The phenomena of heat and mass transfer during the flow of non-Newtonian transfer are amongst the core subjects in mechanical sciences. Recently, the nanomaterials are among the eminent tools for improving the low thermal conductivity of working fluids. Therefore, in view of the existing contributions, this article presents a two-dimensional numerical simulation for the transient flow of a non-Newtonian nanofluid generated by an expanding/contracting circular cylinder. This critical review further explores the impacts of variable magnetic field, thermal radiation, velocity slip and convective boundary conditions. The basic governing equations for Williamson fluid flow are formulated with the assistance of boundary layer approximations. The non-dimensional form of partially coupled ordinary differential equations has been tackled numerically by utilizing versatile Runge–Kutta integration scheme. The momentum, thermal and concentration characteristics are investigated with respect to several critical parameters, like, Weissenberg number, unsteadiness parameter, viscosity ratio parameter, slip parameter, suction parameter, magnetic parameter, thermophoresis parameter, Brownian motion parameter, Prandtl number, Lewis number and Biot number. The outcomes of the systematic reviews of these parameters and forest plots are illustrated. The study reveals that multiple solutions for the considered problem occurs for diverse values of involved physical parameters. The computed results indicate that the friction and heat transfer coefficients are significantly raised by the magnetic parameter for upper branch solutions.