INTRODUCTION: The recent paradigm shift of the treatment of Crohn's disease (CD) and the ability of capsule endoscopy (CE) to detect early lesions in the small bowel has highlighted its importance in CD. AIMS & METHODS: Classify inflammatory activity and evaluate the correlation of demographics, clinical parameters, biomarkers, and endoscopy with the Lewis score (LS) in each tertile in patients with CD submitted to CE. A transversal and multicentric study was carried out in which the LS was systematically determined in 87 CE of patients diagnosed with CD between 2003 and 2010. Laboratory workup was analyzed at the date of diagnosis and the date of CE, and endoscopic findings closest to the date of CE were registered. Correlations were calculated using the Pearson's test and stratified according to each tertile. RESULTS: Of the 87 patients included, 62% were female. According to the Montreal classification, most patients were diagnosed between the ages 17 and 40 years (A2, 74%), with ileo-colonic location (L3, 43%), and non-stricturing, non-penetrating phenotype (B1, 69%). During the first 6 months after diagnosis 61% of the patients required steroids, 16% were immunossupressed with azathioprine, and 6% needed anti-TNF therapy. Inflammatory activity was considered moderate/severe (LS>790) in 34% of patients. The frequency of involvement of the first 2 tertiles was 28% in patients with LS > 135. In the first tertilecorrelations were found between LS and sideropenia (p=0.001) and low levels of total serum proteins (p=0.004) at thedate of diagnosis, and serum albumin (p=0.039) and C-reactive protein levels at CE (p=0.033). There was a correlationbetween the LS and a high platelet count in the second tertile (p_diagnosis =790) in the first tertile was associated with lesions in the cecum and ascending colon (p=0.033), transverse colon (p=0.028), and rectum (p=0.002. CONCLUSION: The LS has a positive correlation with biomarkers and objectively characterizes small bowel involvement in CD. This is the first time that the LS was systematically evaluated and stratified according to the different tertiles in CD in which a correlation between the upper digestive tract disease and biomarkers and endoscopic findings was found, underlining the importance of CE in CD.