in general, their role in the circulation of things is shown. One of the main tasks that were solved through the use of legates and deicommissas was the transfer of rights to things in order to protect the interests of family members (heirs under a will). The author points out the genetic connection between institutions. A. V. Kopylov examined the historically rst forms of institutions (mainly legates and deicommissae), as well as their features that developed by the classical era, and, as necessary, comparisons with the subsequent era take place. In the nal section of the study, the author contains a brief historical outline of the development of the institutions discussed in the book. The review notes that the appendix to the main text contains an extensive list of author’s translations of fragments of the Corpus iuris civilis, the sixth book of the Justinian Code and Novellas, previously unknown to Russian readers. The main conclusions of the review can be reduced to the fact that the monograph by A. V. Kopylov is of great scienti c importance and is of interest both to novelists, philologists, historians, and to a wide range of students and graduate students.