The replacing of world civilization and Ukrainian society in particular played a significant role in the evolution of medical education in Ukraine. The system of higher education simultaneously affects the development of the future generation of doctors and is a remarkable social institution. That is why, the role of the system of higher medical education in difficult periods of the state’s development and proposed ways to innovate and optimize the scientific potential of students of higher medical education was analyzed.
 The aim of the study. The aim of the study is to analyze the current trends of transformational changes in the field of medical education and to propose ways to optimize the scientific potential of students of higher medical education.
 Objects and methods of the study include the system of medical education at the Higher Secondary School of the PSMU in various periods of its formation and development.
 Results and discussion. During our research, an analysis of modern trends in the development of medical education in Ukraine by studying well-known literary data was performed. The basis of own research is: quantitative analysis and synthesis (for the study of the higher education system of Ukraine); comparative analysis (to highlight the peculiarities of the functioning of the system of higher medical education in the conditions of modern challenges).
 Studying the system of higher education of Ukraine, it pays attention to the fact that the entire period of its development was accompanied by certain tests that prompted the transfer of the educational process to online format. At the same time, it should be noted that students are most often concerned with the following problems: poor or no Internet 30.2% of respondents; complex emotional state and psychological problems of higher education applicants 25.9; absence or lack of gadgets for learning 12.1%; a higher education student does not accept distance learning 10% of respondents; 9.2% of respondents noted that they were able to join distance learning partially or only for a certain period. Most of the higher education seekers who pointed out this problem lived in the Donetsk, Dnipropetrovsk, Kharkiv and Luhansk regions before the war; absence or partial distance learning happened to 2.5% of respondents, who for a certain period, namely at the beginning of the war, should not have been able to join the training at all; 2.0% faced the problem of studying during their stay abroad.
 Analyzing the transformational changes that have occurred in our state, one can safely say that the social and medical conditions in which the society found itself have caused many problems in the field of medical education. There is an urgent need to solve the strategy, content, structure, methods of teaching, education and formation of views.