Magnesium Stearate Research Articles

Behaviour of magnesium stearate at particle–particle interfaces: Microdynamic flowability to monitor distribution in powders

Monitoring magnesium stearate (MgSt) surface coverage remains a challenge in powders. Microdynamic flowability is proposed to better understand the nature of these films and how formulation and process variability affect the final product. The method examined small-scale particulate solids in motion and related behaviour at the particle–particle interfaces under varying shear conditions. The study correlated the lubricant-free area of powder particles with the effective bonding area during compaction. On the particle surface, shear microdynamics characterized the dynamic friction between particles. This described for the first time the extent of the lubricant coverage in powders, which was also related to the magnitude of the shear forces during blending and amount of MgSt. In addition, compression studies described the stress applied to tablets and processing equipment. The combination of knowledge gained on a laboratory scale determined the critical process parameter ranges and control points between under- and overlubrication.

Role of dispersion enhancer selection in the development of novel tratinterol hydrochloride dry powder inhalation formulations

Tratinterol hydrochloride (TH) is a new long-acting bronchodilator with strong β2 adrenoceptor stimulation activity. The aim of this study was to design a new carrier-based dry powder inhalation (DPI) formulation for TH and to investigate the effect of dispersion enhancers on the aerosol performance of TH in vitro. To this end, coarse lactose was used as a carrier. TH was micronized by using a jet mill and blended with the carrier to obtain a reference DPI formulation. Commercial magnesium stearate (MgSt) as received, micronized MgSt (MgSt-M), and fine lactose (FL) were used as the dispersion enhancers and formulated with the micronized TH (TH-M) and the carrier as DPI formulations. The obtained DPI formulations were characterized using dynamic light scattering (DLS), X-ray powder diffraction (XRPD), thermal analysis, powder rheometer, and Raman microscopy. A next generation pharmaceutical impactor (NGI) was used to evaluate the aerodynamic performance of the dry powders. The results showed that TH-M was in an inhalable particle size range, and based on the XRPD and thermal analysis, the solid form of TH-M did not change compared to the starting materials. The NGI results showed that the fine particle fraction (FPF) of TH could be increased with the addition of MgSt and FL as dispersion enhancers in the reference formulation. In addition, the FPF of TH could be increased with a decrease in the particle size of MgSt or an increase in the amount of FL. A combination of MgSt-M and FL could further improve the aerosol performance of TH. Raman spectroscopic imaging confirmed the spatial location of MgSt and TH at the surface of the carrier. This study demonstrates that TH could be formulated into carrier-based dry powder formulation for inhalation using coarse lactose as the carrier. The dual strategy based on using both MgSt and FL as dispersion enhancers improved the aerosol performance of a novel TH dry powder formulation.

Evaluation of the Binding Property of Irvingia Gabonesis Gum in Paracetamol Tablet Formulations Produced using Two Different Disintegrants

Paracetamol is mainly used as analgesic and antipyretic drug. This study was conducted to evaluate the binding property of Irvingia gabonensis gum (IGG) in paracetamol tablet formulations in the presence of either maize starch or microcrystalline cellulose as disintegrant. IGG was isolated by acetone precipitation of the filtrate from the maceration of the powdered seeds of Irvingia gabonensis (Irvingiaceae) in distilled water for 24 h. Paracetamol granules were prepared using the wet granulation method. They were produced by using various concentration of IGG as binder, maize starch or microcrystalline cellulose as disintegrants and lactose as filler. The different formulations of paracetamol granules were mixed with magnesium stearate and talc and compressed into the respective tablets. The tablets were evaluated based on uniformity of weight, tablet hardness, friability, disintegration time and in vitro drug release. The tablet hardness for the paracetamol tablet formulations ranged from 2.27±0.09 to 8.00±0.54 Kgf. The friability values ranged from 0.21 ± 0.04 to 3.40±0.10%. The disintegration time ranged from 3.00±0.10 to 23±0.50 min. Tablets from all the formulations released up to 70% of their paracetamol contents within 25 min. For all the formulations, as the binder concentration increased the rate of drug release decreased. For tablets prepared using IGG as binder; formulations that contain microcrystalline cellulose as disintegrant had better release profile than those prepared using maize starch as disintegrant. The study shows that IGG have good binding property. Paracetamol tablets formulated using IGG as binder have comparable hardness value but lower disintegration time than those formulated using maize starch mucilage as binder.

Formation of Dispersible Taohong Siwu Tablets.

Here, we optimize the process used to formulate and prepare dispersible Taohong Siwu tablets and provide a foundation for expanding their clinical application. Taking dispersion uniformity and disintegration time as the indices for investigation, we used a single-factor test to match and filter the excipient categories for Taohong Siwu tablets. The formulation was optimized by an orthogonal test design. The content and dissolution rates of the effective substances in dispersible Taohong Siwu tablets when prepared with optimized prescriptions were determined by ultra-high performance liquid chromatography (UPLC), and the optimal preparation process was determined. The optimal composition for dispersible Taohong Siwu tablets was 17% Taohong Siwu extract powder, 1% magnesium stearate, 49% microcrystalline cellulose, 20% cross-linked polyvinylpyrrolidone, and 13% sodium carboxymethyl starch. When dispersible Taohong Siwu tablets were prepared by direct compression and the optimized prescription powder was uniformly dispersed within 3 min, the dissolution rate reached more than 90% within 50 min.When prepared according to the optimized methods,dispersible Taohong Siwu tablets disintegrate rapidly in water with good dispersion uniformity and controllable quality.

Development Optimization and Evaluation of Fast Disintegrating Tablets of Antiepileptic Drug Carbamazepine

Background: The main objective of present research work is to formulate the Carbamazepine as Fast Disintegrating tablets to give fast relief and an increase in the patient compliance. Carbamazepine, an antiepileptic, belongs to BCS Class-II and used to control some types of seizures in the treatment of epilepsy and Neuropathic Pain by blocking use-dependent sodium channels.
 Methods: The powdered materials were compressed by direct compression technique using super disintegrants like sodium starch glycollate, croscarmellose sodium and starch, Magnesium Stearate and Di Calcium Phosphate are used as lubricant and diluents/fillers respectively.
 Result and Discussion: Totally nine formulations were designed and are evaluated for hardness, friability, thickness, assay, wetting time, Disintegration time, in-vitro drug release. From the Results concluded that all the formulation were found to be with in the Pharmacopeial limits and the In-vitro dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like intercept (a), slope (b) & regression coefficient (r) were calculated. The optimized formulation was characterized with the help of Differential Scanning Calorimetry (DSC), and Fourier Transform Infrared Spectroscopy (FTIR) studies show no interaction between the drug and the excipients. The stability study was conducted as per the ICH guidelines and the formulations were found to be stable, with insignificant changes in hardness, drug content and disintegration time.
 Conclusion: These results revealed that fast disintegrating tablets of the poorly soluble drug, carbamazepine, showing enhanced dissolution and, hence, better patient compliance.

Effects of propolis on inflammation markers in patients undergoing hemodialysis: A randomized, double-blind controlled clinical trial

Background and aimsSeveral studies have been performed in vitro and in animals showing that propolis (a resin made by bees) has excellent anti-inflammatory properties, but no study has been performed in patients with chronic kidney disease (CKD) on hemodialysis (HD). The present study aimed to evaluate the effects of propolis supplementation on inflammatory markers in patients with CKD on HD. MethodsThis is a longitudinal, double-blind, placebo-controlled trial with patients randomized into two groups: propolis (4 capsules of 100 mg/day containing concentrated and standardized dry EPP-AF® green propolis extract) or placebo (4 capsules of 100 mg/day containing microcrystalline cellulose, magnesium stearate and colloidal silicon dioxide) for two months. Routine parameters were analyzed using commercial kits. The plasma levels of inflammatory cytokines were evaluated by flow luminometry. ResultsForty-one patients completed the follow-up, 21 patients in the propolis group (45 ± 12 years, 13 women, BMI, 22.8 ± 3.7 kg/m2) and 20 in the placebo group (45.5 ± 14 years, 13 women, BMI, 24.8 ± 6.8 kg/m2). The obtained data revealed that the intervention with propolis significantly reduced the serum levels of tumour necrosis factor α (TNFα) (p = 0.009) as well as had the tendency to reduce the levels of macrophage inflammatory protein-1β (MIP-1β) (p = 0.07). There were no significant differences in the placebo group. ConclusionShort-term EPP-AF® propolis dry extract 400 mg/day supplementation seems to mitigate inflammation, reducing the plasma levels of TNFα and MIP-1β in patients with CKD on HD. This study was registered at clinicaltrials.gov (NCT04411758).

Formulation study of duloxetine hydrochloride enteric-coated tablets

During storage, duloxetine hydrochloride may have an unexpected cross reaction with enteric coated acrylic resin, which may affect the product quality. Solve the problem of cross-reaction between the Duloxetine enteric-coated tablets core and coated enteric materials and improve the quality of the products. Duloxetine enteric-coated tablets’ core formulation and isolation layer prescription were designed and compared with duloxetine enteric-coated tablets sold on the market. Then, we measured the dissolution rate, content, and releasing rate of prepared duloxetine enteric-coated tablets. In the formulation of tablets core, prescription 3 had advantages in particle mobility, disintegration time, and dissolution rate. Prescription 5 was stable during the coating process, and the dissolution residue in the cup was relatively good, showing obvious dissolution advantages. Thus, prescription 5 was selected as the isolation layer prescription. The most suitable adhesive for the preparation of Duloxetine hydrochloride enteric-coated tablets was povione K30 dissolved in ethanol solution with 1/2 of the prescription amount. When 1.3 g colloidal silica was added to the prescription and the dosage of magnesium stearate was 1.48 g, the dissolution rate of the drug could be relatively improved. The ratio of sucrose and talc was 138/8.7, which could effectively configure the coating solution with a solid content of 15–20% to make the coating smooth.

Mannitol Is a Good Anticaking Agent for Spray-Dried Hydroxypropyl-Beta-Cyclodextrin Microcapsules.

Agglomeration is an undesirable phenomenon that often occurs in spray-dried microcapsules powder. The objective of this work is to determine the best solution for spray-dried hydroxypropyl-β-cyclodextrin (HP-β-CD) microcapsules from four anticaking agents, namely calcium stearate (CaSt), magnesium stearate (MgSt), silicon dioxide (SiO2), and mannitol (MAN), and to explore their anticaking mechanisms. Our results showed that MAN was found to be the superior anticaking agent among those tested. When the MAN ratio is 12%, the microcapsules with a special Xanthium-type shape had higher powder flowability and lower hygroscopicity and exhibited good anticaking properties. Mechanism research revealed that CaSt, MgSt, and SiO2 reduce hygroscopicity and caking by increasing the glass transition temperature of the microcapsules, while MAN prevents the hydroxyl group of HP-β-CD from combining with water molecules in the air by a crystal outer-layer on the microcapsule surface.

Upscaling of external lubrication from a compaction simulator to a rotary tablet press

External lubrication is a highly valuable alternative lubrication method as it minimizes the negative impact on tablet properties encountered when using internal lubrication. In current study, experiments were performed with automated external lubrication systems implemented in a compaction simulator and rotary tablet press using three lubricants (magnesium stearate (MgSt), sodium stearyl fumarate (SSF) and glyceryl dibehenate (DBHG)). The effect of process parameters related to the tableting process (main compaction pressure and tableting speed) and external lubrication systems (spraying time, atomizing pressure, dust extraction system and lubricant feed rate) on the responses was studied for a placebo formulation which is non-processable without lubrication. Low and comparable ejection forces were recorded for all lubricants on both tablet presses. No negative effect on tensile strength was observed for process parameters of both external lubrication systems, irrespective of lubricant type. Disintegration times were slightly higher for SSF compared to MgSt and DBHG for the tablets produced on the rotary tablet press, linked to higher lubricant concentrations on the tablets for SSF, while disintegration times were similar for all lubricant types on the compaction simulator. The potential of external lubrication for implementation on production scale tableting equipment and during scale-up was demonstrated for multiple lubricants.

Analytical Study on the Components of Health Products for Lowering Blood Glucose

Apriori algorithm was used to analyze 480 hypoglycemic health products for component association. Meanwhile, plain Bayesian algorithm was used to analyze the properties and flavors according to the Chinese Pharmacopoeia on the former basis. The results showed that chromium pyridinecarboxylate, magnesium stearate and Astragalus single ingredient played an important role on lowering blood glucose. The extracts of huangjing and mulberry leaf as well as coix seed and Chinese yam were highly correlated in the hypoglycemic health products. the The ingredients of health products used to lower blood glucose are mainly pungent, warm and bitter medicines. This paper, can contribute to the research and application of health products and regulate the health products market according to the analysis of the valid ingredients of health products.

Modafinil-excipient compatibility study using differential scanning calorimetry.

Drug excipient compatibility studies are considered important in successful formulation of drug products. Suggested methods for this purpose are thermal techniques under isothermal or nonisothermal conditions. In this study, modafinil, a wakefulness-promoting drug, was investigated under nonisothermal conditions using differential scanning calorimetry. Four different heating rates, 5, 10, 15, and 20°C/min, were performed for modafinil pure material and its physical mixtures with magnesium stearate (MgSt) or Gelucire 48/16. Activation energy (Ea) was calculated from the straight line of plotting a function of heating rate versus temperature and found that modafinil-Gelucire physical mixture increased Ea. This indicates drug-excipient interaction, supported by evidence from Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy. No significant interaction was detected with MgSt.

Synthesis of Over-Based Magnesium Stearate Using Magnesium Oxide Nanoparticles and Evaluation as Multifunction Lubricating Oil Additives

The use of multifunction additives in the lubricant sector has attracted great interest due to their ability to simultaneously improve and add multiple functions. This work describes the preparation and evaluation of over-based magnesium stearate detergent as a multifunction additive by the reaction of stearic acid with carbon dioxide gas in the presence of magnesium oxide nanoparticles and ammonia. The prepared over-based magnesium stearate was evaluated as a multifunction additive through blending it in various concentrations of 1-5 wt/wt% with sixty stock lubricating oils. The American Society for Testing and Materials (ASTM) and the Institute of Petroleum (IP) were used to determine the total base number (TBN), viscosity index (VI), pour point (PP), rust prevention, copper corrosion inhibition, and oxidation stability. The over-based magnesium stearate detergent gave higher values for TBN and detergency efficiency. The blended oil with one percent of the prepared additive showed more rust, oxidation, and corrosion resistance than the standard antioxidant (hindered phenol HP). The VI values of the blended oils showed that the 5 wt/wt% over-based magnesium stearate, which has approximately the same VI values as the blend with 5% of the standard olefin copolymer (OCP), provides better performance.

Screening of lubricants towards their applicability for external lubrication

Internal lubrication is associated with decreasing tensile strength and prolonged disintegration. These effects can be minimized using external lubrication. In current study, six lubricants (magnesium stearate, sodium stearyl fumarate, stearic acid, glyceryl dibehenate, poloxamer 188 and sucrose monopalmitate) were processed with an external lubrication system implemented in a compaction simulator. The effect of process parameters related to the tableting process (main compaction pressure and tableting speed) and external lubrication system (spraying time, atomizing pressure and dust extraction system) on the responses was studied for a placebo formulation (80% mannitol – 20% microcrystalline cellulose). Internally lubricated blends (0.75 – 4%) were processed as reference. All lubricants proved successful in reducing ejection forces through external lubrication while yielding substantially lower lubricant concentrations compared to internal lubrication. No negative effect of external lubrication on tensile strength and disintegration time was observed, irrespective of lubricant type. Similar tensile strengths and disintegration times were measured for the different lubricants. This was in contrast to internal lubrication where a decrease in tensile strength and prolonged disintegration was generally observed. Additionally, the lubricant types affected tensile strength and disintegration differently. This study demonstrates the versatility of external lubrication as an alternative lubrication method for production of pharmaceutical tablets.

Formulation and Evaluation of Moisture Protective Tablet Compression Coat Using Natural Polymers

This study aims to formulate and evaluate moisture protective coat for tablets using natural polymers of Fenugreek seeds and okra fruits in different concentrations compared with synthetic moisture protective coat. Ethanolic extracts of fenugreek and okra were treated with acetone as solvent for isolation of the mucilage, which is then dried and powders obtained identified and tested for polysaccharides using Molisch's reagent, Barofoead, KOH, Fehling reagent. The physicochemical tests including pH, viscosity, moisture content, percentage yield and swelling index were also carried out. Two formulations of 150 mg Silica gel tablets weighing 300mg and 500mg using PVP, magnesium stearate and Microcrystalline cellulose (MCC) as excipients were prepared and the powder mixture of flow ability was evaluated by measuring Carr's index, Hausener ratio and Angle of repose. The compressed tablets were evaluated according to USP monograph by testing the physical test of both tablets. Two coating materials were prepared and evaluated using natural polymers in different concentration 5%w/w and 10%w/w. The coated tablets with natural and synthetic polymers were compared by observing weight and moisture change of tablets pre and after stability study for 2 weeks in stress conditions at temperature (500 C) and RH 75 %. All the identification tests were positive indicating the presence of polysaccharides. Also, the physicochemical parameters tested were within the acceptable limits. Both fenugreek and okra mucilage's as polymers in low concentration 5%w/w revealed much better results regardless of weight of tablets. Coat defects were observed in tablets coated with 10%w/w of the polymers. The standard film coating polymer showed better moisture protection as moisture content about 4%. coating materials were successfully prepared and evaluated as moisture protective coat of silica gel tablets. Optimum coating formulations were found at 5%w/w concentration for mucilage's of both fenugreek and okra.

Formulation and Optimization of Stable Aspirin 100mg Tablets

Several moisture and temperature-sensitive medicines cannot be manufactured in Sudan due to extreme climatic conditions. Keeping these factors under control during production is difficult task. It is possible to overcome these difficulties by using excipients and utilizing technology in the production of the drug. This study aimed to adjust and improve the formulation of aspirin using different excipients and different technological approaches to produce stable aspirin tablets. Microcrystalline cellulose and lactose were used as fillers and stearic acid as a lubricant, four aspirin formulations, two formulations containing lactose and two formulations containing microcrystalline cellulose were prepared for aspirin 100 mg. For each formulation, wet granulation and direct compression techniques were applied separately, to study the effect of manufacturing technology and the role of excipients on the stability of the product. Prepared tablets were subjected to various quality control tests. Lactose had lower moisture content than MCC. But MCC has moisture scavenger characteristic. Direct-compression CDs with MCC shows less degradation than other tablet formulations. Addition of stearic acid as a substitute for magnesium stearate (a lubricant) changes the overall pH to more acidic which reduces hydrolysis.

UJI FISIK FORMULASI TABLET FLOATING TEOFILIN DENGAN MATRIK HPMC

The purpose of this study was to determine the physical properties of theophylline floating tablet formulation with HPMC as matrix. Floating tablets of theophylline is manufactured by direct compression. Composition per tablet formulation consisting of theophylline 270 mg, HPMC, avicel, magnesium stearate, and sodium bicarbonate. The results of data showed average of tablet weight uniformity 501mg, tablet hardness 6,99 kg, tablet friability 0,593%, disintegration time of tablets 738 seconds, floating lag time (FLT) 584,3 seconds and floating duration time (FDT) more than 8 hours. Floating tablet formulation of theophylline resulted in a good physical test.

Production of effervescent tablet from jambolan (Syzygium cumini L.) fruit

Jambolan (Syzygium cumini L.) fruit contained numerous phytochemical and bioactive constituents beneficial for human health. However, this underutilized fruit was highly susceptible to quality degradation after harvesting. Due to the seasonality and perishability of the jambolan fruit, it’s very necessary to convert this valuable fruit into instant, stable and convenient form for long-term consumption. This research was conducted at STNanotech laboratory in 2021 to evaluate the exploitation of jambolan fruit for juice extraction, spray drying and effervescent tablet production. Different variables of spray drying conditions such as proportion of wall material (maltodextrin 8-16%), inlet/outlet drying temperature (150/80, 160/85, 170/90, 180/95, 190/100 oC/oC), feed flow rate (7.5-17.5 ml/min) were deeply investigated on physicochemical and antioxidant properties of spray-dried jambolan powder (SDJP). In preparation of effervescent tablet, the spray-dried jambolan powder (SDJP) was mixed with sodium bicarbonate (SB) and magnesium stearate (MS) in five different formulas: F1 (65/10/25), F2 (65/5/30), F3 (70/10/20), F4 (65/15/20), F5 (70/15/15). Results showed that jambolan extract should be spray-dried with maltodextrin 14% as wall material (WM), inlet/outlet drying temperature 170/90 oC/oC, feed flow rate (FFR) 12.5 ml/min to obtain the optimal particle size 7.94±0.05 µm, solubility 96.80±0.02%, yield 56.71±0.01%, microencapsulation efficiency (ME) 93.25±0.05%, total phenolic content (TPC) 298.45±0.79 mg GAE/100 g, anthocyanin content (AC) 76.59±0.06 mg/100 g, and antioxidant activity (AA) 85.63±0.04%. The jambolan effervescent tablet produced by formula F2 (65/5/30) achieved the optimal hardness 47.24±0.05 N, disintegration time (DT) 271.05±2.03 s, TPC 201.03±1.28 mg GAE/100 g, AC 40.89±0.30 mg/100 g, AA 73.12±0.24% and overall acceptance (OA) 8.81±0.05. Jambolan fruit could be utilized to produce spray-dried powder and its effervescent tablet as a versatile functional food with excellent physicochemical, antioxidant and sensorial characteristics under safe and convenient way for all year round.

Microcrystalline cellulose promotes superior direct compressed Boesenbergia rotunda (L.) Mansf. extract tablet properties to spray-dried rice starch and spray-dried lactose

This work aimed to select tablet diluent of Boesenbergia rotunda (L.) Mansf. extract tablet. Three tablet diluents, including microcrystalline cellulose (MCC), spray-dried rice starch, and spray-dried lactose were used. MCC exhibited superior performance to the other diluents by providing the hardest tablet, the lowest friability, and the shortest disintegration time. The Box-Behnken design was used to evaluate the effect of hydrophobic excipients when MCC was used as diluent. The optimal formulation was composed of fumed silica 1%, magnesium stearate 1%, and talcum 2%. The tablets had suitable hardness, low friability, and short disintegration time. The marker pinocembrin could be dissolved by 82% within 4 h. Although the marker decreased after three months of stability testing, the antioxidant activity of the formulation remained. In conclusion, MCC was shown to be superior to the other diluents, and the optimal formulation could be used to prepare Boesenbergia rotunda (L.) Mansf. extract tablet as a food supplement.

Development, Evaluation and in vitro Release Kinetics Study of Immediate Release Tablets of Quercetin Isolated from Bauhinia acuminata Leaves Extract

Objective: To isolate quercetin, a flavonoid, from leaves extract of Bauhinia acuminata and to formulate and evaluate immediate release tablets of this quercetin employing direct compression method. Methods: Quercetin was isolated by column chromatography and characterized by FTIR, 1H and 13C NMR. Next different formulation blends were prepared using the isolated quercetin with microcrystalline cellulose, magnesium stearate and sodium starch glycolate. Pre-compression studies were performed and tablets were prepared by direct compression method. Tablets were evaluated for various post formulation parameters including disintegration and in vitro dissolution. Release kinetics and release mechanism were also studied from different kinetics plots. Finding : The pre-compression parameters were within the range of hardness (3.37  0.058 to 3.78  0.058 kg/cm2), weight variation (251.25  5.38 to 251.45  5.66 mg), friability (<1%), Drug content (98.17  0.86 to 98.20  0.99 %), disintegration (187.17  2.48 to 126.5  2.26 sec) and in vitro dissolution study (85.33  0.95 % and 86.47  0.70 %) within 30 minutes and 96.84 % and 98.19 % ) within 1 hr respectively for F2 and F3. Novelty: Only few scientific reports are present for Bauhinia acuminata and majority of them are related to pharmacological properties of the extract from the plant only. Here in this study quercetin was isolated for the very first time from Bauhinia acuminata to the best of our knowledge and not only this, the isolated quercetin was formulated to immediate release tablet which is again being reported from this plant for the first time. Keywords: Bauhinia acuminata; Immediate Release Tablet; Quercetin; Super Disintegrating Agents; Release Kinetics

Role of Aminated Derivatives of Natural Gum in Release Modulating Matrix System of Losartan Potassium

Objective: The investigation aimed to synthesize amino derivatives of various natural gums like Xanthan gum and Tamarind gum for using them as a release modulating polymer in the formulation of the hydrophilic matrix system of losartan potassium and to find the best amongst them. Developing oral sustained release matrix tablets for a drug with a constant release rate has always been a challenge to the pharmaceutical technologist. &#x0D; Materials and Methods: Release modulating hydrophilic matrix tablets of losartan potassium were prepared by wet granulation method. A total number of 6 formulations of release modulating hydrophilic matrix tablets of losartan potassium were prepared using different polymeric ratios of Carbopol 934, aminated Tamarind gum and aminated Xanthan gum based on preliminary trial bathes. The formulated tablets were evaluated for both pre-compression and post-compression evaluation studies. &#x0D; Results: Based on in vitro drug release study the effective formulations AXG 3 are shows a maximum similar release profile to other remains formulations with a theoretical drug release profile of losartan potassium for sustained release. Finally optimized formulation AXG 3 containing carbopol 934 (60 mg), aminated xanthan gum (40 mg), MCC (190 mg) and magnesium stearate (10 mg) showed 100±0.024 % drug release in 12 hr which is acceptable with theoretical drug release of losartan potassium for sustain release dose. Conclusion: Aminated derivatives of xanthan gum and Tamarind gum extend the drug release for 12 hr. Based on in vitro drug release studies of formulations, we concluded that the alteration in the concentration of carbopol 934 with an aminated derivative of xanthan gum in sustain release formulation development was more effective and economical.