Magnesium Absorption Research Articles

Assessment of Irrigation Quality of Disposal Water of Ashuganj-Polash Agro-Irrigation Project, Brahmanbaria Bangladesh

The study was conducted at Ashuganj-Polash agro-irrigation project (APAIP), Brahmanbaria,aim to determine the chemical properties of power plant disposal water and to assess its suitability for irrigation. Initial soil samples (before irrigating crop field) and final soil samples (after crop harvesting) were collected. During irrigation ten water samples (six from crop field and four from irrigation canals) were collected for analysis. All soil samples were analyzed in Humboldt soil testing laboratory and water samples in bio-chemistry laboratory of Bangladesh Agricultural University and compared to FAO irrigation standard. Results show thatthe sodium absorption ratio (SAR) (0.53 to 0.88), residual sodium bi-carbonate (0.8 to 1.3meq L-1), Kelly’s ratio (0.31 to 0.6) and total hardness (85 to 150) found in normal range and largely suitable for irrigation. Soluble sodium percentage values found in satisfactory (20.26 to 41.1) level and magnesium absorption (57.1 to 76.4) found unsuitable for irrigation. Statistically similar value of pH, EC, total nitrogen, organic carbon, calcium, magnesium and phosphorus in initial and final soil sample were observed. But potassium and sulfur value reduced in final soil sample from initial soil. The water samples fall within the permissible limit and found suitable for crop production

Myth or Reality-Transdermal Magnesium?

In the following review, we evaluated the current literature and evidence-based data on transdermal magnesium application and show that the propagation of transdermal magnesium is scientifically unsupported. The importance of magnesium and the positive effects of magnesium supplementation are extensively documented in magnesium deficiency, e.g., cardiovascular disease and diabetes mellitus. The effectiveness of oral magnesium supplementation for the treatment of magnesium deficiency has been studied in detail. However, the proven and well-documented oral magnesium supplementation has become questioned in the recent years through intensive marketing for its transdermal application (e.g., magnesium-containing sprays, magnesium flakes, and magnesium salt baths). In both, specialist and lay press as well as on the internet, there are increasing numbers of articles claiming the effectiveness and superiority of transdermal magnesium over an oral application. It is claimed that the transdermal absorption of magnesium in comparison to oral application is more effective due to better absorption and fewer side effects as it bypasses the gastrointestinal tract.

System impacts of introducing crop grazing into pasture-based systems: the McClymont Memorial Lecture

The present paper briefly discusses the impacts of introducing dual-purpose (DP) crops as a grazing resource into what were previously pasture-only grazing systems. The emphasis is on the high-value crops wheat and canola, since these have the greatest potential to increase profits by providing both winter grazing and a high-value grain or seed crop at harvest. A major potential impact of grazing on such crops is that the reduction in grain yield caused by grazing offsets the value of the grazing obtained. The paper shows that this is not the case and that if crop grazing is performed correctly, there will be minimal impact on grain or seed yield; yield may even be increased. ‘Correctly’ in this context refers mainly to the timely removal of livestock from the crop. Increases in grain yield after grazing arise principally from the conservation of soil water from the winter period through to the grain-ripening stage. The paper emphasises that although the digestibility and crude protein content of DP crops are high, the use of long-season bread wheats as a grazing resource requires that system managers pay greater attention to the sodium and magnesium status of the grazing livestock. This is because of the often high potassium and very low sodium concentrations of wheat forage, which leads to high potassium : sodium ratios in the rumen and reduced absorption of dietary magnesium. Supplementation with sodium and/or magnesium has significantly increased the liveweight gain of stock grazing wheat, but is contra-indicated when grazing canola. The paper also considers the interaction between the amount of grazing provided directly by the crop(s), relative to the possibly increased grazing available from the pasture component of the system, due to ‘pasture spelling’ while livestock are grazing the crop. Data are presented to show that, overall, the introduction of crop grazing into a previously pasture-based system greatly increases the total amount of grazing obtained. In addition, of the total extra grazing obtained in crop–pasture versus pasture-only systems, up to 40% has been found to come from spelled pasture. This has major implications for the management of the total system. The paper concludes by suggesting that, in the future, research on crop–pasture systems should continue, but should pay greater attention to the grazing of DP crops by cattle and particularly by breeding livestock. In addition, there is a need for much better data on the contribution of crop residues to the total grazing system, plus data on the effects of the introduction of DP crops on the wool production of the total grazing system.

Seasonal Uptake of Nutrients by Chenin Blanc in Sand Culture: II. Phosphorus, Potassium, Calcium and Magnesium

The seasonal uptake of phosphorus, potassium, calcium and magnesium as well as their distribution in the vine were determined for Chenin blanc/99R vines grown in sand culture under South African climatic conditions. Phosphorus absorption showed two distinct peaks-the first ranging from after bud burst until veraison, and the second, less prominent, from about five weeks after harvest into the leaf fall period. Potassium was absorbed from about three weeks after bud burst until four to five weeks after harvest. No potassium was absorbed during leaf fall. Active absorption of calcium started after bud burst and continued until veraison. A second, less pronounced absorption period occurred during the six weeks before leaf fall. Similarly, absorption of magnesium started after bud burst and continued until veraison, after which the absorption rate decreased and ceased with the onset of leaf fall. A significant amount of the phosphorus and potassium absorbed during the post harvest period was retained in the permanent parts of the vine. However, most of the post harvest calcium and magnesium gains were lost through leaf fall. Most of the calcium retained by the permanent parts of the vine, was stored in the bark. There was an apparent translocation of potassium from the leaves to the permanent structure of the vine during leaf fall. This was not noticeable for any of the other three nutrients.

Chitin supplementation in the diets of captive giant anteaters (Myrmecophaga tridactyla) for improved gastrointestinal function.

Clinical issues associated with keeping giant anteaters (Myrmecophaga tridactyla) in captivity may be linked with colon health and digestive function. Chronic loose stools are one such problem often suspected to be related to dietary intake. The objective of this study was to determine the acceptability, digestibility and faecal composition in a population of captive giant anteaters on four different experimental diets, including a baseline diet (B) comprising high fibre primate biscuit and dry feline diet, ground and mixed together then blended with water, or a commercial dry insectivore diet (INS), also ground and mixed with water. Other treatments included addition of 5 or 10% of dry matter (DM) as ground chitin added to B. No difference in faecal DM or faecal organic matter content was observed across all experimental diets; faecal ash was increased on B5 compared to B10 or INS treatments, indicating a possible impact on mineral nutrition. Similarly, no differences were observed in DM digestibility, or neutral detergent fibre (NDF) or acid detergent fibre (ADF) fermentation across all diets. The majority of the dietary components of the four different diets are highly digestible and/or fermentable (> 90% for all except fibre fractions). Crude fat and ADIN digestibility, and calcium and magnesium absorption were significantly higher in the diet that was formulated containing 5% chitin. Apparent digestion of NDF (82-91%) or ADF (74-88%), as measures of chitin, did not differ statistically among the diets in this study; ranges of disappearance of these components are high compared to other mammals, but within the ranges reported for other species.

THE APPLICATION OF MG-L-ASPARAGINATE AND COMBINATIONS OF MG SALTS WITH VITAMIN B6 IN MEDICINE

The magnesium is one of the most important microelements, a universal regulator of biochemical and physiological processes. This microelement is a co-factor of enzymes and participates in energetic, plastic and electrolyte metabolism, in regulation of cell growth, synthesis of protein, etc. In many countries the magnesium deficiency is a burning problem. The medications of non-organic and organic salts of magnesium are used for supplying it. The efficient medications are such asparaginic salts of magnesium as magnesium DL-asparaginate, potassium and magnesium L-asparaginate and magnesium L-asparaginate hydrochloride. The other obligate factor is vitamin B6 (pyridoxine) that as magnesium plays important role in main processes of metabolism and benevolently effects the central nervous system. The vitamin B6 supports increasing absorption of magnesium in intestine ameliorates its transportation into cells and processes of intra-cellular accumulation and potentates pharmacological effects of magnesium. By-turn, magnesium supports activation of vitamin B6 in liver. Therefore, it is appropriate to apply jointly magnesium and vitamin B6.

Transdermal magnesium – myth or reality?

Abstract. The importance of magnesium and the positive effects of magnesium substitution in various diseases are extensively documented [ 1 , 2 ]. Magnesium compounds are widely used as medicinal and dietary supplements. The effectiveness of oral magnesium substitution for the treatment of magnesium deficiency is beyond controversy. However, the scientific seriousness of oral magnesium substitution has become questioned for several years through intensive marketing of magnesium-containing sprays for topical application. In both, specialist and lay press and on the internet, there are increasing numbers of articles claiming the effectiveness and superiority of magnesium oil over an oral magnesium intake. Magnesium oil is no real oil but a concentrated magnesium chloride solution which is sprayed on the skin. The transdermal absorption of magnesium in comparison to oral supplementation is presented as being more effective on the one hand due to nearly 100% absorption and on the other hand as it is associated with fewer side effects because of bypassing the intestinal tract. For proving this, various publications are mentioned.

Precipitation controlled spatial variations in groundwater quality indices-suitability for drinking and irrigation purposes in the basalts of South India

Regional study on the impact of variations in input rainfall over groundwater quality and its suitability for utilitarian purposes is essential for its extraction and management. Water chemistry from 456 observations wells for 2007–2011 period in hard rock Basaltic terrain of Upper Godavari basin is supported with 8 field samples (in 2014) in this analysis. Based on mean annual rainfall (MAR), four narrow climatic zones are identified in the basin, defined as “humid” (MAR > 1600 mm), “sub-humid” (1600–1000 mm), “semi-arid” (1000–600 mm), and “arid” (MAR 600 mg/L) and not acceptable for drinking. Suitability of groundwater for irrigation is studied using sodium percentage (Na %), Wilcox diagram, sodium absorption ratio (SAR), US salinity diagram, residual sodium carbonate (RSC), permeability index (PI), Kelly’s ratio (KR), ancd magnesium absorption ratio (MgAR). Na % in four zones is 75% (class 1). KR varied from 0.05 to 12.81, with 70–80% of the area having KR < 1. MgAR ratio ranged from 67% to 96%, with sub-humid, humid zones having higher Mg concentrations (increased salinity). Thus, 90% of the samples indicated non-alkaline water with 1% of normal alkalinity. Hence, the current study systematically analyzed the effect of precipitation and geology on groundwater quality and on its usability for various purposes. This stepwise procedure categorized the regions, and the same can be adopted for any regional hydrogeochemical studies.

Identification of the putative goldfish (Carassius auratus) magnesium transporter SLC41a1 and functional regulation in the gill, kidney, and intestine in response to dietary and environmental manipulations

While magnesium requirements for teleost fish highlight the physiological importance of this cation for homeostasis, little is known regarding the molecular identity of transporters responsible for magnesium absorption or secretion. The recent characterization of the vertebrate magnesium transporter solute carrier 41a1 (SLC41a1) in the kidney of a euryhaline fish has provided a glimpse of possible moieties involved in piscine magnesium regulation. The present study obtained a novel SLC41a1 coding sequence for Carassius auratus and demonstrated ubiquitous expression in all tissues examined. Transcriptional regulation of SLC41a1 in response to dietary and environmental magnesium concentrations was observed across tissues. Specifically, decreased environmental magnesium correlated with decreased expression of SLC41a1 in the intestine, whereas the gill and kidney were unaffected. Dietary magnesium restriction correlated with decreased expression of SLC41a1 in the intestine and gill, while again no effects were detected in the kidney. Finally, elevated dietary magnesium correlated with increased expression of SLC41a1 in the kidney, while expression in the intestine and gill remained stable. Plasma magnesium was maintained in all treatments, and dietary assimilation efficiency increased with decreased dietary magnesium. Consumption of a single meal failed to impact SLC41a1 expression, and transcript abundance remained stable over the course of digestion in all treatments. Transcriptional regulation occurred between 7 and 14days following dietary and environmental manipulations and short-term regulation (e.g. <24h) was not observed. Overall the data supports transcriptional regulation of SLC41a1 reflecting a possible role in magnesium loss or secretion across tissues in fish.

Hypomagnesemia Tetany in Cattle

Grass tetany, sometimes called grass staggers or hypomagnesemia, can be a serious problem in Syria with cattle grazing small grain or ryegrass pastures. hypomagnesemia tetany has been known under a variety of names, including magnesium tetany, lactation tetany and grass staggers, but most of these terms have been discarded because the disease is not always associated with lactation or with grazing animals. The exact cause of hypomagnesemia tetany in ruminant animals is a dietary deficiency of magnesium that may be a contributory factor. Some research workers consider the condition to be caused by a cation-anion imbalance in the diet, and Some research workers believe that high intake of the element (K & Na) may interfere with the absorption and metabolism of magnesium in the animal, which may be an important factor in the etiology of hypomagnesemia tetany. Although the exact cause of hypomagnesemia is still uncertain, the primary factor would appear to be inadequate absorption of magnesium from the digestive tract. A high degree of success in preventing hypomagnesemia may be obtained by increasing the magnesium intake. This can be effected by feeding with magnesium rich mineral mixtures or, alternatively, by increasing the magnesium content of pasture by the application of magnesium fertilizers.

Functional Effects of Prebiotic Fructans in Colon Cancer and Calcium Metabolism in Animal Models.

Inulin-type fructans are polymers of fructose molecules and are known for their capacity to enhance absorption of calcium and magnesium, to modulate gut microbiota and energy metabolism, and to improve glycemia. We evaluated and compared the effects of Chicory inulin “Synergy 1®” and inulin from Mexican agave “Metlin®” in two experimental models of colon cancer and bone calcium metabolism in mice and rats. Inulins inhibited the development of dextran sulfate sodium-induced colitis and colon cancer in mice; these fructans reduced the concentration of tumor necrosis factor alpha and prevented the formation of intestinal polyps, villous atrophy, and lymphoid hyperplasia. On the other hand, inulin treatments significantly increased bone densitometry (femur and vertebra) in ovariectomized rats without altering the concentration of many serum biochemical parameters and urinary parameters. Histopathology results were compared between different experimental groups. There were no apparent histological changes in rats treated with inulins and a mixture of inulins-isoflavones. Our results showed that inulin-type fructans have health-promoting properties related to enhanced calcium absorption, potential anticancer properties, and anti-inflammatory effects. The use of inulin as a prebiotic can improve health and prevent development of chronic diseases such as cancer and osteoporosis.

Production of impure prebiotic galacto-oligosaccharides and their effect on calcium, magnesium, iron and zinc absorption in Sprague-Dawley rats

Prebiotic galacto-oligosaccharides (GOS) are important “functional foods” of current scenario and used for various health benefits including improved mineral absorption. In the present study, it was hypothesized that novel GOS mixture, produced through transgalactosylation, with significant amount of mono and disaccharides may enhance mineral absorption in Sprague-Dawley rats. The non-purified GOS having β-(1→6) and β-(1→3) glycosidic linkage, were evaluated for apparent absorption of calcium, magnesium, iron and zinc. The rats were divided into two main groups (n=12 per group, 6 male/6 female) fed on control and GOS (5g/100g) diet. The feces were collected after 7days interval for 28days. The weight gain, feed and water intake were statistically similar (p<0.05) in both groups irrespective of gender. Similarly, the absorption of minerals was statistically not different in both genders during whole study. The GOS diet significantly (p<0.05) improved absorption of Ca (34.55–39.93%), Mg (51.22–58.05%) and Fe (31.58–39.21%) as compared to control diet at the end of study. However, no impact on Zn absorption was observed during the whole study. It can be inferred that the use of non-purified GOS for 3–4 weeks may enhance Ca, Mg and Fe absorption.

A diagnosis of groundwater quality from a semiarid region in Rajasthan, India

A diagnosis of the groundwater quality of 70 wells sampled during two climatic regimes (dry and raining seasons) from a semiarid area in Rajasthan, India, had been carried out using standard methods. Analysis of the results for various hydrochemical parameters wherein the geological units are alluvium, quartzite and granite gneisses showed that all the parameters did not fall within the World Health Organisation’s acceptable limits for irrigation and drinking water purposes. The order of major cations and anions obtained during the dry and raining seasons are Na+ ˃ Mg2+ ˃ Ca2+ ˃ K+ and Cl−˃ HCO3 − ˃ SO4 2−˃ CO3 −> F− ˃ NO3 −, respectively. A maximum value of nitrate of 491.6 mg/l has been examined and its contamination is due to discriminated highly impacted groundwater samples by agricultural activity and small-scale urbanization. Fluoride (F−) concentration is 6.50 mg/l as a maximum value, whereas values in about 26 % of the samples are more than the permissible limit (1.5 mg/l) for drinking water. The cumulative probability distributions of the selected ions show two individual intersection points with three diverse segments, considered as regional threshold values and highly impacted threshold values for differentiating the samples with the effects of geogenic, anthropogenic and saline water mixing. The first threshold values indicate the background hydrochemical constituents in the study area. The second threshold value of 732 mg/l for bicarbonate indicates that sandy aquifer is being dissolved during wet period, whereas NO3 − concentration of more than the initial threshold value (=75 mg/l) indicates discriminated highly impacted groundwater samples by agricultural activity and urbanization in dry season. Various parameters such as soluble sodium percentage (SSP), salinity (electrical conductivity (EC)), sodium adsorption ratio (SAR), residual sodium carbonate (RSC), Kelley’s ratio (KR), permeability index (PI), residual sodium bicarbonate (RSB) and magnesium absorption ratio (MAR) for the well samples show that, overall, 46 % of groundwater samples are not suitable for irrigation. Further, chloro-alkaline indices (CAIs) were used for distinguishing regional recharge and discharge zones whereas corrosivity ratio (CR) utilized for demarcating areas to use metallic pipes for groundwater supply. In general, groundwater quality is mainly controlled by the chemical weathering of rock-forming minerals. The information obtained represents a base for future work that will help to assess the groundwater condition for periodical monitoring and managing the groundwater from further degradation.

Quality of tube well water intended for irrigation and human consumption with special emphasis on arsenic contamination at the area of Punjab, Pakistan.

In the present study, the tube well water quality and the associated health risks, emphasizing on arsenic contamination, were investigated in rural and urban samples from Tehsil Mailsi located in Punjab, Pakistan. Arsenic concentrations (μg/L) were ranged from 12 to 448.5 and which exceeded the WHO recommended limit (10μg/L) in all cases. The calculated average daily dose (3.3×10-0.4 to 1.2×10-0.2mg/kgday) and hazard quotient (1.1-40) reflected the potential health risk to local population due to tube well water consumption as drinking purpose. Sodium percent (Na%), sodium absorption ratio, residual sodium carbonate, Kelly's index and magnesium absorption ratio were also determined to assess the suitability of tube well water for irrigation purpose. The resulting piper plot revealed the Na-Ca-HCO3 type water chemistry of the area and generally alkaline environment. The spatial distribution of arsenic in the tube well waters pinpoints the significant contribution of anthropogenic activities to arsenic pollution. Nevertheless, different statistical tools, including principal component analysis, hierarchical cluster analysis and correlation matrices, revealed the contribution of both natural and anthropogenic activities and alkaline type of aquifers toward the high level of arsenic contamination.

Biological Activities of Fructooligosaccharides Produced by Aspergillus aculeatus in Mice Fed a High-fat Diet and Caco-2 Cell

We investigated the effects of the dietary supplement of fructooligosaccharides (FOS) on intestinal bacteria, blood cholesterol and mineral absorption in the Balb/c mice fed a high-fat diet. Mice were divided into four groups: Normal control (Balb/c mice fed normal diet), High fat control (Balb/c mice fed 60% fat diet), HF-FOS 5% (Balb/c mice fed 60% fat and 5% FOS diet), and HF-FOS 10% (Balb/c mice fed 60% fat and 10% FOS diet). We used an in vitro assay to evaluate whether the direct effects of FOS on calcium and magnesium transport improve absorption in the differentiated Caco-2 cell. The dietary supplementation with FOS resulted in a significant increase in Lactobacillus and Bifidobacterium in the feces and large intestine compared with the high fat control group. We found that dietary supplementation with FOS suppressed weight gain, hypercholesterolemia and hypertriglyceridemia induction by the high-fat diet although food consumption by the HF-FOS 5% and HF-FOS 10% groups was higher compared to the high fat control. Furthermore, the blood concentrations of calcium and magnesium that were lowered by the high fat diet were significantly increased in the HF-FOS 5% and HF-FOS 10% groups even though the absorption of calcium and magnesium following FOS treatment was low in the in vitro assay. Overall, these results suggest that dietary supplementation with FOS can help prevent a wide range of ailments induced by chronic high fat diet intake.

Mechanisms and causes of hypomagnesemia.

Identification of the mechanisms of magnesium absorption and reabsorption has markedly enhanced our understanding of the causes of hypomagnesemia. New gastrointestinal and renal causes of hypomagnesemia have been recently documented. The recognition of new mechanisms and causes of magnesium absorption and reabsorption should enhance the ability to monitor patients at risk for hypomagnesemia and improve our ability to mitigate the serious symptoms associated with this disorder.

Arsenic and heavy metal contaminations in the tube well water of Punjab, Pakistan and risk assessment: A case study

The present study for the first time highlighted the arsenic and heavy metals (HM) concentrations as well as their source of contamination in tube-well water and associated potential health risk to local residents of Tehsil Mailsi (Punjab), Pakistan. 44 samples were collected from Jala Jeem and Dunia Pur. Results revealed average concentrations of anion and heavy metals such as Iron (Fe), (Cadmium) Cd, (Lead) Pb, (Sodium) Na+, (Bicarbonate) HCO3−, (Sulfate) SO42− and Arsenic (As) exceeded the WHO limits in the tube well water. The calculated target hazard quotient (THQ) of metals from local tube well water above 1 was observed for As (36.5) and Cd (6.2), which employed highly potential health risk to local residents. The suitability of water for irrigation is evaluated based on residual sodium carbonate (RSC), sodium adsorption ratio (SAR), Kelly’s index (KI), Sodium percent (%Na) and Magnesium absorption ratio (MAR). Dominant ions in the study area are HCO3−, Ca2+ and Mg2+ and water chemistry of the area is Ca2+-Mg2+-HCO3− type. However, different statistical tools, including principal component analysis (PCA), hierarchical cluster analysis (CA) and correlation matrices revealed the contribution of both natural as well as anthropogenic activities towards the high level of arsenic and heavy metals contamination in the local tube well water. The results show that consumption of heavy metals contaminated groundwater poses an emerging health threat to the populations in the study area, and hence needs urgent remedial and management measures. Continued monitoring of heavy metals levels is recommended for future management strategies.

Short-term supplementation with dietary fructooligosaccharide and dietary mannitol elevated the absorption of calcium and magnesium in adult rats

Short-term supplementation with dietary fructooligosaccharide and dietary mannitol elevated the absorption of calcium and magnesium in adult rats

Identification of TRPM6 and TRPM7 expression changes in response to a diet supplemented with inulin in porcine kidney

Abstract. Magnesium is the fourth most abundant mineral element in vertebrates and the second most common intracellular cation. Recently identified Mg2+-specific channels – TRPM6 and TRPM7 – have been shown to be essential for whole-body and cellular Mg2+ homeostasis. The aim of the study was to determine the effect of inulin on the expression of TRPM6 and TRPM7 in the renal cortex and medulla of growing pigs. The study was carried out on 16 Danbred × Duroc castrated male piglets fed a cereal-based diet without inulin or with 2 % addition of inulin from chicory root from the 10th day of life. In pigs fed a diet with inulin, TRPM6 expression was greater in both the renal cortex and medulla compared to the control group. The expression of TRPM7 in both the renal cortex and medulla in the control group and in piglets fed a diet enriched with inulin was relatively stable. To our knowledge, this is the first study aimed at the identification of TRPM6 and TRPM7 in the kidneys of pig. It is proposed that inulin addition to fodder resulted not only in a magnesium absorption increase, but also, due to prolonged low plasma Mg concentration of examined piglets, renal magnesium retention. Therefore, higher magnesium reabsorption via increased TRPM6 expression in the kidney was probably observed in order to supplement deficiencies of this element. Diet-unresponsive expression of TRPM7 supports the concept that this channel is not involved in the extracellular magnesium homeostasis.

Development of a Model for In‐Vitro Comparative Absorption of Magnesium from Five Magnesium Sources Commonly Used as Dietary Supplements

The purpose of this study was to develop a model system to mimic the intestinal absorption of magnesium when administered as a dietary supplement and then test various magnesium sources in the system. Caco‐2 cells (ATCC HTB‐37) were seeded in welled culture plates and allowed to mature for 21 days. Maturity was determined by stable trans‐epithelial conductivity measurements. The model was developed by evaluating applicable concentration ranges and incubation times. The optimum conditions for application of magnesium to the cells were determined to be 50 mM concentrations for four hours to 6 well culture plates. Absorption of the cation was determined enzymatically from the fluid in the basal chamber. After determining the model, magnesium bisglycinate (MgBG), magnesium bisglycinate with magnesium oxide (MgBuf), dimagnesium malate (DMM), magnesium oxide (MgO), magnesium citrate (MgCit) and a negative control were tested for absorption. It was found that all magnesium treatments had significantly elevated Mg content in the basal side (p&lt;0.05). Within the magnesium treatments MgBG had the highest absorption of Mg (p&lt;0.05). MgBuf had a numerically lower absorption result than MgBG but was statistically similar. DMM was greater than MgCit and MgO (p&lt;0.05) but was not statistically different from MgBG although it was numerically less. MgCit and MgO were numerically similar and statistically equivalent. MgCit and MgO also exhibited lower absorption than MgBG, MgBuf and DMM. It was concluded that this model is an effective method for determining intestinal absorption of magnesium compounds as would be found in dietary supplements. It was also concluded that magnesium bisglycinate had the greatest absorption and transport across the intestinal epithelial layer and may be the most bioavailable of the compounds tested.Support or Funding InformationAlbion