AbstractThis article analyzes the impact of conjugated dissipative radiative heat transfer with heat source/sink, thermal slip, and the transverse magnetic field on the behavior of the magnetohydrodynamic (MHD) peristaltic thrust containing ferromagnetic gold nanoparticles (AuNPs) with different shape factors through the non‐Newtionian blood flow within compliant walls tube. Entropy generation (EG) plays a prominent role in all aspects connected to thermodynamics and heat transfer aiding in the identification and reduction of system irreversibilities. The sources of irreversibility stem from dissipative friction inherent in fluid flow, the presence of a magnetic field, and the heat transfer process. The ferromagnetic gold nanoparticles (AuNPs) exhibit diverse shapes (bricks, cylinders, and platelets) and possess both magnetic and thermal attributes thereby enhancing the efficiency of heat transfer process. The peristaltic thrust drives the dynamic behavior of the gold blood nanofluid through a compliant tube. The tube walls are flexible and exhibit a curvature effects that can alter the dynamics of fluid flow. The effective Hamilton‐Crosser model is selected to express the thermal conductivity of the nanofluid. Gold blood nanofluids can be treated as incompressible, non‐Newtonian, and MHD fluid flow. The governing equations of the system are solved using the perturbation approach under the assumptions of low Reynolds numbers and long wavelength. Hybrid interactions of magnetic field, radiative heating, thermal slip, elastic wall properties, and gold nanoparticles shapes and concentrations are investigated within the gold blood nanofluid flow. The resulting graphs include the profiles of velocity, temperature distributions, EG, and irreversibility parameters under the influence of the above parameters. The findings reveal that the overall EG rises with increasing values of heat source intensity, Brinkman number, temperature difference factor, compliant wall curvature coefficient, and gold nanoparticles concentrations. Additionally, it is observed that an increase in magnetic flux strength results in the emergence of reversal flow patterns near the walls. This arises due to the augmented magnetic flux obstructing the peristaltic nanofluid flow leading to reduce streamwise velocity. Moreover, heightened magnetic flux strength causes temperature reduction for both thermal slip and non‐slip conditions. Generally, the presence of a thermal slipping parameter further enhances the distribution of temperature. In essence, the rationale and significance of this study primarily revolve around comprehending the interplay of these diverse factors with MHD peristaltic motion of gold blood nanofluid and EG. This not only furthers our theoretical understanding of complex systems but also has practical implications that can improve new technologies, processes, and medical applications. For example, in medical treatments like photothermal therapy (PPT), insights gained from this research can help in developing more effective and precise treatment methods. By understanding the impact of these factors on EG, new ways can be identified to minimize or manage system inefficiencies leading to more sustainable and optimized treatment processes. This research holds promise for application in cancer detection and treatment by employing a combination of PPT and magnetic hyperthermia. This entails dispersing AuNPs into the blood circulation through arteries and blood vessels and subsequently applying photothermal radiation and a magnetic field.