A decrease in bone mineral density (BMD) accompanied by muscle weakness during aging significantly increases the probability of low-energy fracture occurrence, but it can also happen in those with a non-osteoporotic score (treatment gap). To improve the identification process of those at risk, the authors proposed using the interconnectivity between bone mineral density and muscle tissue. A total of 20,776 patient records were collected from the database in the period 2008-2021. After applying inclusion criteria, a total of 7159 records were used in the study. Questionnaires regarding patients' history were collected at admission. Patients underwent lumbar spine and/or femoral neck DXA examination and handgrip testing with a handheld dynamometer. Statistical analysis was conducted using tests suitable for the distribution of the data. Osteoporosis was diagnosed in a total of 1914 patients. Depending on the diagnosis there was a significant (p < 0.001) difference in handgrip strength (HGS) between the BMD statuses (norm-osteopenia-osteoporosis). HGS was significantly (p < 0.001) correlated with both BMD neck (r = 0.2) and spine (r = 0.1) in females, and with BMD neck (r = 0.11) in the male population. In our study group HGS was significantly (p < 0.001) higher for all the analysed fractures in the no-fracture group of women. There was no such relationship in reference to the male population. Due to its relationship with BMD, its low cost, and availability, HGS might prove useful in identifying women at risk of a fragility fracture.
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