This paper investigates the profound impact of entropy generation and activation energy on the dynamics of hydromagnetic nanofluids, focusing on nonlinear thermal radiation, viscous and Ohmic dissipation, and Hall current effects over a linear stretching sheet. Various nanoparticles are incorporated into the nanofluid formulation using the thermophoresis and Brownian motion model. Through similarity transformation, the system of nonlinear equations is solved with high precision using the Spectral Quasilinearization Method (SQLM). Comprehensive analyses of velocity, cross-flow velocity, temperature, concentration, and entropy generation profiles are conducted for numerous physical parameters. Results indicate that velocity and cross-flow velocity increase with the Hall parameter while temperature and concentration profiles decrease. Both the velocity and cross-flow velocity profiles enhance for mixed convection parameters closer to the sheet, whereas the temperature and concentration profiles exhibit the contrary tendency. Prandtl number diminishes the profiles of horizontal velocity, cross-flow velocity and concentration distributions. Temperature distribution profile hikes for both the Brownian motion parameter and thermophoresis parameter. The activation energy parameter enhances the cross-flow velocity, with a corresponding decline in temperature distribution and a similar trend is observed in the concentration profile. Further, entropy generation profiles increase with higher Brinkman and Reynolds numbers while exhibiting mixed tendencies with the Schmidt number. These findings reveal that Hall current introduces complex interactions within the nanofluid flow, significantly influencing thermal, concentration, and entropy generation characteristics, particularly in magnetic fields and activation energy.