The hybrid nanofluids can enhance cooling systems in microelectronics by enhancing heat dissipation from processes which makes them vital for maintaining optimal performance. They are also beneficial in solar systems where efficient heat transfer is essential for exploiting the energy detention. Thus, this study has studied the three-dimensional flow of a water-based hybrid nanofluid comprising of Fe3O4 and CuO nanoparticles on a bi-directional extending sheet. The bi-directional extending sheet is subjected to thermal convective and velocity slip conditions. In addition, the effects of heat source, magnetic field, thermal radiation, viscous dissipation, and Joule heating are employed. The partial differential equations (PDEs) that represent the mathematical model are subsequently converted to ordinary differential equations (ODEs) by applying the appropriate similarity variables. The shooting technique is incorporated to determine the computational solution of the converted ODEs. The effectiveness of the current study is confirmed by published results, which also validate the current outcomes. Based on the results, it is concluded that CuO and Fe3O4 solid nanoparticle volume fractions improved the thermal distribution while decreasing the velocity distributions along x and y-axes. The thermal distribution is improved by the thermal heat source, thermal radiation, thermal Biot number, and thermal Eckert numbers. CuO-water nanofluid has a higher velocity panel than CuO-Fe3O4/water hybrid nanofluid. Conversely, the CuO-Fe3O4/water hybrid nanofluid has a higher thermal profile than the CuO-water nanofluid. CuO-water nanofluid flow has higher surface drags than CuO-Fe3O4/water hybrid nanofluid flow. CuO-water nanofluid has a lower heat transfer rate than CuO-Fe3O4/water hybrid nanofluid.
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