MAA1-O-01 Session Title: Temperature-related Short Term Health Effects Introduction: During the next century, the frequency of temperature extremes, which have been related to increased mortality, is predicted to change. The impact of those changes on public health will be partly determined by our ability to adapt. We aimed to assess in a large sample of cities the increase in daily mortality associated with temperature extremes and to explore the influence of acclimatization. Methods: We conducted a case-crossover study in 50 U.S. cities during the period of 1989–2000. We used hourly weather data and daily mortality data corresponding to 7,531,120 deaths. We selected control days every 3 days within the same month of the same year. Exposure to extreme temperatures was assessed using city-specific indicator variables for extreme cold (≤1st percentile of daily maximum temperature) and extreme heat (≥99th percentile of daily minimum temperature). As a sensitivity analysis, we also assessed the effect of temperature using a piecewise linear variable. In a meta-analysis based on the city-specific conditional logistic regression models, several city characteristics were evaluated as effect modifiers. Results: We observed significant increases in total mortality associated with extreme cold (2-day cumulative change = 1.58%; 95% confidence interval [95% CI] = 0.61–2.56) and especially to extreme heat (5.68%; 3.47–7.89). The increase in mortality occurred mainly at lag 1 for cold and both at lag 0 and lag 1 for heat. Low-educated persons were particularly susceptible to heat, with an additional increase in mortality (lag 0) of 2.55% (95% CI = 0.69–4.41) when compared with those who were highly educated. The heat effects decreased with increasing percentage of air conditioning and mean summer apparent temperature and increased with population density. Subsequent analyses of cause-specific mortality showed a noticeably large increase in cardiac arrest deaths on extremely cold days (2-day cumulative change 14.85%; 95% CI = 5.15–24.55). Most results were similar when exposure was assessed using a piecewise linear temperature variable. For cardiac arrest mortality, the latter analyses showed some indications of a greater impact of cold temperatures in cities with milder winters. Discussion and Conclusions: The study confirmed, in a larger sample of cities than had been previously examined, that temperature extremes are associated with increases in daily mortality. We also found evidence of population acclimatization, especially to heat, which should be taken into account when assessing the public health impact of global warming.
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