An increasing use of high-performance concretes—accompanied by an increasing slenderness of structures—will require a specific fatigue design more often. This holds true especially for structures having to resist very high numbers of load cycles throughout their operating service life. Generally, these are long spanning, slender bridge structures, structures for wind energy turbines or machine foundations. For standard structures—and most common bridges—the fatigue resistance of concrete does not become decisive in design. Before the introduction of Eurocode 2 and CEB/FIP Model Code 1990—with design concepts based on Wöhler-curves—research regarding concrete fatigue was rare and often focused on counting the bearable number of cycles until failure. However, knowledge at time on the gradual deterioration phenomena, which finally results in a fatigue failure, was hardly available. In the time since, design rules were cautiously corrected, for example, in fib Model Code 2010, but, knowledge on the mechanisms of fatigue deterioration is still very limited. With the development of concretes with higher compressive strengths, more slender structures have become possible, in which the ratio of the dead load to the variable loads, relevant for fatigue, has substantially decreased. These concretes often show compressive strengths exceeding 100 MPa, outstanding workability, small maximum grain sizes and additionally contain fiber reinforcement. These concretes are hardly comparable to conventional concrete mixtures. For this reason, research about the phenomena of deterioration of high-performance concrete was intensified over the last decade. Currently, a large joint research project is the Priority Programme 2020 “Cyclic Deterioration of High-Performance Concrete in an Experimental-Virtual Lab” which is funded by the German Research Foundation (DFG). Within various tandem-projects experts in material science, building materials technology and numerical modeling are working together to identify and characterize the damage mechanisms under fatigue loading and to develop quantitative prediction models. On the occasion of the 65th birthday of Professor Ludger Lohaus, Institute of Building Materials Science at Leibniz University of Hannover, Germany, who is the initiator and coordinator of the aforementioned DFG Priority Programme 2020, this issue of “Structural Concrete” is partly dedicated to fatigue and cyclic behavior of concrete and concrete structures. Professor Lohaus has been very active in the research on concrete fatigue and has driven it forward in many regards. It has been his continuing effort to transfer fundamental research results into practice (especially in structures for offshore wind-energy) and standardization, whether for Eurocode 2, fib Model Code 2010 or for the current preparations for fib Model Code 2020. The undersigned congratulate him very warmly on his birthday—also on behalf of the involved researchers of the DFG Priority Programme 2020—and we wish him all the best for the future, especially good health. We hope you enjoy reading this issue and wish you new insights and inspirations. The authors are members of the Programme Committee of the DFG Priority Programme 2020 “Cyclic Deterioration of High-Performance Concrete in an Experimental-Virtual Lab,” funded by the German Research Foundation (DFG).