Large-diameter pipe piles are widely applied in various civil engineering fields due to their outstanding load-bearing capability. The unsaturated characteristics, anisotropy, and heterogeneity of the soil jointly affect the dynamic response of the pipe pile. However, most previous studies were limited to single-phase or two-phase soil. This paper develops an analytical model for the torsional vibration of a pipe pile in transversely isotropic unsaturated soils considering construction disturbance. Based on transversely isotropic unsaturated soil theory, a pipe pile-soil interaction model has been developed, while the effect of construction disturbance is simulated by the radial heterogeneity of the soil. The general solution for the unsaturated soil is obtained using the separation of variables method with the boundary conditions. Then, the solution for the whole pipe pile-soil system is derived by considering the pile-soil interface conditions. The accuracy of the proposed solution is verified through comparisons with previous research results. The results show that unsaturated characteristics, construction disturbance, and transverse isotropy of the soil have significant effects on the impedance of large-diameter pipe piles. Specifically, with a low degree of saturation, there will be significant prediction errors when using previous works based on single-phase or two-phase soil theory to predict the dynamic response of large-diameter pipe piles.