Macroscopic Volume Research Articles

Theoretical Research in Laboratory and Field Trial of Micro-Nano-Oil Displacement System Conformance Control Technology

Abstract In recent years, a series of field tests of a new micro-nano-oil displacement system (MNS) conformance control technology have been carried out in different oilfields, which can increase oil production and reduce water cut obviously. However, compared with its field application, the research on its performance evaluation and oil displacement mechanism is still in the initial stage. And it is urgent to carry out relevant research work. Therefore, this paper made a profound study on its physicochemical properties, reservoir adaptability, transport and deep fluid diversion ability, and oil displacement mechanism. Results show that MNS with a series of particle sizes in different sizes (from nanometer to micrometer) can be obtained. And it has good expansion ability. Through reservoir adaptability evaluation, the matching relationship between the size distributions of MNS particles and pore throat is given, which has important guiding significance for MNS particle size selection for target reservoir before field trial. Furthermore, MNS has strong transport ability. When migrating in the porous media, it shows the motion feature of “trapping, deformation, migration, retrapping, redeformation, and remigration,” which can obtain better oil incremental effect than traditional polymer flooding. Under the condition of the same agent type, composition, and slug size, the oil recovery rate can be further enhanced by 6.96%. In addition, MNS conformance control technology has obtained good technical and economic effect in the 8 oilfields, with the lowest input-output ratio of 1.67 and the highest of 14.37. The reason why MNS have the above-mentioned good performances depends on its advanced mechanism: the unique particle phase separation phenomenon. When transporting in porous media, MNS particles gather in the larger pore to form bridge blocking, and its carrier fluid displaces oil in the small pore. Working in cooperation, MNS can realize deep fluid diversion and expand macroscopic and microscopic swept volume.

DTI Abnormalities Related to Glioblastoma: A Prospective Comparative Study with Metastasis and Healthy Subjects.

(1) Background: Glioblastoma multiforme (GBM) shows complex mechanisms of spreading of the tumor cells, up to remote areas, and little is still known of these mechanisms, thus we focused on MRI abnormalities observable in the tumor and the brain adjacent to the lesion, up to the contralateral hemisphere, with a special interest on tensor diffusion imaging informing on white matter architecture; (2) Material and Methods: volumes, macroscopic volume (MV), brain-adjacent-tumor (BAT) volume and abnormal color-coded DTI volume (aCCV), and region-of-interest samples (probe volumes, ipsi, and contra lateral to the lesion), with their MRI characteristics, apparent diffusion coefficient (ADC), fractional anisotropy (FA) values, and number of fibers (DTI fiber tracking) were analyzed in patients suffering GBM (n = 15) and metastasis (n = 9), and healthy subjects (n = 15), using ad hoc statistical methods (type I error = 5%) (3) Results: GBM volumes were larger than metastasis volumes, aCCV being larger in GBM and BAT ADC was higher in metastasis, ADC decreased centripetally in metastasis, FA increased centripetally either in GBM or metastasis, MV and BAT FA values were higher in GBM, ipsi FA values of GBM ROIs were higher than those of metastasis, and the GBM ipsi number of fibers was higher than the GBM contra number of fibers; (4) Conclusions: The MV, BAT and especially the aCCV, as well as their related water diffusion characteristics, could be useful biomarkers in oncology and functional oncology.

Network Inefficiency: Empirical Findings for Six European Cities

When planning road networks, inhomogeneous traffic conditions and the effects of multimodal interactions are often neglected. This can lead to a substantial overestimation of network capacities. Empirical macroscopic fundamental diagrams (MFDs) or volume delay relationships show considerable scatter, reflecting a reduction in network performance and an inefficient use of infrastructure. The implication is that the external costs of vehicular (car) traffic get underestimated, when planning traffic capacities and speeds based on optimal rather than on real estimates. In this paper, we contribute with an explorative and empirical approach to analyze network inefficiency and quantify its drivers. We propose to measure network efficiency by introducing the idea of excess delays for the MFD. We define excess delays as the difference between the observed speed and the optimal network speed at a given density. We apply the concept to traffic data sets of six European cities that differ in the data collection method and we use quantile regression methods for analysis. We find that excess delays are present in every data set and increase with the road network’s traffic load. We further confirm the intuition that traffic signal control, network loading, and multimodality influence the level of network inefficiency. The excess delay formula allows quantifying this information in a simple way and provides additional insights apart from the standard MFD model. The approach supports planners to obtain better real-world and less optimistic speed predictions for traffic analyses and suggests shifting urban transport to more spatially and temporally efficient modes.

Macroscopic volume phase transitions in supramolecular gels directed by covalent crosslinking

Here we show that covalent crosslinking in multicomponent gels can be an effective strategy to synthesize new functional materials with spatiotemporal dynamic properties.

Controlling Syneresis of Hydrogels Using Organic Salts

AbstractSupramolecular hydrogels can spontaneously undergo syneresis through fibre–fibre interactions and expel significant amounts of water upon aging. In this process, the hydrophobicity of fibres which regulates the 3D‐rearrangement of the self‐assembled structures during syneresis is important. Here, we show that we can control the hydrophobic microenvironment of gels by incorporating organic salts into the co‐assembled gel fibres thereby enabling control of the macroscopic gel volume phase transition.

Controlling Syneresis of Hydrogels Using Organic Salts.

Supramolecular hydrogels can spontaneously undergo syneresis through fibre–fibre interactions and expel significant amounts of water upon aging. In this process, the hydrophobicity of fibres which regulates the 3D‐rearrangement of the self‐assembled structures during syneresis is important. Here, we show that we can control the hydrophobic microenvironment of gels by incorporating organic salts into the co‐assembled gel fibres thereby enabling control of the macroscopic gel volume phase transition.

Small-Angle Scattering from Fractional Brownian Surfaces

Recent developments in nanotechnology have allowed the fabrication of a new generation of advanced materials with various fractal-like geometries. Fractional Brownian surfaces (fBs) are often used as models to simulate and characterize these complex geometries, such as the surface of particles in dilute particulate systems (e.g., colloids) or the interfaces in non-particulate two-phase systems (e.g., semicrystalline polymers with crystalline and amorphous phases). However, for such systems, a realistic simulation involves parameters averaged over a macroscopic volume. Here, a method based on small-angle scattering technique is proposed to extract the main structural parameters of surfaces/interfaces from experimental data. It involves the analysis of scattering intensities and the corresponding pair distance distribution functions. This allows the extraction of information with respect to the overall size, fractal dimension, Hurst and spectral exponents. The method is applied to several classes of fBs, and it is shown that the obtained numerical values of the structural parameters are in very good agreement with theoretical ones.

Deformation behavior of CP-titanium under strain path changes: Experiment and crystal plasticity modeling

The deformation behavior of commercially pure rolled titanium subjected to strain path changes is studied using experiments and a crystal plasticity model. Four different loading combinations are performed at room temperature to study the activation of slip, twinning, de-twinning and double-twinning in hexagonal closed packed titanium. The strain paths considered are: rolling direction compression (RDC) followed by normal direction compression (NDC), RDC followed by transverse direction compression (TDC), NDC followed by RDC, and NDC followed by TDC. An EBSD-based analysis of the distribution of boundary misorientation angles before and after reload was developed to analyze the evolution of {101¯2} tensile and {112¯2} compression twins. This analysis supports the model results concerning the treatment of twin reorientation. A de-twinning and double-twinning model accounting for back stress effects, an important feature of strain path changes, is implemented within the framework of the visco-plastic self-consistent (VPSC) model along with a dislocation density (DD) based hardening scheme. In the model, plasticity is accommodated by prismatic 〈a〉, basal 〈a〉 and pyramidal 〈c+a〉 slip modes, and {101¯2} tensile and {112¯2} compression twinning modes. The VPSC model predicts the evolution of twinning, de-twinning and double-twinning processes for both tensile and compression twinning modes under strain path change. The model predicts macroscopic stress-strain response, texture evolution, and twin volume fraction that are in agreement with experimental observations. The evolution of texture is investigated in detail by separately analyzing the twinned domains, rather than the evolution of the global texture.

Electrocaloric Performance of Multilayer Ceramic Chips: Effect of Geometric Structure Induced Internal Stress

Driven by an ever-growing demand for environmentally benign cooling systems, the past decade has witnessed the booming development in the field of electrocaloric (EC) cooling technology, which is considered as a promising solid-state cooling approach. Multilayer ceramic chip capacitors (MLCCs) represent the optimum structure for EC cooling elements because of large breakdown strengths, low driving voltages, and high macroscopic volumes of active EC materials. However, fundamental relationships between the geometric parameters of MLCCs and the EC coefficient are less understood. In this study, 0.92Pb(Mg1/3Nb2/3)O3-0.08PbTiO3 (PMN-PT) MLCCs with controlled configurations, such as active/inactive layer thickness, number of layers, and active volume ratio, were fabricated, and their EC performance was evaluated. The electric properties of the MLCCs are confirmed to be closely related to the geometric structure, which influences not only the heat flow but also the internal stress, resulting in the variability of EC performance and reliability/breakdown strength. The internal stress arises due to the residual thermal stress originating from the densification-related shrinkage, thermal expansion mismatch during the sintering, and clamping stress arising from the inactive area due to the large strain from the active area under a high electric field. The geometric structure-based stress distribution and the magnitude of stress on the active layers in MLCCs were determined by finite element modeling (FEM) and correlated with the experimental EC coefficients. The results reveal that a low inactive volume percentage is beneficial toward increasing the breakdown field and enhancement of EC performance because of reduced clamping stress on active EC material.

Effect of Antioxidants on Pig Semen Cryopreservation to Preserve Sperm Fertility after Thawing

Boar semen cryopreservation has a high potential in the swine industry, allowing the large-scale use of genetically superior animals, improving efficiency, product quality, helping to reduce the risk of disease spread and gathering needs from the market. From a genetic point of view, semen freezing is desirable for genetic diversification, favouring a more efficient reproduction as well as the constitution of germplasm banks, including for repopulation in case of disease outbreak. However, freezing this semen for long periods for practical use is limited by the reduced viability and fertilization potential caused to sperm during the cryopreservation process and consequently low conception rates and smaller litters after artificial insemination. In part, the decrease in the fertilizing power of frozen spermatozoa may be associated with oxidative damage due to excessive formation of Reactive Oxygen Species (ROS), osmotic stress and cell damage due to ice formation during cryopreservation. To suppress the damage caused by ROS, the present study was conducted to determine the impact of supplementation with three antioxidants, these being ascorbic acid, a-tocopherol and reduced glutathione, evaluating the parameters of semen quality, viability, total and progressive motility, vigour and agglutination rate after thawing. For this purpose, semen was collected from five boars, each being collected three times, at weekly intervals, always at the same time. Immediately after harvesting, the macroscopic (colour, appearance, and volume) and microscopic evaluation of the semen (mass motility, concentration, progressive individual motility, spermatic vigour and spermatic morphology) were evaluated. Subsequently, the semen was placed at 15°C for two hours and centrifuged at 800 x g for 10 minutes also at 15°C, removing the supernatant. For the freezing medium, a base medium consisting of a commercial MR-A extender, supplemented with 3% v/v glycerol, 10% v/v egg yolk and 0.20% w/v Sodium Dodecyl Sulfate (SDS) was used. The nine treatments used in the study were, respectively, ascorbic acid at concentrations of 100, 200 and 400μL, a-Tocopherol at concentrations of 200, 400 and 800μM and reduced Glutathione at concentrations of 2.5, 5 and 10 mg/l and numbered as T1 to T9, respectively. In the control group, semen was frozen in a medium without adding any antioxidant. The semen belonging to the different treatments and to the control was placed in 0.25ml insemination French straws and incubated at 6°C for two hours. The subsequent freezing was carried out in nitrogen vapours (-120°C) for ten minutes and immersed in liquid nitrogen after this period. After 7 days, the semen was thawed in a water bath at 37°C for 20 seconds, the straws dried on paper, placed on a microscope slide heated to 37°C and evaluated according to the parameters described above. Regarding the comparison between the different treatments, it was observed that the sperm viability obtained in the treatments with ascorbic acid as well as glutathione reduced, was not statistically different from the control group. Higher values of ascorbic acid and reduced glutathione reduced sperm viability after thawing. As for the use of a-tocopherol at a concentration of 400μM, the best results of the entire study were obtained, with sperm viability of 31.52% (±1.50). Regarding sperm motility and agglutination rate, a-tocopherol also showed the best results at the concentration of 200μM, in which the mean sperm motility was 2.57 ± 0.15 and 2.07 ± 0.15, respectively. The results of the present study allow us to infer that the addition of 200μM or 400μM of a-tocopherol to the swine semen-freezing medium has a positive effect on sperm viability parameters after thawing.

Bridging Gaussian Density Fluctuations from Microscopic to Macroscopic Volumes: Applications to Non-Polar Solute Hydration Thermodynamics.

The hydration of hydrophobic solutes is intimately related to the spontaneous formation of cavities in water through ambient density fluctuations. Information theory-based modeling and simulations have shown that water density fluctuations in small volumes are approximately Gaussian. For limiting cases of microscopic and macroscopic volumes, water density fluctuations are known exactly and are rigorously related to the density and isothermal compressibility of water. Here, we develop a theory—interpolated gaussian fluctuation theory (IGFT)—that builds an analytical bridge to describe water density fluctuations from microscopic to molecular scales. This theory requires no detailed information about the water structure beyond the effective size of a water molecule and quantities that are readily obtained from water’s equation-of-state—namely, the density and compressibility. Using simulations, we show that IGFT provides a good description of density fluctuations near the mean, that is, it characterizes the variance of occupancy fluctuations over all solute sizes. Moreover, when combined with the information theory, IGFT reproduces the well-known signatures of hydrophobic hydration, such as entropy convergence and solubility minima, for atomic-scale solutes smaller than the crossover length scale beyond which the Gaussian assumption breaks down. We further show that near hydrophobic and hydrophilic self-assembled monolayer surfaces in contact with water, the normalized solvent density fluctuations within observation volumes depend similarly on size as observed in the bulk, suggesting the feasibility of a modified version of IGFT for interfacial systems. Our work highlights the utility of a density fluctuation-based approach toward understanding and quantifying the solvation of non-polar solutes in water and the forces that drive them toward surfaces with different hydrophobicities.

Impact du curage ganglionnaire cervical dans la prise en charge par chimioradiothérapie exclusive des cancers de l’oropharynx de stade N2-3 : étude observationnelle en vie réelle

PurposeThe purpose of this study was to assess the efficacy in terms of neck failure of an initial neck dissection before definitive chemoradiotherapy in N2-3 oropharyngeal squamous cell carcinomas, as well as the dosimetric impact and the acute and delayed morbidity of this approach. Materials and methodsAll patients consecutively treated between 2009 and 2018 with definitive chemoradiotherapy using intensity-modulated conformal radiotherapy (IMRT) for a histologically proven N2-3 oropharyngeal squamous cell carcinomas were retrospectively included. The therapeutic approach consisted of induction chemotherapy, followed by cisplatine-based chemoradiotherapy preceded or not by neck dissection. Neck dissection was discussed on a case-by-case basis in a dedicated multidisciplinary tumour board for patients with a dissociated response to induction chemotherapy, defined as a better response on the primary than on the node. Chemoradiotherapy without neck dissection was systematically performed in case of a major lymph node response to induction chemotherapy (decrease in size of 90% or more). Intensity-modulated radiotherapy using a simultaneous-integrated boost delivered 70Gy in 35 fractions on macroscopic tumour volumes, 63Gy on intermediate-risk levels or extra-nodal extension and 54Gy on prophylactic lymph node areas. ResultsTwo groups were constituted: 47 patients without an initial neck dissection (62.7%), and 28 patients with a neck dissection prior to definitive chemoradiotherapy (37.3%). Initial patient characteristics were not statistically different between the two groups. The median follow-up was 60.1months (range: 3.2–119months). Incidence of neck failure was higher in patients without neck dissection (P=0.015). The neck failure rate at 5years was 19.8% (95% confidence interval: 7.4–30.6%; P=0.015) without neck dissection versus 0% following neck dissection. All lymph node failures occurred in the planned target volume at 70Gy. Upfront neck dissection suggested a decrease in the mean dose received by the homolateral parotid gland (P=0.01), mandible (P=0.02), and thyroid gland (P=0.02). Acute toxicity of chemoradiotherapy after neck dissection suggested a reduction in grade≥3 adverse events (P=0.04), early discontinuation of concomitant chemotherapy (P=0.009) and feeding tube-dependence (P=0.008) in univariate analysis. During follow-up, there was no difference between the two groups in terms of xerostomia, dysgeusia, dysphagia or gastrostomy dependence in univariate analysis. ConclusionNeck dissection prior to definitive chemoradiotherapy in N2-3 oropharyngeal squamous cell carcinoma was associated with high neck control without additional mid and long-term morbidity.

Scenario for a singularity-free generic cosmological solution

We develop a scenario for the emergence of a non-singular generic cosmological solution based on the a WKB characterization of one of the two anisotropy degrees of freedom. We investigate the dynamics of the so-called inhomogeneous mixmaster in the "corner" configuration and inferring that one of the two anisotropic variables becomes small enough to explore the uncertainty principle. Then, we apply a standard WKB approximation to the dynamics of the Universe which has macroscopic volume, one macroscopic anisotropy and one microscopic quantum degree of freedom. Our study demonstrates the possibility that the Universe acquires a non-singular classical behavior, retaining the quantum degree of freedom as a small oscillating ripple on a stationary Universe. The role of the so-called "fragmentation process" is also taken into account in outlining the generality of such a behavior in independent local space regions.

An analysis of Lode effects in ductile failure

An isotropic multi-surface model of porous material plasticity is derived and employed to investigate the effects of the third stress invariant in ductile failure. The constitutive relation accounts for both homogeneous and inhomogeneous yielding of a material containing a random distribution of voids. Individual voids are modeled as spheroidal but the aggregate has no net texture. Ensemble averaging is invoked to operate a scale transition from the inherently anisotropic meso-scale process of single-void growth and coalescence to some macroscopic volume that contains many voids. Correspondingly, expressions for effective yield and associated evolution equations are derived from first principles, under the constraint of persistent isotropy. It is found that the well-known vertex on the hydrostatic axis either disappears for sufficiently flat voids or develops into a lower-order singularity for elongated ones. When failure is viewed as the onset of an instability, it invariably occurs after the transition to inhomogeneous yielding with the delay between the two depending strongly upon the Lode parameter. The strain to failure is found to be weakly dependent on the Lode parameter for shear-dominated loadings, but strongly dependent on it near states of so-called generalized tension or compression. Experimentally determined fracture loci for near plane stress states are discussed in light of the new findings.

Electrically powered repeatable air explosions using microtubular graphene assemblies

Controllable rapid expansion and activation of gases is important for a variety of applications, including combustion engines, thrusters, actuators, catalysis, and sensors. Typically, the activation of macroscopic gas volumes is based on ultra-fast chemical reactions, which require fuel and are irreversible. An “electrically powered explosion”, i.e., the rapid increase in temperature of a macroscopic relevant gas volume induced by an electrical power pulse, is a feasible repeatable and clean alternative, providing adaptable non-chemical power on demand. Till now, the fundamental problem was to find an efficient transducer material that converts electrical energy into an immediate temperature increase of a sufficient gas volume. To overcome these limitations, we developed electrically powered repeatable air explosions (EPRAE) based on free-standing graphene layers of nanoscale thickness in the form of microtubes that are interconnected to a macroscopic framework. These low-density and highly permeable graphene foams are characterized by heat capacities comparable to air. The EPRAE process facilitates cyclic heating of cm3-sized air volumes to several 100 °C for more than 100,000 cycles, heating rates beyond 300,000 K s−1 and repetition rates of several Hz. It enables pneumatic actuators with the highest observed output power densities (>40 kW kg−1) and strains ∼100%, as well as tunable microfluidic pumps, gas flowmeters, thermophones, and micro-thrusters.

Tomographic X-ray scattering based on invariant reconstruction: analysis of the 3D nanostructure of bovine bone.

Small-angle X-ray scattering (SAXS) is an effective characterization technique for multi-phase nanocomposites. The structural complexity and heterogeneity of biological materials require the development of new techniques for the 3D characterization of their hierarchical structures. Emerging SAXS tomographic methods allow reconstruction of the 3D scattering pattern in each voxel but are costly in terms of synchrotron measurement time and computer time. To address this problem, an approach has been developed based on the reconstruction of SAXS invariants to allow for fast 3D characterization of nanostructured inhomogeneous materials. SAXS invariants are scalars replacing the 3D scattering patterns in each voxel, thus simplifying the 6D reconstruction problem to several 3D ones. Standard procedures for tomographic reconstruction can be directly adapted for this problem. The procedure is demonstrated by determining the distribution of the nanometric bone mineral particle thickness (T parameter) throughout a macroscopic 3D volume of bovine cortical bone. The T parameter maps display spatial patterns of particle thickness in fibrolamellar bone units. Spatial correlation between the mineral nano-structure and microscopic features reveals that the mineral particles are particularly thin in the vicinity of vascular channels.

Design of Interfacial Crowding for Elastomeric Reinforcement with Nanocrystals.

Design of the crowding of chains tethered at the faces of β-sheet nanocrystals self-assembled from β-alanine trimers grafted on polyisobutylene (PIB) rubber tailors nanocrystal size and thus the elastic matrix morphology, thereby altering the material's macroscopic elastic properties. Results from transmission electron microscopy, small-angle X-ray scattering, and small-angle neutron scattering characterizations of the morphology demonstrate that increasing the density of chain tethering at the crystalline nanodomain/matrix interface can sharply limit the nanodomain growth in the direction of hydrogen bonding in the crystals. The nanocrystal size, in turn, impacts the gradient in chain stretching away from the crystal surface and the macroscopic volume fraction of unperturbed chains. Nanocomposite mechanical and dynamic mechanical properties at low degrees of deformation are related to the structural hierarchy resulting from the control of interfacial tethering density.

Design of Hydrogels with Thermoresponsive Crosslinked Domain Structures via the Polymerization-Induced Self-Assembly Process and Their Thermoresponsive Toughening in Air

We designed a hydrogel with a thermoresponsive crosslinked domain (CD) structure, which expressed thermoresponsive toughening in an isochoric manner in air. The responsive behavior of conventional thermoresponsive hydrogels is usually a macroscopic volume change along with water transfer to and from the outside of the polymer network. In order to expand the scope of thermoresponsive hydrogels, a network design that requires no external water for thermoresponsive transition has been demanded. To this end, we focused on the polymerization-induced self-assembly process for the direct synthesis of gels with designed domains and performed reversible addition–fragmentation chain transfer polymerization of N-isopropylacrylamide in water at a high temperature using a bifunctional macro-chain transfer agent, yielding a transparent gel. The structural analysis of the obtained gel revealed that dispersed CDs reversibly swelled and shrunk in response to temperature change in air without aggregation. Such an internal structural change induced the increase of elastic modulus and elongation at a high temperature.

Prospects for nuclear spin hyperpolarization of molecular samples using nitrogen-vacancy centers in diamond

After initial proof-of-principle demonstrations, optically pumped nitrogen-vacancy (NV) centres in diamond have been proposed as a non-invasive platform to achieve hyperpolarisation of nuclear spins in molecular samples over macroscopic volumes and enhance the sensitivity in nuclear magnetic resonance (NMR) experiments. In this work, we model the process of polarisation of external samples by NV centres and theoretically evaluate their performance in a range of scenarios. We find that average nuclear spin polarisations exceeding 10% can in principle be generated over macroscopic sample volumes ($\gtrsim\mu$L) with a careful engineering of the system's geometry to maximise the diamond-sample contact area. The fabrication requirements and other practical challenges are discussed. We then explore the possibility of exploiting local polarisation enhancements in nano/micro-NMR experiments based on NV centres. For micro-NMR, we find that modest signal enhancements over thermal polarisation (by 1-2 orders of magnitude) can in essence be achieved with existing technology, with larger enhancements achievable via micro-structuring of the sample/substrate interface. However, there is generally no benefit for nano-NMR where the detection of statistical polarisation provides the largest signal-to-noise ratio. This work will guide future experimental efforts to integrate NV-based hyperpolarisation to NMR systems.

The Reservoir Adaptability Evaluation and Oil Displacement Mechanism of a Novel Particle-Type Polymer Flooding Technology

In recent years, a series of field tests of a novel particle-type polymer (named self-adaptive microgel) flooding technology have been carried out in different oilfields. However, compared with its field application, the research on its performance evaluation and oil displacement mechanism is still in the initial stage. Therefore, this paper made a profound study on its physicochemical properties, reservoir adaptability, transport and deep fluid diversion ability, oil displacement mechanism and the further EOR effect after polymer flooding. Results show that, during its injection process, the particle phase separation phenomenon occurs. So it would plug large pores while leave small ones open, causing no damage to the low permeability layer. Therefore, microgel particles gather in the larger pore to form bridge blocking, and its carrier fluid displace oil in the small pore. Working in cooperation, self-adaptive microgel can realize deep fluid diversion, expand macroscopic and microscopic swept volume. Furthermore, when migrating in the porous media, it shows the motion feature of “trapping, deformation, migration, re-trapping, re-deformation and re-migration”. On this basis, the displacement experiments show that, the combination of self-adaptive microgel flooding with well pattern adjustment, is an effective way to further enhance oil recovery significantly after polymer flooding.