Abstract The asymmetric transfer reduction of prochiral ketones in homogeneous phase in the presence of H 4 Ru 4 (CO) 8 [(−)-DIOP] 2 as catalyst and secondary alcohols or indoline as hydrogen source is reported. Optical yields up to 9.8% were obtained at 120° C. The reduction of ketones with molecular hydrogen under pressure affords alcohols at a higher rate but in lower optical yields.