Luminance Stability Research Articles

Emergence of Impurity-Doped Nanocrystal Light-Emitting Diodes.

In recent years, impurity-doped nanocrystal light-emitting diodes (LEDs) have aroused both academic and industrial interest since they are highly promising to satisfy the increasing demand of display, lighting, and signaling technologies. Compared with undoped counterparts, impurity-doped nanocrystal LEDs have been demonstrated to possess many extraordinary characteristics including enhanced efficiency, increased luminance, reduced voltage, and prolonged stability. In this review, recent state-of-the-art concepts to achieve high-performance impurity-doped nanocrystal LEDs are summarized. Firstly, the fundamental concepts of impurity-doped nanocrystal LEDs are presented. Then, the strategies to enhance the performance of impurity-doped nanocrystal LEDs via both material design and device engineering are introduced. In particular, the emergence of three types of impurity-doped nanocrystal LEDs is comprehensively highlighted, namely impurity-doped colloidal quantum dot LEDs, impurity-doped perovskite LEDs, and impurity-doped colloidal quantum well LEDs. At last, the challenges and the opportunities to further improve the performance of impurity-doped nanocrystal LEDs are described.

Organic stacked light-emitting devices based on PEDOT꞉PSS layer

Organic light-emitting devices (OLEDs) have been the intensive investigation subject in recent years due to their applications in lighting and displays. The typical OLED structure usually consists of a transparent indium-tin-oxide bottom anode, a top metal cathode, and some organic layers sandwiched between electrodes. After 30 years of unremitting efforts, the performance of OLEDs has been close to the level of inorganic semiconductor light-emitting devices. However, in order to achieve the final application goal of dynamic panchromatic HD display, the luminous efficiency and stability of the device need to be further improved. Especially because organic materials are not resistant to high temperature, improving the luminous efficiency of the device and reducing the heat loss become the key to improving the stability and service life of the device. One of the important factors that affect the life of OLEDs is the thermal aging caused by the high current flowing through it. Therefore, it is of great significance to study a kind of high efficiency device operating at low current. Stacked device structure technology is an effective way to realize low current and high efficiency OLEDs. The major challenge in stacked OLEDs in general is to prepare the effective connecting layer between emitting units so that the current can smoothly flow through without manufacturing difficulties. In this paper, we use PEDOT꞉PSS as the connecting layer of the device, and successfully prepare the stack organic light-emitting device with ITO/PEDOT꞉PSS (15 nm) /PFO (80 nm) /PEDOT꞉PSS (40 nm) /PFO (80 nm) /Al (70 nm) structure. By studying the current-voltage characteristics, voltage-brightness characteristics and current-efficiency characteristics, it is found that the illumination voltage and the illumination current are 12.3 V and 1.39 μA, respectively. The current efficiency (3.97 cd /A) is 8 times higher than that of single-layer comparator. The connection layer of this new type of PEDOT꞉PSS stack device needs neither high temperature evaporation coating nor doping. This method not only simplifies the preparation process of the connection unit of the stacked device, avoids the damage of the device film caused by high temperature evaporation, but also overcomes the problem of the damage of the device performance caused by the atomic scattering of the existing doping process. At the same time, the physical mechanism of PEDOT꞉PSS as the connecting layer of stacked OLED is discussed.

Bright and Color-Stable Blue-Light-Emitting Diodes based on Three-Dimensional Perovskite Polycrystalline Films via Morphology and Interface Engineering.

Substantial progress has been achieved in red and green perovskite light-emitting diodes (PeLEDs). However, blue PeLEDs are still inferior in light-emitting efficiency and luminance compared with their green and red counterparts. Herein efficient blue PeLEDs simultaneously achieving high luminance and high color stability are fabricated based on the polycrystalline perovskites with a 3D Rb-Cs alloyed scaffold. The synergistic manipulation of an isopropanol antisolvent treatment and the PEDOT:PSS/blue perovskite interface modification with RbCl effectively improve the photoluminescence properties of the resultant blue polycrystalline 3D perovskite films and the final electroluminescence performance of the blue PeLEDs. The optimized blue PeLEDs show a maximum external quantum efficiency of 1.66% with an emission peak at 484 nm and a full width at half-maximum of 18 nm as well as CIE coordinates of (0.08, 0.21). Moreover, the optimized blue PeLEDs not only show superior color stability under various luminances but also achieve high luminances. The obtained maximum luminance of 9243 cd m-2 is one of the highest values among the efficient and color-stable blue PeLEDs.

Biopharmaceutical classification of desloratadine - not all drugs are classified the easy way.

The biopharmaceutical classification of drugs was designed as a basis for bio-waivers - a mechanism with the double ethical benefit of delivering new drug formulations to the market with less human testing and lower cost. However, many drugs defy simple classification because in vitro permeability and stability assessment can be challenging as shown in this study for desloratadine. Literature shows that desloratadine is highly soluble, while data on luminal stability and permeability are circumstantial. Combined with borderline bioavailability and not really known fraction of absorbed dose, desloratadine was found to be a good example for showing the innovative in vitro approaches necessary to unambiguously classify desloratadine according to Biopharmaceutical Classification System (BCS) guideline. Presented study undoubtedly confirmed that desloratadine solubility is high and dissolution is very rapid for immediate release reference tablets. We have demonstrated deslorata-dine stability under legally required conditions and also in more physiologically relevant media. High in vitro desloratadine permeability was confirmed using Caco-2 and Parallel Artificial Membrane Permeability Assay (PAMPA). Well-established in vitro model with rat intestinal tissue could not be used due to reasons elaborated in this paper.

Encapsulate Materials Effect on ZnxCd1-xS White Light Quantum Dots-Based White Light-Emitting Diodes

In this study, colloidal ternary ZnxCd1-xS white light quantum dots (WQDs) were prepared, which have the characteristics of broad emission window. We used epoxy, styrene ethylene butylene styrene block copolymer (SEBS), and silicone as encapsulate materials to pack the device. The results show that the Zn0.5 and Zn0.8 have band edge and surface state emission. The quantum yield (QY) and particle size of Zn0.5 and Zn0.8 WQDs is 19, 32 % and 4.5±0.5 and 3.1±0.5 nm, respectively. The white light-emitting diodes (WLEDs) were obtained by mixing WQDs with different resins, and pumping by UV chip. The luminous efficacy is 6.7 and 8.5 lm/W for Zn0.5 and Zn0.8-based WLED by using epoxy resin as encapsulate material. Moreover, the long period test can maintain 201 and 184 h for Zn0.5 and Zn0.8-based WLED, respectively. The results of this study present that the device encapsulated by epoxy resin can improve the luminous efficacy and stability of device. This outstanding finding may contribute to the future development of solid-state lighting (SSL).

Enhancing opto-thermal performances of the reflective phosphor-converted laser diode by stacking a sapphire substrate for double-sided phosphor cooling

Phosphor-converted laser diode (pc-LD) has been a very competitive candidate in high-luminance white illumination. For the reflective pc-LD, the phosphor layer is usually bonded onto a reflective substrate, which plays the role of light reflection and heat dissipation. However, the heat generation of phosphor cannot be efficiently dissipated by only cooling the reflective surface, in which case most of heat may be confined in the phosphor layer with low thermal conductivity. In this work, a double-sided phosphor cooling scheme was presented to improve the opto-thermal performances of the reflective pc-LD by stacking a highly transparent and heat-conducting sapphire substrate onto the phosphor layer. By using an opto-thermal phosphor model, it was found that the maximum heat generation density and hotspot were both confined at the incident surface. After stacking a sapphire substrate onto the incident surface, the maximum heat was extracted and conducted from the sapphire substrate to the reflective substrate, leading to a significant decrease of the maximum phosphor temperature from 221 °C to 86 °C under excitation power of 0.8 W. In this case, a higher excitation power was allowed, contributing to a higher attainable output power and luminance. The double-sided phosphor cooling scheme was also experimentally achieved. It was found that the presented scheme exhibited higher optical power, luminance and color stability than the traditional one under higher excitation power.

Largely Enhancing Luminous Efficacy, Color-Conversion Efficiency, and Stability for Quantum-Dot White LEDs Using the Two-Dimensional Hexagonal Pore Structure of SBA-15 Mesoporous Particles.

Quantum-dot (QD) white light-emitting diodes (LEDs) are promising for illumination and display applications due to their excellent color quality. Although they have a high quantum yield close to unity, the reabsorption of QD light leads to high conversion loss, significantly reducing the luminous efficacy and stability of QD white LEDs. In this report, SBA-15 mesoporous particles (MPs) with two-dimensional hexagonal pore structures (2D-HPS) are utilized to largely enhance the luminous efficacy and color-conversion efficiency of QD white LEDs in excess of 50%. The reduction in conversion loss also helps QD white LEDs to achieve a lifetime 1.9 times longer than that of LEDs using QD-only composites at harsh aging conditions. Simulation and testing results suggest that the waveguide effect of 2D-HPS helps in reducing the reabsorption loss by constraining the QD light inside the wall of 2D-HPS, decreasing the probability of being captured by QDs inside the hole of 2D-HPS. As such, materials and mechanisms like SBA-15 MPs with 2D-HPS could provide a new path to improve the photon management of QD light, comprehensively enhancing the performances of QD white LEDs.

The effect of the porosity on the Al2O3-YAG:Ce phosphor ceramic: Microstructure, luminescent efficiency, and luminous stability in laser-driven lighting

Solid-state laser lighting (SSL) fabricated by integrating laser diode with phosphor is a new development to achieve high luminance. Because of the high temperature caused by the laser, the phosphor-conversion apparatus is demanded to possess excellent thermal properties. In this paper, we utilized spark plasma sintering (SPS) to prepare the Al2O3-YAG:Ce phosphor ceramics with outstanding performances. Due to the high thermal conductivity and high transmittance, a high saturation input power (32 W/mm2) can be achieved for the sample with the lowest porosity. The correlated color temperature (CCT) and color rendering index (CRI) of composite ceramics with the lowest porosity are stable as the input power increases from 0.7 W/mm2 to 30.8 W/mm2. Nevertheless, the sample with the highest porosity shows the highest luminescence efficiency (305 lm/W) and luminous emittances (1796 lm/mm2), which can be ascribed to the scattering of the pore.

Reliability Assessment of Light-Emitting Diode Packages With Both Luminous Flux Response Surface Model and Spectral Power Distribution Method

The inherent luminous characteristics and stability of LED packages during the operation period are highly dependent on their junction temperatures and driving currents. In this paper, the luminous flux of LED packages operated under a wide range of driving currents and junction temperatures are investigated to develop a luminous flux response surface model. The coefficients of the proposed model are further extracted to compare the luminous efficacy decay mechanisms of LED packages with different packaging structures. Furthermore, a spectral power distribution (SPD) method modeled by the Gaussian function is proposed to analyze the long-term degradation mechanisms of all selected LED packages. The results of this study show that: (1) The luminous flux of phosphor converted white LED decreases to accompany with the increase of junction temperature, while that of bare blue LED die keeps relatively stable; (2) The proposed general luminous flux response surface model can be used to predict the luminous flux of LEDs with different packaging technologies accurately, and it can be known from the proposed model that the influences of driving current and temperature on LED chip and phosphor vary with different packaging structures; and (3) The driving current and temperature dependent sensitivities and degradation mechanisms of LED packages can be investigated by using both the luminous flux response surface model and the spectral power distribution method.

Development of LED-based standard source for total luminous flux calibration

For total luminous flux calibration by a sphere-spectroradiometer system in 2π geometry, a new LED-based standard light source (standard LED) covering the full visible wavelength range has been developed. The developed standard LED has sufficient spectral power over the full visible wavelength range using UV-LED dies of different peak wavelengths in combination with red, green and blue phosphors. By evaluating spectrum flatness based on the magnitude of the second derivative, the spectrum of the standard LED was customised to minimise the measurement uncertainty. Properties of the standard LED such as the luminous intensity distribution, stability and reproducibility were also evaluated. The evaluation results indicate that the standard LED has good properties as a standard light source for the 2π total spectral radiant flux scale. Furthermore, the result of an operating current dependence suggests that the standard LED has benefits as a standard source that conventional standard lamps do not have.

Updates to OECD guidance document 23: aquatic toxicity testing of difficult substances and mixtures

In this study, tris (8-hydroxyquinoline) aluminum/nano-titanium dioxide (Alq3/nano-TiO2) composites were synthesized using a simply in-situ process with 8-vinyl polyhedral oligomeric silsesquioxane (POSS) as a modifier. The as-prepared Alq3/nano-TiO2 composites were characterized by X-ray powder diffraction (XRD), field emission scanning electron microscopy (FE-SEM), X-ray photoelectron spectroscopy (XPS) and ultraviolet visible (UV–vis) absorption spectra. The effect of modification on luminescence properties for the samples was studied by photoluminescence (PL) spectra, electroluminescence (EL) spectra and time-resolved luminescence decay curves. Organic light emitting diodes (OLEDs) with the corresponded emitting layer structure were investigated. The results show that the amphiphilicity of the 8-vinyl POSS leads to well-dispersion state of the nano-TiO2 in the Alq3. Adding a proper weight percentage of 8-vinyl POSS is beneficial for the PL and EL properties enhancement of the composites. OLED using the Alq3/nano-TiO2 with 1 wt% 8-vinyl POSS emitting layer has the low turn-on voltage (4.7 V at 1 cd/m2), high maximum luminance (7463 cd/m2 at 8.75 V), and high luminous efficiency (1.13 cd/A at 100 mA/cm2). Adding 1 wt% 8-vinyl POSS in Alq3/nano-TiO2 can increase the EL intensity by a factor of 37.1 at 8 V. These values are better than those for OLEDs using the Alq3 emitting layer. The increase in luminance and current efficiency stability can be attributed to the energy transfer process between the Alq3 and the nano-TiO2, and the suppression of the self-quenching by caged 8-vinyl POSS molecules.

Effects of Substrate on Thermal and Optical Characteristics of High-Power ThinGaN White LED

Thin Gallium Nitride (ThinGaN)-based light-emitting diodes (LEDs) demonstrate high extraction efficiency and brightness. Their slim designs make them appropriate for lighting applications that demand high luminous flux, small space, and stability. Thermal resistance and junction temperature values under different boundary conditions can help in understanding thermal management of ThinGaN-based LEDs. In this paper, thermal and optical characteristics of ThinGaN (UX:3) white LED mounted on Metal-Core Printed Circuit Board (MCPCB) and a SinkPad MCPCB are investigated. Thermal and optical parameters of the LED are measured by thermal transient tester (T3Ster) and spectrometer devices. Results show that the LED attached to the SinkPad MCPCB obtained lower thermal resistance and junction temperature than MCPCB.

A charge-sensing region in the stromal interaction molecule 1 luminal domain confers stabilization-mediated inhibition of SOCE in response to S-nitrosylation

Store-operated Ca2+ entry (SOCE) is a major Ca2+ signaling pathway facilitating extracellular Ca2+ influx in response to the initial release of intracellular endo/sarcoplasmic reticulum (ER/SR) Ca2+ stores. Stromal interaction molecule 1 (STIM1) is the Ca2+ sensor that activates SOCE following ER/SR Ca2+ depletion. The EF-hand and the adjacent sterile α-motif (EFSAM) domains of STIM1 are essential for detecting changes in luminal Ca2+ concentrations. Low ER Ca2+ levels trigger STIM1 destabilization and oligomerization, culminating in the opening of Orai1-composed Ca2+ channels on the plasma membrane. NO-mediated S-nitrosylation of cysteine thiols regulates myriad protein functions, but its effects on the structural mechanisms that regulate SOCE are unclear. Here, we demonstrate that S-nitrosylation of Cys49 and Cys56 in STIM1 enhances the thermodynamic stability of its luminal domain, resulting in suppressed hydrophobic exposure and diminished Ca2+ depletion-dependent oligomerization. Using solution NMR spectroscopy, we pinpointed a structural mechanism for STIM1 stabilization driven by complementary charge interactions between an electropositive patch on the core EFSAM domain and the S-nitrosylated nonconserved region of STIM1. Finally, using live cells, we found that the enhanced luminal domain stability conferred by either Cys49 and Cys56S-nitrosylation or incorporation of negatively charged residues into the EFSAM electropositive patch in the full-length STIM1 context significantly suppresses SOCE. Collectively, our results suggest that S-nitrosylation of STIM1 inhibits SOCE by interacting with an electropositive patch on the EFSAM core, which modulates the thermodynamic stability of the STIM1 luminal domain.

S-Nitrosylation of STIM1 by Neuronal Nitric Oxide Synthase Inhibits Store-Operated Ca2 + Entry

Store-operated Ca2+ entry (SOCE) mediated by stromal interacting molecule-1 (STIM1) and Orai1 represents a major route of Ca2+ entry in mammalian cells and is initiated by STIM1 oligomerization in the endoplasmic or sarcoplasmic reticulum. However, the effects of nitric oxide (NO) on STIM1 function are unknown. Neuronal NO synthase is located in the sarcoplasmic reticulum of cardiomyocytes. Here, we show that STIM1 is susceptible to S-nitrosylation. Neuronal NO synthase deficiency or inhibition enhanced Ca2+ release-activated Ca2+ channel current (ICRAC) and SOCE in cardiomyocytes. Consistently, NO donor S-nitrosoglutathione inhibited STIM1 puncta formation and ICRAC in HEK293 cells, but this effect was absent in cells expressing the Cys49Ser/Cys56Ser STIM1 double mutant. Furthermore, NO donors caused Cys49- and Cys56-specific structural changes associated with reduced protein backbone mobility, increased thermal stability and suppressed Ca2+ depletion-dependent oligomerization of the luminal Ca2+-sensing region of STIM1. Collectively, our data show that S-nitrosylation of STIM1 suppresses oligomerization via enhanced luminal domain stability and rigidity and inhibits SOCE in cardiomyocytes.

Enhanced PL and EL properties of Alq3/nano-TiO2 with the modification of 8-vinyl POSS

In this study, tris (8-hydroxyquinoline) aluminum/nano-titanium dioxide (Alq3/nano-TiO2) composites were synthesized using a simply in-situ process with 8-vinyl polyhedral oligomeric silsesquioxane (POSS) as a modifier. The as-prepared Alq3/nano-TiO2 composites were characterized by X-ray powder diffraction (XRD), field emission scanning electron microscopy (FE-SEM), X-ray photoelectron spectroscopy (XPS) and ultraviolet visible (UV–vis) absorption spectra. The effect of modification on luminescence properties for the samples was studied by photoluminescence (PL) spectra, electroluminescence (EL) spectra and time-resolved luminescence decay curves. Organic light emitting diodes (OLEDs) with the corresponded emitting layer structure were investigated. The results show that the amphiphilicity of the 8-vinyl POSS leads to well-dispersion state of the nano-TiO2 in the Alq3. Adding a proper weight percentage of 8-vinyl POSS is beneficial for the PL and EL properties enhancement of the composites. OLED using the Alq3/nano-TiO2 with 1 wt% 8-vinyl POSS emitting layer has the low turn-on voltage (4.7 V at 1 cd/m2), high maximum luminance (7463 cd/m2 at 8.75 V), and high luminous efficiency (1.13 cd/A at 100 mA/cm2). Adding 1 wt% 8-vinyl POSS in Alq3/nano-TiO2 can increase the EL intensity by a factor of 37.1 at 8 V. These values are better than those for OLEDs using the Alq3 emitting layer. The increase in luminance and current efficiency stability can be attributed to the energy transfer process between the Alq3 and the nano-TiO2, and the suppression of the self-quenching by caged 8-vinyl POSS molecules.

Heteroleptic Copper(I) Pseudorotaxanes Incorporating Macrocyclic Phenanthroline Ligands of Different Sizes

A series of copper(I) pseudorotaxanes has been prepared from bis[2-(diphenylphosphino)phenyl] ether (POP) and macrocyclic phenanthroline ligands with different ring sizes (m30, m37, and m42). Variable-temperature studies carried out on the resulting [Cu(mXX)(POP)]+ (mXX = m30, m37, and m42) derivatives have revealed a dynamic conformational equilibrium due to the folding of the macrocyclic ligand. The absorption and luminescence properties of the pseudorotaxanes have been investigated in CH2Cl2. They exhibit metal-to-ligand charge-transfer emission with photoluminescence quantum yields (PLQYs) in the range 20-30%. The smallest system [Cu(m30)(POP)]+ shows minimal differences in spectral shape and position compared to its analogues, suggesting a slightly distorted coordination environment. PLQY is substantially enhanced in poly(methyl methacrylate) films (∼40-45%). The study of emission spectra and excited-state lifetimes in powder samples as a function of temperature (78-338 K) reveals thermally activated delayed fluorescence, with sizable differences in the singlet-triplet energy gap compared to the reference compound [Cu(dmp)(POP)]+ (dmp = 2,9-dimethyl-1,10-phenanthroline) and within the pseudorotaxane series. The system with the largest ring ([Cu(m42)(POP)]+) has been tested as emissive material in OLEDs and affords bright green devices with higher luminance and greater stability compared to [Cu(dmp)(POP)]+, which lacks the macrocyclic ring. This highlights the importance of structural factors in the stability of electroluminescent devices based on Cu(I) materials.

Aronia (Aronia melanocarpa) phenolics bioavailability in a combined in vitro digestion/Caco-2 cell model is structure and colon region dependent

Aronia phenolics are considered to be beneficial for cardiovascular health, but are not always bioavailable. In this study, we evaluated the in vitro bioavailability of Aronia juice phenolics by combination of intestinal digestion models with Caco-2 absorption models. First, intestinal luminal stability and microbial metabolism of Aronia phenolics were investigated using two in vitro digestion models: a short-term batch model and a long term dynamic model (SHIME®). Next, diluted digests were directly applied to Caco-2 cells to simulate enterocyte absorption. Three anthocyanins, 5 flavonol glycosides, 5 phenolic acids and epicatechin were quantified at different stages of digestion and absorption. The location of absorption was compound specific, as procyanidins were mainly absorbed in the distal colon while anthocyanins, flavonol glycosides and phenolic acids were absorbed in the proximal intestinal tract. Further, the food matrix present in the colon significantly increased transport without permanent barrier damage.

Quantification and analysis of color stability based on thermal transient behavior in white LED lamps.

We present measurement and analysis of color stability over time for two categories of white LED lamps based on their thermal management scheme, which also affects their transient lumen depreciation. We previously reported that lumen depreciation in LED lamps can be minimized by properly designing the heat sink configuration that allows lamps to reach a thermal equilibrium condition quickly. Although it is well known that lumen depreciation degrades color stability of white light since color coordinates vary with total lumen power by definition, quantification and characterization of color shifts based on thermal transient behavior have not been previously reported in literature for LED lamps. Here we provide experimental data and analysis of transient color shifts for two categories of household LED lamps (from a total of six lamps in two categories) and demonstrate that reaching thermal equilibrium more quickly provides better stability for color rendering, color temperature, and less deviation of color coordinates from the Planckian blackbody locus line, which are all very important characterization parameters of color for white light. We report for the first time that a lamp's color degradation from the turn-on time primarily depends on thermal transient behavior of the semiconductor LED chip, which experiences a wavelength shift as well as a decrease in its dominant wavelength peak value with time, which in turn degrades the phosphor conversion. For the first time, we also provide a comprehensive quantitative analysis that differentiates color degradation due to the heat rise in GaN/GaInN LED chips and subsequently the boards these chips are mounted on-from that caused by phosphor heating in a white LED module. Finally, we briefly discuss why there are some inevitable trade-offs between omnidirectionality and color and luminous output stability in current household LED lamps and what will help eliminate these trade-offs in future lamp designs.

Variation of Structure and Photoluminescence Properties of Ce3+ Doped MgAlON Transparent Ceramics with Different Doping Content.

Transparent MgAlON:Ce fluorescent ceramics with doping content of 0.005, 0.01, and 0.02 at % were fabricated by pressureless sintering. All the samples were dense and large in grain size. Under the excitation of 320 nm UV, the samples emitted blue lights centered around 410 nm. The 0.005 and 0.01 at % Ce3+ doped samples were single phase by XRD detection, and possessed good optical and mechanical properties, and luminous thermal stability. The fluorescence lifetime, the CL and PL spectra analysis, indicated that most of the luminous centers were segregated in GB, and there was still a small part of second phase existing in 0.01 at % Ce3+ doped sample, which revealed that spectroscopy methods possessed better sensitivity in smaller scale and lower concentration detection than XRD. As the doping content increasing to 0.02 at %, a mass of second phase arose, which resulted in the optical transparency, mechanical property, luminous thermal stability decline, and the PL spectra red shift by the formation of second phase. It revealed that the performances were fatally deteriorated by excess doping of Ce3+ ions.

Highly Efficient Electrochemiluminescence Resonance Energy Transfer System in One Nanostructure: Its Application for Ultrasensitive Detection of MicroRNA in Cancer Cells.

The electrochemiluminesce (ECL) efficiency of luminous emitter can be enhanced by the means of electrochemiluminesce resonance energy transfer (ECL-RET) with a matched donor. However, generally, the donor and acceptor pairs were separated in different independent nanostructures, experiencing the challenging issues of limited energy transfer efficiency and luminous stability. Herein, we designed novel ECL-RET model within one nanostructure containing the donor of tris(4,4'-dicarboxylicacid-2,2'-bipyridyl) ruthenium(II) dichloride (Ru(dcbpy)32+) and the acceptor of CdSe@ZnS quantum dots (QDs) for acting as the ECL emitter (QDs-Ru(dcbpy)32+), which significantly reduced the energy loss and improved the ECL efficiency of QDs because of the short path of energy transmission. To demonstrate the proof-of-concept, the proposed QDs-Ru(dcbpy)32+ was employed to construct a new kind of ECL biosensor that could achieve the ultrasensitive detection of microRNA-141 (miRNA-141) combining target recycling amplification and the double-output conversion strategies. Notably, the proposed double-output conversion strategy enabled a small number of miRNA to be successfully transferred into a large number of reporter DNA which could capture numerous QDs-Ru(dcbpy)32+-labeled signal probes on the sensing surface to realize the ECL response to the logarithm of the concentration of miRNA-141. With the ultrahigh-efficient ECL-RET in one nanostructure and the dual amplification including target recycling as well as double-output conversion strategies, the proposed biosensor realized ultrasensitive detection of miRNA-141 and performed the concentration range from 100 aM to 10 pM and the estimated detection limit was 33 aM (S/N = 3). Impressively, this method can sensitively detect the miRNA-141 of human prostate cancer cells and provide a significant boost for the detection of other biomarkers in early cancer diagnosis and therapeutic monitoring.